Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

Suicide attempt of young woman by Propafenone overdose - case report
  • Home
  • /
  • Suicide attempt of young woman by Propafenone overdose - case report
  1. Home /
  2. Archives /
  3. Vol. 50 No. 1 (2023) /
  4. Case Reports

Suicide attempt of young woman by Propafenone overdose - case report

Authors

  • Marcin Wais 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Lublinie https://orcid.org/0000-0003-4757-8582
  • Dariusz Gruca 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Lublinie https://orcid.org/0000-0002-5583-1229
  • Marlena Zając 7 Szpital Marynarki Wojennej w Gdańsku https://orcid.org/0000-0002-6251-0175

DOI:

https://doi.org/10.12775/JEHS.2023.50.01.009

Keywords

propafenone poisoning, arrhythmia, propafenone, case report

Abstract

Introduction and purpose: Over the last few years, the number of suicide attempts in Polish women has been steadily increasing. This report presents a case of a 18 years old woman hospitalized in the Toxicology and Cardiology Department due to poisoning with antiarrhythmic drug – Propafenone, taken for suicide purpose.

Brief description of the state of knowledge: Propafenone is an antiarrhythmic drug which belongs to class IC according to the Vaughan-Williams classification. The overdose of this drug can cause various symptoms and complications such as cardiac arrhythmias, liver damage, cardiac arrest and even death. This drug has no specific antidote.  

Conclusions: Propafenone poisoning is a significant clinical challenge and the consequences are often unpredictable and life-threatening. Treatment options such as natrium bicarbonicum, insulin, intravenous lipid emulsion, calcium gluconate seem to be good choices and the effects of treatment with these drugs are promising for the future.

References

M. Pikala and M. Burzyńska, “The Burden of Suicide Mortality in Poland: A 20-Year Register-Based Study (2000–2019),” Int. J. Public Health, vol. 68, p. 1605621, Feb. 2023, doi: 10.3389/IJPH.2023.1605621/BIBTEX.

“CV Pharmacology | Class I Antiarrhythmics (Sodium-Channel Blockers).” https://www.cvpharmacology.com/antiarrhy/sodium-blockers (accessed Apr. 19, 2023).

“Propafenone: Uses, Interactions, Mechanism of Action | DrugBank Online.” https://go.drugbank.com/drugs/DB01182 (accessed Apr. 19, 2023).

“Propafenon (chlorowodorek propafenonu) (propafenone hydrochloride) opis substancji - Indeks Leków MP.” https://indeks.mp.pl/desc.php?id=679 (accessed Apr. 19, 2023).

K. Stoschitzky, G. Stoschitzky, P. Lercher, H. Brussee, G. Lamprecht, and W. Lindner, “Propafenone shows class Ic and class II antiarrhythmic effects,” EP Eur., vol. 18, no. 4, pp. 568–571, Apr. 2016, doi: 10.1093/EUROPACE/EUV195.

B. Bayram, E. Dedeoglu, N. Hocaoglu, and E. Gazi, “Propafenone-induced cardiac arrest: full recovery with insulin, is it possible?,” Am. J. Emerg. Med., vol. 31, no. 2, pp. 457.e5-457.e7, Feb. 2013, doi: 10.1016/J.AJEM.2012.08.003.

H. Y. Yi, J. Y. Lee, W. S. Lee, W. Y. Sung, and S. W. Seo, “Comparison of the therapeutic effect between sodium bicarbonate and insulin on acute propafenone toxicity,” Am. J. Emerg. Med., vol. 32, no. 10, pp. 1200–1207, Oct. 2014, doi: 10.1016/J.AJEM.2014.07.010.

X. Chen and Z. Yang, “Successful treatment of propafenone-induced cardiac arrest by calcium gluconate,” Am. J. Emerg. Med., vol. 35, no. 8, pp. 1209.e1-1209.e2, Aug. 2017, doi: 10.1016/J.AJEM.2017.04.006.

B. L. Ten Tusscher, A. Beishuizen, A. R. J. Girbes, E. L. Swart, and R. W. F. Van Leeuwen, “Intravenous fat emulsion therapy for intentional propafenone intoxication,” http://dx.doi.org/10.3109/15563650.2011.597033, vol. 49, no. 7, p. 701, Aug. 2011, doi: 10.3109/15563650.2011.597033.

J. Jacob and K. Heard, “Second case of the use of intravenous fat emulsion therapy for propafenone toxicity,” Clin. Toxicol., vol. 49, no. 10, pp. 946–947, Dec. 2011, doi: 10.3109/15563650.2011.629202.

B. Bayram, I. D. L. D. A. L. Köse, S. Avcit, A. Arslan, and Ç. Acara, “Successful Treatment of Propafenone Intoxication with Intravenous Lipid Emulsion,” Pharmacotherapy, vol. 35, no. 10, pp. e149–e152, Oct. 2015, doi: 10.1002/PHAR.1637.

M. E. Arı and F. Ekici, “Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report,” Balkan Med. J., vol. 34, no. 5, p. 473, 2017, doi: 10.4274/BALKANMEDJ.2016.1185.

B. Ling, P. Geng, D. Tan, and J. Walline, “Full recovery after prolonged resuscitation from cardiac arrest due to propafenone intoxication: A case report,” Medicine (Baltimore)., vol. 97, no. 15, Apr. 2018, doi: 10.1097/MD.0000000000010285.

“ZESZYTY EDUKACYJNE. KARDIOLOGIA POLSKA 2/2021 8,” 2020, Accessed: Nov. 04, 2023. [Online]. Available: https://ptkardio.pl/wytyczne.

T. M. Markman et al., “Safety of Pill-in-the-Pocket Class 1C Antiarrhythmic Drugs for Atrial Fibrillation,” JACC Clin. Electrophysiol., vol. 8, no. 12, pp. 1515–1520, Dec. 2022, doi: 10.1016/J.JACEP.2022.07.010.

H. K. Kim, S. S. Kim, Y. J. Ki, K. H. Park, and D. H. Choi, “Ventricular Tachycardia in Association with Propafenone Overdose,” Acta Cardiol. Sin., vol. 37, no. 1, pp. 100–103, 2021, doi: 10.6515/ACS.202101_37(1).20200914A.

Downloads

  • PDF

Published

2023-12-31

How to Cite

1.
WAIS, Marcin, GRUCA, Dariusz and ZAJĄC, Marlena. Suicide attempt of young woman by Propafenone overdose - case report. Journal of Education, Health and Sport. Online. 31 December 2023. Vol. 50, no. 1, pp. 117-126. [Accessed 28 June 2025]. DOI 10.12775/JEHS.2023.50.01.009.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 50 No. 1 (2023)

Section

Case Reports

License

Copyright (c) 2023 Marcin Wais, Dariusz Gruca, Marlena Zając

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 408
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

propafenone poisoning, arrhythmia, propafenone, case report
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop