Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

The Influence of obesity and overweight on the incidence of gastrointestinal tumors - a systematic review of the literature
  • Home
  • /
  • The Influence of obesity and overweight on the incidence of gastrointestinal tumors - a systematic review of the literature
  1. Home /
  2. Archives /
  3. Vol. 48 No. 1 (2023) /
  4. Review Articles

The Influence of obesity and overweight on the incidence of gastrointestinal tumors - a systematic review of the literature

Authors

  • Sylwia Grad Uniwersytet Medyczny w Lublinie https://orcid.org/0009-0008-3833-5398
  • Anna Jaremek Independent Public Clinical Hospital No. 4 in Lublin, 8 Doktora Kazimierza Jaczewskiego Street, 20-954 Lublin. https://orcid.org/0009-0002-7787-7938
  • Joanna Kępa Independent Public Clinical Hospital No. 4 in Lublin, 8 Doktora Kazimierza Jaczewskiego Street, 20-954 Lublin. https://orcid.org/0009-0007-2951-6018
  • Norbert Kandefer Medical University of Lublin, 1 Al. Racławickie, 20-059 Lublin https://orcid.org/0009-0007-3743-5939
  • Michał Wyszkowski Independent Public Clinical Hospital No. 4 in Lublin, 8 Doktora Kazimierza Jaczewskiego Street, 20-954 Lublin. https://orcid.org/0009-0003-1125-4014
  • Aleksandra Grabarczyk Stefan Kardynał Wyszyński Province Specialist Hospital in Lublin, 100 Aleja Kraśnicka, 20-718 Lublin. https://orcid.org/0009-0002-2232-2265
  • Anna Pawlak Independent Public Clinical Hospital No. 4 in Lublin, 8 Doktora Kazimierza Jaczewskiego Street, 20-954 Lublin https://orcid.org/0009-0009-8502-4987
  • Małgorzata Gregorek Independent Public Clinical Hospital No. 4 in Lublin, 8 Doktora Kazimierza Jaczewskiego Street, 20-954 Lublin. https://orcid.org/0009-0009-5964-6897
  • Paweł Gregorek Independent Public Clinical Hospital No. 4 in Lublin, 8 Doktora Kazimierza Jaczewskiego Street, 20-954 Lublin. https://orcid.org/0000-0001-5678-2054

DOI:

https://doi.org/10.12775/JEHS.2023.48.01.009

Keywords

obesity, overweight, obesity and cancer, cancer

Abstract

Introduction: The percentage of the population struggling with the problem of obesity has been steadily increasing in recent years, both among adults and children. Obesity is a chronic disease resulting from a positive energy balance, which does not tend to disappear spontaneously. The etiology of obesity is multidimensional, it is caused by genetic, environmental and behavioral factors. As a result, excessive amounts of adipose tissue are deposited in the body, which leads to an increased risk of various systemic diseases, including cancers of the digestive system.

Aim of the study: This review aims to show the relationship between overweight and obesity and the increased incidence of gastrointestinal cancers.

Materials and methods: An analysis of previous works present in the PubMed database was performed, using the following keywords: obesity, overweight, obesity and cancer, cancer.

Results: The results of the presented publications show the presence of a positive correlation between overweight and obesity, especially abdominal and the occurrence of gastrointestinal cancers.

References

World Health Organization: Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 894, 1-253 (2000)

Raposo L. Metabolic syndrome in Poland: the WOBASZ II study. Pol Arch Intern Med. 2021 Jun 29;131(6):501-502. doi: 10.20452/pamw.16040. Epub 2021 Jun 29. PMID: 34184853.

Short MW, Burgers KG, Fry VT. Esophageal Cancer. Am Fam Physician. 2017 Jan 1;95(1):22-28. PMID: 28075104.

Du X, Hidayat K, Shi BM. Abdominal obesity and gastroesophageal cancer risk: systematic review and meta-analysis of prospective studies. Biosci Rep. 2017 May 11;37(3):BSR20160474. doi: 10.1042/BSR20160474. PMID: 28336766; PMCID: PMC5426287.

Yang P, Zhou Y, Chen B, Wan HW, Jia GQ, Bai HL, Wu XT. Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies. Eur J Cancer. 2009 Nov;45(16):2867-73. doi: 10.1016/j.ejca.2009.04.019. Epub 2009 May 6. PMID: 19427197.

Li Q, Zhang J, Zhou Y, Qiao L. Obesity and gastric cancer. Front Biosci (Landmark Ed). 2012 Jun 1;17(7):2383-90. doi: 10.2741/4059. PMID: 22652786.

Ilic M, Ilic I. Epidemiology of stomach cancer. World J Gastroenterol. 2022 Mar 28;28(12):1187-1203. doi: 10.3748/wjg.v28.i12.1187. PMID: 35431510; PMCID: PMC8968487.

Kuipers EJ, Grady WM, Lieberman D, Seufferlein T, Sung JJ, Boelens PG, van de Velde CJ, Watanabe T. Colorectal cancer. Nat Rev Dis Primers. 2015 Nov 5;1:15065. doi: 10.1038/nrdp.2015.65. PMID: 27189416; PMCID: PMC4874655.

World Cancer Research Fund/American Institute for Cancer. Food, nutrition, physical activity, and the prevention of cancer: a global perspective

. Chen J, Iverson D. Estrogen in obesity-associated colon cancer: friend or foe? Protecting postmenopausal women but promoting late-stage colon cancer. Cancer Causes Control 2012;23:1767–73.

Dong Y, Zhou J, Zhu Y, Luo L, He T, Hu H, Liu H, Zhang Y, Luo D, Xu S, Xu L, Liu J, Zhang J, Teng Z. Abdoaminal obesity and colorectal cancer risk: systematic review and meta-analysis of prospective studies. Biosci Rep. 2017 Dec 12;37(6):BSR20170945. doi: 10.1042/BSR20170945. PMID: 29026008; PMCID: PMC5725611.

Bardou M, Barkun AN, Martel M. Obesity and colorectal cancer. Gut. 2013 Jun;62(6):933-47. doi: 10.1136/gutjnl-2013-304701. Epub 2013 Mar 12. PMID: 23481261.

Kim BC, Shin A, Hong CW, et al. Association of colorectal adenoma with components of metabolic syndrome. Cancer Causes Control 2012;23:727–35.

Aleksandrova K, Nimptsch K, Pischon T. Obesity and colorectal cancer. Front Biosci (Elite Ed). 2013 Jan 1;5(1):61-77. doi: 10.2741/e596. PMID: 23276970.

Mizrahi JD, Surana R, Valle JW, Shroff RT. Pancreatic cancer. Lancet. 2020 Jun 27;395(10242):2008-2020. doi: 10.1016/S0140-6736(20)30974-0. PMID: 32593337.

Carreras-Torres R, Johansson M, Gaborieau V, Haycock PC, Wade KH, Relton CL, Martin RM, Davey Smith G, Brennan P. The Role of Obesity, Type 2 Diabetes, and Metabolic Factors in Pancreatic Cancer: A Mendelian Randomization Study. J Natl Cancer Inst. 2017 Sep 1;109(9):djx012. doi: 10.1093/jnci/djx012. PMID: 28954281; PMCID: PMC5721813.

Genkinger JM, Spiegelman D, Anderson KE, Bernstein L, van den Brandt PA, Calle EE, et al. A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk. Int J Cancer 2011;129:1708e17.

Michaud DS. Obesity and Pancreatic Cancer. Recent Results Cancer Res. 2016;208:95-105. doi: 10.1007/978-3-319-42542-9_6. PMID: 27909904.

Preziosi G, Oben JA, Fusai G. Obesity and pancreatic cancer. Surg Oncol. 2014 Jun;23(2):61-71. doi: 10.1016/j.suronc.2014.02.003. Epub 2014 Mar 12. PMID: 24746917.

Kulik L, El-Serag HB. Epidemiology and Management of Hepatocellular Carcinoma. Gastroenterology. 2019 Jan;156(2):477-491.e1. doi: 10.1053/j.gastro.2018.08.065. Epub 2018 Oct 24. PMID: 30367835; PMCID: PMC6340716.

Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. 2003. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S adults. N. Engl. J. Med. 348:1625–38

Kim K, Choi S, Park SM. Association of high body mass index and hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a Korean population-based cohort study. JAMA Oncol. 2018;4:737–739.

Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, et al.. Gut Microbiota Promotes Obesity-Associated Liver Cancer Through PGE2-Mediated Suppression of Antitumor Immunity. Cancer Discov (2017) 7(5):522–38. doi: 10.1158/2159-8290.cd-16-0932

Góralska J, Raźny U, Polus A, Dziewońska A, Gruca A, Zdzienicka A, et al.. Malczewska-Malec: Enhanced GIP Secretion in Obesity Is Associated With Biochemical Alteration and miRNA Contribution to the Development of Liver Steatosis. Nutrients (2020) 12(2):476. doi: 10.3390/nu12020476.

Downloads

  • PDF

Published

2023-11-25

How to Cite

1.
GRAD, Sylwia, JAREMEK, Anna, KĘPA, Joanna, KANDEFER, Norbert, WYSZKOWSKI, Michał, GRABARCZYK, Aleksandra, PAWLAK, Anna, GREGOREK, Małgorzata and GREGOREK, Paweł. The Influence of obesity and overweight on the incidence of gastrointestinal tumors - a systematic review of the literature. Journal of Education, Health and Sport. Online. 25 November 2023. Vol. 48, no. 1, pp. 135-146. [Accessed 28 June 2025]. DOI 10.12775/JEHS.2023.48.01.009.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 48 No. 1 (2023)

Section

Review Articles

License

Copyright (c) 2023 Sylwia Grad, Anna Jaremek, Joanna Kępa, Norbert Kandefer, Michał Wyszkowski, Aleksandra Grabarczyk, Anna Pawlak; Małgorzata Gregorek; Paweł Gregorek

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 565
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

obesity, overweight, obesity and cancer, cancer
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop