Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

Effect of red rice on the lipid profile and risk of cardiovascular diseases
  • Home
  • /
  • Effect of red rice on the lipid profile and risk of cardiovascular diseases
  1. Home /
  2. Archives /
  3. Vol. 46 No. 1 (2023) /
  4. Review Articles

Effect of red rice on the lipid profile and risk of cardiovascular diseases

Authors

  • Michał Lazar Kliniczny Szpital Wojewódzki Nr 2. im. Św. Jadwigi Królowej w Rzeszowie https://orcid.org/0009-0004-9470-1955
  • Karolina Miszczyk Nowodworskie Centrum Medyczne, Nowy Dwór Mazowiecki https://orcid.org/0009-0005-4210-489X
  • Patrycja Maj 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Lublinie, Al. Racławickie 23, 20-049 Lublin https://orcid.org/0009-0008-4867-1715
  • Natalia Sergiel 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Lublinie, Al. Racławickie 23, 20-049 Lublin https://orcid.org/0000-0003-3253-4800
  • Agata Kania Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego. ul.Banacha 1A, 02-097 Warszawa https://orcid.org/0009-0008-2685-5126
  • Malwina Gonet Poznan University of Medical Sciences, Faculty of Medicine, Poznan, Poland. (Fredry 10, 61-701 Poznan, Poland) https://orcid.org/0009-0008-8254-8681
  • Karolina Włodarczyk-Cybulska 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Lublinie, Al. Racławickie 23, 20-049 Lublin https://orcid.org/0009-0004-8600-0040
  • Piotr Mozer 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Lublinie, Al. Racławickie 23, 20-049 Lublin https://orcid.org/0009-0009-2529-4117
  • Jakub Maternia Kliniczny Szpital Wojewódzki Nr 2. im. Św. Jadwigi Królowej w Rzeszowie. Lwowska 60, 35-301 Rzeszów https://orcid.org/0009-0004-4535-7211
  • Aleksandra Serwik-Trandasir Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego. ul.Banacha 1A, 02-097 Warszawa https://orcid.org/0009-0005-7671-889X

DOI:

https://doi.org/10.12775/JEHS.2023.46.01.005

Keywords

red yeast rice, cardiovascular risk, prevention of cardiovascular diseases

Abstract

Red yeast rice (RRY) and its ingredient, monacolin K, are increasingly being studied for their potential effects on the lipid profile and risk of cardiovascular diseases. This article presents an overview of the latest research on this topic, including randomized controlled trials and systematic reviews, Analysis of medical standards, that RRY supplementation can lower LDL cholesterol and triglycerides, which can prevent development of cardiovascular diseases. Studies have also seen beneficial changes in other parameters, including levels of total cholesterol, endothelial funciton and arterial stiffness. Substantially, additional and larger studies are needed to confirm long-term safety of RRY. All of this indicates, that RRY can be a tool in the fight against dyslipidemia and cardiovascular diseases, especially in people who cannot tolarate statins.

References

World Health Organization. Cardiovascular diseases (CVDs). Dostępne na: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)

Gałęcka, M. (2020). The prevention of lipid disorders with a view to reducing the risk of cardiovascular disease – the role of supplementation. Lekarz POZ, 6(2), 97-102.

Cichocka, A., Kłosiewicz-Latoszek, L., Cybulska, B. (2006). Zaburzenia lipidowe, Warszawa: PZWL Wydawnictwo Lekarskie.

Endo A. Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. J Antibiot (Tokyo). 1979 Aug;32(8):852-4. doi: 10.7164/antibiotics.32.852. PMID: 500505.

Heber D, Yip I, Ashley JM, Elashoff DA, Elashoff RM, Go VL. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am J Clin Nutr. 1999 Feb;69(2):231-6. doi: 10.1093/ajcn/69.2.231. PMID: 9989685.

Cicero AF, Derosa G, Parini A, Maffioli P, D'Addato S, Reggi A, Giovannini M, Borghi C. Red yeast rice improves lipid pattern, high-sensitivity C-reactive protein, and vascular remodeling parameters in moderately hypercholesterolemic Italian subjects. Nutr Res. 2013 Aug;33(8):622-8. doi: 10.1016/j.nutres.2013.05.015. Epub 2013 Jul 12. PMID: 23890351.

Verhoeven V, Van der Auwera A, Van Gaal L, Remmen R, Apers S, Stalpaert M, Wens J, Hermans N. Can red yeast rice and olive extract improve lipid profile and cardiovascular risk in metabolic syndrome?: A double blind, placebo controlled randomized trial. BMC Complement Altern Med. 2015 Mar 10;15:52. doi: 10.1186/s12906-015-0576-9. PMID: 25879228; PMCID: PMC4364089.

Klimek M, Wang S, Ogunkanmi A. Safety and efficacy of red yeast rice (Monascus purpureus) as an alternative therapy for hyperlipidemia. P T. 2009 Jun;34(6):313-27. PMID: 19572049; PMCID: PMC2697909.

Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998 May 12;97(18):1837-47. doi: 10.1161/01.cir.97.18.1837. PMID: 9603539.

Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, Halsey J, Qizilbash N, Peto R, Collins R. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007 Dec 1;370(9602):1829-39. doi: 10.1016/S0140-6736(07)61778-4. Erratum in: Lancet. 2008 Jul 26;372(9635):292. PMID: 18061058.

Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007 Jul 18;298(3):299-308. doi: 10.1001/jama.298.3.299. PMID: 17635890.

Li Y, Jiang L, Jia Z, Xin W, Yang S, Yang Q, Wang L. A meta-analysis of red yeast rice: an effective and relatively safe alternative approach for dyslipidemia. PLoS One. 2014 Jun 4;9(6):e98611. doi: 10.1371/journal.pone.0098611. PMID: 24897342; PMCID: PMC4045580.

Cicero AF, Morbini M, Rosticci M, D''Addato S, Grandi E, Borghi C. Middle-Term Dietary Supplementation with Red Yeast Rice Plus Coenzyme Q10 Improves Lipid Pattern, Endothelial Reactivity and Arterial Stiffness in Moderately Hypercholesterolemic Subjects. Ann Nutr Metab. 2016;68(3):213-9. doi: 10.1159/000445359. Epub 2016 Apr 8. PMID: 27055107.

Guardamagna O, Abello F, Baracco V, Stasiowska B, Martino F. The treatment of hypercholesterolemic children: efficacy and safety of a combination of red yeast rice extract and policosanols. Nutr Metab Cardiovasc Dis. 2011 Jun;21(6):424-9. doi: 10.1016/j.numecd.2009.10.015. Epub 2010 Feb 12. PMID: 20153154.

Cicero AFG, Fogacci F, Banach M. Red Yeast Rice for Hypercholesterolemia. Methodist Debakey Cardiovasc J. 2019 Jul-Sep;15(3):192-199. doi: 10.14797/mdcj-15-3-192. PMID: 31687098; PMCID: PMC6822657.

Lin CC, Li TC, Lai MM. Efficacy and safety of Monascus purpureus Went rice in subjects with hyperlipidemia. Eur J Endocrinol. 2005 Nov;153(5):679-86. doi: 10.1530/eje.1.02012. PMID: 16260426.

Huang CF, Li TC, Lin CC, Liu CS, Shih HC, Lai MM. Efficacy of Monascus purpureus Went rice on lowering lipid ratios in hypercholesterolemic patients. Eur J Cardiovasc Prev Rehabil. 2007 Jun;14(3):438-40. doi: 10.1097/HJR.0b013e32801da137. PMID: 17568245.

Gordon RY, Cooperman T, Obermeyer W, Becker DJ. Marked variability of monacolin levels in commercial red yeast rice products: buyer beware! Arch Intern Med. 2010 Oct 25;170(19):1722-7. doi: 10.1001/archinternmed.2010.382. PMID: 20975018.

Becker DJ, Gordon RY, Halbert SC, French B, Morris PB, Rader DJ. Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. Ann Intern Med. 2009 Jun 16;150(12):830-9, W147-9. doi: 10.7326/0003-4819-150-12-200906160-00006. PMID: 19528562.

Cicero AF, Morbini M, Parini A, Urso R, Rosticci M, Grandi E, Borghi C. Effect of red yeast rice combined with antioxidants on lipid pattern, hs-CRP level, and endothelial function in moderately hypercholesterolemic subjects. Ther Clin Risk Manag. 2016 Feb 23;12:281-6. doi: 10.2147/TCRM.S91817. PMID: 26966368; PMCID: PMC4770063.

Downloads

  • PDF

Published

2023-08-29

How to Cite

1.
LAZAR, Michał, MISZCZYK, Karolina, MAJ, Patrycja, SERGIEL, Natalia, KANIA, Agata, GONET, Malwina, WŁODARCZYK-CYBULSKA, Karolina, MOZER, Piotr, MATERNIA, Jakub and SERWIK-TRANDASIR, Aleksandra. Effect of red rice on the lipid profile and risk of cardiovascular diseases. Journal of Education, Health and Sport. Online. 29 August 2023. Vol. 46, no. 1, pp. 76-88. [Accessed 28 June 2025]. DOI 10.12775/JEHS.2023.46.01.005.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 46 No. 1 (2023)

Section

Review Articles

License

Copyright (c) 2023 Michał Lazar, Karolina Miszczyk, Patrycja Maj, Natalia Sergiel, Agata Kania, Malwina Gonet, Karolina Włodarczyk-Cybulska, Piotr Mozer, Jakub Maternia, Aleksandra Serwik-Trandasir

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 725
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

red yeast rice, cardiovascular risk, prevention of cardiovascular diseases
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop