Role of Contrast in Ultrasonography: significance, types, benefits, and limitations. A comprehensive review
DOI:
https://doi.org/10.12775/JEHS.2024.72.51114Keywords
ultrasound, contrast-enhanced ultrasonography, ultrasound contrast agents, UCAs, CEUS, diagnostic imagingAbstract
Contrast-enhanced ultrasonography (CEUS) has revolutionized diagnostic imaging by significantly improving the accuracy and capabilities of ultrasound technology. By utilizing contrast agents, CEUS offers enhanced visualization of blood flow, superior detection of vascular diseases, and delineation of pathological from healthy tissues. Real-time imaging capabilities afforded by CEUS have been shown to be instrumental in guiding interventions and assessing treatment efficacy, thereby contributing to personalized patient care and improved clinical outcomes. This document provides a comprehensive review of the current benefits, limitations, and future directions of contrast-enhanced ultrasonography. It acknowledges the potential for allergic reactions, the necessity for specialized training, high costs, and the occurrence of image artifacts as drawbacks, while also anticipating advancements in targeted agents and imaging techniques. Moreover, the document emphasizes the need for ongoing research to evaluate the long-term safety and efficacy of contrast agents and their impact across various medical disciplines. Despite the challenges, the integration of CEUS into clinical practice holds enormous potential to further refine diagnostic processes and enhance patient management.
References
Contreras-Ortiz SH, Chiu T, Fox MD. Ultrasound image enhancement: A review. Biomed Signal Process Control [Internet]. 2012 Apr; Available from: https://doi.org/10.1016/j.bspc.2012.02.002
Ultrasound Imaging. 2020 Apr; Available from: https://www.fda.gov/radiation-emitting-products/medical-imaging/ultrasound-imaging
Kavic MS. The Case for Ultrasound. 1997 Apr; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021265/
Čarovac A, Smajlović F, Junuzović D. Application of Ultrasound in Medicine. 2011 Apr;19(3):168. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564184/
Liu J, Wansaicheong G, Merton DA, Forsberg F, Goldberg BB. Contrast-enhanced Ultrasound Imaging: State of the Art. 2005 Apr; Available from: https://doi.org/10.1016/s0929-6441(09)60100-4
Maurer G. Contrast Echocardiography: Clinical Utility. Wiley [Internet]. 2000 Apr;17(s6). Available from: https://onlinelibrary.wiley.com/doi/10.1111/j.1540-8175.2000.tb01192.x
Paefgen V, Doleschel D, Kießling F. Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery. Front Pharmacol [Internet]. 2015 Apr;6. Available from: https://doi.org/10.3389/fphar.2015.00197
Feinstein SB, Cheirif J, ten Cate FJ, Silverman P, Heidenreich PA, Dick CD, et al. Safety and efficacy of a new transpulmonary ultrasound contrast agent: Initial multicenter clinical results. J Am Coll Cardiol [Internet]. 1990 Apr;16(2):316–24. Available from: https://doi.org/10.1016/0735-1097(90)90580-i
Kamaya A, Machtaler S, Sanjani SS, Nikoozadeh A, Sommer FG, Khuri‐Yakub BT, et al. New Technologies in Clinical Ultrasound. 2013 Apr; Available from: https://doi.org/10.1053/j.ro.2013.03.009
Huang S. Liposomes in ultrasonic drug and gene delivery. Adv Drug Deliv Rev [Internet]. 2008 Apr;60(10):1167–76. Available from: https://doi.org/10.1016/j.addr.2008.03.003
Zeng W, Yue X, Dai Z. Ultrasound contrast agents from microbubbles to biogenic gas vesicles. Medical review [Internet]. 2022 Apr;3(1):31–48. Available from: https://doi.org/10.1515/mr-2022-0020
Cosgrove DO. Ultrasound contrast agents: An overview. Eur J Radiol [Internet]. 2006 Apr; Available from: https://doi.org/10.1016/j.ejrad.2006.06.022
Claudon M, Cosgrove DO, Albrecht T, Bolondi L, Bosio M, Calliada F, et al. Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008. Ultraschall in der Medizin [Internet]. 2008 Apr;29(01):28–44. Available from: https://doi.org/10.1055/s-2007-963785
Wu W, Jing X, Xue G qin, Zhu X, Wang J, Du R qing, et al. A Multicenter Randomized Controlled Study of Contrast-enhanced US versus US-guided Biopsy of Focal Liver Lesions. Radiology [Internet]. 2022 Apr;305(3):721–8. Available from: https://doi.org/10.1148/radiol.212317
