IQOS - new heat-not-burn tobacco products and its impact on health
DOI:
https://doi.org/10.12775/JEHS.2023.46.01.001Keywords
Iqos, Heat not burn, Iqos health impactAbstract
Introduction: Iqos and other heat-not-burn products according to tobacco companies are a safer alternative to cigarettes.
The aim of this article is to objectively review the potential impact of iQOS® on human health by searching for and integrating published research findings.
This article provides a comprehensive review and analysis of the scientific research conducted on the effects of Iqos use on human health, distinguishing between specific medical fields.
Materials and methods: This study is based on medical articles collected from the PubMed database spanning the years 2016-2023. The research was conducted through the analysis of keywords such as "Iqos", "Heat not burn", and "Iqos health impact".
Results: Tobacco heaters are seen as potentially less harmful. However, emerging research on their harmfulness clearly shows that despite reduced concentrations of compounds hazardous to health, the aerosol produced by heaters still contains the same harmful substances. Further studies show that the toxic impact of the aerosol is at a similar level to that of smoke from traditional cigarettes.
References
Karolien Adriaens ,,Dinska Van Gucht,Frank Baeyens. IQOSTM vs. e-Cigarette vs. Tobacco Cigarette: A Direct Comparison of Short-Term Effects after Overnight-Abstinence. Int. J. Environ. Res. Public Health 2018, 15(12), 2902; https://doi.org/10.3390/ijerph15122902
Simonavicius E, McNeill A, Shahab L, Brose LS. Heat-not-burn tobacco products: a systematic literature review. Tob Control. Sep 2019;28(5):582–594. doi: 10.1136/tobaccocontrol-2018-054419
Zongshuan Duan, PhD, Christina N Wysota, MPH, Katelyn F Romm, PhD, Hagai Levine, MD, Yael Bar-Zeev, PhD, Kelvin Choi, PhD, Carla J Berg, PhD. Correlates of Perceptions, Use, and Intention to Use Heated Tobacco Products Among US Young Adults in 2020 Nicotine & Tobacco Research, Volume 24, Issue 12, December 2022, Pages 1968–1977, https://doi.org/10.1093/ntr/ntac185
Başaran R, Güven NM, Eke BC. An Overview of iQOS® as a New Heat-Not-Burn Tobacco Product and Its Potential Effects on Human Health and the Environment. TurkTurk J Pharm Sci. 2019 Sep; 16(3): 371–374. J Pharm Sci. 2019 Sep; 16(3): 371–374.
doi: 10.4274/tjps.galenos.2018.79095 PMID: 32454738.
Ruprecht AA, De Marco C, Saffari A, Pozzi P, Mazza R, Veronese C, Angellotti G, Munarini E, Ogliari AC, Westerdahl D, Hasheminassab S, Shafer MM, Schauer JJ, Repace J, Sioutas C, Boffi R. Environmental pollution and emission factors of electronic cigarettes, heat-not-burn tobacco products, and conventional cigarettes. Aerosol Sci Technol. 2017;51:674–684.
Simon McDermott, Kerstin Reichmann, Elizabeth Mason, Ian M Fearon, Grant O'Connell, Thomas Nahde. An assessment of nicotine pharmacokinetics and subjective effects of the pulze heated tobacco system compared with cigarettes. Sci Rep. 2023 Jun 3;13(1):9037. doi: 10.1038/s41598-023-36259-1.
Kephart WC, Mumford PW, McCloskey AE, Holland AM, Shake JJ, Mobley CB, Jagodinsky AE, Weimar WH, Oliver GD, Young KC, Moon JR, Roberts MD. Post-exercise branched chain amino acid supplementation does not affect recovery markers following three consecutive high intensity resistance training bouts compared to carbohydrate supplementation. J Int Soc Sports Nutr. 2016 Jul 26;13:30. doi: 10.1186/s12970-016-0142-y. PMID: 27468258; PMCID: PMC4962429.
Clement N. Uguna* and Colin E. Snape. Should IQOS Emissions Be Considered as Smoke and Harmful to Health? A Review of the Chemical Evidence. ACS Omega. 2022 Jul 5; 7(26): 22111–22124. PMID: 35811880 doi: 10.1021/acsomega.2c01527
Tariq A Bhat, PhD,1 Suresh G Kalathil, PhD,1 Noel Leigh, MS,2 Thivanka Muthumalage, PhD,3 Irfan Rahman, PhD,3 Maciej L Goniewicz, PharmD, PhD,2 and Yasmin M Thanavala, PhD1 Acute Effects of Heated Tobacco Product (IQOS) Aerosol Inhalation on Lung Tissue Damage and Inflammatory Changes in the Lungs. Nicotine Tob Res 2021 Jun 8;23(7):1160-1167. doi: 10.1093/ntr/ntaa267. PMID: 33346355
Naoko Arano Nitta , Tadashi Sato, Moegi Komura, Hitomi Yoshikawa, Yohei Suzuki, Aki Mitsui, Eriko Kuwasaki, Fumiyuki Takahashi, Yuzo Kodama, Kuniaki Seyama, Kazuhisa Takahashi. Exposure to the heated tobacco product IQOS generates apoptosis-mediated pulmonary emphysema in murine lungs. Am J Physiol Lung Cell Mol Physiol
. 2022 May 1;322(5):L699-L711. doi: 10.1152/ajplung.00215.2021. Epub 2022 Apr 5.
