Supplementation of creatine and its role in brain function
DOI:
https://doi.org/10.12775/JEHS.2023.15.01.017Keywords
creatine, creatine supplementation, sports nutrition, brain functionAbstract
Introduction and aim. In recent years growing awareness of the society regarding healthy lifestyle leads to increased interest in regular physical activity and usage of dietary supplements. Creatine supplementation is often used among athletes to improve muscle mass, performance and recovery. The aim of this paper is to present the effects of creatine supplementation as well as its function in the body, forms and ways of intake, and potential benefits of its use.
Material and methods. A review of the available literature was performed by searching the PubMed and GoogleScholar databases using the following keywords: creatine, creatine supplementation, sports nutrition, brain function
Analysis of literature. Creatine is one of the most popular supplements recommended for athletes. It catalyzes transfer of phosphate groups into high energy compounds contributing in energy transportation and cellular energy buffering for cells and tissues with high energy demands. Its supplementation improves exercise performance, increases muscle mass and enhances recovery after training. In addition, there are indications that creatine shows promise in reducing symptoms associated with concussion, mild traumatic brain injury, and depression.
Conclusion. Creatine supplementation is used in sport mainly to improve exercise performance and muscle gain, however, it also plays an important role in brain function. In future it may be used in reducing symptoms associated with concussion, mild traumatic brain injury and depression.
References
Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev. 2000;80(3):1107-213. doi: 10.1152/physrev.2000.80.3.1107
Petras P Dzeja, Robert J Zeleznikar, Nelson D Goldberg. Suppression of Creatine Kinase-catalyzed Phosphotransfer Results in Increased Phosphoryl Transfer by Adenylate Kinase in Intact Skeletal Muscle, Journal of Biological Chemistry. 1996;271(22):12847-12851. doi.org/10.1074/jbc.271.22.12847
Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017;14:18. doi: 10.1186/s12970-017-0173-z
Op ‘t Eijnde B, Ursø B, Richter EA, et al. Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization. Diabetes. 2001;50(1):18-23. doi: 10.2337/diabetes.50.1.18
Farshidfar F, Pinder MA, Myrie SB. Creatine Supplementation and Skeletal Muscle Metabolism for Building Muscle Mass - Review of the Potential Mechanisms of Action. Curr Protein Pept Sci. 2017;18(12):1273-1287. doi: 10.2174/1389203718666170606105108
Andres S, Ziegenhagen R, Trefflich I, et al. Creatine and creatine forms intended for sports nutrition. Mol Nutr Food Res. 2017;61(6). doi: 10.1002/mnfr.201600772
Jäger R, Purpura M, Shao A, Inoue T, Kreider RB. Analysis of the efficacy, safety, and regulatory status of novel forms of creatine. Amino Acids. 2011;40(5):1369-83. doi: 10.1007/s00726-011-0874-6
Andres S, Ziegenhagen R, Trefflich I i wsp. Creatine and creatine forms intended for sports nutrition. Mol Nutr Food Res. 2017 Jun;61(6). doi: 10.1002/mnfr.201600772
Harris RC, Söderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond). 1992;83(3):367-74. doi: 10.1042/cs0830367
Green AL, Hultman E, Macdonald IA, Sewell DA, Greenhaff PL. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol. 1996;271(5 Pt 1):E821-6. doi: 10.1152/ajpendo.1996.271.5.E821
Greenhaff PL, Casey A, Short AH, Harris R, Soderlund K, Hultman E. Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Clin Sci (Lond). 1993;84(5):565-71. doi: 10.1042/cs0840565
Cooper R, Naclerio F, Allgrove J, Jimenez A. Creatine supplementation with specific view to exercise/sports performance: an update. J. Int. Soc. Sports. Nutr. 2012:9(33). doi.org/10.1186/1550-2783-9-33
Kaviani M, Abassi A, Chilibeck PD. Creatine monohydrate supplementation during eight weeks of progressive resistance training increases strength in as little as two weeks without reducing markers of muscle damage. J Sports Med Phys Fitness. 2019;59(4):608-612. doi: 10.23736/S0022-4707.18.08406-2
Kim HJ1, Kim CK, Carpentier A, Poortmans JR. Studies on the safety of creatine supplementation. Amino Acids. 2011;40(5):1409-18. doi: 10.1007/s00726-011-0878-2
Williams MH, Kreider RB, and Branch JD, Creatine: The power supplement. Human kinetics. 1999
Gualano B, Artioli GG, Poortmans JR, Junior AH. Exploring the therapeutic role of creatine supplementation. Amino Acids. 2010;38(1):31-44. doi: 10.1007/s00726-009-0263-6
Turner CE, Byblow WD, Gant N. Creatine Supplementation Enhances Corticomotor Excitability and Cognitive Performance during Oxygen Deprivation. J Neurosci. 2015;35(4):1773-80. doi: 10.1523/JNEUROSCI.3113-14.2015
Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The ‘phosphocreatine circuit’ for cellular energy homeostasis. Biochem J. 1992;281:21-40. doi: 10.1042/bj2810021
Wallimann, T.; Turner, D.C.; Eppenberger, H.M. Localization of creatine kinase isoenzymes in myofibrils. I. Chicken skeletal muscle. J. Cell Biol. 1977;75:297-317. doi: 10.1083/jcb.75.2.297
Sahlin, K.; Harris, R.C. The creatine kinase reaction: A simple reaction with functional complexity. Amino Acids. 2011;40(5):1363-7. doi: 10.1007/s00726-011-0856-8
Bender A, Klopstock T. Creatine for neuroprotection in neurodegenerative disease: End of story? Amin. Acids 2016;48(8):1929-40. doi: 10.1007/s00726-015-2165-0
Mercimek-Andrews S, Salomons GS. Creatine Deficiency Syndromes. National Library of Medicine. https://www.ncbi.nlm.nih.gov/books/NBK3794. Updated February 10, 2022. Accessed June 17, 2023.
Salomons GS, Van Dooren SJM, Verhoeven NM, et al. X-linked creatine transporter defect: An overview. J. Inherit. Metab. Dis. 2003;26(2-3):309-18. doi: 10.1023/a:1024405821638
Stöckler S, Holzbach U, Hanefeld F, et al. Creatine deficiency in the brain: A new, treatable inborn error of metabolism. Pediatr. Res. 1994;36:409–413. https://doi.org/10.1203/00006450-199409000-00023
Kaldis P, Hemmer W, Zanolla E, Holtzman D, Wallimann T. “Hot spots” of creatine kinase localization in brain: Cerebellum, hippocampus and choroid plexus. Dev. Neurosci. 1996;18(5-6):542-54. doi: 10.1159/000111452
Faulkner P, Paioni SL, Kozhuharova P, et al. Relationship between depression, prefrontal creatine and grey matter volume. J. Psychopharmacol. 2021;35(12):1464-1472. doi: 10.1177/02698811211050550
Kondo DG, Sung YH, Hellem TL, et al. Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: A 31-phosphorus magnetic resonance spectroscopy study. J. Affect. Disord. 2011;135(1-3):354-61. doi: 10.1016/j.jad.2011.07.010
Hellem TL, Sung Y-H, Shi X-F, et al. Creatine as a Novel Treatment for Depression in Females Using Methamphetamine: A Pilot Study. J. Dual Diagn. 2015;11(3-4):189-202. doi: 10.1080/15504263.2015.1100471
Amital D, Vishne T, Rubinow A, Levine J. Observed effects of creatine monohydrate in a patient with depression and fibromyalgia. Am. J. Psychiatry 2006;163(10):1840-1. doi: 10.1176/ajp.2006.163.10.1840b
Lyoo IK, Yoon S, Kim TS, et al. A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder. Am J Psychiatry. 2012;169(9):937-945. doi: 10.1176/appi.ajp.2012.12010009
Roitman S, Green T, Osher Y, Karni N, Levine J. Creatine monohydrate in resistant depression: A preliminary study. Bipolar Disord. 2007;9(7):754-8. doi: 10.1111/j.1399-5618.2007.00532.x
Toniolo RA, Fernandes FBF, Silva M, Dias RDS, Lafer B. Cognitive effects of creatine monohydrate adjunctive therapy in patients with bipolar depression: Results from a randomized, double-blind, placebo-controlled trial. J Affect Disord. 2017;224:69-75. doi: 10.1016/j.jad.2016.11.029
Toniolo RA, Silva M, Fernandes FBF, Amaral JAMS, Dias RDS, Lafer B. A randomized, double-blind, placebo-controlled, proof-of-concept trial of creatine monohydrate as adjunctive treatment for bipolar depression. J Neural Transm. 2018;125(2):247-257. doi: 10.1007/s00702-017-1817-5
Okwuofu EO, Ogundepo GE, Akhigbemen AM, et al. Creatine attenuates seizure severity, anxiety and depressive-like behaviors in pentylenetetrazole kindled mice. Metab Brain Dis. 2021;36(4):571-579. doi: 10.1007/s11011-021-00684-w
Rosa JM, Pazini FL, Cunha MP, et al. Antidepressant effects of creatine on amyloid β1-40-treated mice: The role of GSK-3β/Nrf2 pathway. Prog Neuropsychopharmacol Biol Psychiatry. 2018;86:270-278. doi: 10.1016/j.pnpbp.2018.05.001
Pazini FL, Cunha MP, Azevedo D, et al. Creatine Prevents Corticosterone-Induced Reduction in Hippocampal Proliferation and Differentiation: Possible Implication for Its Antidepressant Effect. Mol Neurobiol. 2017;54(8):6245-6260. doi: 10.1007/s12035-016-0148-0
Ainsley Dean PJ, Arikan G, Opitz B, Sterr A. Potential for use of creatine supplementation following mild traumatic brain injury. Concussion. 2017;2(2):CNC34. doi: 10.2217/cnc-2016-0016
Vagnozzi R, Signoretti S, Floris R, et al. Decrease in N-acetylaspartate following concussion may be coupled to decrease in creatine. Journal of Head Trauma Rehabilitation. 2013;28(4):284-292. doi: 10.1097/HTR.0b013e3182795045
Sullivan PG, Geiger JD, Mattson MP, Scheff SW. Dietary supplement creatine protects against traumatic brain injury. Ann Neurol. 2000;48(5):723-9
Ipsiroglu OS, Stromberger C, Ilas J, Höger H, Mühl A, Stöckler-Ipsiroglu S. Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species. Life Sci. 2001;69(15):1805-15. doi: 10.1016/s0024-3205(01)01268-1
Sakellaris G, Kotsiou M, Tamiolaki M, et al. Prevention of complications related to traumatic brain injury in children and adolescents with creatine administration: an open label randomized pilot study. J Trauma. 2006;61(2):322-9. doi: 10.1097/01.ta.0000230269.46108.d5
Sakellaris G, Nasis G, Kotsiou M, Tamiolaki M, Charissis G, Evangeliou A. Prevention of traumatic headache, dizziness and fatigue with creatine administration. A pilot study. Acta Paediatr. 2008;97(1):31-4. doi: 10.1111/j.1651-2227.2007.00529.x
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