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Journal of Education, Health and Sport

Syphilis - a disease that still occurs
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Syphilis - a disease that still occurs

Authors

  • Rami Ben Rhaiem Samodzielny Publiczny Zespół Opieki Zdrowotnej w Kędzierzynie-Koźlu ul. 24 Kwietnia 5, 47-200 Kędzierzyn-Koźle, Polska https://orcid.org/0009-0006-6034-4130
  • Przemysław Kępka Szpital Wojewódzki w Bielsku-Białej, Al. Armii Krajowej 101, 43-316 Bielsko-Biała, Polska https://orcid.org/0009-0006-4560-677X
  • Daria Kuziemkowska SP ZOZ MSWiA w Katowicach im. Sierżanta Grzegorza Załogi ul. Głowackiego 10 40-052 Katowice, Polska https://orcid.org/0009-0000-1018-0410
  • Jan Kuźma Górnośląskie Centrum Medyczne im. Prof. L. Gieca w Katowicach, Ziołowa 45-47, 40-635 Katowice, Polska https://orcid.org/0009-0001-7721-7748
  • Anna Łącka-Majcher Samodzielny Publiczny Zakład Opieki Zdrowotnej w Bochni, “Szpital Powiatowy” im. Bł. Marty Wieckiej, ul. Krakowska 31, 32-700 Bochnia, Polska https://orcid.org/0009-0001-8889-6782
  • Aleksandra Łokczewska-Bojar Szpital Specjalistyczny im. Jędrzeja Śniadeckiego w Nowym Sączu ul. Młyńska 10, 33-300 Nowy Sącz, Polska https://orcid.org/0009-0008-9443-7751
  • Grzegorz Tarsa Bonifraterskie Centrum Medyczne sp. zoo ul. Ks. Leopolda Markiefki 87, 40-211 Katowice, Polska https://orcid.org/0009-0001-4088-9137
  • Magdalena Skotalczyk Uniwersyteckie Centrum Kliniczne im. prof. K. Gibińskiego Śląskiego Uniwersytetu Medycznego w Katowicach, ul. Medyków 14, 40-752 Katowice, Polska https://orcid.org/0009-0007-7445-1030
  • Zuzanna Sawińska Student, Śląski Uniwersytet Medyczny w Katowicach, ul. Poniatowskiego 15, 40-055 Katowice, Polska https://orcid.org/0009-0008-3170-0145
  • Katarzyna Sudelska Student, Śląski Uniwersytet Medyczny w Katowicach, ul. Poniatowskiego 15, 40-055 Katowice, Polska https://orcid.org/0009-0008-5113-8065

DOI:

https://doi.org/10.12775/JEHS.2023.16.01.014

Keywords

treatment of syphilis, penicillin

Abstract

Introduction: Syphilis is a systemic disease caused by Treponema pallidum. Humans are the only hosts, and the incubation period lasts from 9-90 days. Currently it can be divided into congenital or acquired. This division is due to the moment in which the infection occurred. Congenital Syphilis- when the infection happens during the prenatal period, whereas acquired, when the infection took place in the period after birth. In early acquired syphilis the I and II stages can be distinguished as well as early latent syphilis. As defined, early latent syphilis includes an acquired infection up to 1 or 2 years back, depending on the guidelines. Late syphilis however includes: late latent syphilis, tertiary syphilis, late cardiovascular syphilis, late neurosyphilis. Congenital syphilis has also been divided into early (which includes the first 2 years) as well as late, which is characterised by signs of congenital syphilis, the so-called stigmata of congenital syphilis constituting the untreated infection during the fetal stage or the infancy stage.  Aim of the Study: The aim of our study is to divert the attention to one of the sexually transmitted diseases, which despite the downward trend at the end of the 20th century, rebounded at the beginning of the 21st century, especially among men who have sexual contact with other men. We paid attention to the symptoms accompanying this disease, also in the context of congenital syphilis, as well as the different methods of pharmacological treatment according to European guidelines.  Materials and methods: Reviewed literature available at scientific articles , Google Scholar using keywords: “syphilis – epidemiology”, “syphilis treatment”, “symptoms of syphilis”, as well as European guidelines regarding the treatment of syphilis.

References

European Centre for Disease Prevention and Control: http://www.ecdc.e uropa.eu/

World Health Organization: WHO guidelines for the treatment of Treponema pallidum (syphilis) 2016. <http://www.who.int/reproductivehea lth/publications/rtis/syphilis-treatment-guidelines/en>

Spiteri G., Unemo M., Moardh O., Amato-Gauci A.J.: The resurgence of syphilis in high-income countries in the 2000s: a focus on Europe. Epidemiol. Infect., 2019; 147: e143. https://doi.org/10.1017/ S0 950 268 819 000 281

Janier M., Hegyi V., Dupin N., Unemo M., Tiplica G.S., French P, et al.: 2014 European guideline on the management of syphilis. J. Eur. Acad. Dermatol. Venereol., 2014; 20: 300-309

Grassly N.C., Fraser C., Garnett G.P.: Host immunity and synchronized epidemics of syphilis across the United Stades. Nature, 2005; 433: 417-421

Centers for Diseases Control and Prevention: Syphilis (Treponema pallidum) 2018. Case definition. CSTE 17-ID-11

Hook EW, 3rd. Syphilis. Lancet, 2017; 389: 1550-1557

Dupin N.: Syphilis. Rev. Med. Interne, 2016; 37: 735-742

Park K.H., Lee M.S., Hong I.K., et al.: Bone involvement in secondary syphilis: a case report and systematic review of the literature. Sex. Transm. Dis., 2014; 41: 532-537

Davey D.J., Kojima N., Konda K.A., et al.: Transient aortitis documented by positron emission tomography in a case series of men and transgender women infected with syphilis. Sex. Transm. Infect., 2017; 93: 551-555

Ballard R., Hook E.W. III: Syphilis. In: Unemo M., Ballard R., Ison C., Lewis D., Ndowa F., Peeling R., eds.: Laboratory diagnosis of sexually transmitted infections, including human immunodeficiency virus. Geneva, World Health Organization (WHO). 2013: 107-129

Gayet-Ageron A., Sednaoui P., Lautenschlager S., et al.: Use of Treponema pallidum PCR in testing of ulcers for diagnosis of primary syphilis. Emerg. Infect. Dis., 2015; 21: 127-129

Muller H., Eisendle K., Brauninger W., Kutzner H., Cerroni L., Zelger B.: Comparative analysis of immuno-histochemistry, polymerase chain reaction and focus-floating microscopy for the detection of Treponema pallidum in mucocutaneous lesions of primary, secondary and tertiary syphilis. Br. J. Dermatol., 2011; 165: 50-60

Peng R.R., Wang A.L., Li J., Tucker J.D., Yin Y.P., Chen X.S.: Molecular typing of Treponema pallidum: a systematic review and meta-analysis. PLoS Negl. Trop. Dis., 2011; 5: e1273

Busse C., Navid M.H., Strubel A., Schnitzler P.: Evaluation of a new recombinant antigen-based Virotech Treponema pallidum screen ELISA for diagnosis of syphilis. Clin. Lab., 2013; 59: 523-529

Marangoni A., Nardini P., Foschi C., et al.: Evaluation of the BioPlex 2200 syphilis system as a first-line method of reverse-sequence screening for syphilis diagnosis. Clin. Vaccine Immunol., 2013; 20: 1084-1088

Sena A.C., White B., Sparling P.F.: Novel Treponema pallidum serologic tests: a paradigm shift in syphilis screening for the 21st century. Clin. Infect. Dis., 2010; 51: 700-708

Gliddon H.D., Peeling R., Kamb M.L., Toskin I., Wi T.E., Taylor M.M.: A systematic review and meta-analysis of studies evaluating the performance and operational characteristics of dual point-of-care tests for HIV and syphilis. Sex. Transm. Infect., 2017; 93 (S4): S3-S15

