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Journal of Education, Health and Sport

Dysbiotic aspects of pathogenesis and antidysbiotic prophylactics of experimental nephropathy
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Dysbiotic aspects of pathogenesis and antidysbiotic prophylactics of experimental nephropathy

Authors

  • A. P. Levitsky State Establishment «The Institute of Stomatology and Maxillo-Facial Surgery of the National Academy of Medical Science of Ukraine
  • A. I. Gozhenko SE «Institute of Transport Medicine MZU of Ukraine»
  • V. T. Stepan Bukovina State Medical University
  • M. F. Jarynich Bukovina State Medical University

Keywords

kidney, nephropathy, dysbiosis, inflammation, lysozyme, antidysbiotic means

Abstract

The aim:  To determine the role of dysbiosis in pathogenesis and antidysbiotic prophylactics of experimental nephropathy.

The materials and methods:  Pathogens, which were used: hydrazine sulfate, cyclophosphan, prednisolone, lincomycin, lipopolysaccharide. Antidysbiotic means, which were used: quertulin, quertulin-gel, lequin, lecasil, Biotrit-gel, grapes-gel. Nephropathy was made into rats by the pathogens introduction. The activity of lysozyme, elastase, urease and content of malonic dialdehide were determined into kidneys. The degree of dysbiosis were determined by ration of urease activity to activity of lysozyme.

The findings: The whole of pathogens were raised the activity of elastase, urease and content of malonic dialdehide but were lowered the activity of lysozyme into kidney. The antidysbiotic means were raised the activity lysozyme, but were lowered the activity elastase, urease the content of malonic dialdehide and the degree of dysbiosis. Lipopolysaccharide was more active than the rest of pathogens.

The conclusion: The must force pathogen for kidney is lipopolysaccharide particular by oral application. The dysbiosis is important in the nephropathy pathogenesis. The antidysbiotic means have nephroprotective action.

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Published

2017-06-30

How to Cite

1.
LEVITSKY, A. P., GOZHENKO, A. I., STEPAN, V. T. & JARYNICH, M. F. Dysbiotic aspects of pathogenesis and antidysbiotic prophylactics of experimental nephropathy. Journal of Education, Health and Sport [online]. 30 June 2017, T. 7, nr 6, s. 1123–1136. [accessed 30.3.2023].
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Issue

Vol. 7 No. 6 (2017)

Section

Research Articles

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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