Suicide attempt of young woman by Propafenone overdose - case report
DOI:
https://doi.org/10.12775/JEHS.2023.50.01.009Keywords
propafenone poisoning, arrhythmia, propafenone, case reportAbstract
Introduction and purpose: Over the last few years, the number of suicide attempts in Polish women has been steadily increasing. This report presents a case of a 18 years old woman hospitalized in the Toxicology and Cardiology Department due to poisoning with antiarrhythmic drug – Propafenone, taken for suicide purpose.
Brief description of the state of knowledge: Propafenone is an antiarrhythmic drug which belongs to class IC according to the Vaughan-Williams classification. The overdose of this drug can cause various symptoms and complications such as cardiac arrhythmias, liver damage, cardiac arrest and even death. This drug has no specific antidote.
Conclusions: Propafenone poisoning is a significant clinical challenge and the consequences are often unpredictable and life-threatening. Treatment options such as natrium bicarbonicum, insulin, intravenous lipid emulsion, calcium gluconate seem to be good choices and the effects of treatment with these drugs are promising for the future.
References
M. Pikala and M. Burzyńska, “The Burden of Suicide Mortality in Poland: A 20-Year Register-Based Study (2000–2019),” Int. J. Public Health, vol. 68, p. 1605621, Feb. 2023, doi: 10.3389/IJPH.2023.1605621/BIBTEX.
“CV Pharmacology | Class I Antiarrhythmics (Sodium-Channel Blockers).” https://www.cvpharmacology.com/antiarrhy/sodium-blockers (accessed Apr. 19, 2023).
“Propafenone: Uses, Interactions, Mechanism of Action | DrugBank Online.” https://go.drugbank.com/drugs/DB01182 (accessed Apr. 19, 2023).
“Propafenon (chlorowodorek propafenonu) (propafenone hydrochloride) opis substancji - Indeks Leków MP.” https://indeks.mp.pl/desc.php?id=679 (accessed Apr. 19, 2023).
K. Stoschitzky, G. Stoschitzky, P. Lercher, H. Brussee, G. Lamprecht, and W. Lindner, “Propafenone shows class Ic and class II antiarrhythmic effects,” EP Eur., vol. 18, no. 4, pp. 568–571, Apr. 2016, doi: 10.1093/EUROPACE/EUV195.
B. Bayram, E. Dedeoglu, N. Hocaoglu, and E. Gazi, “Propafenone-induced cardiac arrest: full recovery with insulin, is it possible?,” Am. J. Emerg. Med., vol. 31, no. 2, pp. 457.e5-457.e7, Feb. 2013, doi: 10.1016/J.AJEM.2012.08.003.
H. Y. Yi, J. Y. Lee, W. S. Lee, W. Y. Sung, and S. W. Seo, “Comparison of the therapeutic effect between sodium bicarbonate and insulin on acute propafenone toxicity,” Am. J. Emerg. Med., vol. 32, no. 10, pp. 1200–1207, Oct. 2014, doi: 10.1016/J.AJEM.2014.07.010.
X. Chen and Z. Yang, “Successful treatment of propafenone-induced cardiac arrest by calcium gluconate,” Am. J. Emerg. Med., vol. 35, no. 8, pp. 1209.e1-1209.e2, Aug. 2017, doi: 10.1016/J.AJEM.2017.04.006.
B. L. Ten Tusscher, A. Beishuizen, A. R. J. Girbes, E. L. Swart, and R. W. F. Van Leeuwen, “Intravenous fat emulsion therapy for intentional propafenone intoxication,” http://dx.doi.org/10.3109/15563650.2011.597033, vol. 49, no. 7, p. 701, Aug. 2011, doi: 10.3109/15563650.2011.597033.
J. Jacob and K. Heard, “Second case of the use of intravenous fat emulsion therapy for propafenone toxicity,” Clin. Toxicol., vol. 49, no. 10, pp. 946–947, Dec. 2011, doi: 10.3109/15563650.2011.629202.
B. Bayram, I. D. L. D. A. L. Köse, S. Avcit, A. Arslan, and Ç. Acara, “Successful Treatment of Propafenone Intoxication with Intravenous Lipid Emulsion,” Pharmacotherapy, vol. 35, no. 10, pp. e149–e152, Oct. 2015, doi: 10.1002/PHAR.1637.
M. E. Arı and F. Ekici, “Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report,” Balkan Med. J., vol. 34, no. 5, p. 473, 2017, doi: 10.4274/BALKANMEDJ.2016.1185.
B. Ling, P. Geng, D. Tan, and J. Walline, “Full recovery after prolonged resuscitation from cardiac arrest due to propafenone intoxication: A case report,” Medicine (Baltimore)., vol. 97, no. 15, Apr. 2018, doi: 10.1097/MD.0000000000010285.
“ZESZYTY EDUKACYJNE. KARDIOLOGIA POLSKA 2/2021 8,” 2020, Accessed: Nov. 04, 2023. [Online]. Available: https://ptkardio.pl/wytyczne.
T. M. Markman et al., “Safety of Pill-in-the-Pocket Class 1C Antiarrhythmic Drugs for Atrial Fibrillation,” JACC Clin. Electrophysiol., vol. 8, no. 12, pp. 1515–1520, Dec. 2022, doi: 10.1016/J.JACEP.2022.07.010.
H. K. Kim, S. S. Kim, Y. J. Ki, K. H. Park, and D. H. Choi, “Ventricular Tachycardia in Association with Propafenone Overdose,” Acta Cardiol. Sin., vol. 37, no. 1, pp. 100–103, 2021, doi: 10.6515/ACS.202101_37(1).20200914A.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Marcin Wais, Dariusz Gruca, Marlena Zając
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 315
Number of citations: 0