Owusu-Edusei K. Jr, Gift T.L., Ballard R.C.: Cost-effectiveness of a dual non-treponemal/ treponemal syphilis point-of-care test to prevent adverse pregnancy outcome in sub-Saharan Africa. Sex. Transm. Dis., 2011; 38: 997-1003

Lukehart S.A., Hook E.W. III, Bakerzander S.A., Collier A.C., Critchlow C.W., Handsfield H.H.: Invasion of the central nervous system by Treponema pallidum: implications for diagnosis and treatment. Ann. Intern. Med., 1988; 109: 855-862

Davis A.P., Stern J., Tantalo L., et al.: How well do neurologic symptoms identify individuals with neurosyphilis. Clin. Infect. Dis., 2018; 66: 363-367

Marra C.M., Tantalo L.C., Maxwell C.L., Ho E.L., Sahi S.K., Jones T.: The rapid plasma reagin test cannot replace the venereal disease research laboratory test for neurosyphilis diagnosis. Sex. Transm. Dis., 2012; 39: 453-457

Shi M., Peng R.R., Gao Z., et al.: Risk profiles of neurosyphilis in HIV-negative patients with primary, secondary and latent syphilis: implications for clinical intervention. J. Eur. Acad. Dermatol. Venereol., 2016; 30: 659-666

Rolfs R.T., Joesoef M.R., Hendershot E.F., et al.: A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. N. Engl. J. Med., 1997; 337: 307-314

Rolfs R.T.: Treatment of syphilis, 1993. Clin. Infect. Dis., 1995; 20 (suppl. 1): S23-38

Goh B.T., Smith G.W., Samarasinghe L., Singh V., Lim K.S.: Penicillin concentrations in serum and cerebrospinal fluid after intramuscular injection of aqueous procaine penicillin 0.6 MU with and without oral probenecid. Br. J. Venereol. Dis., 1984; 60: 371-373

Marra C.M., Boutin P., McArthur J.C., et al.: A pilot study evaluating ceftriaxone and penicillin G as treatment agents for neurosyphilis in human immunodeficiency virus-infected individuals. Clin. Infect. Dis., 2000; 30: 540-544

Dowell M.E., Ross P.G., Musher D.M., Cate T.R., Baughn R.E.: Response of latent syphilis or neurosyphilis to ceftriaxone therapy in persons infected with human immunodeficiency virus. Am. J. Med., 1992; 93: 481-488

Cao Y., Su X., Wang Q., et al.: A multicentre study evaluating ceftriaxone and benzathine penicillin G as treatment agents for early syphilis in Jiangsu. China. Clin. Infect. Dis., 2017; 65: 1683-1688

Amir J., Ginat S., Cohen Y.H., Marcus T.E., Keller N., Varsano I.: Lidocaine as a diluent for administration of benzathine penicillin G. Pediatr. Infect. Dis., 1998; 17: 890-893

Crowe G., Theodore C., Forster G.E., Goh B.T.: Acceptability and compliance with daily injections of procaine penicillin in the treatment of syphilis-treponemal infection. Sex. Transm. Dis., 1997; 24: 127-130

Wong T., Singh A.E., De P.: Primary syphilis treatment response to doxycycline/tetracycline versus benzathine penicillin. Am. J. Med., 2008; 121: 903-908

Boot J.M., Oranje A.P., De Groot R., Tan G., Stolz E.: Congenital syphilis. Int. J. STD AIDS, 1992; 3: 161-167

Hong F.C., Wu X.B., Yang F., et al.: Risk of congenital syphilis (CS) following treatment of maternal syphilis: results of a CS control program in China. Clin. Infect. Dis., 2017; 65: 588-594

Janier M., Chastang C., Spindler E., et al.: A prospective study of the influence of HIV status on the seroreversion of serological tests for syphilis. Dermatology, 1999; 198: 362-369

