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Journal of Education, Health and Sport

Prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditis
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  • Prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditis
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Prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditis

Authors

  • M. I. Sheremet Department of Higher Education of Ukraine "Bukovina State Medical University"
  • V. O. Shidlovsky Department of Higher Education of Ukraine "Ternopil State Medical University"
  • L. P. Sidorchuk Department of Higher Education of Ukraine "Bukovina State Medical University"

Keywords

autoimmune thyroiditis, apoptosis, anneksin V test, CD95, TNF-α, INF-γ, complex treatment.

Abstract

This article presents results of apoptosis detection among blood lymphocytes from the patients with autoimmune thyroiditis (AIT) at euthyroid and hypothyroid conditions. Contents of CD95+, annexin V-presenting (apoptotic) cells and TNF-α in blood were analyzed. It was shown, that altered regulation of programmed lymphocyte death in autoimmune thyroid disorders is demonstrated by increased content of TNF-α, INF-γ and CD95+ lymphocytes, being accompanied by decreased numbers of apoptotic cells in blood. After the complex treatment, positive dynamics of the disturbed parameters of the immune status was noted, first of all, the normalization of the disturbed balance of the subpopulation of apoptotic T-lymphocytes and antibodies to thyroglobulin and thyroid peroxidase, decrease in the content of cytokines, and returning to the limit of normal values of thyroid hormones levels. The application of the proposed therapeutic tactics and the diagnostic and treatment complex allowed to reduce the probability of progression of autoimmune and oxidative processes in the thyroid residue (by 79.3%), to exclude the probability of the development of relapses of the nodal goiter on the background of autoimmune thyroiditis.

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Published

2017-07-31

How to Cite

1.
SHEREMET, M. I., SHIDLOVSKY, V. O. and SIDORCHUK, L. P. Prevention of complications in remote period after operational treatment of patients with nodular goiter on background autoimmune thyroiditis. Journal of Education, Health and Sport. Online. 31 July 2017. Vol. 7, no. 7, pp. 1270-1284. [Accessed 18 May 2025].
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Issue

Vol. 7 No. 7 (2017)

Section

Research Articles

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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autoimmune thyroiditis, apoptosis, anneksin V test, CD95, TNF-α, INF-γ, complex treatment.
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