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Journal of Education, Health and Sport

Features of liver structural organization in posttraumatic stress disorder
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  3. Vol. 70 (2024) /
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Features of liver structural organization in posttraumatic stress disorder

Authors

  • Sofiia Chorniy I.Horbachevsky Ternopil National Medical University https://orcid.org/0000-0003-2718-5191
  • Olga Denefil I. Horbachevsky Ternopil National Medical University https://orcid.org/0000-0002-3606-5215
  • Viktoriia Miroshnyk I.Horbachevsky Ternopil National Medical University https://orcid.org/0009-0001-9195-9537

DOI:

https://doi.org/10.12775/JEHS.2024.70.55689

Keywords

posttraumatic stress disorder, morphological changes, hepatocytes, dystrophy, hepatobiliary system, stress, hemodynamic disorders, rats, hypothalamus-pituitary-adrenal axis

Abstract

Posttraumatic stress disorder (PTSD) is a severe psychological condition resulting from traumatic experiences, leading to long-term physiological changes in the body. It affects mental health and induces hormonal imbalances that disrupt the hypothalamus-pituitary-adrenal axis, influencing multiple organ systems. While PTSD is often linked with comorbid conditions like depression and anxiety, its effects on the hepatobiliary system are less understood.

Aim. This study aimed to assess PTSD's impact on liver morphology in rats of different sexes and compare the severity of changes between males and females, contributing to the understanding of stress-related physiological effects.

Materials and Methods. The experiment involved 40 Wistar rats, divided into control and PTSD-induced groups for both sexes. A validated stress induction protocol was used, followed by a thorough morphological analysis of liver specimens fixed in 10% formalin and stained with hematoxylin-eosin. Histopathological evaluation focused on liver architecture, hepatocyte condition, vascular integrity, and cellular organization.

Results. Control animals displayed standard liver structure, while PTSD-induced groups exhibited significant morphological changes, such as dystrophic alterations in hepatocytes, congestion in hepatic veins, and the formation of blood clots. Female rats showed more pronounced changes than males, including hepatocyte swelling and vacuolization, indicating heightened cellular stress and reduced regenerative capacity.

Conclusions. The findings highlight that PTSD-related liver changes were more significant in female rats, emphasizing the importance of considering gender differences in stress-related disorders. These alterations suggest a complex interaction between chronic psychological stress and liver physiology, warranting further research on mechanisms by which PTSD affects the hepatobiliary system and potential therapeutic interventions. for at-risk populations.

Author Biographies

Sofiia Chorniy, I.Horbachevsky Ternopil National Medical University

Student of Medical faculty of I.Horbachevsky Ternopil National Medical University

Olga Denefil, I. Horbachevsky Ternopil National Medical University

DMS, professor, Pathological  Physiology  Department

References

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Published

2024-10-25

How to Cite

1.
CHORNIY, Sofiia, DENEFIL, Olga and MIROSHNYK , Viktoriia. Features of liver structural organization in posttraumatic stress disorder. Journal of Education, Health and Sport. Online. 25 October 2024. Vol. 70, p. 55689. [Accessed 7 July 2025]. DOI 10.12775/JEHS.2024.70.55689.
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Issue

Vol. 70 (2024)

Section

Medical Sciences

License

Copyright (c) 2024 Sofiia Chorniy, Olga Denefil, Viktoriia Miroshnyk

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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