Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

Cannabidiol: main mechanisms of action and therapeutic targets
  • Home
  • /
  • Cannabidiol: main mechanisms of action and therapeutic targets
  1. Home /
  2. Archives /
  3. Vol. 38 No. 1 (2023) /
  4. Review Articles

Cannabidiol: main mechanisms of action and therapeutic targets

Authors

  • Klaudia Kowalczyk Pharmacy “Centrum Zdrowia”, Grunwaldzka 21 street, 72-600 Świnoujście, Poland https://orcid.org/0009-0006-9661-2299
  • Natalia Trąbka Independent Public Clinical Hospital No. 4 in Lublin, Jaczewskiego 8 street, 20-954 Lublin, Poland https://orcid.org/0000-0001-8204-4741
  • Gabriela Demidowicz Independent Public Clinical Hospital No. 4 in Lublin, Jaczewskiego 8 street, 20-954 Lublin, Poland https://orcid.org/0009-0007-6150-130X
  • Nina Lasota County Health Center in Brzeziny sp. z.o.o. st. Marii Skłodowska-Curie 6, 95-006 Brzeziny https://orcid.org/0009-0005-6625-4139
  • Katarzyna Cichoń Independent Public Clinical Hospital No. 4 in Lublin. Jaczewskiego 8 street, 20-954 Lublin https://orcid.org/0009-0008-6965-3508
  • Małgorzata Chyćko 7th Navy Hospital in Gdańsk Polanki 117 street, 80-305 Gdańsk https://orcid.org/0000-0002-1515-6038
  • Julia Czarnota Franciszek Raszeja Memorial Municipal Hospital in Poznań Mickiewicza 2 street, 60-834 Poznań https://orcid.org/0009-0009-9918-9168
  • Wojciech Wiśniewski Stefan Kardynał Wyszyński Province Specialist Hospital in Lublin, Kraśnicka 100 avenue, 20-718 Lublin, Poland https://orcid.org/0009-0002-0860-5808
  • Maciej Lambach Medical University of Lublin, Racławickie 1 avenue, 20-059 Lublin https://orcid.org/0009-0004-3348-4272
  • Martyna Younes Najświętszej Maryi Panny Specialist District Hospital in Częstochowa Bialska 104/118 street 42-202 Częstochowa https://orcid.org/0009-0000-0544-600X

DOI:

https://doi.org/10.12775/JEHS.2023.38.01.020

Keywords

cannabidiol, CBD, CBD therapeutic targets, CBD's mechanism of action, endocannabinoid system

Abstract

Introduction: Over the past few years, multiple publications have proven many beneficial properties associated with CBD. Currently, its use in the treatment of inflammatory and autoimmune diseases is suggested. Also, very often the use of CBD in the treatment of anxiety disorders, schizophrenia and depression, as well as Parkinson's disease and Alzheimer's disease is the subject of scientific research. CBD could be also used in treatment of the chronic pain in cancer patients or in people with diabetic complications. So far, it has been proven that CBD has anti-inflammatory, anticonvulsant, antioxidant, anti-arthritic, procognitive, cardio- and neuroprotective effects. The potential of cannabidiol in the prevention and treatment of many diseases is seen in its complex and multidirectional mechanisms of action. CBD has low affinity for cannabinoid receptors and acts as an inverse agonist of type 2 cannabinoid receptors (CB2-R). Additionally, CBD exerts its effects through many other molecular targets.

Aim of the study: The aim of this review is to present mechanisms of action of cannabidiol and its possible therapeutic targets.

Materials and methods: The literature available in the PubMed and Google Scholar data bases was reviewed, using the following keywords: "cannabidiol", "CBD", "CBD's mechanism of action", "CBD therapeutic targets", "endocannabinoid system".

Conclusions: Cannabidiol is a promising candidate in the treatment of many common diseases. Furthermore, research is needed to confirm its beneficial effects and turn it into an effective drug that supports therapy with other drugs.

References

Lu HC, Mackie K. Review of the Endocannabinoid System. Vol. 6, Biol Psychiatry Cognitive Neuroscience and Neuroimaging. 2021;6(6):607-615. doi:10.1016/j.bpsc.2020.07.016

Crocq MA. History of cannabis and the endocannabinoid system. Dialogues Clin Neurosci. 2020 Sep 1;22(3):223–228. doi:10.31887/DCNS.2020.22.3/mcrocq

Karabowicz P, Grzęda E, Baranowska-Kuczko M, Malinowska B. Znaczenie endokannabinoidu 2-arachidonyloglicerolu w fizjologii i patofizjologii układu krążenia [Role of endocannabinoid 2-arachidonoylglycerol in the physiology and pathophysiology of the cardiovascular system]. Postepy Hig Med Dosw (Online). 2014;68:814-827. Published 2014 Jun 12. doi:10.5604/17322693.1108875

Di Marzo V, Piscitelli F. The Endocannabinoid System and its Modulation by Phytocannabinoids. Neurotherapeutics. 2015;12(4):692-698. doi:10.1007/s13311-015-0374-6

Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol. 2007;150(5):613-623. doi:10.1038/sj.bjp.0707133

Lunn CA, Fine JS, Rojas-Triana A, et al. A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J Pharmacol Exp Ther. 2006;316(2):780-788. doi:10.1124/jpet.105.093500

Booz GW. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Vol. 51, Free Radical Biology and Medicine. 2011. p. 1054–61; doi:10.1016/j.freeradbiomed.2011.01.007.

Tanasescu R, Constantinescu CS. Cannabinoids and the immune system: An overview. Immunobiology. 2010 Aug;215(8):588–97; DOI: 10.1016/j.imbio.2009.12.005.

Castillo A, Tolón MR, Fernández-Ruiz J, Romero J, Martinez-Orgado J. The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB2 and adenosine receptors. Neurobiol Dis. 2010 Feb;37(2):434–40; DOI: 10.1016/j.nbd.2009.10.023.

Durst R, Danenberg H, Gallily R, Mechoulam R, Meir K, Grad E, et al. Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury. Am J Physiol Heart Circ Phys-iol [Internet]. 2007;293:3602–7; DOI: 10.1152/ajpheart.00098.2007.

Gonca E, Darici F. The Effect of Cannabidiol on ischemia/reperfusion-induced ventricular arrhythmias: The role of adenosine a1 receptors. J Cardiovasc Pharmacol Ther. 2015 Jan 12;20(1):76–83; DOI: 10.1177/1074248414532013.

Polska E, med Katarzyna Winczyk hab, Neuroendokrynologii Z, Endokrynologii K. PRACE POGLĄDOWE/REWIEVS. Vol. 59, Polish Journal of Endocrinology Tom. 2008.

Vanden Berghe W, Vermeulen L, Delerive # P, De Bosscher K, Staels # B, Haegeman G. A Paradigm for Gene Regulation: Inflammation, NF-KB and PPAR; DOI: 10.1007/978-1-4419-9072-3_22.

Delerive P, Fruchart JC, Staels B. EUROSTERONE MEETING Peroxisome proliferator-activated receptors in inflammation control [Internet]. Vol. 169, Journal of Endocrinology. 2001; DOI: 10.1677/joe.0.1690453.

Delerive P, De Bosscher K, Besnard S, Vanden Berghe W, Peters JM, Gonzalez FJ, et al. Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1. Journal of Biological Chemistry. 1999 Nov 5;274(45):32048–54; DOI: 10.1074/jbc.274.45.32048.

Delerive P, Gervois P, Fruchart JC, Staels B. Induction of IκBα expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-α activators. Journal of Biological Chemistry. 2000 Nov 24;275(47):36703–7, DOI: 10.1074/jbc.M004045200.

O’Sullivan SE, Kendall DA. Cannabinoid activation of peroxisome proliferator-activated receptors: Potential for modulation of inflammatory disease. Immunobiology. 2010 Aug;215(8):611–6; DOI: 10.1016/j.imbio.2009.09.007.

