Features changes phagocytic activity of leukocytes in development of peptic ulcer under pneumonia

Abstract

Pneumonia remains the global and urgent medical and social problem. Among the most common diseases are the cause of death from infectious diseases and leads to economic losses throughout the world regardless of their level of development.

As we know, based on the origin and progression of pneumonia in pathogenetic perspective, with a variety of biologically active substances, products of lipid peroxidation, inflammation, etc. components, and prolonged use of a drug substance can lead to comorbidity.

For the experiment, we selected two models of disease: experimental pneumonia (EP) and peptic ulcer (PU). Currently, promising to study the role nonspecific resistance in the pathogenesis of these pathologies. Factors nonspecific reactivity are important in the immune defense of the body.

Materials and methods. The study was conducted on 39 male guinea pigs. The experimental pneumonia caused by the method Shlyapnykova V. N., Solodova T. L., gastric ulcer simulated method Komarov V. I. Nonspecific resistance of animals we evaluated, examining the phagocytic activity of leukocytes (FAL), nitroblue tetrazolium test (NST- test). Phagocytic activity of leukocytes (FAL) in blood were studied in terms phagocytic index (FI) and the phagocytic number (SF) and determined by the method Menshikov V. V. NST - test method Vyksmana M. E., Mayanskoho A. H. The figures research results processed by statistical method Student. Results and discussion. Found that the 4- th day after simulation pneumonia and gastric ulcer occurred a gradual increase in phagocytic index by 39.5% (P <0.05) in relation to the same figure intact group of porpoises. Then on the 8-th day of disease models showed a significant increase in FI - 72, 8% compared to the 1st group of animals. On the 4-th day and EP at PU was found a significant increase in the number of phagocytic levels by 43.6% (P <0.05) compared with controls. After 8 days the EP and PU it was a further increase of 76.9% (P <0.05).

The results showed that at 4 days of experimental NST diseases without stimulating increased by 51.2% (P <0.05) compared with control values, and only 8 per day PU at EP and its significant increase of 81.8 % (P <0.05) compared with the values of intact animals.

Conclusions. In forming the experimental pneumonia and gastric ulcers increases the performance PHI, SF, NBT-test, which allows to assume the stimulation of phagocytic activity of leukocytes and include protective mechanisms of the body.