The Role of Mindfulness-Based Interventions in Treating Depression among Population Subgroups
DOI:
https://doi.org/10.12775/JEHS.2024.66.007Keywords
Mindfulness, Mindfulness-Based Cognitive Therapy, Mindfulness-Based Stress Reduction, depression, major depressive disorder (MDD)Abstract
Introduction
Major depressive disorder (MDD) is one of the most common psychiatric disorders, with its prevalence on the rise. The use of mindfulness-based interventions (MBIs), primarily including mindfulness-based cognitive therapy (MBCT) and mindfulness-based stress reduction (MBSR), in MDD is scientifically justified. But will every population subgroup benefit from such an approach?
Aim of the study
The aim of our study is to analyze, based on the latest scientific findings, the effects of MBIs within specific subgroups of patients suffering from depression, including adolescents, elderly patients, cancer patients, individuals experiencing postnatal and perinatal depression, and patients with chronic pain. Additionally, we sought to summarize the current knowledge regarding the structural and functional effects of MBIs on the human brain.
Materials and methods
We conducted a comprehensive search of scientific databases including PubMed and Google Scholar to identify relevant articles focusing on MBIs and their effects on treating depression within various subgroups. Additionally, we performed a review of literature available on PubMed and Google Scholar to summarize the current knowledge regarding the impact of MBIs on the human brain.
Conclusions
Across various subgroups MBIs show promise in reducing depressive symptoms, indicating their potential as adjunctive treatments or preventive measures. While longer intervention durations are associated with larger effects, further research is needed to establish a solid evidence base, particularly in older populations and cancer patients with different cancer types.
References
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fifth Edition. American Psychiatric Association; 2013. https://doi.org/10.1176/appi.books.9780890425596.
Ittasakul P, Thaipisuttikul P, Waleeprakhon P, Wisajun P, Jullagate S. Psychiatric comorbidities in patients with major depressive disorder. Neuropsychiatr Dis Treat 2014:2097. https://doi.org/10.2147/NDT.S72026.
Farmer A, Korszun A, Owen MJ, Craddock N, Jones L, Jones I, et al. Medical disorders in people with recurrent depression. Br J Psychiatry 2008;192:351–5. https://doi.org/10.1192/bjp.bp.107.038380.
Greenberg PE, Fournier A-A, Sisitsky T, Pike CT, Kessler RC. The Economic Burden of Adults With Major Depressive Disorder in the United States (2005 and 2010). J Clin Psychiatry 2015;76:155–62. https://doi.org/10.4088/JCP.14m09298.
Barth J, Munder T, Gerger H, Nüesch E, Trelle S, Znoj H, et al. Comparative Efficacy of Seven Psychotherapeutic Interventions for Patients with Depression: A Network Meta-Analysis. PLOS Med 2013;10:e1001454. https://doi.org/10.1371/journal.pmed.1001454.
Bishop SR, Lau M, Shapiro S, Carlson L, Anderson ND, Carmody J, et al. Mindfulness: A proposed operational definition. Clin Psychol Sci Pract 2004;11:230–41. https://doi.org/10.1093/clipsy.bph077.
Kabat-Zinn J. Mindfulness-based interventions in context: Past, present, and future. Clin Psychol Sci Pract 2003;10:144–56. https://doi.org/10.1093/clipsy.bpg016.
Borkovec TD. Life in the future versus life in the present. Clin Psychol Sci Pract 2002;9:76–80. https://doi.org/10.1093/clipsy.9.1.76.
Salmon P, Sephton S, Weissbecker I, Hoover K, Ulmer C, Studts JL. Mindfulness meditation in clinical practice. Cogn Behav Pract 2004;11:434–46. https://doi.org/10.1016/S1077-7229(04)80060-9.
Hofmann SG, Sawyer AT, Witt AA, Oh D. The Effect of Mindfulness-Based Therapy on Anxiety and Depression: A Meta-Analytic Review. J Consult Clin Psychol 2010;78:169–83. https://doi.org/10.1037/a0018555.
Teasdale JD, Segal ZV, Williams JM, Ridgeway VA, Soulsby JM, Lau MA. Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. J Consult Clin Psychol 2000;68:615–23. https://doi.org/10.1037//0022-006x.68.4.615.
Ma SH, Teasdale JD. Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects. J Consult Clin Psychol 2004;72:31–40. https://doi.org/10.1037/0022-006X.72.1.31.
Nyklíček I, Kuijpers KF. Effects of Mindfulness-Based Stress Reduction Intervention on Psychological Well-being and Quality of Life: Is Increased Mindfulness Indeed the Mechanism? Ann Behav Med Publ Soc Behav Med 2008;35:331–40. https://doi.org/10.1007/s12160-008-9030-2.
Shapiro SL, Carlson LE, Astin JA, Freedman B. Mechanisms of mindfulness. J Clin Psychol 2006;62:373–86. https://doi.org/10.1002/jclp.20237.
Jakobsen JC, Gluud C, Kirsch I. Should antidepressants be used for major depressive disorder? BMJ Evid-Based Med 2020;25:130. https://doi.org/10.1136/bmjebm-2019-111238.
Eustis EH, Ernst S, Sutton K, Battle CL. Innovations in the Treatment of Perinatal Depression: the Role of Yoga and Physical Activity Interventions During Pregnancy and Postpartum. Curr Psychiatry Rep 2019;21:133. https://doi.org/10.1007/s11920-019-1121-1.
Solem S, Hagen R, Wang CEA, Hjemdal O, Waterloo K, Eisemann M, et al. Metacognitions and Mindful Attention Awareness in Depression: A Comparison Of Currently Depressed, Previously Depressed and Never Depressed Individuals. Clin Psychol Psychother 2017;24:94–102. https://doi.org/10.1002/cpp.1983.
Geiger PJ, Boggero IA, Brake CA, Caldera CA, Combs HL, Peters JR, et al. Mindfulness-Based Interventions for Older Adults: A Review of the Effects on Physical and Emotional Well-being. Mindfulness 2016;7:296–307. https://doi.org/10.1007/s12671-015-0444-1.
Creswell JD, Irwin MR, Burklund LJ, Lieberman MD, Arevalo JMG, Ma J, et al. Mindfulness-Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. Brain Behav Immun 2012;26:1095–101. https://doi.org/10.1016/j.bbi.2012.07.006.
Khoury B, Sharma M, Rush SE, Fournier C. Mindfulness-based stress reduction for healthy individuals: A meta-analysis. J Psychosom Res 2015;78:519–28. https://doi.org/10.1016/j.jpsychores.2015.03.009.
Lustyk MKB, Chawla N, Nolan RS, Marlatt GA. Mindfulness meditation research: issues of participant screening, safety procedures, and researcher training. Adv Mind Body Med 2009;24:20–30.
Wong C, Yip BH-K, Gao T, Lam KYY, Woo DMS, Yip ALK, et al. Mindfulness-Based Stress Reduction (MBSR) or Psychoeducation for the Reduction of Menopausal Symptoms: A Randomized, Controlled Clinical Trial. Sci Rep 2018;8:6609. https://doi.org/10.1038/s41598-018-24945-4.
Tang Y-Y, Lu Q, Fan M, Yang Y, Posner MI. Mechanisms of white matter changes induced by meditation. Proc Natl Acad Sci 2012;109:10570–4. https://doi.org/10.1073/pnas.1207817109.
Taylor VA, Daneault V, Grant J, Scavone G, Breton E, Roffe-Vidal S, et al. Impact of meditation training on the default mode network during a restful state. Soc Cogn Affect Neurosci 2013;8:4–14. https://doi.org/10.1093/scan/nsr087.
Smith AM, Leeming A, Fang Z, Hatchard T, Mioduszewski O, Schneider MA, et al. Mindfulness-based stress reduction alters brain activity for breast cancer survivors with chronic neuropathic pain: preliminary evidence from resting-state fMRI. J Cancer Surviv 2021;15:518–25. https://doi.org/10.1007/s11764-020-00945-0.
Huang F-Y, Hsu A-L, Hsu L-M, Tsai J-S, Huang C-M, Chao Y-P, et al. Mindfulness Improves Emotion Regulation and Executive Control on Bereaved Individuals: An fMRI Study. Front Hum Neurosci 2019;12:541. https://doi.org/10.3389/fnhum.2018.00541.
Paul NA, Stanton SJ, Greeson JM, Smoski MJ, Wang L. Psychological and neural mechanisms of trait mindfulness in reducing depression vulnerability. Soc Cogn Affect Neurosci 2013;8:56–64. https://doi.org/10.1093/scan/nss070.
Aydın O, Tvrtkovic S, Çakıroğlu E, Ünal-Aydın P, Esen-Danacı A. The effect of emotion recognition and mindfulness on depression symptoms: A case-control study. Scand J Psychol 2023. https://doi.org/10.1111/sjop.12992.
Kang D-H, Jo HJ, Jung WH, Kim SH, Jung Y-H, Choi C-H, et al. The effect of meditation on brain structure: cortical thickness mapping and diffusion tensor imaging. Soc Cogn Affect Neurosci 2013;8:27–33. https://doi.org/10.1093/scan/nss056.
Yang C-C, Barrós-Loscertales A, Li M, Pinazo D, Borchardt V, Ávila C, et al. Alterations in Brain Structure and Amplitude of Low-frequency after 8 weeks of Mindfulness Meditation Training in Meditation-Naïve Subjects. Sci Rep 2019;9:10977. https://doi.org/10.1038/s41598-019-47470-4.
Kral TRA, Davis K, Korponay C, Hirshberg MJ, Hoel R, Tello LY, et al. Absence of structural brain changes from mindfulness-based stress reduction: Two combined randomized controlled trials. Sci Adv 2022;8:eabk3316. https://doi.org/10.1126/sciadv.abk3316.
Santarnecchi E, D’Arista S, Egiziano E, Gardi C, Petrosino R, Vatti G, et al. Interaction between Neuroanatomical and Psychological Changes after Mindfulness-Based Training. PLoS ONE 2014;9:e108359. https://doi.org/10.1371/journal.pone.0108359.
Naicker K, Galambos NL, Zeng Y, Senthilselvan A, Colman I. Social, Demographic, and Health Outcomes in the 10 Years Following Adolescent Depression. J Adolesc Health 2013;52:533–8. https://doi.org/10.1016/j.jadohealth.2012.12.016.
Quiroga CV, Janosz M, Bisset S, Morin AJS. Early adolescent depression symptoms and school dropout: Mediating processes involving self-reported academic competence and achievement. J Educ Psychol 2013;105:552–60. https://doi.org/10.1037/a0031524.
Verboom CE, Sijtsema JJ, Verhulst FC, Penninx BWJH, Ormel J. Longitudinal associations between depressive problems, academic performance, and social functioning in adolescent boys and girls. Dev Psychol 2014;50:247–57. https://doi.org/10.1037/a0032547.
Curry J, Silva S, Rohde P, Ginsburg G, Kennard B, Kratochvil C, et al. Onset of alcohol or substance use disorders following treatment for adolescent depression. J Consult Clin Psychol 2012;80:299–312. https://doi.org/10.1037/a0026929.
Tuisku V, Kiviruusu O, Pelkonen M, Karlsson L, Strandholm T, Marttunen M. Depressed adolescents as young adults - predictors of suicide attempt and non-suicidal self-injury during an 8-year follow-up. J Affect Disord 2014;152–154:313–9. https://doi.org/10.1016/j.jad.2013.09.031.
Zenner C, Herrnleben-Kurz S, Walach H. Mindfulness-based interventions in schools—a systematic review and meta-analysis. Front Psychol 2014;5. https://doi.org/10.3389/fpsyg.2014.00603.
Kallapiran K, Koo S, Kirubakaran R, Hancock K. Review: Effectiveness of mindfulness in improving mental health symptoms of children and adolescents: a meta‐analysis. Child Adolesc Ment Health 2015;20:182–94. https://doi.org/10.1111/camh.12113.
Chi X, Bo A, Liu T, Zhang P, Chi I. Effects of Mindfulness-Based Stress Reduction on Depression in Adolescents and Young Adults: A Systematic Review and Meta-Analysis. Front Psychol 2018;9:1034. https://doi.org/10.3389/fpsyg.2018.01034.
