Exosomes - breakthrough in the regenerative medicine and a way to improve the quality of the life
DOI:
https://doi.org/10.12775/JEHS.2024.62.002Keywords
Exosomes, regenerative medicine, stem cellsAbstract
Introduction
Exosomes are small, membrane-bound extracellular vesicles that play a pivotal role in intercellular communication. Exosomes have garnered significant interest in regenerative medicine due to their unique properties that support tissue repair, regeneration, and healing. These extracellular vesicles play a crucial role in intercellular communication, and their regenerative potential makes them promising tools in the field of regenerative medicine.
Purpose of the study
This review aims to present the regenerative properties of exosomes and their clinical applications in many fields of medicine. The main aim is to present exosomes as a substance that restores health, youth and vitality.
Material and method
Literature review was primarily based on scientific materials, English and Polish databases and original research. The following English keywords and its Polish equivalents were used to search Google Scholar and PubMed: “ exosomes", “regenerative medicine”, “stem cells”.
References
MD Hade, CN Suire, Z Suo. Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine. Cells. 2021 Aug 1;10(8):1959. doi: 10.3390/cells10081959
J Qin, Q Xu Functions and applications of exosomes, Acta Poloniae Pharmaceutica - Drug Research, Volume 71, Number 4, 537-539
S Sonbhadra, Mehak, LM Pandey. Biogenesis, Isolation, and Detection of Exosomes and Their Potential in Therapeutics and Diagnostics. Biosensors (Basel). 2023 Aug 10;13(8):802. doi: 10.3390/bios13080802
S Gurunathan, M-H Kang, M Jeyaraj, M Qasim, J-H Kim. Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes. Cells. 2019; 8(4):307. https://doi.org/10.3390/cells8040307
L Urbanelli, A Magini,S Buratta, A Brozzi, K Sagini, A Polchi, B Tancini, C Emiliani. Signaling Pathways in Exosomes Biogenesis, Secretion and Fate. Genes. 2013; 4(2):152-170. https://doi.org/10.3390/genes4020152
C Théry, L Zitvogel & S Amigorena. Exosomes: composition, biogenesis and function. Nat Rev Immunol 2, 569–579 (2002). https://doi.org/10.1038/nri855
W Stoorvogel, M.J. Kleijmeer, H., J. Geuze and G Raposo(2002), The Biogenesis and Functions of Exosomes. Traffic, 3: 321-330. https://doi.org/10.1034/j.1600-0854.2002.30502.x
K Nazimek, K Bryniarski, M Santocki, & W Ptak. (2015). Exosomes as mediators of intercellular communication: clinical implications. Polish Archives of Internal Medicine, 125(5).
P Robbins, A Morelli. Regulation of immune responses by extracellular vesicles. Nat Rev Immunol 14, 195–208 (2014). https://doi.org/10.1038/nri3622
EWJ Kerris, C Hoptay, T Calderon, RJ Freishtat. Platelets and Platelet Extracellular Vesicles in Hemostasis and Sepsis. Journal of Investigative Medicine. 2020;68(4):813-820. doi:10.1136/jim-2019-001195
I Russo, L Bubacco, E Greggio. Exosomes-associated neurodegeneration and progression of Parkinson's disease. Am J Neurodegener Dis. 2012;1(3):217-25. Epub 2012 Nov 18.
L Su, R Li, Z Zhang, J Liu, J Du, H Wei. Identification of altered exosomal microRNAs and mRNAs in Alzheimer's disease. Ageing Res Rev. 2022 Jan;73:101497. doi: 10.1016/j.arr.2021.101497
A Ibrahim and E Marban.November 30, 2015Exosomes: Fundamental Biology and Roles in Cardiovascular Physiology. doi: 10.1146/annurev-physiol-021115-104929
Sundararajan V, Sarkar FH, Ramasamy TS. The multifaceted role of exosomes in cancer progression: diagnostic and therapeutic implications [corrected]. Cell Oncol (Dordr). 2018 Jun;41(3):223-252. doi: 10.1007/s13402-018-0378-4
N Shomali, M Hemmatzadeh, Y Yousefzadeh, M Sadegh Soltani-Zangbar, K Hamdi, A Mehdizadeh, M yousefi. Exosomes: Emerging biomarkers and targets in folliculogenesis and endometriosis. November 2020. https://doi.org/10.1016/j.jri.2020.103181
A Reza Hesari, S A G Moghadam, A Siasi, M Rahmani, N Behboodi, A Rastgar-Moghadam, G A. Ferns, F Ghasemi, A Avan. Tumor-derived exosomes: Potential biomarker or therapeutic target in breast cancer? 18 August 2017, https://doi.org/10.1002/jcb.26364
R Pluta, M Ułamek-Kozioł, S Januszewski, and S J Czuczwar. Exosomes as possible spread factor and potential biomarkers in Alzheimer's disease: current concepts. Biomarkers in Medicine 2018 12:9, 1025-1033
NB Vu, HT Nguyen, R Palumbo, R Pellicano, S Fagoonee, PV Pham. Stem cell-derived exosomes for wound healing: current status and promising directions. Minerva Med. 2021 Jun;112(3):384-400. doi: 10.23736/S0026-4806.20.07205-5
K Archacka, K Kowalski, E Brzóska. Are satellite cells stem cells?. 2013;59(2):205-18. Polish. PMID: 24044285.
FM Barros, F Carneiro, JC Machado, SA Melo. Exosomes and Immune Response in Cancer: Friends or Foes? Front Immunol. 2018 Apr 11;9:730. doi: 10.3389/fimmu.2018.00730.
M Uzarska, D Porowińska, A Bajek, T Drewa. Epidermal stem cells--biology and potential applications in regenerative medicine. Postepy Biochem. 2013;59(2):219-27. Polish. PMID: 24044286.
B Torrecillas-Baena, V Pulido-Escribano, Dorado, MÁ Gálvez-Moreno, M Camacho-Cardenosa, A Casado-Díaz. Clinical Potential of Mesenchymal Stem Cell-Derived Exosomes in Bone Regeneration. Journal of Clinical Medicine. 2023; 12(13):4385. https://doi.org/10.3390/jcm12134385
S Keshtkar, N Azarpira, MH Ghahremani. Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine. Stem Cell Res Ther. 2018 Mar 9;9(1):63. doi: 10.1186/s13287-018-0791-7.
L Bacakova, J Zarubova, M Travnickova, J Musilkova, J Pajorova, P Slepicka, NS Kasalkova, V Svorcik, Z Kolska, H Motarjemi, M Molitor. Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells - a review. Biotechnol Adv. 2018 Jul-Aug;36(4):1111-1126. doi: 10.1016/j.biotechadv.2018.03.011.
B Derkus, KC Emregul, E Emregul. A new approach in stem cell research-Exosomes: Their mechanism of action via cellular pathways. Cell Biol Int. 2017 May;41(5):466-475. doi: 10.1002/cbin.10742.
Y Xue, N Riva, L Zhao, J Shieh, Y Chin, A Gatt, JJ Guo, Recent advances of exosomes in soft tissue injuries in sports medicine: A critical review on biological and biomaterial applications, Journal of Controlled Release, 2023.Pages 90-108 https://doi.org/10.1016/j.jconrel.2023.10.031.
WH Fang, DK Agrawal, FG Thankam. "Smart Exosomes": A Smart Approach for Tendon Regeneration. Tissue Eng Part B Rev. 2022 Jun;28(3):613-625. doi: 10.1089/ten.TEB.2021.0075.
JP Cata, ML Uhelski, A Gorur, PM Dougherty. Nociception and Pain: New Roles for Exosomes. Neuroscientist. 2022 Aug;28(4):349-363. doi: 10.1177/10738584211027105.
KE Gilligan, RM Dwyer. Engineering Exosomes for Cancer Therapy. International Journal of Molecular Sciences. 2017; 18(6):1122. https://doi.org/10.3390/ijms18061122
Szwedowicz U, Łapińska Z, Gajewska-Naryniecka A, Choromańska A. Exosomes and Other Extracellular Vesicles with High Therapeutic Potential: Their Applications in Oncology, Neurology, and Dermatology. Molecules. 2022 Feb 15;27(4):1303. doi: 10.3390/molecules27041303.
XF Gao, ZM Wang, F Wang, Y Gu, JJ Zhang, ZL Chen. Exosomes in Coronary Artery Disease. Int J Biol Sci. 2019 Sep 7;15(11):2461-2470. doi: 10.7150/ijbs.36427.
A Anel, A Gallego-Lleyda, D de Miguel, J Naval, L Martínez-Lostao. Role of Exosomes in the Regulation of T-Cell Mediated Immune Responses and in Autoimmune Disease. Cells. 2019; 8(2):154. https://doi.org/10.3390/cells8020154
J Feng, A Waqas, Z Zhu, L Chen. Exosomes: Applications in Respiratory Infectious Diseases and Prospects for Coronavirus Disease 2019 (COVID-19). J Biomed Nanotechnol. 2020 Apr 1;16(4):399-418. doi: 10.1166/jbn.2020.2910.
Y Liang, X Xu, X Li, J Xiong, B Li, L Duan, D Wang, J Xia. Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy. ACS Appl Mater Interfaces. 2020 Aug 19;12(33):36938-36947. doi: 10.1021/acsami.0c10458.
A Hajialiasgary Najafabadi, MH Soheilifar, N Masoudi-Khoram. Exosomes in skin photoaging: biological functions and therapeutic opportunity. Cell Commun Signal. 2024 Jan 12;22(1):32. doi: 10.1186/s12964-023-01451-3.
M Nooshabadi Khanmohamadi, E Valipour, S Mahdipour, A Salati, ZV Malekshahi, S Shafei, E Amini, S Farzamfar, J Ai. Impact of exosome-loaded chitosan hydrogel in wound repair and layered dermal reconstitution in mice animal model. J Biomed Mater Res A. 2020 Nov 1;108(11):2138-2149. doi: 10.1002/jbm.a.36959.
AK Gupta, T Wang, JA Rapaport. Systematic review of exosome treatment in hair restoration: Preliminary evidence, safety, and future directions. J Cosmet Dermatol. 2023 Sep;22(9):2424-2433. doi: 10.1111/jocd.15869.
YC Ku, Omer H Sulaiman, SR Anderson, AR Abtahi. The Potential Role of Exosomes in Aesthetic Plastic Surgery: A Review of Current Literature. Plast Reconstr Surg Glob Open. 2023 Jun 12;11(6):e5051. doi: 10.1097/GOX.0000000000005051.
R Afrisham, S Sadegh-Nejadi, R Meshkani, S Emamgholipour, M Bagherieh, M Paknejad. Anti-Inflammatory Effects of Plasma Circulating Exosomes Obtained from Normal-Weight and Obese Subjects on Hepatocytes. Endocr Metab Immune Disord Drug Targets. 2021;21(3):478-484. doi: 10.2174/1871530320666200505121426.
M Trentini, I Zanolla, F Zanotti, E Tiengo D Licastro, S Dal Monego, L Lovatti, B Zavan. Apple Derived Exosomes Improve Collagen Type I Production and Decrease MMPs during Aging of the Skin through Downregulation of the NF-κB Pathway as Mode of Action. Cells. 2022; 11(24):3950. https://doi.org/10.3390/cells11243950
Cho Seung, Byong, and D I Duncan. 2023. ‘Perspective Chapter: Development of Exosomes for Esthetic Use’. Exosomes - Recent Advances From Bench to Bedside. IntechOpen. doi:10.5772/intechopen.111846.
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Copyright (c) 2024 Anna Brzozowska, Monika Maj-Dziedzic, Marcelina Sikora, Marta Zarzycka, Ines Plewniok, Jeremiasz Dubiel, Adrian Maj, Martyna Warno, Wiktor Kozik, Greta Śmietana
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