Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

Impact of soy isoflavones on the prevention and treatment of obesity
  • Home
  • /
  • Impact of soy isoflavones on the prevention and treatment of obesity
  1. Home /
  2. Archives /
  3. Vol. 53 (2024) /
  4. Review Articles

Impact of soy isoflavones on the prevention and treatment of obesity

Authors

  • Karolina Wąsik 1 Military Clinical Hospital in Lublin, al. Racławickie 23, 20-049 Lublin, Poland https://orcid.org/0000-0003-2817-0848
  • Sebastian Tomaszuk Multidisciplinary Hospital Warsaw-Międzylesie, Bursztynowa 2, 04-749 Warszawa, Poland https://orcid.org/0000-0002-1572-5181
  • Magda Wojtuś Stefan Wyszyński Regional Specialist Hospital in Lublin, al. Kraśnicka 100, 20-718 Lublin, Poland https://orcid.org/0000-0003-4299-2143

DOI:

https://doi.org/10.12775/JEHS.2024.53.002

Keywords

soy isoflavones, Obesity, NAFLD, health, prevention

Abstract

Introduction and purpose:

Currently, as the frequency of obesity is alarming, the role of many factors that could contribute in preventing and treating this condition are being researched, among them the certain food with beneficial health profiles - one of them is soybeans, specifically the isoflavones it contains. Populations that consume soy are known for lower risk of various disorders - among them obesity. The aim of this paper is to summarize the existing paper about the role of these bioactive components in the treatment of this condition. The search was conducted using PubMed and Google Scholarship databases.

Brief description of the state of knowledge:

Obesity is one of the leading challenges in today’s healthcare as it leads to various chronic diseases that are fraught in consequences. Current knowledge is pointing into the association between composition of the soy isoflavones and the lower risk of obesity. Results of the studies indicate that patients affected with obesity could benefit from introducing soy isoflavones into their diet along with other necessary modifications. 

Conclusions:

Soy isoflavones are potential agents in the holistic obesity treatment. Consumption of isoflavones merits further recognition as foregoing results of conducted studies are pointing to its possibly meaningful role. It is worth mentioning that consumption of soy isoflavones is not only an anti-obese factor, but also presents various other health benefits and when consumed rationally poses no risk to human’s well being. We conclude that further studies would enable us to fully reveal the potential of those polyphenols.

References

Kucuk O. Soy foods, isoflavones, and breast cancer. Cancer. 2017 Jun 1;123(11):1901-1903. doi: 10.1002/cncr.30614. Epub 2017 Mar 6. PMID: 28263364.

Messina MJ, Wood CE. Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary. Nutr J. 2008 Jun 3;7:17. doi: 10.1186/1475-2891-7-17. PMID: 18522734; PMCID: PMC2443803.

Boutas I, Kontogeorgi A, Dimitrakakis C, Kalantaridou SN. Soy Isoflavones and Breast Cancer Risk: A Meta-analysis. In Vivo. 2022 Mar-Apr;36(2):556-562. doi: 10.21873/invivo.12737. PMID: 35241506; PMCID: PMC8931889.

Applegate CC, Rowles JL, Ranard KM, Jeon S, Erdman JW. Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis. Nutrients. 2018 Jan 4;10(1):40. doi: 10.3390/nu10010040. PMID: 29300347; PMCID: PMC5793268.

Sahin I, Bilir B, Ali S, Sahin K, Kucuk O. Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy. Integr Cancer Ther. 2019 Jan-Dec;18:1534735419835310. doi: 10.1177/1534735419835310. PMID: 30897972; PMCID: PMC6431760.

Hooshiar SH, Tobeiha M, Jafarnejad S. Soy Isoflavones and Bone Health: Focus on the RANKL/RANK/OPG Pathway. Biomed Res Int. 2022 Oct 25;2022:8862278. doi: 10.1155/2022/8862278. PMID: 36330454; PMCID: PMC9626210.

Purnell JQ. Definitions, Classification, and Epidemiology of Obesity. [Updated 2023 May 4]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279167/

Bray GA, Kim KK, Wilding JPH; World Obesity Federation. Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation. Obes Rev. 2017 Jul;18(7):715-723. doi: 10.1111/obr.12551. Epub 2017 May 10. PMID: 28489290.

Akhlaghi M, Zare M, Nouripour F. Effect of Soy and Soy Isoflavones on Obesity-Related Anthropometric Measures: A Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials. Adv Nutr. 2017 Sep 15;8(5):705-717. doi: 10.3945/an.117.015370. PMID: 28916571; PMCID: PMC5593113.

Ørgaard A, Jensen L. The effects of soy isoflavones on obesity. Exp Biol Med (Maywood). 2008 Sep;233(9):1066-80. doi: 10.3181/0712-MR-347. Epub 2008 Jun 5. PMID: 18535167.

Zhu J, Zhao Q, Qiu Y, Zhang Y, Cui S, Yu Y, Chen B, Zhu M, Wang N, Liu X, Jiang Y, Xu W, Zhao G. Soy Isoflavones Intake and Obesity in Chinese Adults: A Cross-Sectional Study in Shanghai, China. Nutrients. 2021 Aug 6;13(8):2715. doi: 10.3390/nu13082715. PMID: 34444874; PMCID: PMC8399780.

A. Naaz, S. Yellayi, M. A. Zakroczymski, D. Bunick, D. R. Doerge, D. B. Lubahn, W. G. Helferich and P. S. Cooke, Endocrinology, 2003, 144, 3315-3320.

Wang S, Wang Y, Pan MH, Ho CT. Anti-obesity molecular mechanism of soy isoflavones: weaving the way to new therapeutic routes. Food Funct. 2017 Nov 15;8(11):3831-3846. doi: 10.1039/c7fo01094j. PMID: 29043346.

Luo Q, Li Y, Huang C, Cheng D, Ma W, Xia Y, Liu W, Chen Z. Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway. Molecules. 2019 Aug 15;24(16):2966. doi: 10.3390/molecules24162966. PMID: 31443330; PMCID: PMC6719105.

Huang C, Pang D, Luo Q, Chen X, Gao Q, Shi L, Liu W, Zou Y, Li L, Chen Z. Soy Isoflavones Regulate Lipid Metabolism through an AKT/mTORC1 Pathway in Diet-Induced Obesity (DIO) Male Rats. Molecules. 2016 May 3;21(5):586. doi: 10.3390/molecules21050586. PMID: 27153053; PMCID: PMC6273643.

Li L, Chen X, Luo Q, Huang C, Liu W, Chen Z. Effects of soy isoflavones on testosterone synthetase in diet-induced obesity male rats. Int J Clin Exp Pathol. 2017 Sep 1;10(9):9202-9212. PMID: 31966792; PMCID: PMC6965929.

Tang S, Du Y, Oh C, No J. Effects of Soy Foods in Postmenopausal Women: A Focus on Osteosarcopenia and Obesity. J Obes Metab Syndr. 2020 Sep 30;29(3):180-187. doi: 10.7570/jomes20006. PMID: 32843586; PMCID: PMC7539339.

Liu ZM, Ho SC, Chen YM, Ho YP. A mild favorable effect of soy protein with isoflavones on body composition--a 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women. Int J Obes (Lond). 2010 Feb;34(2):309-18. doi: 10.1038/ijo.2009.236. Epub 2009 Nov 17. PMID: 19918248.

Llaneza P, González C, Fernandez-Iñarrea J, Alonso A, Diaz F, Arnott I, Ferrer-Barriendos J. Soy isoflavones, diet and physical exercise modify serum cytokines in healthy obese postmenopausal women. Phytomedicine. 2011 Feb 15;18(4):245-50. doi: 10.1016/j.phymed.2010.07.011. Epub 2010 Aug 21. PMID: 20732799.

Organization WHO (2015) Obesity and overweight. http://www.who.int/mediacentre/fact

Scaglione, Rosario, et al. "Visceral obesity and metabolic syndrome: two faces of the same medal?." Internal and emergency medicine 5 (2010): 111-119.

Ruscica M, Pavanello C, Gandini S, Gomaraschi M, Vitali C, Macchi C, Morlotti B, Aiello G, Bosisio R, Calabresi L, Arnoldi A, Sirtori CR, Magni P. Effect of soy on metabolic syndrome and cardiovascular risk factors: a randomized controlled trial. Eur J Nutr. 2018 Mar;57(2):499-511. doi: 10.1007/s00394-016-1333-7. Epub 2016 Oct 18. PMID: 27757595.

Bakhtiari A, Hajian-Tilaki K, Omidvar S, Nasiri-Amiri F. Clinical and metabolic response to soy administration in older women with metabolic syndrome: a randomized controlled trial. Diabetol Metab Syndr. 2019 Jun 20;11:47. doi: 10.1186/s13098-019-0441-y. PMID: 31249633; PMCID: PMC6584999.

Azadbakht L, Kimiagar M, Mehrabi Y, Esmaillzadeh A, Hu FB, Willett WC. Soy consumption, markers of inflammation, and endothelial function: a cross-over study in postmenopausal women with the metabolic syndrome. Diabetes Care. 2007 Apr;30(4):967-73. doi: 10.2337/dc06-2126. PMID: 17392557.

Woo HW, Kim MK, Lee YH, Shin DH, Shin MH, Choi BY. Habitual consumption of soy protein and isoflavones and risk of metabolic syndrome in adults ≥ 40 years old: a prospective analysis of the Korean Multi-Rural Communities Cohort Study (MRCohort). Eur J Nutr. 2019 Oct;58(7):2835-2850. doi: 10.1007/s00394-018-1833-8. Epub 2018 Sep 27. PMID: 30264377.

Xiao CW, Hendry A. Hypolipidemic Effects of Soy Protein and Isoflavones in the Prevention of Non-Alcoholic Fatty Liver Disease- A Review. Plant Foods Hum Nutr. 2022 Sep;77(3):319-328. doi: 10.1007/s11130-022-00984-1. Epub 2022 Jun 9. PMID: 35678936; PMCID: PMC9463339.

Hakkak R, Spray B, Børsheim E, Korourian S. Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats. Front Nutr. 2022 Jun 22;9:913571. doi: 10.3389/fnut.2022.913571. PMID: 35811988; PMCID: PMC9258741.

Downloads

  • PDF

Published

2024-01-14

How to Cite

1.
WĄSIK, Karolina, TOMASZUK, Sebastian and WOJTUŚ, Magda. Impact of soy isoflavones on the prevention and treatment of obesity. Journal of Education, Health and Sport. Online. 14 January 2024. Vol. 53, pp. 21-31. [Accessed 5 July 2025]. DOI 10.12775/JEHS.2024.53.002.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 53 (2024)

Section

Review Articles

License

Copyright (c) 2024 Karolina Wąsik, Sebastian Tomaszuk, Magda Wojtuś

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 545
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

soy isoflavones, Obesity, NAFLD, health, prevention
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop