Clinical and psychopathological features of the course and outcome of the first psychotic episode.

Authors

  • Yuri Bazhora Odessa National Medical University
  • Valentyn Gudz Odessa National Medical University
  • Valentina Mozgova Odessa National Medical University
  • Kateryna Usychenko Odessa National Medical University
  • Nikol Shvets Odessa National Medical University

DOI:

https://doi.org/10.12775/JEHS.2023.48.01.021

Keywords

chronic hepatitis, gene’s polymorphism, fibrosis progression

Abstract

Recently it has been established that cytokines are involved in the regulation of the body’s defense reactions in response to a pathogen and form an independent system  for regulating homeostasis.  The aim of this work is to study the relationship of the polymorphic marker TNFα (rs1800620) with its quantitative content and the degree of liver fibrosis in patients with various chronic hepatitis (VHC, VHB, VHB+C). The 82 patients with chronic hepatitis B, 62 patients with hepatitis B+C, and 100 patients with chronic hepatitis C were examined. GGTNFα (rs1800620) genotype is protective for patients with various viral hepatitis, and the GATNFα (rs1800620)and AATNFα (rs1800620)genotypes are profibrogenic for patients with chronic hepatitis B, chronic hepatitis B+C and chronic hepatitis C, respectively, since a high degree of fibrosis than in carriers of the homozygous GGTNFα (rs1800620)genotype. It is possible that the rate of fibrosis progression is influenced not only by the qualitative content of TNFα, but also by a certain genotype.

References

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Published

2023-11-30

How to Cite

1.
BAZHORA, Yuri, GUDZ, Valentyn, MOZGOVA, Valentina, USYCHENKO, Kateryna and SHVETS, Nikol. Clinical and psychopathological features of the course and outcome of the first psychotic episode. Journal of Education, Health and Sport. Online. 30 November 2023. Vol. 48, no. 1, pp. 279-286. [Accessed 28 June 2025]. DOI 10.12775/JEHS.2023.48.01.021.

Issue

Vol. 48 No. 1 (2023)

Section

Medical Sciences

License

Copyright (c) 2023 Yuri Bazhora, Valentyn Gudz, Valentina Mozgova, Kateryna Usychenko, Nikol Shvets

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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