Autoimmune pancreatitis - role of intestinal microbiota in pathogenesis. Review of the literature
DOI:
https://doi.org/10.12775/JEHS.2024.52.010Keywords
autoimmune pancreatitis, intestinal microbiome, intestinal dysbiosisAbstract
Introduction: Autoimmune pancreatitis is a type of chronic autoimmune inflammation that can be divided into two types. Type 1 is a clinical manifestation of IgG4-mediated disease, while type 2 may coexist with inflammatory bowel diseases.
Objective: The aim of the study is to review the literature on the role of the intestinal microbiota in the pathogenesis of autoimmune pancreatitis.
Methods: A literature review was conducted on databases such as PubMed and Google Scholar using the terms: ”autoimmune pancreatits”, “intestinal dysbiosis”, “intestinal microbiome”, and “pathogenesis”.
Conclusions: The intestinal microbiota has an impact on the development of autoimmune pancreatitis, but it is not the main pathogenic factor, but rather a risk factor.
References
Shimosegawa T, Chari ST, Frulloni L, Kamisawa T, Kawa S, Mino-Kenudson M, Kim MH, Klöppel G, Lerch MM, Löhr M, Notohara K, Okazaki K, Schneider A, Zhang L; International Association of Pancreatology. International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology. Pancreas. 2011 Apr;40(3):352-8. doi: 10.1097/MPA.0b013e3182142fd2. PMID: 21412117.
Nista EC, De Lucia SS, Manilla V, Schepis T, Pellegrino A, Ojetti V, Pignataro G, Zileri Dal Verme L, Franceschi F, Gasbarrini A, Candelli M. Autoimmune Pancreatitis: From Pathogenesis to Treatment. Int J Mol Sci. 2022 Oct 21;23(20):12667. doi: 10.3390/ijms232012667. PMID: 36293522; PMCID: PMC9604056.
Omiyale AO. Autoimmune pancreatitis. Gland Surg. 2016 Jun;5(3):318-26. doi: 10.21037/gs.2015.11.02. PMID: 27294040; PMCID: PMC4884700.
Okazaki K., Chari S.T., Frulloni L., Lerch M.M., Kamisawa T., Kawa S., Kim M.H., Lévy P., Masamune A., Webster G., et al. International Consensus for the Treatment of Autoimmune Pancreatitis. Pancreatology. 2017;17:1–6. doi: 10.1016/j.pan.2016.12.003.
Kim H.M., Chung M.J., Chung J.B. Remission and Relapse of Autoimmune Pancreatitis: Focusing on Corticosteroid Treatment. Pancreas. 2010;39:555–560. doi: 10.1097/MPA.0b013e3181c8b4a5.
Ishiguro N., Moriyama M., Furusho K., Furukawa S., Shibata T., Murakami Y., Chinju A., Haque A.S.M.R., Gion Y., Ohta M., et al. Activated M2 Macrophages Contribute to the Pathogenesis of IgG4-Related Disease via Toll-like Receptor 7/Interleukin-33 Signaling. Arthritis Rheumatol. 2020;72:166–178. doi: 10.1002/art.41052.
Cayrol C., Girard J.P. IL-33: An Alarmin Cytokine with Crucial Roles in Innate Immunity, Inflammation and Allergy. Curr. Opin. Immunol. 2014;31:31–37. doi: 10.1016/j.coi.2014.09.004.
Furukawa S., Moriyama M., Miyake K., Nakashima H., Tanaka A., Maehara T., Iizuka-Koga M., Tsuboi H., Hayashida J.-N., Ishiguro N., et al. Interleukin-33 Produced by M2 Macrophages and Other Immune Cells Contributes to Th2 Immune Reaction of IgG4-Related Disease. Sci. Rep. 2017;7:srep42413. doi: 10.1038/srep42413.
Minaga K., Watanabe T., Hara A., Kamata K., Omoto S., Nakai A., Otsuka Y., Sekai I., Yoshikawa T., Yamao K., et al. Identification of Serum IFN-α and IL-33 as Novel Biomarkers for Type 1 Autoimmune Pancreatitis and IgG4-Related Disease. Sci. Rep. 2020;10:14879. doi: 10.1038/s41598-020-71848-4
Reizis B. Plasmacytoid Dendritic Cells: Development, Regulation, and Function. Immunity. 2019;50:37–50. doi: 10.1016/j.immuni.2018.12.027.
Jun S.Y., Chun J., Kim S.J., Oh D., Kim J.H., Kim M.H., Hong S.M. Granulocytic Epithelial Lesion (GEL) in Heterotopic Pancreas. Pancreatology. 2022;22:435–442. doi: 10.1016/j.pan.2022.03.001.
Ku Y., Hong S.M., Fujikura K., Kim S.J., Akita M., Abe-Suzuki S., Shiomi H., Masuda A., Itoh T., Azuma T., et al. IL-8 Expression in Granulocytic Epithelial Lesions of Idiopathic Duct-Centric Pancreatitis (Type 2 Autoimmune Pancreatitis) Am. J. Surg. Pathol. 2017;41:1129–1138. doi: 10.1097/PAS.0000000000000891.
Pearl D.S., Shah K., Whittaker M.A., Nitch-Smith H., Brown J.F., Shute J.K., Trebble T.M. Cytokine Mucosal Expression in Ulcerative Colitis, the Relationship between Cytokine Release and Disease Activity. J. Crohn’s Colitis. 2013;7:481–489. doi: 10.1016/j.crohns.2012.07.022.
Dong F., Chen Q.Q., Zhuang Z.H., He Q.L., Wang F.Q., Liu Q.C., Liu H.K., Wang Y. Multiple Gene Mutations in Patients with Type 2 Autoimmune Pancreatitis and Its Clinical Features. Cent. J. Immunol. 2014;39:77. doi: 10.5114/ceji.2014.42129.
Schepis T., De Lucia S.S., Nista E.C., Manilla V., Pignataro G., Ojetti V., Piccioni A., Gasbarrini A., Franceschi F., Candelli M. Clinical Medicine Microbiota in Pancreatic Diseases: A Review of the Literature. J. Clin. Med. 2021;10:5920. doi: 10.3390/jcm10245920.
Yoshikawa T, Watanabe T, Kamata K, Hara A, Minaga K, Kudo M. Intestinal Dysbiosis and Autoimmune Pancreatitis. Front Immunol. 2021 Mar 23;12:621532. doi: 10.3389/fimmu.2021.621532. PMID: 33833754; PMCID: PMC8021793.
Lynch SV, Pedersen O. The Human Intestinal Microbiome in Health and Disease. N Engl J Med (2016) 375:2369–79. 10.1056/NEJMra1600266
Honjo H, Watanabe T, Arai Y, Kamata K, Minaga K, Komeda Y, et al.. ATG16L1 negatively regulates RICK/RIP2-mediated innate immune responses. Int Immunol (2021) 33:91–105. 10.1093/intimm/dxaa062
Kamata K, Watanabe T, Minaga K, Hara A, Yoshikawa T, Okamoto A, et al.. Intestinal dysbiosis mediates experimental autoimmune pancreatitis via activation of plasmacytoid dendritic cells. Int Immunol (2019) 31:795–809. 10.1093/intimm/dxz050
Kamata K., Watanabe T., Minaga K., Hara A., Sekai I., Otsuka Y., Yoshikawa T., Park A.-M., Kudo M. Gut Microbiome Alterations in Type 1 Autoimmune Pancreatitis after Induction of Remission by Prednisolone. Clin. Exp. Immunol. 2020;202:308–320. doi: 10.1111/cei.13509.
Yamaki K., Ohta M., Nakashima I., Noda A., Asai J., Kato N. Microbial Adjuvant and Autoimmunity. Microbiol. Immunol. 1980;24:945–956. doi: 10.1111/j.1348-0421.1980.tb02900.x.
Yoshikawa T, Minaga K, Hara A, Sekai I, Kurimoto M, Masuta Y, Otsuka Y, Takada R, Kamata K, Park AM, Takamura S, Kudo M, Watanabe T. Disruption of the intestinal barrier exacerbates experimental autoimmune pancreatitis by promoting the translocation of Staphylococcus sciuri into the pancreas. Int Immunol. 2022 Dec 31;34(12):621-634. doi: 10.1093/intimm/dxac039. PMID: 36044992.
Ji J., Shu D., Zheng M., Wang J., Luo C., Wang Y., Guo F., Zou X., Lv X., Li Y., et al. Microbial Metabolite Butyrate Facilitates M2 Macrophage Polarization and Function. Sci. Rep. 2016;6:24838. doi: 10.1038/srep24838.
Biagioli M, Carino A, Cipriani S, Francisci D, Marchiano S, Scarpelli P, et al.. The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis. J Immunol (2017) 199:718–33. 10.4049/jimmunol.1700183
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Katarzyna Wiejak, Katarzyna Schok, Jakub Jasek
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 257
Number of citations: 0