Therapeutic potential of curcuminoids in the treatment of selected autoimmune diseases
DOI:
https://doi.org/10.12775/JEHS.2024.67.55013Keywords
autoimmune diseases, curcumin, immunomodulatory effects, turmericAbstract
Introduction
The cause of autoimmune diseases is often unknown. Continuous research into the mechanism of these diseases allows us to discover new metabolic pathways, and thus new potential drugs that may become promising therapeutic tools in the future. Alternative methods of treatment are increasingly used when standard therapy does not bring the intended effects. One of the alternative methods of treatment is turmeric contained in Curcuma longa L.
Aim of the study
The aim of this article was to present the extremely promising potential of turmeric in the treatment of autoimmune diseases.
Materials and methods
The article is the result of a review of recent scientific literature using PubMed, Scopus and Google Scholar databases. The literature was reviewed using the keywords.
Results
In recent years, research on turmeric has accelerated significantly. Due to the insufficient effects of therapy achieved with standard methods of treatment, researchers want to find a new agent to fight serious diseases. Currently available medical literature has confirmed the beneficial effects of turmeric on inflammation in the body. The very mild side effect profile is also worth noting.
Conclusions
The anti-inflammatory effect obtained after the administration of appropriate doses of turmeric requires further research before it can be registered as one of the preparations for the treatment of autoimmune diseases. However, this topic is very interesting, and the substance itself is very interesting in the context of future disease therapy.
References
Terlikowska K, Witkowska A, Terlikowski S. Kurkumina w chemoprewencji raka piersi. Postępy Hig Med Dośw. 2014;68:571–578. DOI https://doi.org/10.5604/17322693.1102294.
Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The Essential Medicinal Chemistry of Curcumin. J. Med. Chem. 2017;60(5):1620–1637. DOI https://doi.org/10.1021/acs.jmedchem.6b00975.
Kuźmińska J, Sobczak A, Wierzchowski M, Goslinski T. Historia i chemia kurkuminy. Farmacja Współcz. 2021;14:140–145.
Putowski M, Piróg M, Padała O, Piecewicz-Szczęsna H. and Zukow, W. Wybrane składniki diety w profilaktyce najczęściej występujących nowotworów w Polsce – przegląd aktualnych wyników badań = Selected components of the diet in the prevention of the most common cancers in Poland - overview of current research results. J. Educ. Health Sport. 2015;5(8):73–84.
Wang L, Wang FS, Gershwin ME. Human autoimmune diseases: a comprehensive update. J. Intern. Med. 2015;278(4):369–395. DOI https://doi.org/10.1111/joim.12395.
Jung SM, Kim WU. Targeted Immunotherapy for Autoimmune Disease. Immune Netw. 2022;22(1):e9. DOI https://doi.org/10.4110/in.2022.22.e9.
Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H. Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A Systematic Review and Meta-Analysis of 31 Randomized Controlled Trials. Front. Immunol. 2022;13:896476. DOI https://doi.org/10.3389/fimmu.2022.896476.
Liu Y, Wang X, Yang F, Zheng Y, Ye T, Yang L. Immunomodulatory Role and Therapeutic Potential of Non-Coding RNAs Mediated by Dendritic Cells in Autoimmune and Immune Tolerance-Related Diseases. Front. Immunol. 2021;12:678918. DOI https://doi.org/10.3389/fimmu.2021.678918.
Mollazadeh H, Cicero AFG, Blesso CN, Pirro M, Majeed M, Sahebkar A. Immune modulation by curcumin: The role of interleukin-10. Crit Rev Food Sci Nutr. 2019;59(1):89–101. DOI https://doi.org/10.1080/10408398.2017.1358139.
Decoté-Ricardo D, Chagas KK, Rocha JD. Modulation of in vitro murine B-lymphocyte response by curcumin. Phytomedicine. 2009;16(10):982–988. DOI https://doi.org/10.1016/j.phymed.2009.01.004.
Sharma S, Chopra K, Kulkarni SK, Agrewala JN. Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway. Clin. Exp. Immunol. 2007;147(1):155–163. DOI https://doi.org/10.1111/j.1365-2249.2006.03257.x.
Yasunaga M. Antibody therapeutics and immunoregulation in cancer and autoimmune disease. Semin. Cancer Biol. 2020;64:1–12. DOI https://doi.org/10.1016/j.semcancer.2019.06.001.
Soleimani V, Sahebkar A, Hosseinzadeh H. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytother Res. 2018;32(6):985–995. DOI https://doi.org/10.1002/ptr.6054.
