Clinical differentiation between ovarian granulosa cell tumor and ovarian cancer: a review
DOI:
https://doi.org/10.12775/JEHS.2023.48.01.006Keywords
ovarian cancer, granuloma cell tumour, GCT, oGCTAbstract
Differentiation of granulosa cell tumor and ovarian cancer doesn’t seem to cause much trouble in everyday clinical work. Despite quite easy distinction, within the researches discussed within this review, findings were suggesting less obvious results. There was a huge urge to take into consideration immunohistochemical differentiation. Common symptoms of many gynecological tumors are very similar, studies investigated that GCT and ovarian cancer frequently overlap. Symptoms, method of treatment and prevalence rate (at some point) are often shared between these neoplasms. Fortunately, great distinction was provided by immunohistochemical findings.
References
Hanby, A.M., walker, C. Tavassoli FA, Devilee P: Pathology and Genetics: Tumours of the Breast and Female Genital Organs. WHO Classification of Tumours series - volume IV. Lyon, France: IARC Press. Breast Cancer Res 6, 133 (2004). doi:10.1186/bcr788
Kanthan, Rani et al. “The multifaceted granulosa cell tumours-myths and realities: a review.” ISRN obstetrics and gynecology vol. 2012 (2012): 878635. doi:10.5402/2012/878635
Pecorelli, S et al. “Cisplatin (P), vinblastine (V) and bleomycin (B) combination chemotherapy in recurrent or advanced granulosa(-theca) cell tumours of the ovary. An EORTC Gynaecological Cancer Cooperative Group study.” European journal of cancer (Oxford, England : 1990) vol. 35,9 (1999): 1331-7. doi:10.1016/s0959-8049(99)00142-2
Nikumbh, Dhiraj B et al. “Ovarian juvenile granulosa cell tumour in childhood: uncommon gynecological malignancy.” Journal of clinical and diagnostic research : JCDR vol. 8,10 (2014): FL01-2. doi:10.7860/JCDR/2014/9510.4935
Hashemipour, Mahin et al. “Granulosa cell tumor in a six-year-old girl presented as precocious puberty.” Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences vol. 15,4 (2010): 240-2.
Vassal, G et al. “Juvenile granulosa cell tumor of the ovary in children: a clinical study of 15 cases.” Journal of clinical oncology : official journal of the American Society of Clinical Oncology vol. 6,6 (1988): 990-5. doi:10.1200/JCO.1988.6.6.990
Plantaz, D et al. “Tumeurs de la granulosa de l'ovaire chez l'enfant et l'adolescente. Etude multicentrique rétrospective de 40 patientes âgées de 7 mois à 22 ans” [Granulosa cell tumors of the ovary in children and adolescents. Multicenter retrospective study in 40 patients aged 7 months to 22 years]. Archives francaises de pediatrie vol. 49,9 (1992): 793-8.
Li, Xiuwen et al. “Adult-type granulosa cell tumor of the ovary.” American journal of cancer research vol. 12,8 3495-3511. 15 Aug. 2022
Oliveira, J. et al. “Ultrasound accuracy in Granulosa Cell Tumors diagnosis.” Australasian Journal of Ultrasound in Medicine vol. 22,2 150. 17 Apr. 2019, doi:10.1002/ajum.12157
Khosla, Divya et al. “Ovarian granulosa cell tumor: clinical features, treatment, outcome, and prognostic factors.” North American journal of medical sciences vol. 6,3 (2014): 133-8. doi:10.4103/1947-2714.128475
Gitsch, G et al. “Expression of cytokeratins in granulosa cell tumors and ovarian carcinomas.” Archives of gynecology and obstetrics vol. 251,4 (1992): 193-7. doi:10.1007/BF02718386
Gomes, Tiago Augusto et al. “Preoperative Differentiation of Benign and Malignant Non-epithelial Ovarian Tumors: Clinical Features and Tumor Markers.” “Diferenciação pré-operatória de tumores ovarianos não epiteliais benignos e malignos: características clínicas e marcadores tumorais.” Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia vol. 42,9 (2020): 555-561. doi:10.1055/s-0040-1712993
Reid, Brett M et al. “Epidemiology of ovarian cancer: a review.” Cancer biology & medicine vol. 14,1 (2017): 9-32. doi:10.20892/j.issn.2095-3941.2016.0084
Zhang, He et al. “MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors.” Journal of ovarian researchvol. 11,1 46. 5 Jun. 2018, doi:10.1186/s13048-018-0416-x
Chan, John K et al. “Symptoms of Women With High-Risk Early-Stage Ovarian Cancer.” Obstetrics and gynecology vol. 139,2 (2022): 157-162. doi:10.1097/AOG.0000000000004642
Edmondson, R J, and J M Monaghan. “The epidemiology of ovarian cancer.” International journal of gynecological cancer : official journal of the International Gynecological Cancer Society vol. 11,6 (2001): 423-9. doi:10.1046/j.1525-1438.2001.01053.x
WHO Classification of Tumours Editorial Board, ed. (2020). "1. Tumours of the ovary: introduction". Female genital tumours: WHO Classification of Tumours. Vol. 4 (5th ed.). Lyon (France): International Agency for Research on Cancer. pp. 32–35. ISBN 978-92-832-4504-9.
Ho, Shuk-Mei. “Estrogen, progesterone and epithelial ovarian cancer.” Reproductive biology and endocrinology : RB&E vol. 1 73. 7 Oct. 2003, doi:10.1186/1477-7827-1-73
Pectasides, D et al. “Granulosa cell tumor of the ovary.” Cancer treatment reviews vol. 34,1 (2008): 1-12. doi:10.1016/j.ctrv.2007.08.007
Orr, Brian, and Robert P Edwards. “Diagnosis and Treatment of Ovarian Cancer.” Hematology/oncology clinics of North America vol. 32,6 (2018): 943-964. doi:10.1016/j.hoc.2018.07.010
Winter-Roach, Brett A et al. “Adjuvant (post-surgery) chemotherapy for early stage epithelial ovarian cancer.” The Cochrane database of systematic reviews vol. 3,3 CD004706. 14 Mar. 2012, doi:10.1002/14651858.CD004706.pub4
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Małgorzata Chyćko, Julia Czarnota, Katarzyna Cichoń, Nina Lasota, Maciej Lambach, Martyna Younes, Gabriela Demidowicz, Wojciech Wiśniewski, Klaudia Kowalczyk, Natalia Trąbka
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 558
Number of citations: 0
