A Therapeutic Potential of Vitamin D in Asthma Control
DOI:
https://doi.org/10.12775/JEHS.2024.69.49174Keywords
asthma, vitamin D, vit DAbstract
In 2019, according to WHO estimates, 262 million people were affected by asta, resulting in 455,000 deaths. Asthma, is a chronic inflammatory disease of the airways that causes reversible bronchoconstriction, making it difficult for patients to breathe. Exacerbations of the disease can be caused by a variety of factors but share similar symptoms such as wheezing, coughing, shortness of breath and chest tightness. Severe asthma exacerbations are defined as symptoms that do not respond to inhaled medications and improve only after oral or intravenous steroid administration. Asthma-related deaths often occur during exacerbations. Vitamin D, which is produced naturally in the body and found in some foods, is a steroid-derived vitamin. Adequate doses of this vitamin, administered through medication or supplements, can be used to maintain its proper levels in the organism. Vitamin D is essential for regulating calcium levels in the body and for bone remodeling. It also has immunomodulatory effects, affecting both innate and adaptive immunity. This partly explains its association with changes in the airway epithelium that occur as a result of inflammation in asthma.
The study aims to summarize the current knowledge on the relationship of vitamin D with asthma symptom control.
The present study is based on literature available in scientific databases from 2013-2016, such as PubMed, Corchane Library and Google Scholar, using the following keywords: "vitamin D" and "asthma."
Vitamin D deficiency is prevalent in children and adults worldwide. A critical analysis of the literature reveals that the therapeutic administration of vitamin D has no apparent advantage in treating asthma, especially in children. Nevertheless, for adults with mild asthma, vitamin D supplementation shows promise for improved outcomes. However, there is a pressing need for large-scale clinical trials to determine the efficacy and safety of this therapeutic approach for both age groups.
References
“Asthma.” Available: https://www.who.int/news-room/fact-sheets/detail/asthma
N. Ullmann et al., “Asthma: Differential Diagnosis and Comorbidities,” Front Pediatr, vol. 6, 2018, doi: 10.3389/FPED.2018.00276.
“NFZ o zdrowiu. Astma - ezdrowie.gov.pl.” Available: https://ezdrowie.gov.pl/portal/home/badania-i-dane/zdrowe-dane/raporty/nfz-o-zdrowiu-astma Polish
S. C. Hall and D. K. Agrawal, “Vitamin D and Bronchial Asthma: An overview of the last five years,” Clin Ther, vol. 39, no. 5, p. 917, May 2017, doi: 10.1016/J.CLINTHERA.2017.04.002.
L. R. Wilson, L. Tripkovic, K. H. Hart, and S. A. Lanham-New, “Vitamin D deficiency as a public health issue: using vitamin D2 or vitamin D3 in future fortification strategies,” Proceedings of the Nutrition Society, vol. 76, no. 3, pp. 392–399, Aug. 2017, doi: 10.1017/S0029665117000349.
I. Chinellato et al., “Serum vitamin D levels and exercise-induced bronchoconstriction in children with asthma,” Eur Respir J, vol. 37, no. 6, pp. 1366–1370, Jun. 2011, doi: 10.1183/09031936.00044710.
K. Douros, B. Boutopoulou, S. Fouzas, and I. Loukou, “Asthma and Allergy ‘Epidemic’ and the Role of Vitamin D Deficiency,” Adv Exp Med Biol, vol. 996, pp. 169–183, 2017, doi: 10.1007/978-3-319-56017-5_14.
A. Rusińska et al., “ZASADY SUPLEMENTACJI I LECZENIA WITAMINĄ D-NOWELIZACJA 2018 r. VITAMIN D SUPPLEMENTATION GUIDELINES FOR POLAND-A 2018 UPDATE,” JAROSŁAW PEREGUD-POGORZELSKI, vol. 24, no. 1, 2018, doi: 10.31350/postepyneonatologii/2018/1/PN2018001. Polish
D. D. Bikle, “Chemistry & Biology Review Vitamin D Metabolism, Mechanism of Action, and Clinical Applications,” Chem Biol, vol. 21, pp. 319–329, 2014, doi: 10.1016/j.chembiol.2013.12.016.
M. Kohlmeier, “Vitamin D,” Nutrient Metabolism, pp. 478–490, 2003, doi: 10.1016/B978-012417762-8.50072-7.
D. D. Bikle, “Vitamin D Metabolism, Mechanism of Action, and Clinical Applications,” Chem Biol, vol. 21, no. 3, p. 319, Mar. 2014, doi: 10.1016/J.CHEMBIOL.2013.12.016.
P. Płudowski et al., “Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe - recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency,” Endokrynol Pol, vol. 64, no. 4, pp. 319–327, 2013, doi: 10.5603/EP.2013.0012.
