How does the consumption of processed food affect the pathogenesis of various diseases? - literature review
DOI:
https://doi.org/10.12775/JEHS.2024.61.007Keywords
Ultra-processed food, UPF, obesity, type 2 diabetes, cardiovascular diseases, inflammatory bowel diseases, pregnancy, depression, NOVAAbstract
Introduction and purpose:
With the development of civilization, the amount of technology enabling food processing increases. Due to the implementation of these procedures, food can gain new properties that will make it more attractive in the eyes of the consumer. The aim of our work is to collect information on the relationship between the consumption of processed and ultra-processed food and the development of various diseases, with particular emphasis on civilization diseases.
State of knowledge:
Processed food often contains non-nutritive ingredients, for example, artificial food additives, which have a negative impact on health. Numerous studies demonstrate the correlation between the consumption of ultra-processed food and the development
of various diseases. Scientific research suggests that ultra-processed foods may lead to addictive behavioral and biological responses through their reinforcing effects. It also influences the development of various conditions, including obesity, type II diabetes, cardiovascular diseases, depression, and anxiety. Furthermore, its components pass through the placenta.
Summary:
In light of the research discussed, we are convinced that we cannot remain indifferent to the role of ultra-processed food in the pathogenesis of many diseases. Its multidirectional negative effects show that it is worth conducting further research to discover more consequences of its mechanisms. At the same time, consumers should become more aware of food composition data to be able to make conscious choices and countries should strive to change the food policies.
References
Gruchelski M, Niemczyk J. Additives in food: food market efficiency versus
consumer health ®. Postępy Techniki Przetwórstwa Spożywczego. 2019;(1):108–12.
Baker P, Machado P, Santos T, Sievert K, Backholer K, Hadjikakou M, Russell C,
Huse O, Bell C, Scrinis G, Worsley A, Friel S, Lawrence M. Ultra-processed foods
and the nutrition transition: Global, regional and national trends, food systems
transformations and political economy drivers. Obes Rev. 2020 Dec;21(12):e13126.
doi: 10.1111/obr.13126. Epub 2020 Aug 6. PMID: 32761763.
Monteiro CA, Cannon G, Levy RB, Moubarac JC, Louzada ML, Rauber F, Khandpur
N, Cediel G, Neri D, Martinez-Steele E, Baraldi LG, Jaime PC. Ultra-processed
foods: what they are and how to identify them. Public Health Nutr. 2019
Apr;22(5):936-941. doi: 10.1017/S1368980018003762. Epub 2019 Feb 12. PMID:
; PMCID: PMC10260459.
Moubarac JC, Parra DC, Cannon G, Monteiro CA. Food Classification Systems
Based on Food Processing: Significance and Implications for Policies and Actions: A
Systematic Literature Review and Assessment. Curr Obes Rep. 2014 Jun;3(2):256-72.
doi: 10.1007/s13679-014-0092-0. PMID: 26626606.
Monteiro CA, Cannon G, Moubarac JC, Levy RB, Louzada MLC, Jaime PC. The UN
Decade of Nutrition, the NOVA food classification and the trouble with ultra-
processing. Public Health Nutr. 2018 Jan;21(1):5-17. doi:
1017/S1368980017000234. Epub 2017 Mar 21. PMID: 28322183; PMCID:
PMC10261019.
Lawrence MA, Baker PI. Ultra-processed food and adverse health outcomes. BMJ.
May 29;365:l2289. doi: 10.1136/bmj.l2289. PMID: 31142449.
Pagliai G, Dinu M, Madarena MP, Bonaccio M, Iacoviello L, Sofi F. Consumption of
ultra-processed foods and health status: a systematic review and meta-analysis. Br J
Nutr. 2021 Feb 14;125(3):308-318. doi: 10.1017/S0007114520002688. Epub 2020
Aug 14. PMID: 32792031; PMCID: PMC7844609.
Gibney MJ, Forde CG, Mullally D, Gibney ER. Ultra-processed foods in human
health: a critical appraisal. Am J Clin Nutr. 2017 Sep;106(3):717-724. doi:
3945/ajcn.117.160440. Epub 2017 Aug 9. Erratum in: Am J Clin Nutr. 2018 Mar
;107(3):482-483. PMID: 28793996.
Gearhardt AN, Schulte EM. Is Food Addictive? A Review of the Science. Annu Rev
Nutr. 2021 Oct 11;41:387-410. doi: 10.1146/annurev-nutr-110420-111710. Epub
Jun 21. PMID: 34152831.
Lopez-Quintero C, Pérez de los Cobos J, Hasin DS, Okuda M, Wang S, Grant BF,
Blanco C. Probability and predictors of transition from first use to dependence on
nicotine, alcohol, cannabis, and cocaine: results of the National Epidemiologic Survey
on Alcohol and Related Conditions (NESARC). Drug Alcohol Depend. 2011 May
;115(1-2):120-30. doi: 10.1016/j.drugalcdep.2010.11.004. Epub 2010 Dec 8. PMID:
; PMCID: PMC3069146.