Burke CA. Mindfulness-Based Approaches with Children and Adolescents: A Preliminary Review of Current Research in an Emergent Field. J Child Fam Stud 2010;19:133–44. https://doi.org/10.1007/s10826-009-9282-x.
Virgili M. Mindfulness-Based Interventions Reduce Psychological Distress in Working Adults: a Meta-Analysis of Intervention Studies. Mindfulness 2015;6:326–37. https://doi.org/10.1007/s12671-013-0264-0.
Zoogman S, Goldberg SB, Hoyt WT, Miller L. Mindfulness Interventions with Youth: A Meta-Analysis. Mindfulness 2015;6:290–302. https://doi.org/10.1007/s12671-013-0260-4.
Khoury B, Lecomte T, Fortin G, Masse M, Therien P, Bouchard V, et al. Mindfulness-based therapy: a comprehensive meta-analysis. Clin Psychol Rev 2013;33:763–71. https://doi.org/10.1016/j.cpr.2013.05.005.
Carmody J, Baer RA, L B Lykins E, Olendzki N. An empirical study of the mechanisms of mindfulness in a mindfulness-based stress reduction program. J Clin Psychol 2009;65:613–26. https://doi.org/10.1002/jclp.20579.
Frazer CJ, Christensen H, Griffiths KM. Effectiveness of treatments for depression in older people. Med J Aust 2005;182:627–32. https://doi.org/10.5694/j.1326-5377.2005.tb06849.x.
Ho CS, Feng L, Fam J, Mahendran R, Kua EH, Ng TP. Coexisting medical comorbidity and depression: multiplicative effects on health outcomes in older adults. Int Psychogeriatr 2014;26:1221–9. https://doi.org/10.1017/S1041610214000611.
Martin M, Doswell S. Mindfulness and Older People: A Small Study. Br J Occup Ther 2012;75:36–41. https://doi.org/10.4276/030802212X13261082051454.
Gonçalves DC, Albuquerque PB, Byrne GJ, Pachana NA. Assessment of depression in aging contexts: General considerations when working with older adults. Prof Psychol Res Pract 2009;40:609–16. https://doi.org/10.1037/a0017305.
Thomas R, Chur-Hansen A, Turner M. A Systematic Review of Studies on the Use of Mindfulness-Based Cognitive Therapy for the Treatment of Anxiety and Depression in Older People. Mindfulness 2020;11:1599–609. https://doi.org/10.1007/s12671-020-01336-3.
Lindayani L, Hendra A, Juniarni L, Nurdina G. Effectiveness Of Mindfulness Based Stress Reduction On Depression In Elderly: A Systematic Review. J Nurs Pract 2020;4:8–12. https://doi.org/10.30994/jnp.v4i1.101.
Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin 2023;73:17–48. https://doi.org/10.3322/caac.21763.
Cao W, Chen H-D, Yu Y-W, Li N, Chen W-Q. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. Chin Med J (Engl) 2021;134:783–91. https://doi.org/10.1097/CM9.0000000000001474.
Deckx L, van den Akker M, Buntinx F. Risk factors for loneliness in patients with cancer: a systematic literature review and meta-analysis. Eur J Oncol Nurs Off J Eur Oncol Nurs Soc 2014;18:466–77. https://doi.org/10.1016/j.ejon.2014.05.002.
Pitman A, Suleman S, Hyde N, Hodgkiss A. Depression and anxiety in patients with cancer. BMJ 2018;361:k1415. https://doi.org/10.1136/bmj.k1415.
Rush SE, Sharma M. Mindfulness-Based Stress Reduction as a Stress Management Intervention for Cancer Care. J Evid-Based Complement Altern Med 2017;22:348–60. https://doi.org/10.1177/2156587216661467.
Li J, Li C, Puts M, Wu Y-C, Lyu M-M, Yuan B, et al. Effectiveness of mindfulness-based interventions on anxiety, depression, and fatigue in people with lung cancer: A systematic review and meta-analysis. Int J Nurs Stud 2023;140:104447. https://doi.org/10.1016/j.ijnurstu.2023.104447.
Reangsing C, Punsuwun S, Keller K. Effects of Mindfulness-Based Interventions on Depression in Patients With Breast Cancer: A Systematic Review and Meta-Analysis. Integr Cancer Ther 2023;22:15347354231220617. https://doi.org/10.1177/15347354231220617.
Piet J, Würtzen H, Zachariae R. The effect of mindfulness-based therapy on symptoms of anxiety and depression in adult cancer patients and survivors: A systematic review and meta-analysis. J Consult Clin Psychol 2012;80:1007–20. https://doi.org/10.1037/a0028329.
Zhang M-F, Wen Y-S, Liu W-Y, Peng L-F, Wu X-D, Liu Q-W. Effectiveness of Mindfulness-based Therapy for Reducing Anxiety and Depression in Patients With Cancer: A Meta-analysis. Medicine (Baltimore) 2015;94:e0897-0890. https://doi.org/10.1097/MD.0000000000000897.
Chayadi E, Baes N, Kiropoulos L. The effects of mindfulness-based interventions on symptoms of depression, anxiety, and cancer-related fatigue in oncology patients: A systematic review and meta-analysis. PLOS ONE 2022;17:e0269519. https://doi.org/10.1371/journal.pone.0269519.
Yu J, Han M, Miao F, Hua D. Using mindfulness-based stress reduction to relieve loneliness, anxiety, and depression in cancer patients: A systematic review and meta-analysis. Medicine (Baltimore) 2023;102:e34917. https://doi.org/10.1097/MD.0000000000034917.
Merkitch KG, Jonas KG, O’Hara MW. Modeling trait depression amplifies the effect of childbearing on postpartum depression. J Affect Disord 2017;223:69–75. https://doi.org/10.1016/j.jad.2017.07.017.
Vieten C, Astin J. Effects of a mindfulness-based intervention during pregnancy on prenatal stress and mood: results of a pilot study. Arch Womens Ment Health 2008;11:67–74. https://doi.org/10.1007/s00737-008-0214-3.
Woody CA, Ferrari AJ, Siskind DJ, Whiteford HA, Harris MG. A systematic review and meta-regression of the prevalence and incidence of perinatal depression. J Affect Disord 2017;219:86–92. https://doi.org/10.1016/j.jad.2017.05.003.
Leng LL, Yin XC, Ng SM. Mindfulness-based intervention for clinical and subthreshold perinatal depression and anxiety: A systematic review and meta-analysis of randomized controlled trial. Compr Psychiatry 2023;122:152375. https://doi.org/10.1016/j.comppsych.2023.152375.
Reangsing C, Punsuwun S, Oerther S. Effects of mindfulness-based interventions (MBIs) on depression in pregnant women: A systematic review and meta-analysis. J Affect Disord 2024;352:51–9. https://doi.org/10.1016/j.jad.2024.02.049.
Corbally L, Wilkinson M. The Effect of Mindfulness-Based Interventions on Stress, Depression and Anxiety During the Perinatal Period in Women Without Pre-existing Stress, Depressive or Anxiety Disorders: a Systematic Review and Meta-analysis of Controlled Trials. Mindfulness 2021;12:2357–70. https://doi.org/10.1007/s12671-021-01697-3.
Trapani S, Caglioni M, Villa G, Manara DF, Caruso R. Mindfulness-Based Interventions During Pregnancy and Long-Term Effects on Postpartum Depression and Maternal Mental Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Integr Complement Med 2024;30:107–20. https://doi.org/10.1089/jicm.2023.0114.
Yang M, Song B, Jiang Y, Lin Y, Liu J. Mindfulness-Based Interventions for Postpartum Depression: A Systematic Review and Meta-Analysis. Iran J Public Health 2023;52:2496–505. https://doi.org/10.18502/ijph.v52i12.14311.
Goldberg DS, McGee SJ. Pain as a global public health priority. BMC Public Health 2011;11:770. https://doi.org/10.1186/1471-2458-11-770.