A. Martineau, A. Takeda, U. Nurmatov, A. Sheikh, and C. J. Griffiths, “Vitamin D for the management of asthma,” Cochrane Database of Systematic Reviews, vol. 2015, no. 3, Mar. 2015, doi: 10.1002/14651858.CD011511/INFORMATION/EN.
C. P. Kerley, B. Elnazir, J. Faul, and L. Cormican, “Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms,” Pulm Pharmacol Ther, vol. 32, pp. 60–74, Jun. 2015, doi: 10.1016/J.PUPT.2015.02.004.
J. A. Schrumpf, A. M. van der Does, and P. S. Hiemstra, “Impact of the Local Inflammatory Environment on Mucosal Vitamin D Metabolism and Signaling in Chronic Inflammatory Lung Diseases,” Front Immunol, vol. 11, p. 530202, Jul. 2020, doi: 10.3389/FIMMU.2020.01433/BIBTEX.
E. Forno et al., “Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial,” JAMA, vol. 324, no. 8, pp. 752–760, Aug. 2020, doi: 10.1001/JAMA.2020.12384.
B. D. Riverin, J. L. Maguire, and P. Li, “Vitamin D Supplementation for Childhood Asthma: A Systematic Review and Meta-Analysis,” PLoS One, vol. 10, no. 8, Aug. 2015, doi: 10.1371/JOURNAL.PONE.0136841.
T. K. Kavitha, N. Gupta, S. K. Kabra, and R. Lodha, “Association of serum vitamin D levels with level of control of childhood asthma,” Indian Pediatr, vol. 54, no. 1, pp. 29–32, Jan. 2017, doi: 10.1007/S13312-017-0992-7/METRICS.
S. Puranik, E. Forno, A. Bush, and J. C. Celedón, “Predicting severe asthma exacerbations in children,” Am J Respir Crit Care Med, vol. 195, no. 7, pp. 854–859, Apr. 2017, doi: 10.1164/RCCM.201606-1213PP/SUPPL_FILE/DISCLOSURES.PDF.
S. J. Niruban, K. Alagiakrishnan, J. Beach, and A. Senthilselvan, “Association between vitamin D and respiratory outcomes in Canadian adolescents and adults,” J Asthma, vol. 52, no. 7, pp. 653–661, Aug. 2015, doi: 10.3109/02770903.2015.1004339.
K. Maes, J. Serré, C. Mathyssen, W. Janssens, and G. Gayan-Ramirez, “Targeting Vitamin D Deficiency to Limit Exacerbations in Respiratory Diseases: Utopia or Strategy With Potential?,” Calcif Tissue Int, vol. 106, no. 1, pp. 76–87, Jan. 2020, doi: 10.1007/S00223-019-00591-4.
M. Wang et al., “Association between vitamin D status and asthma control: A meta-analysis of randomized trials,” Respir Med, vol. 150, pp. 85–94, Apr. 2019, doi: 10.1016/j.rmed.2019.02.016.
A. Jin et al., “TSLP-induced collagen type-I synthesis through STAT3 and PRMT1 is sensitive to calcitriol in human lung fibroblasts,” Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol. 1868, no. 10, p. 119083, Sep. 2021, doi: 10.1016/J.BBAMCR.2021.119083.
J. Jaura, G. Kelsberg, S. Safranek, and J. Neher, “Does vitamin D supplementation reduce asthma exacerbations?,” MDedge Family Medicine, vol. 69, no. 4, pp. E4–E6, May 2020, Accessed: Dec. 11, 2023. [Online]. Available: https://www.mdedge.com/familymedicine/article/222051/asthma/does-vitamin-d-supplementation-reduce-asthma-exacerbations
J. A. Schrumpf, D. K. Ninaber, A. M. Van Der Does, and P. S. Hiemstra, “TGF-β1 Impairs Vitamin D-Induced and Constitutive Airway Epithelial Host Defense Mechanisms,” J Innate Immun, vol. 12, no. 1, p. 74, Jan. 2020, doi: 10.1159/000497415.
L. Salameh et al., “The Role of Vitamin D Supplementation on Airway Remodeling in Asthma: A Systematic Review,” Nutrients, vol. 15, no. 11, Jun. 2023, doi: 10.3390/NU15112477/S1.
C. A. Camargo et al., “Effect of Monthly Vitamin D Supplementation on Preventing Exacerbations of Asthma or Chronic Obstructive Pulmonary Disease in Older Adults: Post Hoc Analysis of a Randomized Controlled Trial,” Nutrients, vol. 13, no. 2, pp. 1–12, Feb. 2021, doi: 10.3390/NU13020521.
P. Solidoro et al., “Asthmatic Patients with Vitamin D Deficiency have Decreased Exacerbations after Vitamin Replacement,” Nutrients, vol. 9, no. 11, Nov. 2017, doi: 10.3390/NU9111234.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Aldona Pażyra, Paweł Stanicki, Julita Szarpak, Natalia Kusak, Natalia Żak, Barbara Jaworska
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 198
Number of citations: 0
