Condition of pro-oxidant system in guinea pigs’ bronchi in experimental allergic alveolitis development and their correction with thiotriazolin
Keywordsexperimental allergic alveolitis, malonic dialdegyde, conjugated diens, thiotriazolin
Exogenic allergic alveolitis has been ascribed to multiple inhaled antigens found in a large variety of environmental settings. The immune mechanisms leading to this deases development are still incompletely understood. Initially, believed to be a classes III and IV immune response, we now have a clearer understanding of the complex inflammatory events involved. These include the release of pro inflammatory cytokines and a decrease in the immune control mechanisms via surfactant, dendritic and T-regulatory cells. Free radicals and reactive oxygen species could play a major role in the pathophysiology of allergic alveolitis . Despite the improved understanding, the treatment and outcome of this pathology have not known enough. This work determinate on accumulation of lipid peroxidaton products in the animals` bronchi during experimental allergic alveolitis and corrective effect of antioxidant-thiotriazolin on these indicators.
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