Mäntyselkä P, Kumpusalo E, Ahonen R, Kumpusalo A, Kauhanen J, Viinamäki H, et al. Pain as a reason to visit the doctor: a study in Finnish primary health care. Pain 2001;89:175–80. https://doi.org/10.1016/s0304-3959(00)00361-4.
Perrot S, Cohen M, Barke A, Korwisi B, Rief W, Treede R-D, et al. The IASP classification of chronic pain for ICD-11: chronic secondary musculoskeletal pain. Pain 2019;160:77–82. https://doi.org/10.1097/j.pain.0000000000001389.
Bennett MI, Kaasa S, Barke A, Korwisi B, Rief W, Treede R-D, et al. The IASP classification of chronic pain for ICD-11: chronic cancer-related pain. Pain 2019;160:38–44. https://doi.org/10.1097/j.pain.0000000000001363.
Bondesson E, Larrosa Pardo F, Stigmar K, Ringqvist Å, Petersson IF, Jöud A, et al. Comorbidity between pain and mental illness - Evidence of a bidirectional relationship. Eur J Pain Lond Engl 2018;22:1304–11. https://doi.org/10.1002/ejp.1218.
Hooten WM. Chronic Pain and Mental Health Disorders: Shared Neural Mechanisms, Epidemiology, and Treatment. Mayo Clin Proc 2016;91:955–70. https://doi.org/10.1016/j.mayocp.2016.04.029.
Miniati M, Orrù G, Paroli M, Cinque M, Paolicchi A, Gemignani A, et al. Patients with Chronic Pain: Are Mindfulness Traits Protective Against Distress, Anxiety and Depression? Clin Neuropsychiatry 2023;20:429. https://doi.org/10.36131/cnfioritieditore20230505.
Poulin PA, Romanow HC, Rahbari N, Small R, Smyth CE, Hatchard T, et al. The relationship between mindfulness, pain intensity, pain catastrophizing, depression, and quality of life among cancer survivors living with chronic neuropathic pain. Support Care Cancer 2016;24:4167–75. https://doi.org/10.1007/s00520-016-3243-x.
Brooks JM, Iwanaga K, Cotton BP, Deiches J, Blake J, Chiu C, et al. Perceived Mindfulness and Depressive Symptoms Among People with Chronic Pain. J Rehabil 2018;84:33.
Marske C, Shah S, Chavira A, Hedberg C, Fullmer R, Clark CJ, et al. Mindfulness-Based Stress Reduction in the Management of Chronic Pain and Its Comorbid Depression. J Osteopath Med 2020;120:575–81. https://doi.org/10.7556/jaoa.2020.096.
de Jong M, Peeters F, Gard T, Ashih H, Doorley J, Walker R, et al. A Randomized Controlled Pilot Study on Mindfulness-Based Cognitive Therapy for Unipolar Depression in Patients With Chronic Pain. J Clin Psychiatry 2018;79:15m10160. https://doi.org/10.4088/JCP.15m10160.
de Jong M, Lazar SW, Hug K, Mehling WE, Hölzel BK, Sack AT, et al. Effects of Mindfulness-Based Cognitive Therapy on Body Awareness in Patients with Chronic Pain and Comorbid Depression. Front Psychol 2016;7:967. https://doi.org/10.3389/fpsyg.2016.00967.
Hearn JH, Finlay KA. Internet-delivered mindfulness for people with depression and chronic pain following spinal cord injury: a randomized, controlled feasibility trial. Spinal Cord 2018;56:750–61. https://doi.org/10.1038/s41393-018-0090-2.
Veehof MM, Trompetter HR, Bohlmeijer ET, Schreurs KMG. Acceptance- and mindfulness-based interventions for the treatment of chronic pain: a meta-analytic review. Cogn Behav Ther 2016;45:5–31. https://doi.org/10.1080/16506073.2015.1098724.
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Copyright (c) 2024 Nazarii Saiuk, Magdalena Kołodziej, Michał Andrzej Kozicz, Wojciech Mądry, Aleksandra Mazurkiewicz, Joanna Męczyńska, Tomasz Seredyński, Adriana Wojciechowska, Justyna Marcicka, Weronika Salasa
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