Probiotic supplementation as a supportive treatment in inflammatory bowel diseases - literature overview
DOI:
https://doi.org/10.12775/JEHS.2024.54.001Keywords
probiotics, Crohn's Disease, gut microbiome, Colitis UlcerosaAbstract
Introduction and purpose: The human body hosts a diverse ecosystem of commensal microbes, known as the human microbiome. This review aims to asses the current state of knowledge regarding the effectiveness, mechanisms of action, and potential benefits of probiotic supplementation in patients with inflammatory bowel diseases.
Materials and methods: A literature review was conducted using the “PubMed” and “Google Scholar” databases with the keywords “Probiotics”, “Gut Microbiome”, “Probiotics and the treatment of Crohns Disease”, “Probiotics and the treatment of Colitis Ulcerosa”.
State of knowledge: Dysbiosis is known to disrupt the function of the intestinal mucosis and has been associated with chronic tissue inflammation. The use of probiotics is a promising method to improve the state of gut microbiota. It is known that the gut microbiome is disrupted in inflammatory bowel diseases.
Summary: The use of probiotics in Ulcerative Colitis is supported by a significant amount of evidence supporting its effectiveness. In the case of Crohn’s Disease there is a lack of evidence to definitively determine whether the use of probiotics yields therapeutic benefits. Therefore there is a need for further research in this area.
References
Quaglio AEV, Grillo TG, De Oliveira ECS, Di Stasi LC, Sassaki LY. Gut microbiota, inflammatory bowel disease and colorectal cancer. World J Gastroenterol. 2022;28(30):4053-4060. doi:10.3748/wjg.v28.i30.4053
Dixit K, Chaudhari D, Dhotre D, Shouche Y, Saroj S. Restoration of dysbiotic human gut microbiome for homeostasis. Life Sci. 2021;278:119622. doi:10.1016/j.lfs.2021.119622
Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D. Role of the normal gut microbiota. World J Gastroenterol. 2015;21(29):8787-8803. doi:10.3748/wjg.v21.i29.8787
Shanahan F, Ghosh TS, O'Toole PW. The Healthy Microbiome-What Is the Definition of a Healthy Gut Microbiome?. Gastroenterology. 2021;160(2):483-494. doi:10.1053/j.gastro.2020.09.057
Qiu P, Ishimoto T, Fu L, Zhang J, Zhang Z, Liu Y. The Gut Microbiota in Inflammatory Bowel Disease. Front Cell Infect Microbiol. 2022;12:733992. Published 2022 Feb 22. doi:10.3389/fcimb.2022.733992
Zatorski H, Sałaga M, Zielińska M, Fichna J. Czynniki genetyczne w patogenezie, przebiegu i leczeniu nieswoistych chorób zapalnych jelit. Postepy Higieny i Medycyny Doswiadczalnej. 2015;69:335–344.
Stanisław Wojtuń, Jerzy Gil, Łukasz Szwed, Przemysław Dyrla.Basic symptoms and differentiation of inflammatory bowel diseases. Pediatr Med rodz Vol 10 Numer 1, p. 61–66. doi: 10.15557/PiMR.2014.0009.
Sairenji T, Collins KL, Evans DV. An Update on Inflammatory Bowel Disease. Prim Care. 2017;44(4):673-692. doi:10.1016/j.pop.2017.07.010.
Zhang YZ, Li YY. Inflammatory bowel disease: pathogenesis. World J Gastroenterol. 2014;20(1):91-99. doi:10.3748/wjg.v20.i1.91.
Lloyd-Price J, Arze C, Ananthakrishnan AN, et al. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature. 2019;569(7758):655-662. doi:10.1038/s41586-019-1237-9.
Borren NZ, Plichta D, Joshi AD, et al. Alterations in Fecal Microbiomes and Serum Metabolomes of Fatigued Patients With Quiescent Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2021;19(3):519-527.e5. doi:10.1016/j.cgh.2020.03.013.
Boland K, Bedrani L, Turpin W, et al. Persistent Diarrhea in Patients With Crohn's Disease After Mucosal Healing Is Associated With Lower Diversity of the Intestinal Microbiome and Increased Dysbiosis. Clin Gastroenterol Hepatol. 2021;19(2):296-304.e3. doi:10.1016/j.cgh.2020.03.044.
Mentella MC, Scaldaferri F, Pizzoferrato M, Gasbarrini A, Miggiano GAD. Nutrition, IBD and Gut Microbiota: A Review. Nutrients. 2020;12(4):944. Published 2020 Mar 29. doi:10.3390/nu12040944.
Sanders ME, Heimbach JT, Pot B, et al. Health claims substantiation for probiotic and prebiotic products. Gut Microbes. 2011;2(3):127-133. doi:10.4161/gmic.2.3.16174.
Sarowska J, Choroszy-Król I, Regulska-Ilow B, Frej-Mądrzak M, Jama-Kmiecik A. The therapeutic effect of probiotic bacteria on gastrointestinal diseases. Adv Clin Exp Med. 201322(5):759-766.
Monika Jach, Renata Łoś, Maciej Maj,Anna Malm .Probiotics–technological and manufacturing aspects. POST. MIKROBIOL., 2013, 52,2,161–170.
Sarowska J, Choroszy-Król I, Regulska-Ilow B, Frej-Mądrzak M, Jama-Kmiecik A. The therapeutic effect of probiotic bacteria on gastrointestinal diseases. Adv Clin Exp Med. 2013;22(5):759-766.
Yang Liu, Yifeng Li, Xinjie Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Qixiao Zhai, and Wei Chen. Physiological Characteristics of Lactobacillus casei Strains and Their Alleviation Effects against Inflammatory Bowel Disease. J. Microbiol. Biotechnol. 2021; 31(1): 92-103. doi:10,4014/jmb.2003.03041.
Nakase H, Sato N, Mizuno N, Ikawa Y. The influence of cytokines on the complex pathology of ulcerative colitis. Autoimmun Rev. 2022;21(3):103017. doi:10.1016/j.autrev.2021.103017.
Klimaszewska K., Krajewska-Kułak E. (red.): Współczesne wyzwania w ochronie zdrowia. Tom VI. Uniwersytet Medyczny w Białymstoku, Białystok 2022, 1-505, ISBN 978-83-67454-01-8.
Abraham BP, Quigley EMM. Probiotics in Inflammatory Bowel Disease. Gastroenterol Clin North Am. 2017;46(4):769-782. doi:10.1016/j.gtc.2017.08.003.
Lewandowski K, Kaniewska M, Szczubełek M, Tulewicz-Marti E, Rydzewska G. Zastosowanie kliniczne probiotyku zawierającego szczep Lactobacillus paracasei CNCM I-1572. Lekarz POZ. 2022;8(5).
Kaur L, Gordon M, Baines PA, Iheozor-Ejiofor Z, Sinopoulou V, Akobeng AK. Probiotics for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2020;3(3):CD005573. Published 2020 Mar 4. doi:10.1002/14651858.CD005573.pub3.
Kim JK, Cheon JH. Factors associated with the prescription of probiotics in patients with inflammatory bowel disease: a cross-sectional study. J Yeungnam Med Sci. 2023;40(1):37-48. doi:10.12701/jyms.2022.00031.
Jakubczyk D, Leszczyńska K, Górska S. The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)-A Critical Review. Nutrients. 2020;12(7):1973. Published 2020 Jul 2. doi:10.3390/nu12071973.
Feuerstein JD, Cheifetz AS. Crohn Disease: Epidemiology, Diagnosis, and Management. Mayo Clin Proc. 2017;92(7):1088-1103. doi:10.1016/j.mayocp.2017.04.010.
Limketkai BN, Akobeng AK, Gordon M, Adepoju AA. Probiotics for induction of remission in Crohn's disease. Cochrane Database Syst Rev. 2020;7(7):CD006634. Published 2020 Jul 17. doi:10.1002/14651858.CD006634.pub3.
Ganji-Arjenaki M, Rafieian-Kopaei M. Probiotics are a good choice in remission of inflammatory bowel diseases: A meta analysis and systematic review. J Cell Physiol. 2018;233(3):2091-2103. doi:10.1002/jcp.25911.
Akutko K, Stawarski A. Probiotics, Prebiotics and Synbiotics in Inflammatory Bowel Diseases. J Clin Med. 2021;10(11):2466. Published 2021 Jun 2. doi:10.3390/jcm10112466.
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Copyright (c) 2024 Alicja Grabarczyk, Martyna Grabowska-Szczurek, Jakub Rybak, Karol Magiera, Barbara Magiera, Piotr Bator, Michał Razik, Patrycja Rozwadowska
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