Influence of obesity and other metabolic disorders on rosacea
DOI:
https://doi.org/10.12775/JEHS.2023.45.01.011Keywords
rosacea, metabolic disorder, obesityAbstract
Introduction:Rosacea is a chronic, inflammatory disease, characterized by skin lesions or ocular symptoms. Skin lesions are located primarily on the central face. Thickening of the skin can occur in some people. There are four subtypes of rosacea and one variant. Rosacea significantly impairs the quality of life. The exact cause of rosacea is not yet fully understood, but it is thought to involve a combination of genetic, environmental, and lifestyle factors. Treatment starts with avoidance of triggering factors. Obesity leads to multiple negative health effects. It has been associated with some inflammatory dermatoses, such as psoriasis and atopic dermatitis.As obesity disrupt cutaneous vasculature and temperature regulation, it may be also associated with increased risk for rosacea and worse course of this disease.
Aim of study:The purpose of the study was to review the literature on the influence of obesity and other metabolic disorders on development of rosacea.
Matherials and methods:A systemic review was conducted using PubMed, ScienceDirect, Google Scholar databases. The search strategy was based on following terms: rosacea, BMI, obesity, overweight, metabolic changes, insulin resistance and rosacea
Results and Conclusions:The complex relationship between obesity and other metabolic disorders and rosacea goes beyond obvious binary relationships. Chronic inflammation, genetic predisposition, common risk factors, and changes in metabolic and vascular function contribute to their complex interaction.Recognition and understanding of this relationship offers the potential for the development of new treatment strategies in the future that will prevent the occurrence of rosacea by modifying i.a. the risk factors we describe before they affect the patient's health and cause the disease described. Future research should continue to explore the underlying mechanisms and therapeutic interventions
References
Wilkin J, Dahl M, Detmar M, et al. Standard classification of rosacea: report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol. 2002;46(4):584–7
Őrnek N., Carabulut A.A., Őrnek K., Onaran Z., Usta G.: Corneal and conjunctival sensitivity in rosacea patients. Saudi J Ophtalmol 2016, 30, 29-32
Crawford GH, Pelle MT, James WD. Rosacea: I. Etiology, pathogenesis, and subtype classification. J Am Acad Dermatol. 2004;51(3):327–41. quiz 342–324
Chen DM, Crosby DL. Periorbital edema as an initial presentation of rosacea. J Am Acad Dermatol. 1997;37(2 Pt 2):346–8.
Baldwin HE. Diagnosis and treatment of rosacea: state of the art. J Drugs Dermatol JDD. 2012;11(6):725–30
Chang A.L.S., Raber I., Xu J., Li R., Spitale R., Chan J. i inni: Assesment of genetic basis of rosacea by genome-wide association study. J Invest Dermatol 2015, 135, 1548-1555
Spoendlin J, Voegel JJ, Jick SS, Meier CR. A study on the epidemiology of rosacea in the U.K. Br J Dermatol. 2012;167(3):598– 605
Steinhoff M, Schauber J, Leyden JJ. New insights into rosacea pathophysiology: a review of recent findings. J Am Acad Dermatol. 2013;69(6 Suppl 1):S15–26. This manuscript highlights the recent findings with regards to the innate immune system’s role in the pathophysiology of rosacea
Jarmuda S, O’Reilly N, Zaba R, Jakubowicz O, Szkaradkiewicz A, Kavanagh K. Potential role of Demodex mites and bacteria in the induction of rosacea. J Med Microbiol. 2012;61(Pt 11):1504–10. This manuscript reveals the association between infectious agents and rosacea
Bae YI, Yun SJ, Lee JB, Kim SJ, Won YH, Lee SC. Clinical evaluation of 168 Korean patients with rosacea: the sun exposure correlates with the erythematotelangiectatic subtype. Ann Dermatol. 2009;21(3):243–9
Abram K, Silm H, Maaroos HI, Oona M. Risk factors associated with rosacea. J Eur Acad Dermatol Venereol JEADV. 2010;24(5): 565–71
Gupta AK, Chaudhry MM. Rosacea and its management: an overview. J Eur Acad Dermatol Venereol JEADV. 2005;19(3):273–85
Haslam DW, James WP. Obesity. Lancet. 2005;366:1197-1209
Setty AR, Curhan G, Choi HK. Obesity, waist circumference, weight change, and the risk of psoriasis in women: nurses’ Health Study II. Arch Intern Med. 2007;167: 1670-1675,
Tsai MC, Chen W, Cheng YW, Wang CY, Chen GY, Hsu TJ. Higher body mass index is a significant risk factor for acne formation in schoolchildren. Eur J Dermatol. 2006;16: 251-253
Drucker AM, Li WQ, Lin L, et al. Atopic dermatitis (eczema) in US female nurses: lifestyle risk factors and atopic comorbidities. Br J Dermatol. 2016;174:1395-1397.
Kapiotis S, Holzer G, Schaller G, et al. A proinflammatory state is detectable in obese children and is accompanied by functional and morphological vascular changes. Arteriosclerosis, Thromb Vasc Biol. 2006;26:2541-2546
Spoendlin J, Voegel JJ, Jick SS, Meier CR. A study on the epidemiology of rosacea in the U.K. Br J Dermatol. 2012;167: 598-605.
Duman N, Ersoy Evans S, Atakan N. Rosacea and cardiovascular risk factors: a case-control study. J Eur Acad Dermatol Venereol. 2014;28:1165-1169
Reszke R, Pelka D, Walasek A, Machaj Z, Reich A. Skin disorders in elderly subjects. Int J Dermatol. 2015;54: e332-e338.
Stefanadi EC, Dimitrakakis G, Antoniou CK, Challoumas D, Punjabi N, Dimitrakaki IA, Punjabi S, Stefanadis CI. Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients. Diabetol Metab Syndr. 2018 Feb 21;10:9. doi: 10.1186/s13098-018-0311-z. PMID: 29483947; PMCID: PMC5822485.
Seremet S, Gurel MS. Miscellaneous skin disease and the metabolic syndrome. Clin Dermatol. 2018 Jan-Feb;36(1):94-100. doi: 10.1016/j.clindermatol.2017.09.016. Epub 2017 Sep 8. PMID: 29241760.
Akin Belli A, Ozbas Gok S, Akbaba G, Etgu F, Dogan G. The relationship between rosacea and insulin resistance and metabolic syndrome. Eur J Dermatol. 2016 Jun 1;26(3):260-4. doi: 10.1684/ejd.2016.2748. PMID: 27328660.
Nam JH, Yang J, Park J, Seo JH, Chang Y, Ryu S, Kim WS. Association between rosacea severity and relative muscle mass: A cross-sectional study. J Dermatol. 2019 Jan;46(1):11-17. doi: 10.1111/1346-8138.14689. Epub 2018 Oct 31. PMID: 30379346.
Li S, Cho E, Drucker AM, Qureshi AA, Li WQ. Obesity and risk for incident rosacea in US women. J Am Acad Dermatol. 2017 Dec;77(6):1083-1087.e5. doi: 10.1016/j.jaad.2017.08.032. Epub 2017 Oct 21. PMID: 29033249.
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Copyright (c) 2023 Kamila Fularska, Aleksandra Kuźniar, Dominik Szawica, Edward Wąsiewicz, Michał Oleszko, Fryderyk Sobczak, Radosław Bernacki, Piotr Bernacki, Martyna Dutka, Witold Zardzewiały
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