The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer

Authors

  • I. I. Yakovtcova Kharkiv medical academy of postgraduate education
  • P. V. Tkachenko Kharkiv medical academy of postgraduate education
  • I. V. Ivakhno Kharkiv medical academy of postgraduate education

Keywords

prostatic cancer, angiogenesis, vascular endothelial growth factor, microvessel density.

Abstract

Angiogenesis is a key factor in tumor growth, invasion, and metastasis. The aim of the present study is to investigate the diagnostic and predictive value of prostatic cancer (PC) angiogenesis by immunohistochemically examination of CD34, VEGF and Ki-67 in40 cases of PC, 8 cases of nodular hyperplasia and 8 cases of intraepithelial neoplasia. It was found that the density of microvessels and intensity data of stroma but not epithelium VEGF staining in PC more than in benign pathology, and increased with risk of recurrence and as the differentiation of cancer was reduced. Results indicate that the vascularization is a sign of growth and progression of PC and may be used as predictor of the disease.

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Published

2017-08-30

How to Cite

1.
YAKOVTCOVA, I. I., TKACHENKO, P. V. and IVAKHNO, I. V. The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer. Journal of Education, Health and Sport. Online. 30 August 2017. Vol. 7, no. 8, pp. 415-422. [Accessed 14 December 2024].

Issue

Vol. 7 No. 8 (2017)

Section

Articles

License

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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