Jura-Półtorak A, Olczyk K. Aktualne poglądy na etiopatogenezę reumatoidalnego zapalenia stawów. AAMS. 2011;65(4):51–57.
Kontny E. Patogeneza reumatoidalnego zapalenia stawów. Część III–cytokiny i procesy destrukcyjne. Reumatologia. 2011;49(3):180–186.
van Riel PL, Renskers L. The Disease Activity Score (DAS) and the Disease Activity Score using 28 joint counts (DAS28) in the management of rheumatoid arthritis. Clin. Exp. Rheumatol. 2016;34(5):40–44.
Long Z, Xiang W, He Q, Xiao W, Wei H, Li H, Guo H, Chen Y, Yuan M, Yuan X, Zeng L, Yang K, Deng Y, Huang Z. Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials. Front. Immunol. 2023;14:1024120. DOI https://doi.org/10.3389/fimmu.2023.1024120.
Cotsapas C, Mitrovic M, Hafler D. Multiple sclerosis. Handb. Clin. Neurol. 2018;148:723–730. DOI https://doi.org/10.1016/B978-0-444-64076-5.00046-6.
Wiśniewska, K, Ostańska A, Szafran A, Terelak W, Ciechański M, Witkowska E, Piasek L., Godek G, Więcław K, Stańko K. (). Multiple sclerosis - A review of recent advances in diagnostics and treatments. Quality in Sport. 2023;14:57–64. https://doi.org/10.12775/QS.2023.14.01.004.
Smith JA. Update on ankylosing spondylitis: current concepts in pathogenesis. Curr. Allergy Clin. Immunol. 2015;15(1):489. DOI https://doi.org/10.1007/s11882-014-0489-6.
Kiriakidou M, Ching CL. Systemic Lupus Erythematosus. Ann. Intern. Med. 2020;172(11):81–96. DOI https://doi.org/10.7326/AITC202006020.
Uribe AG, Vilá LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcón GS. The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. J. Rheumatol. 2004;31(10):1934–1940.
Vollono L, Falconi M, Gaziano R, Iacovelli F, Dika E, Terracciano C, Bianchi L, Campione E. Potential of Curcumin in Skin Disorders. Nutrients. 2019;11(9):2169. DOI https://doi.org/10.3390/nu11092169.
Pompili M, Bonanni L, Gualtieri F, Trovini G, Persechino S, Baldessarini RJ. Suicidal risks with psoriasis and atopic dermatitis: Systematic review and meta-analysis. J. Psychosom. Res. 2021;141:110347. DOI https://doi.org/10.1016/j.jpsychores.2020.110347.
Mattei PL, Corey KC, Kimball AB. Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI): the correlation between disease severity and psychological burden in patients treated with biological therapies. J. Eur. Acad. Dermatol. Venereol. 2014;28(3):333–337. DOI https://doi.org/10.1111/jdv.12106.
Tokuyama M, Mabuchi T. New Treatment Addressing the Pathogenesis of Psoriasis. Int. J. Mol. Sci. 2020;21(20):7488. DOI https://doi.org/10.3390/ijms21207488.
Reddy S, Aggarwal BB. Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase. FEBS Lett. 1994;341(1):19–22. DOI https://doi.org/10.1016/0014-5793(94)80232-7.
Varma SR, Sivaprakasam TO, Mishra A, Prabhu S, M R, P R. Imiquimod-induced psoriasis-like inflammation in differentiated Human keratinocytes: Its evaluation using curcumin. Eur. J. Pharmacol. 2017;813:33–41. DOI https://doi.org/10.1016/j.ejphar.2017.07.040.
Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195–218. DOI https://doi.org/10.1208/s12248-012-9432-8.
Rahimnia AR, Panahi Y, Alishiri G, Sharafi M, Sahebkar A. Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial. Drug Res. 2015;65(10):521–525. DOI https://doi.org/10.1055/s-0034-1384536.
Lukefahr AL, McEvoy S, Alfafara C, Funk JL. Drug-induced autoimmune hepatitis associated with turmeric dietary supplement use. BMJ Case Rep. 2018;2018:bcr2018224611. DOI https://doi.org/10.1136/bcr-2018-224611.
Shuhtin VV, Sknar VN, Shuhtina IN, Zukow W. The role of the level of biochemical markers of inflammation and protective systems of the organism in blood serum and in seminal fluid in patients with chronic prostatitis. Pedagogy and Psychology of Sport. 2016;2(2):11–17. https://doi.org/10.12775/PPS.2015.02.02.001
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