Esposito G, Pesce M, Seguella L, Sanseverino W, Lu J, Corpetti C, et al. The potential of cannabidiol in the COVID-19 pandemic. Br J Pharmacol. 2020 Nov 1;177(21):4967–70; DOI: 10.1111/bph.15157.

Milam JE, Keshamouni VG, Phan SH, Hu B, Gangireddy SR, Hogaboam CM, et al. PPAR-agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis. 2008; DOI: 10.1152/ajplung.00333.2007.

Vuolo F, Abreu SC, Michels M, Xisto DG, Blanco NG, Hallak JE, et al. Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma. Eur J Pharmacol. 2019 Jan 15;843:251–9; DOI: 10.1016/j.ejphar.2018.11.029.

Huang S, Zhu B, Cheon IS, Goplen NP, Jiang L, Zhang R, et al. PPAR-γ in Macrophages Limits Pulmonary Inflammation and Promotes Host Recovery following Respiratory Viral Infection. J Virol. 2019 May;93(9); DOI: 10.1128/JVI.00030-19.

O'Sullivan SE, Stevenson CW, Laviolette SR. Could Cannabidiol Be a Treatment for Coronavirus Disease-19-Related Anxiety Disorders?. Cannabis Cannabinoid Res. 2021;6(1):7-18. Published 2021 Feb 12; DOI:10.1089/can.2020.0102.

Russo EB, Burnett A, Hall B, Parker KK. Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res. 2005 Aug;30(8):1037–43; DOI: 10.1007/s11064-005-6978-1.

Mishima K, Hayakawa K, Abe K, Ikeda T, Egashira N, Iwasaki K, et al. Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke. 2005 May;36(5):1071–6; DOI: 10.1161/01.STR.0000163083.59201.34.

Campos AC, Guimarães FS. Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology (Berl). 2008 Aug;199(2):223–30; DOI: 10.1007/s00213-008-1168-x.

de Almeida DL, Devi LA. Diversity of molecular targets and signaling pathways for CBD. Pharmacol Res Perspect. 2020;8(6):e00682. doi:10.1002/prp2.682.

Xiong W, Koo BN, Morton R, Zhang L. Psychotropic and nonpsychotropic cannabis derivatives inhibit human h5-HT3A receptors through a receptor desensitization-dependent mechanism. Neuroscience. 2011 Jun 16;184:28–37; DOI: 10.1016/j.neuroscience.2011.03.066.

Scichilone N, Caponetto C, Fagone E, Benfante A, Paternò A, Heffler E, et al. The Arg/Arg polymorphism of the ADRB2 is associated with the severity of allergic asthma. J Allergy Clin Immunol Pract [Internet]. 2016 Nov 1 [cited 2022 Apr 5];4(6):1251–2; DOI: 10.1016/j.ctarc.2020.100278.

Booz GW. PARP inhibitors and heart failure--translational medicine caught in the act. Congest Heart Fail. 2007;13(2):105-112. doi:10.1111/j.1527-5299.2007.06595.x.

Downloads

  • PDF

Published

2023-10-06

How to Cite

1.
KOWALCZYK, Klaudia, TRĄBKA, Natalia, DEMIDOWICZ, Gabriela, LASOTA, Nina, CICHOŃ, Katarzyna, CHYĆKO, Małgorzata, CZARNOTA, Julia, WIŚNIEWSKI, Wojciech, LAMBACH, Maciej and YOUNES, Martyna. Cannabidiol: main mechanisms of action and therapeutic targets. Journal of Education, Health and Sport. Online. 6 October 2023. Vol. 38, no. 1, pp. 294-308. [Accessed 28 June 2025]. DOI 10.12775/JEHS.2023.38.01.020.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 38 No. 1 (2023)

Section

Review Articles

License

Copyright (c) 2023 Klaudia Kowalczyk, Natalia Trąbka, Gabriela Demidowicz, Nina Lasota, Katarzyna Cichoń, Małgorzata Chyćko, Julia Czarnota, Wojciech Wiśniewski, Maciej Lambach, Martyna Younes

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 561
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

cannabidiol, CBD, CBD therapeutic targets, CBD's mechanism of action, endocannabinoid system
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop