The use of platelet-rich plasma injections in the treatment of meniscal injuries - review of the literature
DOI:
https://doi.org/10.12775/JEHS.2024.54.010Keywords
platelet-rich plasma, meniscus tears, platelet-rich plasma injectionsRemove platelet-rich plasma injections, menisectomyAbstract
Introduction: In the knee joint are two menisci, which are fibrocartilaginous structures. The tears of the meniscus are one of the most common injuries within knee. Arthroscopy with suturing of torn or menisectomy are the most popular methods of treatment, however in long term observation menisectomy often results in osteoarthritis 10-20 years after surgery. For this reason, less invasive treatment methods are being sought, such as platelet-rich plasma injections. Platelet-rich plasma has many growth factors, which stimulates healing.
Objective: The aim of this study is to review latest the literature on the use of platelet-rich plasma injections in the patients with meniscus tears.
Material and methods: A literature review was conducted on databases such as PubMed and Google Scholar using the terms: ”meniscus”, “meniscus tear”, “platelet-rich plasma”, “platelet-rich plasma injections”, “meniscus injuries treatment’.
Conclusions: The injuries of meniscus are very common, and often must be treated by arthroscopy. Platelet-rich plasma has a positive impact on tissue healing. Platelet-rich plasma injuries in the patients with meniscal tears repair lead to improve healing rates compare with patients without PRP injections, but there is no guidelines and further studies are necessary.
References
Tarafder S, Park G, Lee CH. Explant models for meniscus metabolism, injury, repair, and healing. Connect Tissue Res. 2020 May-Jul;61(3-4):292-303. doi: 10.1080/03008207.2019.1702031. Epub 2019 Dec 16. PMID: 31842590; PMCID: PMC7190414.
Abraham AC, Edwards CR, Odegard GM, Donahue TL. Regional and fiber orientation dependent shear properties and anisotropy of bovine meniscus. J Mech Behav Biomed Mater. 2011 Nov;4(8):2024-30. doi: 10.1016/j.jmbbm.2011.06.022. Epub 2011 Jul 7. PMID: 22098902; PMCID: PMC3222856.
Baker BM, Gee AO, Sheth NP, Huffman GR, Sennett BJ, Schaer TP, Mauck RL. Meniscus tissue engineering on the nanoscale: from basic principles to clinical application. J Knee Surg. 2009 Jan;22(1):45-59. doi: 10.1055/s-0030-1247727. PMID: 19216353; PMCID: PMC5559708.
Athanasiou KA and Sanchez-Adams J, Engineering the Knee Meniscus. Synthesis Lectures on Tissue Engineering, ed. Athanasiou KA and Kent Leach JK. 2009: Morgan and Claypool Publishers.
McDevitt CA, Webber RJ. The ultrastructure and biochemistry of meniscal cartilage. Clin Orthop Relat Res. 1990 Mar;(252):8-18. PMID: 2406077.
Greif DN, Baraga MG, Rizzo MG, Mohile NV, Silva FD, Fox T, Jose J. MRI appearance of the different meniscal ramp lesion types, with clinical and arthroscopic correlation. Skeletal Radiol. 2020 May;49(5):677-689. doi: 10.1007/s00256-020-03381-4. Epub 2020 Jan 25. PMID: 31982971.
Cook JL, Fox DB. A novel bioabsorbable conduit augments healing of avascular meniscal tears in a dog model. Am J Sports Med. 2007 Nov;35(11):1877-87. doi: 10.1177/0363546507304330. Epub 2007 Aug 16. PMID: 17702993.
Kumar NS, et al. Anatomic repair of posteromedial meniscocapsular separation using an all-inside technique. Arthrosc Tech. 2017;6(4):e921–6.
Buyukdogan K, Laidlaw MS, Miller MD. Meniscal ramp lesion repair by a trans-septal portal technique. Arthrosc Tech.2017;6(4):e1379–86.
Thaunat M, et al. Classification and surgical repair of ramp lesions of the medial meniscus. Arthrosc Tech. 2016;5(4):e871–5.
Noyes FR and Barber-Westin SD, Repair of complex and avascular meniscal tears and meniscal transplantation. J Bone Joint Surg Am, 2010. 92(4): p. 1012–29.
Freedman KB, Nho SJ, Cole BJ. Marrow stimulating technique to augment meniscus repair. Arthroscopy. 2003 Sep;19(7):794-8. doi: 10.1016/s0749-8063(03)00695-9. PMID: 12966391.
Deviandri R, Daulay MC, Iskandar D, Kautsar AP, Lubis AMT, Postma MJ. Health-economic evaluation of meniscus tear treatments: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2023 Sep;31(9):3582-3593. doi: 10.1007/s00167-022-07278-8. Epub 2023 Jan 13. PMID: 36637478; PMCID: PMC10435400.
Doral MN, Bilge O, Huri G, Turhan E, Verdonk R. Modern treatment of meniscal tears. EFORT Open Rev. 2018;3(5):260–268. doi: 10.1302/2058-5241.3.170067.
Mordecai SC, Al-Hadithy N, Ware HE, Gupte CM. Treatment of meniscal tears: An evidence based approach. World J Orthop. 2014;5(3):233–241. doi: 10.5312/wjo.v5.i3.233.
Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020. Int J Mol Sci. 2020 Oct 21;21(20):7794. doi: 10.3390/ijms21207794. PMID: 33096812; PMCID: PMC7589810.
Li Z, Weng X. Platelet-rich plasma use in meniscus repair treatment: a systematic review and meta-analysis of clinical studies. J Orthop Surg Res. 2022 Oct 8;17(1):446. doi: 10.1186/s13018-022-03293-0. PMID: 36209223; PMCID: PMC9548158.