Frohlich-Knaute D., Graf N., Lautenschlager S., Weber R., Bosshard P.P.: Serological response to treatment of syphilis according to disease stage and HIV status. Clin. Infect. Dis., 2012; 55: 1615-1622

Gonzalez-Lopez J.J., Fernandez-Guerrero M.L., Lujan R., Fernandez-Tostado S., de Gorgolas M., Requena L.: Factors determining serologic response to treatment in patients with syphilis. Clin. Infect. Dis., 2009; 49: 1505-1511

Courjon J., Hubiche T., Dupin N., Grange P.A., Del Giudice P.: Clinical aspects of syphilis reinfection in HIV-infected patients. Dermatology, 2015; 230: 302-307

Ganesan A., Mesner O., Okulicz J.F., et al.: A single dose of benzathine penicillin G is as effective as multiple doses of benzathine penicillin G for the treatment of HIV-infected persons with early syphilis. Clin. Infect. Dis., 2015; 60: 653-660

Costa-Silva M., Azevedo C., Azevedo F., Lisboa C.: Early syphilis treatment in HIV-infected patients: single dose vs. three doses of benzathine penicillin G. J. Eur. Acad. Dermatol. Venereol., 2016; 10: 1805-1809

Cortes N.J., Afzali B., MacLean D., et al.: Transmission of syphilis by solid organ transplantation. Am. J. Transplant., 2006; 6: 2497-2499

Arando M., Fernandez-Naval C., Mota-Foix M., et al.: The Jarisch-Herxheimer reaction in syphilis: could molecular typing help to understand it better? J. Eur. Acad. Dermatol. Venereol., 2018; 32: 1791-1795

Traeger M.W., Schroeder S.E., Wright E.J., et al.: Effects of pre-exposure prophylaxis for the prevention of Human Immunodeficiency Virus infec- tion on sexual risk behaviour in men who have sex with men: a systematic review and meta-analysis. Clin. Infect. Dis., 2018; 67: 676-686

Grant J.S., Stafylis C., Celum C., et al.: Doxycycline prophylaxis for bacterial sexually transmitted infections. Clin. Infect. Dis., 2020; 70: 1247-1253

Katz K.A., Lee M.A., Gray T., Marcus J.L., Pierce E.F.: Repeat syphilis among men who have sex with men-San Diego county, 2004-2009. Sex. Transm. Dis., 2011; 38: 349-352

Sena A.C., Zang X.-H., Li T., et al.: A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy. BMC Infect. Dis., 2015; 15: 479. https://doi. org/10.1186/s12 879-015-1209-0

Sena A.C., Wolff M., Behets F., et al.: Rate of decline in Nontreponemal antibody titers and seroreversion after treatment of early syphilis. Sex. Transm. Dis., 2017; 44: 6-10

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Published

2023-09-09

How to Cite

1.
BEN RHAIEM, Rami, KĘPKA, Przemysław, KUZIEMKOWSKA, Daria, KUŹMA, Jan, ŁĄCKA-MAJCHER, Anna, ŁOKCZEWSKA-BOJAR, Aleksandra, TARSA, Grzegorz, SKOTALCZYK, Magdalena, SAWIŃSKA, Zuzanna and SUDELSKA, Katarzyna. Syphilis - a disease that still occurs. Journal of Education, Health and Sport. Online. 9 September 2023. Vol. 16, no. 1, pp. 146-161. [Accessed 8 July 2025]. DOI 10.12775/JEHS.2023.16.01.014.
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Vol. 16 No. 1 (2023)

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Review Articles

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Copyright (c) 2023 Rami Ben Rhaiem, Przemysław Kępka, Daria Kuziemkowska, Jan Kuźma, Anna Łącka-Majcher, Aleksandra Łokczewska-Bojar, Grzegorz Tarsa, Magdalena Skotalczyk, Zuzanna Sawińska, Katarzyna Sudelska

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