Physical Activity as a Trigger for Anaphylaxis: Understanding Food-Dependent Exercise-Induced Anaphylaxis
DOI:
https://doi.org/10.12775/JEHS.2024.74.52562Keywords
food-dependent exercise induced anaphylaxis, exercise induced-anaphylaxis, food allergies, pathogenesis of FDEIA, diagnosis of FDEIA, sport and anaphylaxisAbstract
Introduction:
Food-dependent exercise-induced anaphylaxis (FDEIA) is a distinctive form of anaphylaxis, a severe and potentially life-threatening allergic reaction, that is triggered by physical activity following the consumption of specific food allergens. Unique in its manifestation, FDEIA embodies a complex interaction between food intake and exercise, making it a condition of noteworthy concern particularly among athletes and active individuals.
Aim of the study:
This article endeavors to explore the multifaceted nature of food-dependent exercise-induced anaphylaxis, beginning with a foundational understanding of anaphylaxis and the specific dynamics involved in exercise-induced reactions.
Material and methods:
Literature available in the PubMed database was reviewed using the following keywords: food-dependent exercise induced anaphylaxis; exercise induced-anaphylaxis; food allergies; pathogenesis of FDEIA; diagnosis of FDEIA; sport and anaphylaxis.
Conclusions:
FDEIA is a unique and complex condition that requires a comprehensive understanding for effective management. By exploring its various aspects, from pathophysiology to diagnosis and treatment, we can better equip individuals with the knowledge and tools to navigate this condition and minimize the risk of potentially life-threatening reactions.
References
F. E. R. Simons et al., “International consensus on (ICON) anaphylaxis,” World Allergy Organ. J., vol. 7, no. 1, pp. 1–19, 2014, doi: 10.1186/1939-4551-7-9.
W. H. Organization, Brief overview of anaphylaxis as an adverse event following immunization (AEFI) and practical guidance on its identification, case management and response in a primary care setting. Geneva PP - Geneva: World Health Organization.
D. Fischer, T. K. Vander Leek, A. K. Ellis, and H. Kim, “Anaphylaxis,” Allergy, Asthma Clin. Immunol., vol. 14, no. 2, p. 54, 2018, doi: 10.1186/s13223-018-0283-4.
A. Muraro et al., “EAACI guidelines: Anaphylaxis (2021 update).,” Allergy, vol. 77, no. 2, pp. 357–377, Feb. 2022, doi: 10.1111/all.15032.
J. Ring et al., “Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update,” Allergo J. Int., vol. 30, no. 1, pp. 1–25, 2021, doi: 10.1007/s40629-020-00158-y.
A. M. Feldweg, “Exercise-Induced Anaphylaxis,” Immunol. Allergy Clin. North Am., vol. 35, no. 2, pp. 261–275, 2015, doi: https://doi.org/10.1016/j.iac.2015.01.005.
M. P. Giannetti, “Exercise-Induced Anaphylaxis: Literature Review and Recent Updates,” Curr. Allergy Asthma Rep., vol. 18, no. 12, p. 72, 2018, doi: 10.1007/s11882-018-0830-6.
N. Sayaca, “Exercise-Induced Anaphylaxis,” D. Kaya Utlu, Ed. Cham: Springer International Publishing, 2023, pp. 561–572.
R. A. Wood et al., “Anaphylaxis in America: the prevalence and characteristics of anaphylaxis in the United States.,” J. Allergy Clin. Immunol., vol. 133, no. 2, pp. 461–467, Feb. 2014, doi: 10.1016/j.jaci.2013.08.016.
G. Du Toit, “Food-dependent exercise-induced anaphylaxis in childhood,” Pediatr. Allergy Immunol., vol. 18, no. 5, pp. 455–463, Aug. 2007, doi: https://doi.org/10.1111/j.1399-3038.2007.00599.x.
Y. Aihara et al., “Frequency of food-dependent, exercise-induced anaphylaxis in Japanese junior-high-school students,” J. Allergy Clin. Immunol., vol. 108, no. 6, pp. 1035–1039, Dec. 2001, doi: 10.1067/mai.2001.119914.
M. C. Castells, R. F. Horan, and A. L. Sheffer, “Exercise-induced anaphylaxis,” Curr. Allergy Asthma Rep., vol. 3, no. 1, pp. 15–21, 2003, doi: 10.1007/s11882-003-0005-x.
J. P. Wade, M. H. Liang, and A. L. Sheffer, “Exercise-induced anaphylaxis: epidemiologic observations.,” Prog. Clin. Biol. Res., vol. 297, pp. 175–182, 1989.
C. W. Kim et al., “Combined effects of food and exercise on anaphylaxis.,” Nutr. Res. Pract., vol. 7, no. 5, pp. 347–351, Oct. 2013, doi: 10.4162/nrp.2013.7.5.347.
C. Povesi Dascola and C. Caffarelli, “Exercise-induced anaphylaxis: A clinical view.,” Ital. J. Pediatr., vol. 38, p. 43, Sep. 2012, doi: 10.1186/1824-7288-38-43.
D. Zogaj, A. Ibranji, and M. Hoxha, “Exercise-induced Anaphylaxis: the Role of Cofactors.,” Mater. Sociomed., vol. 26, no. 6, pp. 401–404, Dec. 2014, doi: 10.5455/msm.2014.26.401-404.