Kurnaz R, Balta O. Effect of platelet-rich plasma and platelet-rich fibrin matrix on healing of vertical meniscal tears in a rabbit model. Acta Orthop Traumatol Turc. 2020;54(2):186–195. doi: 10.5152/j.aott.2020.02.20.
Freymann U, Metzlaff S, Krüger J-P, Hirsh G, Endres M, Petersen W, et al. Effect of human serum and 2 different types of platelet concentrates on human meniscus cell migration, proliferation, and matrix formation. Arthroscopy. 2016;32(6):1106–1116. doi: 10.1016/j.arthro.2015.11.033.
Zhang JY, Fabricant PD, Ishmael CR, Wang JC, Petrigliano FA, Jones KJ. Utilization of platelet-rich plasma for musculoskeletal injuries: an analysis of current treatment trends in the United States. Orthop J Sports Med. 2016;4(12):2325967116676241. doi: 10.1177/2325967116676241.
Mitev K, Longurov A. Intra-articular platelet-rich plasma injections for treating knee pain associated with articular cartilage and degenerative meniscal lesions. Open Access Maced J Med Sci. 2019;7(15):2484–2487. doi: 10.3889/oamjms.2019.674.
Dai W-L, Zhang H, Lin Z-M, Shi Z-J, Wang J. Efficacy of platelet-rich plasma in arthroscopic repair for discoid lateral meniscus tears. BMC Musculoskelet Disord. 2019;20(1):113. doi: 10.1186/s12891-019-2500-9.
Sheean AJ, Anz AW, Bradley JP. Platelet-rich plasma: fundamentals and clinical applications. Arthroscopy. 2021;37(9):2732–2734. doi: 10.1016/j.arthro.2021.07.003.
Filardo G, Kon E, Roffi A, Di Matteo B, Merli ML, Marcacci M. Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration. Knee Surg Sports Traumatol Arthrosc. 2015;23(9):2459–2474. doi: 10.1007/s00167-013-2743-1.
Moretti L, Maccagnano G, Coviello M, Cassano GD, Franchini A, Laneve A, et al. Platelet rich plasma injections for knee osteoarthritis treatment: a prospective clinical study. J Clin Med. 2022;11(9):2640. doi: 10.3390/jcm11092640.
Barkai O, Puig S, Lev S, Title B, Katz B, Eli-Berchoer L, et al. Platelet-derived growth factor activates nociceptive neurons by inhibiting M-current and contributes to inflammatory pain. Pain. 2019;160(6):1281–1296. doi: 10.1097/j.pain.0000000000001523.
Kon E, Di Matteo B, Delgado D, Cole BJ, Dorotei A, Dragoo JL, et al. Platelet-rich plasma for the treatment of knee osteoarthritis: an expert opinion and proposal for a novel classification and coding system. Expert Opin Biol Ther. 2020;20(12):1447–1460. doi: 10.1080/14712598.2020.1798925.
Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med. 2009;37(11):2259–2272.
Haunschild ED, Huddleston HP, Chahla J, Gilat R, Cole BJ, Yanke AB. Platelet-Rich Plasma Augmentation in Meniscal Repair Surgery: A Systematic Review of Comparative Studies. Arthroscopy. 2020 Jun;36(6):1765-1774. doi: 10.1016/j.arthro.2020.01.038. Epub 2020 Feb 10. PMID: 32057981.
Pujol N, Salle De Chou E, Boisrenoult P, Beaufils P. Platelet-rich plasma for open meniscal repair in young patients: Any benefit? Knee Surg Sports Traumatol Arthrosc 2015;23:51-58.
Sochacki KR, Safran MR, Abrams GD, Donahue J, Chu C, Sherman SL. Platelet-Rich Plasma Augmentation for Isolated Arthroscopic Meniscal Repairs Leads to Significantly Lower Failure Rates: A Systematic Review of Comparative Studies. Orthop J Sports Med. 2020 Nov 20;8(11):2325967120964534. doi: 10.1177/2325967120964534. PMID: 33283008; PMCID: PMC7682240.
Everhart JS, Cavendish PA, Eikenberry A, Magnussen RA, Kaeding CC, Flanigan DC. Platelet-rich plasma reduces failure risk for isolated meniscal repairs but provides no benefit for meniscal repairs with anterior cruciate ligament reconstruction. Am J Sports Med. 2019;47(8):1789–1796.
Sabbag OD, Hevesi M, Sanders TL, et al. High rate of recurrent meniscal tear and lateral compartment osteoarthritis in patients treated for symptomatic lateral discoid meniscus: a population-based study. Orthop J Sports Med. 2019;7(7):2325967119856284.
Dai WL, Zhang H, Lin ZM, Shi ZJ, Wang J. Efficacy of platelet-rich plasma in arthroscopic repair for discoid lateral meniscus tears. BMC Musculoskelet Disord. 2019;20(1):113.
Ornetti P, Nourissat G, Berenbaum F, Sellam J, Richette P, Chevalier X. Does platelet-rich plasma have a role in the treatment of osteoarthritis? Joint, bone, spine : revue du rhumatisme. 2016;83(1):31–36. doi: 10.1016/j.jbspin.2015.05.002.
Trams E, Kulinski K, Kozar-Kaminska K, Pomianowski S, Kaminski R. The Clinical Use of Platelet-Rich Plasma in Knee Disorders and Surgery-A Systematic Review and Meta-Analysis. Life (Basel). 2020 Jun 25;10(6):94. doi: 10.3390/life10060094. PMID: 32630404; PMCID: PMC7344495.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Katarzyna Wiejak, Kinga Przyborowska, Michał Łata, Beata Getka, Justyna Kwiecień, Mateusz Rukat, Agnieszka Strojny
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 432
Number of citations: 0