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Journal of Education, Health and Sport

The importance of serotonin in the gastrointestinal tract
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The importance of serotonin in the gastrointestinal tract

Authors

  • Jarosław Koza Department of Gastroenterology and Nutrition Disorders, Nicolaus Copernicus University in Toruń, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz
  • Renata Kwiatkowska Department of Gastroenterology and Nutrition Disorders, Nicolaus Copernicus University in Toruń, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz
  • Adam Jurgoński Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn
  • Małgorzata Pujanek Department of Gastroenterology and Nutrition Disorders, Nicolaus Copernicus University in Toruń, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz
  • Monika Ameryk Department of Gastroenterology and Nutrition Disorders, Nicolaus Copernicus University in Toruń, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz
  • Piotr Sikorski Department of Gastroenterology and Nutrition Disorders, Nicolaus Copernicus University in Toruń, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz
  • Agnieszka Meder Department of Gastroenterology and Nutrition Disorders, Nicolaus Copernicus University in Toruń, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz
  • Maciej Świątkowski Department of Gastroenterology and Nutrition Disorders, Nicolaus Copernicus University in Toruń, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz

Keywords

serotonin, gastrointestinal tract

Abstract

Introduction. Serotonin also called as 5-hydroxytryptamine (5-HT) is a very important neurotransmitter in the central nervous system, also plays an important role in the gastrointestinal tract. It is known that the basis of the peristaltic reflex in the gut is the result of serotonin release from enterochromaffin cells. The vast majority of serotonin in the human body is associated with the gastrointestinal tract. It is produced by enterochromaffin cells, the activation of which causes the serotonin secretion into the intercellular space and its active action through the receptors. There are seven main types of serotonin receptors and some of them have also subtypes.
Description of the current knowledge and conclusions. Serotonin is responsible for some symptoms of carcinoid syndrome. It is the result of higher 5-hydroxytryptamine content in the body. Moreover disrupted serotonin system is found in different gastrointestinal disorders e.g. in gastroesophageal reflux disease, functional heartburn, hypersensitive esophagus, functional dyspepsia, irritable bowel syndrome (both diarrhoea predominant and constipation predominant) as well as in inflammatory bowel diseases. Knowledge of changed mechanisms in particular diseases facilitates the optimal choice of treatment. Drugs affecting the serotonin system in gastroenterological clinical practice are useful especially in the case of abnormalities in the brain - gut axis.

Author Biography

Jarosław Koza, Department of Gastroenterology and Nutrition Disorders, Nicolaus Copernicus University in Toruń, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz

Department of Gastroenterology and Nutrition Disorders

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Published

2017-12-12

How to Cite

1.
KOZA, Jarosław, KWIATKOWSKA, Renata, JURGOŃSKI, Adam, PUJANEK, Małgorzata, AMERYK, Monika, SIKORSKI, Piotr, MEDER, Agnieszka and ŚWIĄTKOWSKI, Maciej. The importance of serotonin in the gastrointestinal tract. Journal of Education, Health and Sport. Online. 12 December 2017. Vol. 7, no. 12, pp. 104-110. [Accessed 28 June 2025].
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Issue

Vol. 7 No. 12 (2017)

Section

Review Articles

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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