Jianjun Gu, Daohui Gong, Yuxiu Wang, Tingting Feng, Jun Zhang, Suwei Hu, Lingfeng Min. Chronic exposure to IQOS results in impaired pulmonary function and lung tissue damage in mice. Toxicol Lett. 2023 Feb 1;374:1-10. doi: 10.1016/j.toxlet.2022.11.022. Epub 2022 Dec 1.
St Helen G, Jacob P, 3rd, Nardone N, Benowitz NL. IQOS: examination of Philip Morris International's claim of reduced exposure. Tob Control. 2018;27(Suppl 1):s30–s36. doi: 10.1136/tobaccocontrol-2018-054321
Harry Tattan-Birch, Jamie Hartmann-Boyce, Loren Kock , Erikas Simonavicius, Leonie Brose, Sarah Jackson , Lion Shahab , Jamie Brown. Heated tobacco products for smoking cessation and reducing smoking prevalence Cochrane Database Syst Rev
. 2022 Jan 6;1(1):CD013790. doi: 10.1002/14651858.CD013790.pub2.
Davis B, To V, Talbot P. Comparison of cytotoxicity of IQOS aerosols to smoke from Marlboro Red and 3R4F reference cigarettes. Toxicol In Vitro. 2019;61:104652. doi: 10.1016/j.tiv.2019.104652.
Yoshihisa Morishita,1 Shogo Hasegawa,corresponding author1 Shin Koie,1 Sei Ueda,1 Satoru Miyabe,1 Satoshi Watanabe,1 Mitsuo Goto,1 Hitoshi Miyachi,1 Shuji Nomoto,2 and Toru Nagao1.Cytotoxic, genotoxic, and toxicogenomic effects of heated tobacco products and cigarette smoke in human primary keratinocytes. Tob Induc Dis. 2022; 20: 82.
Published online 2022 Sep 30. doi: 10.18332/tid/152510 PMID: 36249345
Justus Klein, Patrick Diaba-Nuhoho, Sindy Giebe, Coy Brunssen, Henning Morawietz. Regulation of endothelial function by cigarette smoke and next-generation tobacco and nicotine products Pflugers Arch 2023 Jul;475(7):835-844. doi: 10.1007/s00424-023-02824-w. Epub 2023 Jun 7.
Katherine A. Charlotte N. E. Tompkins, Ann McNeill, Sara C. Hitchman ‘I perceive it to be less harmful, I have no idea if it is or not:’ a qualitative exploration of the harm perceptions of IQOS among adult users. Harm Reduct J. 2021; 18: 42.
Published online 2021 Apr 13. doi: 10.1186/s12954-021-00490-8
Nicholas D Fried, Jason D Gardner. Heat-not-burn tobacco products: an emerging threat to cardiovascular health. Am J Physiol Heart Circ Physiol. 2020 Dec 1;319(6):H1234-H1239. doi: 10.1152/ajpheart.00708.2020. Epub 2020 Oct 2.
Ioakeimidis N, Emmanouil E, Terentes-Printzios D, Dima I, Aznaouridis K, Tousoulis D, Vlachopoulos C. Acute effect of heat-not-burn versus standard cigarette smoking on arterial stiffness and wave reflections in young smokers. Eur J Prev Cardiol 2047487320918365, 2020. doi: 10.1177/2047487320918365.
Biondi-Zoccai G, Sciarretta S, Bullen C, Nocella C, Violi F, Loffredo L, Pignatelli P, Perri L, Peruzzi M, Marullo AGM, De Falco E, Chimenti I, Cammisotto V, Valenti V, Coluzzi F, Cavarretta E, Carrizzo A, Prati F, Carnevale R, Frati G. Acute effects of heat-not-burn, electronic vaping, and traditional tobacco combustion cigarettes: the Sapienza University of Rome-Vascular Assessment of Proatherosclerotic Effects of Smoking (SUR-VAPES) 2 Randomized Trial. J Am Heart Assoc 8: e010455, 2019. doi: 10.1161/JAHA.118.010455.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Krzysztof Jachowicz, Krzysztof Feja, Ewa Łuczak, Borys Bieńkowski, Piotr Petryla, Zuzanna Suwała, Filip Korol, Adam Dobek, Natalia Rektor, Michał Symulewicz
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 3129
Number of citations: 0
