The Influence of obesity and overweight on the incidence of gastrointestinal tumors - a systematic review of the literature
DOI:
https://doi.org/10.12775/JEHS.2023.48.01.009Keywords
obesity, overweight, obesity and cancer, cancerAbstract
Introduction: The percentage of the population struggling with the problem of obesity has been steadily increasing in recent years, both among adults and children. Obesity is a chronic disease resulting from a positive energy balance, which does not tend to disappear spontaneously. The etiology of obesity is multidimensional, it is caused by genetic, environmental and behavioral factors. As a result, excessive amounts of adipose tissue are deposited in the body, which leads to an increased risk of various systemic diseases, including cancers of the digestive system.
Aim of the study: This review aims to show the relationship between overweight and obesity and the increased incidence of gastrointestinal cancers.
Materials and methods: An analysis of previous works present in the PubMed database was performed, using the following keywords: obesity, overweight, obesity and cancer, cancer.
Results: The results of the presented publications show the presence of a positive correlation between overweight and obesity, especially abdominal and the occurrence of gastrointestinal cancers.
References
World Health Organization: Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 894, 1-253 (2000)
Raposo L. Metabolic syndrome in Poland: the WOBASZ II study. Pol Arch Intern Med. 2021 Jun 29;131(6):501-502. doi: 10.20452/pamw.16040. Epub 2021 Jun 29. PMID: 34184853.
Short MW, Burgers KG, Fry VT. Esophageal Cancer. Am Fam Physician. 2017 Jan 1;95(1):22-28. PMID: 28075104.
Du X, Hidayat K, Shi BM. Abdominal obesity and gastroesophageal cancer risk: systematic review and meta-analysis of prospective studies. Biosci Rep. 2017 May 11;37(3):BSR20160474. doi: 10.1042/BSR20160474. PMID: 28336766; PMCID: PMC5426287.
Yang P, Zhou Y, Chen B, Wan HW, Jia GQ, Bai HL, Wu XT. Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies. Eur J Cancer. 2009 Nov;45(16):2867-73. doi: 10.1016/j.ejca.2009.04.019. Epub 2009 May 6. PMID: 19427197.
Li Q, Zhang J, Zhou Y, Qiao L. Obesity and gastric cancer. Front Biosci (Landmark Ed). 2012 Jun 1;17(7):2383-90. doi: 10.2741/4059. PMID: 22652786.
Ilic M, Ilic I. Epidemiology of stomach cancer. World J Gastroenterol. 2022 Mar 28;28(12):1187-1203. doi: 10.3748/wjg.v28.i12.1187. PMID: 35431510; PMCID: PMC8968487.
Kuipers EJ, Grady WM, Lieberman D, Seufferlein T, Sung JJ, Boelens PG, van de Velde CJ, Watanabe T. Colorectal cancer. Nat Rev Dis Primers. 2015 Nov 5;1:15065. doi: 10.1038/nrdp.2015.65. PMID: 27189416; PMCID: PMC4874655.
World Cancer Research Fund/American Institute for Cancer. Food, nutrition, physical activity, and the prevention of cancer: a global perspective
. Chen J, Iverson D. Estrogen in obesity-associated colon cancer: friend or foe? Protecting postmenopausal women but promoting late-stage colon cancer. Cancer Causes Control 2012;23:1767–73.
Dong Y, Zhou J, Zhu Y, Luo L, He T, Hu H, Liu H, Zhang Y, Luo D, Xu S, Xu L, Liu J, Zhang J, Teng Z. Abdoaminal obesity and colorectal cancer risk: systematic review and meta-analysis of prospective studies. Biosci Rep. 2017 Dec 12;37(6):BSR20170945. doi: 10.1042/BSR20170945. PMID: 29026008; PMCID: PMC5725611.
Bardou M, Barkun AN, Martel M. Obesity and colorectal cancer. Gut. 2013 Jun;62(6):933-47. doi: 10.1136/gutjnl-2013-304701. Epub 2013 Mar 12. PMID: 23481261.
Kim BC, Shin A, Hong CW, et al. Association of colorectal adenoma with components of metabolic syndrome. Cancer Causes Control 2012;23:727–35.
Aleksandrova K, Nimptsch K, Pischon T. Obesity and colorectal cancer. Front Biosci (Elite Ed). 2013 Jan 1;5(1):61-77. doi: 10.2741/e596. PMID: 23276970.
Mizrahi JD, Surana R, Valle JW, Shroff RT. Pancreatic cancer. Lancet. 2020 Jun 27;395(10242):2008-2020. doi: 10.1016/S0140-6736(20)30974-0. PMID: 32593337.
Carreras-Torres R, Johansson M, Gaborieau V, Haycock PC, Wade KH, Relton CL, Martin RM, Davey Smith G, Brennan P. The Role of Obesity, Type 2 Diabetes, and Metabolic Factors in Pancreatic Cancer: A Mendelian Randomization Study. J Natl Cancer Inst. 2017 Sep 1;109(9):djx012. doi: 10.1093/jnci/djx012. PMID: 28954281; PMCID: PMC5721813.
Genkinger JM, Spiegelman D, Anderson KE, Bernstein L, van den Brandt PA, Calle EE, et al. A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk. Int J Cancer 2011;129:1708e17.
Michaud DS. Obesity and Pancreatic Cancer. Recent Results Cancer Res. 2016;208:95-105. doi: 10.1007/978-3-319-42542-9_6. PMID: 27909904.
Preziosi G, Oben JA, Fusai G. Obesity and pancreatic cancer. Surg Oncol. 2014 Jun;23(2):61-71. doi: 10.1016/j.suronc.2014.02.003. Epub 2014 Mar 12. PMID: 24746917.
Kulik L, El-Serag HB. Epidemiology and Management of Hepatocellular Carcinoma. Gastroenterology. 2019 Jan;156(2):477-491.e1. doi: 10.1053/j.gastro.2018.08.065. Epub 2018 Oct 24. PMID: 30367835; PMCID: PMC6340716.
Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. 2003. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S adults. N. Engl. J. Med. 348:1625–38
Kim K, Choi S, Park SM. Association of high body mass index and hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a Korean population-based cohort study. JAMA Oncol. 2018;4:737–739.
Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, et al.. Gut Microbiota Promotes Obesity-Associated Liver Cancer Through PGE2-Mediated Suppression of Antitumor Immunity. Cancer Discov (2017) 7(5):522–38. doi: 10.1158/2159-8290.cd-16-0932
Góralska J, Raźny U, Polus A, Dziewońska A, Gruca A, Zdzienicka A, et al.. Malczewska-Malec: Enhanced GIP Secretion in Obesity Is Associated With Biochemical Alteration and miRNA Contribution to the Development of Liver Steatosis. Nutrients (2020) 12(2):476. doi: 10.3390/nu12020476.
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Copyright (c) 2023 Sylwia Grad, Anna Jaremek, Joanna Kępa, Norbert Kandefer, Michał Wyszkowski, Aleksandra Grabarczyk, Anna Pawlak; Małgorzata Gregorek; Paweł Gregorek
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