Resveratrol - its properties, occurrence and health benefits
DOI:
https://doi.org/10.12775/JEHS.2024.51.009Keywords
wine, resveratrol, non-flavonoids, polyphenols, alcoholAbstract
Introduction and purpose: Wine ingredients relevant to health are polyphenols, which are divided into flavonoids and non-flavonoids. Resveratrol is a non-flavonoid component of wine widely known for its health-promoting properties. This article will discuss its chemical structure, synthesis, metabolism, occurrence in nature and impact on human health.
Review methods: The purpose of this article was to assemble and analyse the available data about resveratrol. The search of articles in Pubmed database was carried out using following keywords: “wine”, “resveratrol”, “polyphenols”, “alcohol”. Inclusion criteria: indexed in Pubmed database, published in last 10 years. Exclusion criteria: Case reports, studies in language other than English, studies that seemed to be biased.
Descripiton of the state of knowledge: Resveratrol has a wide range of health-promoting effects. It inhibits some stages of platelet activation by reducing the synthesis of thromboxane A2 and their aggregation caused by agonists i.e. collagen, ADP, cathepsin G or thrombin. Furthermore, it causes a reduction in blood glucose and glycated hemoglobin levels, increases insulin sensitivity and potentially has protective effect on pancreatic cells. It lowers total plasma cholesterol and low-density lipoproteins levels while increasing insulin sensitivity and high-density lipoproteins level. In addition to this, it has neuroprotective, anti-tumour and anti-angiogenic effect proven in specific types of cancer.
Summary: Resveratrol is said to improve the therapeutic outcome in patients suffering from cardiovascular diseases, diabetes type 2, Alzheimer's disease, other neurodegeneration diseases and in certain cancers. Nevertheless, the issue of resveratrol's effect on the human body requires further research.
References
Tian B, Liu J. Resveratrol: a review of plant sources, synthesis, stability, modification and food application. J Sci Food Agric. 2020 Mar 15;100(4):1392-1404. doi: 10.1002/jsfa.10152
Zhang LX, Li CX, Kakar MU, Khan MS, Wu PF, Amir RM, Dai DF, Naveed M, Li QY, Saeed M, Shen JQ, Rajput SA, Li JH. Resveratrol (RV): A pharmacological review and call for further research. Biomed Pharmacother. 2021 Nov;143:112164. doi: 10.1016/j.biopha.2021.112164
Breuss JM, Atanasov AG, Uhrin P. Resveratrol and Its Effects on the Vascular System. Int J Mol Sci. 2019 Mar 27;20(7):1523. doi: 10.3390/ijms20071523
Tian B, Liu J. Resveratrol: a review of plant sources, synthesis, stability, modification and food application. J Sci Food Agric. 2020 Mar 15;100(4):1392-1404. doi: 10.1002/jsfa.10152
Repossi G, Das UN, Eynard AR. Molecular Basis of the Beneficial Actions of Resveratrol. Arch Med Res. 2020 Feb;51(2):105-114. doi: 10.1016/j.arcmed.2020.01.010
Giovinazzo G, Grieco F. Functional Properties of Grape and Wine Polyphenols. Plant Foods Hum Nutr. 2015 Dec;70(4):454-62. doi: 10.1007/s11130-015-0518-1
Migliori M, Panichi V, de la Torre R, Fitó M, Covas M, Bertelli A, Muñoz-Aguayo D, Scatena A, Paoletti S, Ronco C. Anti-inflammatory effect of white wine in CKD patients and healthy volunteers. Blood Purif. 2015;39(1-3):218-223. doi: 10.1159/000371570
Lubin BR, Inbar N, Pinkus A, Stanevsky M, Cohen J, Rahimi O, Anker Y, Shoseyov O, Drori E. Ecogeographic Conditions Dramatically Affect Trans-Resveratrol and Other Major Phenolics' Levels in Wine at a Semi-Arid Area. Plants (Basel). 2022 Feb 25;11(5):629. doi: 10.3390/plants11050629
Lippi G, Franchini M, Favaloro EJ, Targher G. Moderate red wine consumption and cardiovascular disease risk: beyond the "French paradox". Semin Thromb Hemost. 2010 Feb;36(1):59-70. doi: 10.1055/s-0030-1248725
Bavaresco L, Lucini L, Busconi M, Flamini R, De Rosso M. Wine Resveratrol: From the Ground Up. Nutrients. 2016 Apr 14;8(4):222. doi: 10.3390/nu8040222
Bailey HH, Johnson JJ, Lozar T, Scarlett CO, Wollmer BW, Kim K, Havinghurst T, Ahmad N. A randomized, double-blind, dose-ranging, pilot trial of piperine with resveratrol on the effects on serum levels of resveratrol. Eur J Cancer Prev. 2021 May 1;30(3):285-290. doi: 10.1097/CEJ.0000000000000621
Galiniak S, Aebisher D, Bartusik-Aebisher D. Health benefits of resveratrol administration. Acta Biochim Pol. 2019 Feb 28;66(1):13-21. doi: 10.18388/abp.2018_2749
Szkudelski T, Szkudelska K. Resveratrol and diabetes: from animal to human studies. Biochim Biophys Acta. 2015 Jun;1852(6):1145-54. doi: 10.1016/j.bbadis.2014.10.013
Huang DD, Shi G, Jiang Y, Yao C, Zhu C. A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications. Biomed Pharmacother. 2020 May;125:109767. doi: 10.1016/j.biopha.2019.109767
Hou CY, Tain YL, Yu HR, Huang LT. The Effects of Resveratrol in the Treatment of Metabolic Syndrome. Int J Mol Sci. 2019 Jan 28;20(3):535. doi: 10.3390/ijms20030535
Wiciński M, Socha M, Walczak M, Wódkiewicz E, Malinowski B, Rewerski S, Górski K, Pawlak-Osińska K. Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions. Nutrients. 2018 Nov 21;10(11):1813. doi: 10.3390/nu10111813
Castaldo L, Narváez A, Izzo L, Graziani G, Gaspari A, Minno GD, Ritieni A. Red Wine Consumption and Cardiovascular Health. Molecules. 2019 Oct 8;24(19):3626. doi: 10.3390/molecules24193626
Li T, Tan Y, Ouyang S, He J, Liu L. Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis. Gene. 2022 Jan 15;808:145968. doi: 10.1016/j.gene.2021.145968
Yu Z, Xu W, Wang H. Resveratrol treatment inhibits acute pharyngitis in the mice model through inhibition of PGE2/COX-2 expression. Saudi J Biol Sci. 2018 Nov;25(7):1468-1472. doi: 10.1016/j.sjbs.2017.05.005
Houacine C, Khan I, Yousaf SS. Potential Cardio-Protective Agents: A Resveratrol Review (2000-2019). Curr Pharm Des. 2021;27(26):2943-2955. doi: 10.2174/1381612826666200909125354
Huang DD, Shi G, Jiang Y, Yao C, Zhu C. A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications. Biomed Pharmacother. 2020 May;125:109767. doi: 10.1016/j.biopha.2019.109767
Rao YL, Ganaraja B, Joy T, Pai MM, Ullal SD, Murlimanju BV. Neuroprotective effects of resveratrol in Alzheimer's disease. Front Biosci (Elite Ed). 2020 Jan 1;12(1):139-149. doi: 10.2741/E863
Vervandier-Fasseur D, Latruffe N. The Potential Use of Resveratrol for Cancer Prevention. Molecules. 2019 Dec 9;24(24):4506. doi: 10.3390/molecules24244506
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Copyright (c) 2024 Wiktoria Jabłońska, Marta Wardęszkiewicz, Amelia Kasprzak, Szymon Markowiak, Maciej Świercz, Magdalena Kubisz, Aleksandra Mańkowska, Monika Truchta, Anna Pejas, Agata Kolano
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