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Journal of Education, Health and Sport

Tyrosol and Hydroxytyrosol: Their Role in Cardioprotection
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Tyrosol and Hydroxytyrosol: Their Role in Cardioprotection

Authors

  • Cezary Guzowski Department and Clinic of Geriatrics, Nicolaus Copernicus University in Toruń Ludwik Rydygier Collegium Medicum in Bydgoszcz, ul. Marii Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Poland https://orcid.org/0000-0002-0022-9943
  • Joanna Murawska Department and Clinic of Geriatrics, Nicolaus Copernicus University in Toruń Ludwik Rydygier Collegium Medicum in Bydgoszcz, ul. Marii Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Poland https://orcid.org/0000-0001-7564-938X
  • Martyna Michalska Department and Clinic of Geriatrics, Nicolaus Copernicus University in Toruń Ludwik Rydygier Collegium Medicum in Bydgoszcz, ul. Marii Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Poland https://orcid.org/0009-0002-3467-4364
  • Karolina Winiarek Department and Clinic of Geriatrics, Nicolaus Copernicus University in Toruń Ludwik Rydygier Collegium Medicum in Bydgoszcz, ul. Marii Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Poland https://orcid.org/0000-0001-7305-0613
  • Aleksandra Czernicka Department and Clinic of Geriatrics, Nicolaus Copernicus University in Toruń Ludwik Rydygier Collegium Medicum in Bydgoszcz, ul. Marii Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Poland https://orcid.org/0009-0006-3772-8152
  • Kornelia Kędziora-Kornatowska Department and Clinic of Geriatrics, Nicolaus Copernicus University in Toruń Ludwik Rydygier Collegium Medicum in Bydgoszcz, ul. Marii Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Poland https://orcid.org/0000-0003-4777-5252

DOI:

https://doi.org/10.12775/JEHS.2024.63.003

Keywords

Tyrosol, Hydroxytyrozol, cardioprotection, cardiovascular diesease, olive oil, cardioprotective role

Abstract

Introduction: Recent research are focused on natural compounds for preventing cardiovascular diseases, with emphasis on tyrosol and hydroxytyrosol in olive oil. Cardiovascular diseases are linked to risk factors, and adopting a Mediterranean diet rich in these compounds is recognized for reducing risks.  Understanding these compounds' actions may inform new strategies for preventing and treating cardiovascular diseases. 

Aim: The aim of this paper is a systematic review of articles and research regarding the Role of tyrosol and hydroxytyrosol in Cardioprotection 

Review methods: An systematic review of scientific literature was conducted using the following keywords: Tyrosol, hydroxytyrosol, cardioprotection, cardiovascular diseases, olive oil cardioprotective role. Thirty-four articles published until 2023 were searched and analyzed. 

Abbreviated description of the state of knowledge: Tyrosol and hydroxytyrosol, prominent in olive oil, are studied for their potential cardioprotective properties. Linked to a Mediterranean diet, these compounds show promise in reducing cardiovascular disease risk. They counter oxidative stress, improve lipid profiles, and modulate inflammatory processes. Clinical studies suggest their positive impact, with tyrosol also explored as a potential anticoagulant. Ongoing research aims to uncover optimal doses and mechanisms, highlighting their significance in cardiovascular health. 

Conclusions: Tyrosol and hydroxytyrosol, found in olive oil, show promise in cardioprotection by combating oxidative stress, improving lipid profiles, and modulating inflammation. Clinical studies suggest their positive impact on cardiovascular health. Tyrosol has potential as a anticoagulant and exhibits antioxidant effects. These compounds present a compelling avenue for future therapeutic interventions, with emphasis on understanding mechanisms and optimizing supplementation. 

References

Zeraattalab-Motlagh S, Jayedi A, Shab-Bidar S. Mediterranean dietary pattern and the risk of type 2 diabetes: a systematic review and dose–response meta-analysis of prospective cohort studies. European Journal of Nutrition. 2022 Jan 10; https://doi.org/10.1007/s00394-021-02761-3

Grosso G, Marventano S, Yang J et al. A comprehensive meta-analysis on evidence of Mediterranean diet and cardiovascular disease: Are individual components equal? Crit Rev Food Sci Nutr. 2017 Oct 13;57(15):3218-3232. https://doi.org/10.1080/10408398.2015.1107021

Ramic-Catak A, Mesihović-Dinarevic S, Prnjavorac B. Public Health Dimensions of CVD Prevention and Control - Global Perspectives and Current Situation in the Federation of BiH. Mater Sociomed. 2023;35(2):152-156. doi: 10.5455/msm.2023.35.152-156.

Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. The New England Journal of Medicine. 2023 Aug 26; https://doi.org/10.1056/NEJMoa2206916

Robles-Almazan M, Pulido-Moran M, Moreno-Fernandez J et al. Hydroxytyrosol: Bioavailability, toxicity, and clinical applications. Food Res Int. 2018 Mar;105:654-667. doi: 10.1016/j.foodres.2017.11.053. Epub 2017 Nov 21. https://doi.org/10.1016/j.foodres.2017.11.053

PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 82755, Hydroxytyrosol; [cited 2023 Dec. 7]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxytyrosol

Covas MI, de la Torre R, Fitó M. Virgin olive oil: a key food for cardiovascular risk protection. Br J Nutr. 2015 Apr;113 Suppl 2:S19-28. https://doi.org/10.1017/S0007114515000136

Sun Y, Zhou D, Shahidi F. Antioxidant properties of tyrosol and hydroxytyrosol saturated fatty acid esters. Food Chem. 2018 Apr;245:1262-8. https://doi.org/10.1016/j.foodchem.2017.11.051

Paradiso VM, Squeo G, Pasqualone A et al. An easy and green tool for olive oils labelling according to the contents of hydroxytyrosol and tyrosol derivatives: Extraction with a natural deep eutectic solvent and direct spectrophotometric analysis. Food Chem. 2019 Sep 1;291:1-6. doi: 10.1016/j.foodchem.2019.03.139. Epub 2019 Mar 27. https://doi.org/10.1016/j.foodchem.2019.03.139

PubChem. 2-(4-Hydroxyphenyl)ethanol [Internet]. pubchem.ncbi.nlm.nih.gov. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/10393

Rodríguez-Morató J, Boronat A, Kotronoulas A et al. Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol. Drug Metab Rev. 2016 May;48(2):218-36. https://doi.org/10.1080/03602532.2016.1179754

Piñeiro Z, Cantos-Villar E, Palma M, Puertas B. Direct liquid chromatography method for the simultaneous quantification of hydroxytyrosol and tyrosol in red wines. J Agric Food Chem. 2011 Nov 9;59(21):11683-9. doi: 10.1021/jf202254t. Epub 2011 Oct 5. https://doi.org/10.1021/jf202254t

Almeida C, Duarte IF, Barros A et al. Composition of beer by 1H NMR spectroscopy: effects of brewing site and date of production. J Agric Food Chem. 2006 Feb 8;54(3):700-6. doi: 10.1021/jf0526947. https://doi.org/10.1021/jf0526947

Chen W, Becker T, Qian F, Ring J. Beer and beer compounds: physiological effects on skin health. J Eur Acad Dermatol Venereol. 2014 Feb;28(2):142-50. doi: 10.1111/jdv.12204. Epub 2013 Jun 27. https://doi.org/10.1111/jdv.12204

Romero C, Brenes M. Analysis of Total Contents of Hydroxytyrosol and Tyrosol in Olive Oils. Journal of Agricultural and Food Chemistry. 2012 Aug 31;60(36):9017–22. https://doi.org/10.1021/jf3026666

Lucci P, Bertoz V, Pacetti D et al. Effect of the Refining Process on Total Hydroxytyrosol, Tyrosol, and Tocopherol Contents of Olive Oil. Foods [Internet]. 2020 Mar 1 [cited 2022 Dec 10];9(3):292. Available from: https://www.mdpi.com/2304-8158/9/3/292/htm#B18-foods-09-00292

Aebisher D, Cichonski J, Szpyrka E et al. Essential Oils of Seven Lamiaceae Plants and Their Antioxidant Capacity. Molecules. 2021 Jun 22;26(13):3793. https://doi.org/10.3390/molecules26133793

Bucciantini M, Leri M, Nardiello P et al. Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties. Antioxidants (Basel). 2021 Jun 29;10(7):1044. https://doi.org/10.3390/antiox10071044

De Santis S, Cariello M, Piccinin E et al. Extra Virgin Olive Oil: Lesson from Nutrigenomics. Nutrients. 2019 Sep 4;11(9):2085. https://doi.org/10.3390/nu11092085

Flynn, M., & Wang, S. Olive Oil as Medicine: The Effect on Blood Lipids and Lipoproteins. UC Davis Olive Center. 2015.

Chandramohan R, Pari L. Antihyperlipidemic effect of tyrosol, a phenolic compound in streptozotocin-induced diabetic rats. Toxicol Mech Methods. 2021 Sep;31(7):507-516. Epub 2021 Jun 28. https://doi.org/10.1080/15376516.2021.1926030

T João Tomé-Carneiro, María Carmen Crespo, María Carmen López de las Hazas et al. Olive oil consumption and its repercussions on lipid metabolism, Nutrition Reviews, Volume 78, Issue 11, November 2020, Pages 952–968. https://doi.org/10.1093/nutrit/nuaa014

Serreli G, Deiana M. Extra Virgin Olive Oil Polyphenols: Modulation of Cellular Pathways Related to Oxidant Species and Inflammation in Aging. Cells. 2020 Feb 19;9(2):478. https://doi.org/10.3390/cells9020478

Sivandzade F, Prasad S, Bhalerao A, Cucullo L. NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches. Redox Biol. 2019 Feb;21:101059. Epub 2018 Nov 28. https://doi.org/10.1016/j.redox.2018.11.017

Morales-González JA, Madrigal-Santillán E, Morales-González Á et al. What is Known Regarding the Participation of Factor Nrf-2 in Liver Regeneration? Cells. 2015 May 20;4(2):169-77. https://doi.org/10.3390/cells4020169

Liu T, Zhang L, Joo D, Sun SC. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2017;2:17023–. Epub 2017 Jul 14. https://doi.org/10.1038/sigtrans.2017.23

Camargo A, Rangel-Zuñiga OA, Haro C et al. Olive oil phenolic compounds decrease the postprandial inflammatory response by reducing postprandial plasma lipopolysaccharide levels. Food Chem. 2014 Nov 1;162:161-71. Epub 2014 Apr 24. https://doi.org/10.1016/j.foodchem.2014.04.047

D’Angelo C, Franceschelli S, Quiles JL, Speranza L. Wide Biological Role of Hydroxytyrosol: Possible Therapeutic and Preventive Properties in Cardiovascular Diseases. Cells. 2020 Aug 21;9(9):1932. https://doi.org/10.3390/cells9091932

Alvarez AM, DeOcesano-Pereira C, Teixeira C, Moreira V. IL-1β and TNF-α Modulation of Proliferated and Committed Myoblasts: IL-6 and COX-2-Derived Prostaglandins as Key Actors in the Mechanisms Involved. Cells. 2020 Sep 1;9(9):2005. https://doi.org/10.3390/cells9092005

Mahboubi Rabbani SMI, Zarghi A. Selective COX-2 inhibitors as anticancer agents: a patent review (2014-2018). Expert Opin Ther Pat. 2019 Jun;29(6):407-427. Epub 2019 May 27. https://doi.org/10.1080/13543776.2019.1623880

Tune JD, Goodwill AG, Sassoon DJ, Mather KJ. Cardiovascular consequences of metabolic syndrome. Transl Res. 2017 May;183:57-70. Epub 2017 Jan 9. https://doi.org/10.1016/j.trsl.2017.01.001

Alfieri, Maria Laura et al. “Sulfated Oligomers of Tyrosol: Toward a New Class of Bioinspired Nonsaccharidic Anticoagulants.” Biomacromolecules vol. 22,2 (2021): 399-409. doi:10.1021/acs.biomac.0c01254

Soldevila-Domenech, Natalia et al. “Generation of the Antioxidant Hydroxytyrosol from Tyrosol Present in Beer and Red Wine in a Randomized Clinical Trial.” Nutrients vol. 11,9 2241. 18 Sep. 2019, doi:10.3390/nu11092241

Boronat, Anna et al. “Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial.” Free radical biology & medicine vol. 143 (2019): 471-481. doi:10.1016/j.freeradbiomed.2019.08.032

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Published

2024-02-22

How to Cite

1.
GUZOWSKI, Cezary, MURAWSKA, Joanna, MICHALSKA, Martyna, WINIAREK, Karolina, CZERNICKA, Aleksandra and KĘDZIORA-KORNATOWSKA, Kornelia. Tyrosol and Hydroxytyrosol: Their Role in Cardioprotection . Journal of Education, Health and Sport. Online. 22 February 2024. Vol. 63, pp. 40-54. [Accessed 13 December 2025]. DOI 10.12775/JEHS.2024.63.003.
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Vol. 63 (2024)

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Copyright (c) 2024 Cezary Guzowski, Joanna Murawska, Martyna Michalska, Karolina Winiarek, Aleksandra Czernicka, Kornelia Kędziora-Kornatowska

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