Schulte EM, Avena NM, Gearhardt AN. Which foods may be addictive? The roles of
processing, fat content, and glycemic load. PLoS One. 2015 Feb 18;10(2):e0117959.
doi: 10.1371/journal.pone.0117959. PMID: 25692302; PMCID: PMC4334652.
Whatnall M, Clarke E, Collins CE, Pursey K, Burrows T. Ultra-processed food
intakes associated with 'food addiction' in young adults. Appetite. 2022 Nov
;178:106260. doi: 10.1016/j.appet.2022.106260. Epub 2022 Jul 31. PMID:
Machado PP, Steele EM, Levy RB, da Costa Louzada ML, Rangan A, Woods J, Gill
T, Scrinis G, Monteiro CA. Ultra-processed food consumption and obesity in the
Australian adult population. Nutr Diabetes. 2020 Dec 5;10(1):39. doi:
1038/s41387-020-00141-0. PMID: 33279939; PMCID: PMC7719194.
Rauber F, Chang K, Vamos EP, da Costa Louzada ML, Monteiro CA, Millett C, Levy
RB. Ultra-processed food consumption and risk of obesity: a prospective cohort
study of UK Biobank. Eur J Nutr. 2021 Jun;60(4):2169-2180. doi: 10.1007/s00394-
-02367-1. Epub 2020 Oct 18. PMID: 33070213; PMCID: PMC8137628.
Juul F, Martinez-Steele E, Parekh N, Monteiro CA, Chang VW. Ultra-processed food
consumption and excess weight among US adults. Br J Nutr. 2018 Jul;120(1):90-100.
doi: 10.1017/S0007114518001046. Epub 2018 May 6. PMID: 29729673.
Sartorelli DS, Crivellenti LC, Zuccolotto DCC, Franco LJ. Relationship between
minimally and ultra-processed food intake during pregnancy with obesity and
gestational diabetes mellitus. Cad Saude Publica. 2019 May 2;35(4):e00049318. doi:
1590/0102-311X00049318. PMID: 31066773.
Mendonça RD, Pimenta AM, Gea A, de la Fuente-Arrillaga C, Martinez-Gonzalez
MA, Lopes AC, Bes-Rastrollo M. Ultraprocessed food consumption and risk of
overweight and obesity: the University of Navarra Follow-Up (SUN) cohort study.
Am J Clin Nutr. 2016 Nov;104(5):1433-1440. doi: 10.3945/ajcn.116.135004. Epub
Oct 12. PMID: 27733404.
International Diabetes Federation International Diabetes Federation - Facts & figures -
Atlas 8th Edition 2017. https://www.idf.org/aboutdiabetes/what-is-diabetes/facts-
figures.html. Accessed May 15, 2019.
Srour B, Fezeu LK, Kesse-Guyot E, Allès B, Debras C, Druesne-Pecollo N, Chazelas
E, Deschasaux M, Hercberg S, Galan P, Monteiro CA, Julia C, Touvier M.
Ultraprocessed Food Consumption and Risk of Type 2 Diabetes Among Participants
of the NutriNet-Santé Prospective Cohort. JAMA Intern Med. 2020 Feb 1;180(2):283-
doi: 10.1001/jamainternmed.2019.5942. PMID: 31841598; PMCID:
PMC6990737.
Levy RB, Rauber F, Chang K, Louzada MLDC, Monteiro CA, Millett C, Vamos EP.
Ultra-processed food consumption and type 2 diabetes incidence: A prospective
cohort study. Clin Nutr. 2021 May;40(5):3608-3614. doi: 10.1016/j.clnu.2020.12.018.
Epub 2020 Dec 28. PMID: 33388205.
González-Palacios S, Oncina-Cánovas A, García-de-la-Hera M, Martínez-González
MÁ, Salas-Salvadó J, Corella D, Schröder H, Martínez JA, Alonso-Gómez ÁM,
Wärnberg J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J,
Serra-Majem JL, Cano-Ibañez N, Tur JA, Martín-Sánchez V, Pintó X, Delgado-
Rodríguez M, Matía-Martín P, Vidal J, Vázquez C, Daimiel L, Ros E, Bes-Rastrollo
M, Atzeni A, Sorli JV, Zomeño MD, Peña-Orihuela PJ, Compañ-Gabucio LM,
Barón-López FJ, Zulet MÁ, Konieczna J, Casas RM, Garrido-Garrido EM, Tojal-
Sierra L, Gomez-Perez AM, Ruiz-Canela M, Palau A, Saiz C, Pérez-Vega KA,
Garcia-Rios A, Torres-Collado L, Basterra-Gortari J, Garcidueñas-Fimbres TE,
Malcampo M, Vioque J; PREDIMED-PLUS Trial investigators. Increased ultra-
processed food consumption is associated with worsening of cardiometabolic risk
factors in adults with metabolic syndrome: Longitudinal analysis from a randomized
trial. Atherosclerosis. 2023 Jul;377:12-23. doi: 10.1016/j.atherosclerosis.2023.05.022.
Epub 2023 Jun 7. PMID: 37343432.
Z Chen X, Chu J, Hu W, Sun N, He Q, Liu S, Feng Z, Li T, Han Q, Shen Y.
Associations of ultra-processed food consumption with cardiovascular disease and all-
cause mortality: UK Biobank. Eur J Public Health. 2022 Oct 3;32(5):779-785. doi:
1093/eurpub/ckac104. PMID: 36006020; PMCID: PMC9527958.
Srour B, Fezeu LK, Kesse-Guyot E, Allès B, Méjean C, Andrianasolo RM, Chazelas
E, Deschasaux M, Hercberg S, Galan P, Monteiro CA, Julia C, Touvier M. Ultra-
processed food intake and risk of cardiovascular disease: prospective cohort study
(NutriNet-Santé). BMJ. 2019 May 29;365:l1451. doi: 10.1136/bmj.l1451. PMID:
; PMCID: PMC6538975.
Raoul P, Cintoni M, Palombaro M, Basso L, Rinninella E, Gasbarrini A, Mele MC.
Food Additives, a Key Environmental Factor in the Development of IBD through Gut
Dysbiosis. Microorganisms. 2022 Jan 13;10(1):167. doi:
3390/microorganisms10010167. PMID: 35056616; PMCID: PMC8780106.
Laudisi F, Di Fusco D, Dinallo V, Stolfi C, Di Grazia A, Marafini I, Colantoni A,
Ortenzi A, Alteri C, Guerrieri F, Mavilio M, Ceccherini-Silberstein F, Federici M,
MacDonald TT, Monteleone I, Monteleone G. The Food Additive Maltodextrin
Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates
Intestinal Inflammation. Cell Mol Gastroenterol Hepatol. 2019;7(2):457-473. doi:
1016/j.jcmgh.2018.09.002. Epub 2018 Sep 11. PMID: 30765332; PMCID:
PMC6369223.
Reddavide R, Rotolo O, Caruso MG, Stasi E, Notarnicola M, Miraglia C, Nouvenne
A, Meschi T, De' Angelis GL, Di Mario F, Leandro G. The role of diet in the
prevention and treatment of Inflammatory Bowel Diseases. Acta Biomed. 2018 Dec
;89(9-S):60-75. doi: 10.23750/abm.v89i9-S.7952. PMID: 30561397; PMCID:
PMC6502201.
Filardi T, Panimolle F, Lenzi A, Morano S. Bisphenol A and Phthalates in Diet: An
Emerging Link with Pregnancy Complications. Nutrients. 2020 Feb 19;12(2):525.
doi: 10.3390/nu12020525. PMID: 32092855; PMCID: PMC7071371.
Fenton SE, Ducatman A, Boobis A, DeWitt JC, Lau C, Ng C, Smith JS, Roberts SM.
Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current
State of Knowledge and Strategies for Informing Future Research. Environ Toxicol
Chem. 2021 Mar;40(3):606-630. doi: 10.1002/etc.4890. Epub 2020 Dec 7. PMID:
; PMCID: PMC7906952.
Naspolini NF, Machado PP, Moreira JC, Asmus CIRF, Meyer A. Maternal
consumption of ultra-processed foods and newborn exposure to perfluoroalkyl
substances (PFAS). Cad Saude Publica. 2021 Dec 1;37(11):e00152021. doi:
1590/0102-311X00152021. PMID: 34877989.
Asmus CIRF, Barbosa AP, Meyer A, Damasceno N, Rosa ACS, Medronho R, da
Cunha AJLA, Moreira JC, Fernandes TVRB, Martins M, Luiz RR, de Magalhães
Câmara V. Rio Birth Cohort Study on Environmental Exposure and Childhood
Development - PIPA Project. Ann Glob Health. 2020 Jun 11;86(1):59. doi:
5334/aogh.2709. PMID: 32566487; PMCID: PMC7292139.
Naspolini NF, Machado PP, Fróes-Asmus CIR, Câmara VM, Moreira JC, Meyer A.
Food consumption according to the degree of processing, dietary diversity and socio-
demographic factors among pregnant women in Rio de Janeiro, Brazil: The Rio Birth
Cohort Study of Environmental Exposure and Childhood Development (PIPA
project). Nutr Health. 2021 Mar;27(1):79-88. doi: 10.1177/0260106020960881. Epub
Oct 19. PMID: 33076740.
Lane MM, Gamage E, Travica N, Dissanayaka T, Ashtree DN, Gauci S, Lotfaliany
M, O'Neil A, Jacka FN, Marx W. Ultra-Processed Food Consumption and Mental
Health: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients.
Jun 21;14(13):2568. doi: 10.3390/nu14132568. PMID: 35807749; PMCID:
PMC9268228.
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Copyright (c) 2024 Paweł Smuszkiewicz-Różański, Gabriela Różańska-Smuszkiewicz, Karolina Koszyczarek, Maja Kotowska, Wiktoria Zamirska, Albin Ziemiański, Katarzyna Zięba, Anna Zygmunt
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