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Journal of Education, Health and Sport

Critical Analysis of the Efficacy and Limitations of GLP-1 Pharmaceuticals in Obesity Management: A Comprehensive Literature Review
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  • Critical Analysis of the Efficacy and Limitations of GLP-1 Pharmaceuticals in Obesity Management: A Comprehensive Literature Review
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Critical Analysis of the Efficacy and Limitations of GLP-1 Pharmaceuticals in Obesity Management: A Comprehensive Literature Review

Authors

  • Katarzyna Gierlach District Railway Hospital in Katowice, Panewnicka 65 Street, 40-760 Katowice https://orcid.org/0009-0004-6767-4875
  • Karolina Nowak Rear Admiral Professor Wiesław Łasiński 7th Military Navy Hospital with Outpatient Clinic in Gdańsk, Polanki 117 Street, 80-305 Gdańsk https://orcid.org/0009-0007-4885-9622
  • Karolina Nowak Rear Admiral Professor Wiesław Łasiński 7th Military Navy Hospital with Outpatient Clinic in Gdańsk, Polanki 117 Street, 80-305 Gdańsk https://orcid.org/0009-0000-2719-8326
  • Zuzanna Olejarz Rear Admiral Professor Wiesław Łasiński 7th Military Navy Hospital with Outpatient Clinic in Gdańsk, Polanki 117 Street, 80-305 Gdańsk https://orcid.org/0009-0009-3750-7124
  • Magdalena Słowik St. Barbara Specialist Hospital No. 5 in Sosnowiec, Medyków Square 1, 41-200 Sosnowiec https://orcid.org/0009-0006-4337-5277
  • Zuzanna Drygała 4th Military Hospital, Weigla 5 Street, 53-114 Wrocław https://orcid.org/0009-0000-1484-2696
  • Julia Wyrwał 4th Military Hospital, Weigla 5 Street, 53-114 Wrocław https://orcid.org/0009-0003-2566-3353
  • Zuzanna Zielińska St. Alexander Hospital, Kościuszki 25 Street, 25-316 Kielce https://orcid.org/0009-0007-1417-0106
  • Maria Nieć Ludwik Rydygier Specialist Hospital, Złota Jesień 1 Street, 31-826 Kraków https://orcid.org/0009-0006-7569-9137
  • Martyna Krasuska Mikulicz-Radecki University Clinical Hospital in Wrocław, Borowska 213 Street, 50-556 Wrocław https://orcid.org/0009-0005-1210-3511

DOI:

https://doi.org/10.12775/JEHS.2024.55.006

Keywords

Obesity, Diabetes, Pharmacotherapy, Prevention, GLP-1, Epidemiology

Abstract

Introduction and purpose

Obesity, a pervasive global pandemic intricately linked to various comorbidities, necessitates a comprehensive and nuanced approach. This article delves into the intricate realm of obesity guidelines, underscoring the significance of lifestyle modifications, preventive measures for childhood obesity, population-based strategies, clinical management protocols, and vigilant monitoring.

GLP-1 drugs, originally designed for type 2 diabetes management, exhibit multifaceted effects beyond glycemic control. They influence appetite regulation, gastric emptying dynamics, and potentially contribute to cardiovascular health improvements. However, the commendable effects come with a caveat - potential side effects necessitating careful consideration in clinical decision-making. Despite gaining popularity through celebrity endorsements, this article firmly underscores the need to view GLP-1 pharmacotherapy as a recommended intervention rather than a miraculous solution.

A brief description of the state of knowledge

Integral to the obesity discourse is the imperative to address weight stigma, demanding evidence-based approaches in both clinical and public health domains. The narrative extends into the future landscape of obesity pharmacotherapy, contemplating the potential role of probiotics. Emphasizing the necessity for long-term studies and randomized trials, it positions probiotics as a low-risk alternative with significant potential in mitigating obesity while simultaneously addressing concerns related to antibiotic resistance.

Summary

The pursuit of a balanced and effective approach to obesity management necessitates a nuanced understanding of medical interventions, consideration of societal perceptions, and exploration of innovative possibilities within the evolving landscape of healthcare.

References

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Published

2024-01-26

How to Cite

1.
GIERLACH, Katarzyna, NOWAK, Karolina, NOWAK, Karolina, OLEJARZ, Zuzanna, SŁOWIK, Magdalena, DRYGAŁA, Zuzanna, WYRWAŁ, Julia, ZIELIŃSKA, Zuzanna, NIEĆ, Maria and KRASUSKA, Martyna. Critical Analysis of the Efficacy and Limitations of GLP-1 Pharmaceuticals in Obesity Management: A Comprehensive Literature Review. Journal of Education, Health and Sport. Online. 26 January 2024. Vol. 55, pp. 87-103. [Accessed 6 July 2025]. DOI 10.12775/JEHS.2024.55.006.
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Vol. 55 (2024)

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Review Articles

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Copyright (c) 2024 Katarzyna Gierlach, Karolina Nowak, Karolina Nowak, Zuzanna Olejarz, Magdalena Słowik, Zuzanna Drygała, Julia Wyrwał, Zuzanna Zielińska, Maria Nieć, Martyna Krasuska

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