S. Miceli Sopo, M. Gelsomino, E. Del Vescovo, and G. Bersani, “Food Dependent Exercise-Induced Anaphylaxis in pediatric age. Can we trust the oral food challenge with exercise and acetylsalicylic acid?,” Acta Biomed., vol. 92, no. 1, p. e2021068, Dec. 2020, doi: 10.23750/abm.v92i1.10093.
M. Shin, “Food allergies and food-induced anaphylaxis: role of cofactors.,” Clin. Exp. Pediatr., vol. 64, no. 8, pp. 393–399, Aug. 2021, doi: 10.3345/cep.2020.01088.
W. Srisuwatchari, K. Kanchanaphoomi, J. Nawiboonwong, T. Thongngarm, and M. Sompornrattanaphan, “Food-Dependent Exercise-Induced Anaphylaxis: A Distinct Form of Food Allergy-An Updated Review of Diagnostic Approaches and Treatments.,” Foods (Basel, Switzerland), vol. 12, no. 20, Oct. 2023, doi: 10.3390/foods12203768.
W. Barg, W. Medrala, and A. Wolanczyk-Medrala, “Exercise-induced anaphylaxis: an update on diagnosis and treatment.,” Curr. Allergy Asthma Rep., vol. 11, no. 1, pp. 45–51, Feb. 2011, doi: 10.1007/s11882-010-0150-y.
B. I. Nwaru, S. Dhami, and A. Sheikh, “Idiopathic Anaphylaxis.,” Curr. Treat. options allergy, vol. 4, no. 3, pp. 312–319, 2017, doi: 10.1007/s40521-017-0136-2.
C. R. Weiler, “Mast Cell Activation Syndrome: Tools for Diagnosis and Differential Diagnosis.,” J. allergy Clin. Immunol. Pract., vol. 8, no. 2, pp. 498–506, Feb. 2020, doi: 10.1016/j.jaip.2019.08.022.
S. Longo, J. M. Legramante, S. Rizza, and M. Federici, “Vasovagal syncope: An overview of pathophysiological mechanisms.,” Eur. J. Intern. Med., vol. 112, pp. 6–14, Jun. 2023, doi: 10.1016/j.ejim.2023.03.025.
S. Vaina et al., “Anaphylactic cardiovascular collapse manifesting as myocardial infarction following salad consumption. A case of Kounis variant type I syndrome.,” Acta Biomed., vol. 91, no. 1, pp. 134–138, Mar. 2020, doi: 10.23750/abm.v91i1.8176.
C. R. Hildebrand K, Przybyłowski T, Maskey-Warzęchowska M, “Przydatność wybranych testów w rozpoznawaniu powysiłkowego skurczu oskrzeli [Usefulness of selected tests in the diagnosis of exercise induced bronchoconstriction],” Pneumonol. Alergol. Pol., vol. 79, no. 6, pp. 397–406, 2011.
C. D. Friesen and R. J. M. Engler, “Recurrent Panic/Anxiety Attacks: Masquerader of Anaphylaxis and Challenge to Comprehensive History Taking,” J. Allergy Clin. Immunol., vol. 119, no. 1, p. S34, Jan. 2007, doi: 10.1016/j.jaci.2006.11.152.
R. Gauer and B. K. Meyers, “Heat-Related Illnesses.,” Am. Fam. Physician, vol. 99, no. 8, pp. 482–489, Apr. 2019.
S. Bhivgade, S. Melkote, S. Ghate, and H. R. Jerajani, “Hereditary angioedema: not an allergy.,” Indian J. Dermatol., vol. 57, no. 6, p. 503, Nov. 2012, doi: 10.4103/0019-5154.103081.
T. E. Dribin, M. S. Motosue, and R. L. Campbell, “Overview of Allergy and Anaphylaxis.,” Emerg. Med. Clin. North Am., vol. 40, no. 1, pp. 1–17, Feb. 2022, doi: 10.1016/j.emc.2021.08.007.
B. Minty, “Food-dependent exercise-induced anaphylaxis.,” Can. Fam. Physician, vol. 63, no. 1, pp. 42–43, Jan. 2017.
A. F. Whyte, J. Soar, A. Dodd, A. Hughes, N. Sargant, and P. J. Turner, “Emergency treatment of anaphylaxis: concise clinical guidance.,” Clin. Med., vol. 22, no. 4, pp. 332–339, Jul. 2022, doi: 10.7861/clinmed.2022-0073.
K. M. Järvinen and J. Celestin, “Anaphylaxis avoidance and management: educating patients and their caregivers.,” J. Asthma Allergy, vol. 7, pp. 95–104, 2014, doi: 10.2147/JAA.S48611.
J. H. Choi, H. B. Lee, I. S. Ahn, C. W. Park, and C. H. Lee, “Wheat-dependent, Exercise-induced Anaphylaxis: A Successful Case of Prevention with Ketotifen.,” Annals of dermatology, vol. 21, no. 2. Korea (South), pp. 203–205, May 2009, doi: 10.5021/ad.2009.21.2.203.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Kamila Szewczyk, Bartłomiej Szewczyk, Weronika Hołownia, Paulina Pytel, Wiktoria Julia Krzesłowska, Szymon Wiśniewski
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 349
Number of citations: 0
