The Hidden Health Crisis: Microplastics and Their Medical Consequences
DOI:
https://doi.org/10.12775/JEHS.2024.72.51690Keywords
Microplastics, Enviromental Exposure, Toxicity TestsAbstract
Introduction and Purpose: Microplastics, ubiquitous environmental contaminants, are increasingly recognized for their potential to impact human health. This review aims to consolidate existing knowledge on the pathways through which microplastics interact with biological systems and to elucidate their health implications.
State of Knowledge: Microplastics are pervasive in various environments, from aquatic to terrestrial ecosystems, and they eventually enter the human body via ingestion, inhalation, or dermal absorption. Studies have suggested that microplastics carry toxic substances, such as heavy metals and organic pollutants, which are known endocrine disruptors and carcinogens. Additionally, the physical presence of microplastics has been linked to inflammation and other negative health outcomes. Research in this field is complex and interdisciplinary, involving toxicology, environmental science, and public health disciplines.
Summary: The presence of microplastics in the human body is concerning, and there is a clear need for further research to understand the extent of health risks associated with chronic exposure. Public health strategies should include both reducing microplastic pollution and strengthening regulations on plastic waste. Meanwhile, medical professionals should consider the potential for microplastic exposure when diagnosing and treating chronic conditions. Future research should aim to clarify the mechanisms of toxicity and establish safe levels of exposure, with a multidisciplinary approach being essential for comprehensive understanding and effective intervention.
References
Global Plastics Outlook. OECD; 2022. doi:10.1787/de747aef-en
Arthur C, Baker J, Bamford H (eds. ). Proceedings of the International Research Workshop on the Occurrence, Effects and Fate of Microplastic Marine Debris.; 2009.
Ghosh S, Sinha JK, Ghosh S, Vashisth K, Han S, Bhaskar R. Microplastics as an Emerging Threat to the Global Environment and Human Health. Sustainability. 2023;15(14):10821. doi:10.3390/su151410821
Karbalaei S, Hanachi P, Walker TR, Cole M. Occurrence, sources, human health impacts and mitigation of microplastic pollution. Environmental Science and Pollution Research. 2018;25(36):36046-36063. doi:10.1007/s11356-018-3508-7
Cole M, Lindeque P, Halsband C, Galloway TS. Microplastics as contaminants in the marine environment: A review. Mar Pollut Bull. 2011;62(12):2588-2597. doi:10.1016/j.marpolbul.2011.09.025
Conkle JL, Báez Del Valle CD, Turner JW. Are We Underestimating Microplastic Contamination in Aquatic Environments? Environ Manage. 2018;61(1):1-8. doi:10.1007/s00267-017-0947-8
Ioakeimidis C, Fotopoulou KN, Karapanagioti HK, et al. The degradation potential of PET bottles in the marine environment: An ATR-FTIR based approach. Sci Rep. 2016;6(1):23501. doi:10.1038/srep23501
Burghardt TE, Pashkevich A, Babić D, Mosböck H, Babić D, Żakowska L. Microplastics and road markings: the role of glass beads and loss estimation. Transp Res D Transp Environ. 2022;102:103123. doi:10.1016/j.trd.2021.103123
Mason SA, Welch VG, Neratko J. Synthetic Polymer Contamination in Bottled Water. Front Chem. 2018;6. doi:10.3389/fchem.2018.00407
Zhou G, Wu Q, Tang P, et al. How many microplastics do we ingest when using disposable drink cups? J Hazard Mater. 2023;441:129982. doi:10.1016/j.jhazmat.2022.129982
Anderson AG, Grose J, Pahl S, Thompson RC, Wyles KJ. Microplastics in personal care products: Exploring perceptions of environmentalists, beauticians and students. Mar Pollut Bull. 2016;113(1-2):454-460. doi:10.1016/j.marpolbul.2016.10.048
De Falco F, Di Pace E, Cocca M, Avella M. The contribution of washing processes of synthetic clothes to microplastic pollution. Sci Rep. 2019;9(1):6633. doi:10.1038/s41598-019-43023-x
Derraik JGB. The pollution of the marine environment by plastic debris: a review. Mar Pollut Bull. 2002;44(9):842-852. doi:10.1016/S0025-326X(02)00220-5
Hussain KA, Romanova S, Okur I, et al. Assessing the Release of Microplastics and Nanoplastics from Plastic Containers and Reusable Food Pouches: Implications for Human Health. Environ Sci Technol. 2023;57(26):9782-9792. doi:10.1021/acs.est.3c01942
Gross L, Enck J. Confronting plastic pollution to protect environmental and public health. PLoS Biol. 2021;19(3):e3001131. doi:10.1371/journal.pbio.3001131
Enyoh CE, Devi A, Kadono H, Wang Q, Rabin MH. The Plastic Within: Microplastics Invading Human Organs and Bodily Fluids Systems. Environments. 2023;10(11):194. doi:10.3390/environments10110194
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. Published online March 29, 2021:n71. doi:10.1136/bmj.n71
Yin J, Ju Y, Qian H, et al. Nanoplastics and Microplastics May Be Damaging Our Livers. Toxics. 2022;10(10):586. doi:10.3390/toxics10100586
Molina E, Benedé S. Is There Evidence of Health Risks From Exposure to Micro- and Nanoplastics in Foods? Front Nutr. 2022;9. doi:10.3389/fnut.2022.910094
Schwarzfischer M, Rogler G. The Intestinal Barrier—Shielding the Body from Nano- and Microparticles in Our Diet. Metabolites. 2022;12(3):223. doi:10.3390/metabo12030223
Zhao B, Rehati P, Yang Z, Cai Z, Guo C, Li Y. The potential toxicity of microplastics on human health. Science of The Total Environment. 2024;912:168946. doi:10.1016/j.scitotenv.2023.168946
Ali N, Katsouli J, Marczylo EL, Gant TW, Wright S, Bernardino de la Serna J. The potential impacts of micro-and-nano plastics on various organ systems in humans. EBioMedicine. 2024;99:104901. doi:10.1016/j.ebiom.2023.104901
Aristizabal M, Jiménez‐Orrego K V., Caicedo‐León MD, et al. Microplastics in dermatology: Potential effects on skin homeostasis. J Cosmet Dermatol. 2024;23(3):766-772. doi:10.1111/jocd.16167
Rosellini M, Omer EA, Schulze A, et al. Impact of plastic-related compounds on the gene expression signature of HepG2 cells transfected with CYP3A4. Arch Toxicol. 2024;98(2):525-536. doi:10.1007/s00204-023-03648-4
Blackburn K, Green D. The potential effects of microplastics on human health: What is known and what is unknown. Ambio. 2022;51(3):518-530. doi:10.1007/s13280-021-01589-9
Cheng W, Li X, Zhou Y, et al. Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids. Science of The Total Environment. 2022;806:150328. doi:10.1016/j.scitotenv.2021.150328
Zhang D, Wu C, Liu Y, et al. Microplastics are detected in human gallstones and have the ability to form large cholesterol-microplastic heteroaggregates. J Hazard Mater. 2024;467:133631. doi:10.1016/j.jhazmat.2024.133631
Cao Y, Zhao Q, Jiang F, et al. Interactions between inhalable aged microplastics and lung surfactant: Potential pulmonary health risks. Environ Res. 2024;245:117803. doi:10.1016/j.envres.2023.117803
Martin-Folgar R, González-Caballero MC, Torres-Ruiz M, et al. Molecular effects of polystyrene nanoplastics on human neural stem cells. PLoS One. 2024;19(1):e0295816. doi:10.1371/journal.pone.0295816
Ma S, Xiao Y, Zhang X, et al. Dietary exposure to polystyrene microplastics exacerbates liver damage in fulminant hepatic failure via ROS production and neutrophil extracellular trap formation. Science of The Total Environment. 2024;907:167403. doi:10.1016/j.scitotenv.2023.167403
Xie P, Li P, Zhu X, et al. Hepatotoxic of polystyrene microplastics in aged mice: Focus on the role of gastrointestinal transformation and AMPK/FoxO pathway. Science of The Total Environment. 2024;917:170471. doi:10.1016/j.scitotenv.2024.170471
Sun R, Liu M, Xiong F, et al. Polystyrene micro- and nanoplastics induce gastric toxicity through ROS mediated oxidative stress and P62/Keap1/Nrf2 pathway. Science of The Total Environment. 2024;912:169228. doi:10.1016/j.scitotenv.2023.169228
Bonanomi M, Salmistraro N, Porro D, Pinsino A, Colangelo AM, Gaglio D. Polystyrene micro and nano-particles induce metabolic rewiring in normal human colon cells: A risk factor for human health. Chemosphere. 2022;303:134947. doi:10.1016/j.chemosphere.2022.134947
Chen Z, Li Y, Xia H, et al. Chronic exposure to polystyrene microplastics increased the chemosensitivity of normal human liver cells via ABC transporter inhibition. Science of The Total Environment. 2024;912:169050. doi:10.1016/j.scitotenv.2023.169050
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Jakub Roman, Daniel Gondko, Patrycja Dębiec, Nikodem Pietrzak
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 279
Number of citations: 0