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Journal of Education, Health and Sport

Does gut microbiota have an impact on the origin of Alzheimer's and Parkinson's disease? – literature review
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  • Does gut microbiota have an impact on the origin of Alzheimer's and Parkinson's disease? – literature review
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Does gut microbiota have an impact on the origin of Alzheimer's and Parkinson's disease? – literature review

Authors

  • Izabela Oleksak First Military Clinical Hospital with Polyclinic in Lublin, Aleje Racławickie 23, 20-049 Lublin, Poland https://orcid.org/0000-0001-7155-9010
  • Michał Leśniewski Independent Public Clinical Hospital No. 4 in Lublin, Doktora Kazimierza Jaczewskiego 8, 20-954 Lublin, Poland https://orcid.org/0009-0008-5224-1531
  • Iwona Welian-Polus Specialist Hospital named after Ludwik Rydygier in Kraków, os. Złotej Jesieni 1; 31-826 Kraków, Poland https://orcid.org/0000-0001-7193-9734
  • Karolina Maliszewska First Military Clinical Hospital with Polyclinic in Lublin, Aleje Racławickie 23, 20-049 Lublin, Poland https://orcid.org/0000-0003-2068-3112
  • Joanna Ziółkowska Mazovian Provincial Hospital named after John Paul II in Siedlce, Księcia Józefa Poniatowskiego 26, 08-110 Siedlce, Poland https://orcid.org/0009-0003-7404-2844

DOI:

https://doi.org/10.12775/JEHS.2024.57.005

Keywords

neurodegenerative diseases, Alzheimer disease, Parkinson's disease, gut microbiota

Abstract

Introduction and purpose:

Among neurodegenerative disorders, Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent. It has been observed recently that alterations in the gut microbiota are associated with the onset of neurodegenerative disorders. This research aims to estimate the pathomechanisms and disease courses associated with the gut microbiota that lead to AD and PD development.

Material and methods

The following review was based on articles from the PubMed and Google Scholar databases. Key search terms included Alzheimer’s disease; Parkinson’s disease; gut microbiota; neurodegenerative diseases.

State of knowledge

The advancement of neurodegenerative processes is linked to the varying progressive course of both disorders. There are numerous likely reasons that connect the development of AD and PD and the gut microbiome. These include the hypotheses on inflammation, the decrease in the quantity of bacteria that produce short-chain fatty acids, and hygiene. The researchers' suggested treatment plans for the two illnesses are comparable.

Conclusions

A major influence on the development of neurodegenerative disorders is the gut microbiome. To clarify the precise connections between the gut microbiota and the development of AD and PD, further thorough research is required. More human research is required. Furthermore, it's possible that early interventions, such switching to a Mediterranean diet, are anticipated to lower the risk of AD or PD.

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Published

2024-02-07

How to Cite

1.
OLEKSAK, Izabela, LEŚNIEWSKI, Michał, WELIAN-POLUS, Iwona, MALISZEWSKA, Karolina and ZIÓŁKOWSKA, Joanna. Does gut microbiota have an impact on the origin of Alzheimer’s and Parkinson’s disease? – literature review. Journal of Education, Health and Sport. Online. 7 February 2024. Vol. 57, pp. 70-85. [Accessed 9 July 2025]. DOI 10.12775/JEHS.2024.57.005.
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Vol. 57 (2024)

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Copyright (c) 2024 Izabela Oleksak, Michał Leśniewski, Iwona Welian-Polus, Karolina Maliszewska, Joanna Ziółkowska

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