Kießling F, Fokong S, Bzyl J, Lederle W, Palmowski M. Recent advances in molecular, multimodal and theranostic ultrasound imaging. Adv Drug Deliv Rev [Internet]. 2014 Apr; Available from: https://doi.org/10.1016/j.addr.2013.11.013
Jang Y, Park J, Kim P, Park EJ, Sun H, Baek Y, et al. Development of exosome membrane materials-fused microbubbles for enhanced stability and efficient drug delivery of ultrasound contrast agent. Acta Pharm Sin B [Internet]. 2023 Apr;13(12):4983–98. Available from: https://doi.org/10.1016/j.apsb.2023.08.022
Ihnatsenka B, Boezaart AP. Ultrasound: Basic understanding and learning the language. 2010 Apr; Available from: https://doi.org/10.4103/0973-6042.76960
Demi L, van Sloun RR, Wijkstra H, Mischi M. Towards Dynamic Contrast Specific Ultrasound Tomography. Sci Rep [Internet]. 2016 Apr;6(1). Available from: https://doi.org/10.1038/srep34458
Staub D, Partovi S, Imfeld S, Uthoff H, Baldi T, Aschwanden M, et al. Novel applications of contrast-enhanced ultrasound imaging in vascular medicine. Hogrefe Verlag [Internet]. 2013 Apr;42(1):17–31. Available from: https://econtent.hogrefe.com/doi/10.1024/0301-1526/a000244
Cantisani V, Wilson SR. CEUS: Where are we in 2015? Elsevier BV [Internet]. 2015 Apr;84(9):1621–2. Available from: http://ejradiology.com/retrieve/pii/S0720048X15002752
Deftereos SP, Foutzitzi S, Skarentzos K, Aggelidou M, Οικονόμου Π, Kambouri K. Role of Contrast Enhanced Ultrasound (CEUS) in the Paediatric Population with Blunt Abdominal Trauma: A Prospective Study from a Single Center Experience for Paediatric Blunt Abdominal Trauma. PubMed [Internet]. 2022 Apr;17(1):44–51. Available from: https://pubmed.ncbi.nlm.nih.gov/35733753
McCarville MB. Contrast-enhanced sonography in pediatrics. Springer Science+Business Media [Internet]. 2011 Apr;41(S1):238–42. Available from: https://link.springer.com/article/10.1007/s00247-011-2005-7
2188: Incidental liver lesions: Role of ultrasound contrast agents. Available from: http://umbjournal.org/retrieve/pii/S0301562906005230
Contrast-enhanced ultrasound for characterizing renal masses. 2018 Apr; Available from: http://ejradiology.com/retrieve/pii/S0720048X18301785
Contrast-enhanced sonographic detection of vesicoureteral reflux in children: comparison with voiding cystourethrography. 2004 Apr; Available from: https://www.thieme-connect.de/DOI/DOI?10.1055/s-2004-813170
Luciano DE, Exacoustòs C, Luciano AA. Contrast Ultrasonography for Tubal Patency. J Minim Invasive Gynecol [Internet]. 2014 Apr;21(6):994–8. Available from: https://doi.org/10.1016/j.jmig.2014.05.017
Huang P. An Integrated Approach to Ultrasound Imaging in Medicine and Biology. 2020 Apr; Available from: https://doi.org/10.15212/bioi-2020-0036
Wilson SR, Burns PN. Microbubble-enhanced US in Body Imaging: What Role? Radiology [Internet]. 2010 Apr;257(1):24–39. Available from: https://doi.org/10.1148/radiol.10091210
Mikhail E, Ghaly J, Malik BH, Ghatol A. Anaphylaxis to Lumason Contrast agent in Echocardiography after Immune Sensitization: A Case Report and Literature Review. J Community Hosp Intern Med Perspect [Internet]. 2023 Apr;13(4). Available from: https://doi.org/10.55729/2000-9666.1207
Catalano O. Color Doppler and CEUS Artifacts. Springer eBooks [Internet]. 2021 Apr;43–52. Available from: https://doi.org/10.1007/978-3-030-60794-4_3
Campo I, Basile A, Derchi LE, Piccoli G, Cassetti P, Cova MA, et al. Tips and tricks for a correct interpretation of contrast-enhanced ultrasound. Radiol Med [Internet]. 2024 Apr;129(4):536–48. Available from: https://doi.org/10.1007/s11547-024-01784-0
Wilson SR, Greenbaum LD, Goldberg BB. Contrast-Enhanced Ultrasound: What Is the Evidence and What Are the Obstacles? American journal of roentgenology [Internet]. 2009 Apr;193(1):55–60. Available from: https://doi.org/10.2214/ajr.09.2553
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Copyright (c) 2024 Krzysztof Rosiak, Kamil Waloch, Zofia Uszok, Michał Łepik, Kacper Płeska, Kacper Reguła, Szymon Piaszczyński, Andrzej Czajka, Joanna Wojtania, Bartłomiej Szymański
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