Supplementation of vitamin D in children with obesity and vitamin D deficiency - review of outcomes in terms of obesity parameters and comorbidities
DOI:
https://doi.org/10.12775/JEHS.2023.44.01.021Keywords
children, obesity, vitamin D, vitamin D deficiencyAbstract
In recent years, vitamin D deficiency and obesity in paediatric population have reached epidemic levels worldwide as crucial health concerns with far-reaching consequences. There has been a substantial growth in studies dedicated to these two public health issues over the last years. Numerous studies have confirmed that excess body weight has negative impact on vitamin D metabolism, leading to a higher risk of low levels of this essential vitamin, among individuals who are overweight or obese. Vitamin D deficiency may play a role in the development of obesity-related conditions as insulin resistance, type two diabetes, NAFLD and cardiovascular disease due to anti-inflammatory properties, impact on the endocrine system and metabolic functions of this vital nutrient. Vitamin D supplementation seems to be a beneficial addition to pharmacology and lifestyle changes during obesity treatment.
References
Ng M., Fleming T., Robinson M., Thomson B., Graetz N., Margono C., Mullany E.C., Biryukov S., Abbafati C., Abera S.F., et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:766–781. doi: 10.1016/S0140-6736(14)60460-8.
He QX, Zhao L, Tong JS, Liang XY, Li RN, Zhang P, Liang XH. The impact of obesity epidemic on type 2 diabetes in children and adolescents: A systematic review and meta-analysis. Prim Care Diabetes. 2022 Dec;16(6):736-744. doi: 10.1016/j.pcd.2022.09.006. Epub 2022 Sep 30. PMID: 36184528.
Fan, Jingwen et al. “Birth weight, childhood obesity and risk of hypertension: a Mendelian randomization study.” Journal of hypertension vol. 39,9 (2021): 1876-1883. doi:10.1097/HJH.0000000000002871
Liu, Jiaye et al. “Estimating Global Prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease in Overweight or Obese Children and Adolescents: Systematic Review and Meta-Analysis.” International journal of public health vol. 66 1604371. 6 Oct. 2021, doi:10.3389/ijph.2021.1604371
Gulotta G, Iannella G, Vicini C, et al. Risk factors for obstructive sleep apnea syndrome in children: state of the art. Int J Environ Res Public Health. 2019;16(18):3235. doi: 10.3390/ijerph16183235
Umer A, Kelley GA, Cottrell LE, Giacobbi P Jr, Innes KE, Lilly CL. Childhood obesity and adult cardiovascular disease risk factors: a systematic review with meta‐analysis. BMC Public Health. 2017;17:683. doi: 10.1186/s12889-017-4691-z [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Bouillon, Roger et al. “Vitamin D and human health: lessons from vitamin D receptor null mice.” Endocrine reviews vol. 29,6 (2008): 726-76. doi:10.1210/er.2008-0004
Lips, P. “Vitamin D physiology.” Progress in biophysics and molecular biology vol. 92,1 (2006): 4-8. doi:10.1016/j.pbiomolbio.2006.02.016
Hattangdi-Haridas, Sonal R et al. “Vitamin D Deficiency and Effects of Vitamin D Supplementation on Disease Severity in Patients with Atopic Dermatitis: A Systematic Review and Meta-Analysis in Adults and Children.” Nutrients vol. 11,8 1854. 9 Aug. 2019, doi:10.3390/nu11081854
Saintonge, Sandy et al. “Implications of a new definition of vitamin D deficiency in a multiracial us adolescent population: the National Health and Nutrition Examination Survey III.” Pediatrics vol. 123,3 (2009): 797-803. doi:10.1542/peds.2008-1195
Wimalawansa, Sunil J. “Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome.” The Journal of steroid biochemistry and molecular biology vol. 175 (2018): 177-189. doi:10.1016/j.jsbmb.2016.09.017
Holick, Michael F. “Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.” The American journal of clinical nutrition vol. 80,6 Suppl (2004): 1678S-88S. doi:10.1093/ajcn/80.6.1678S
Fiamenghi, Verônica Indicatti, and Elza Daniel de Mello. “Vitamin D deficiency in children and adolescents with obesity: a meta-analysis.” Jornal de pediatria vol. 97,3 (2021): 273-279. doi:10.1016/j.jped.2020.08.006
Malden S, Gillespie J, Hughes A, Gibson AM, Farooq A, Martin A, Summerbell C, Reilly JJ. Obesity in young children and its relationship with diagnosis of asthma, vitamin D deficiency, iron deficiency, specific allergies and flat-footedness: A systematic review and meta-analysis. Obes Rev. 2021 Mar;22(3):e13129. doi: 10.1111/obr.13129. Epub 2020 Aug 18. PMID: 32808447; PMCID: PMC7611974.
Yao Y, Zhu L, He L, Duan Y, Liang W, Nie Z, Jin Y, Wu X, Fang Y. A meta-analysis of the relationship between vitamin D deficiency and obesity. Int J Clin Exp Med. 2015 Sep 15;8(9):14977-84. PMID: 26628980; PMCID: PMC4658869.
Samaranayake, D B D L et al. “Vitamin D supplementation in obese Sri Lankan children: a randomized controlled trial.” BMC pediatrics vol. 20,1 426. 5 Sep. 2020, doi:10.1186/s12887-020-02329-w
Brzeziński, Michał et al. “Long-Term Effects of Vitamin D Supplementation in Obese Children During Integrated Weight-Loss Programme-A Double Blind Randomized Placebo-Controlled Trial.” Nutrients vol. 12,4 1093. 15 Apr. 2020, doi:10.3390/nu12041093
Valaiyapathi, Badhma et al. “Pathophysiology of Type 2 Diabetes in Children and Adolescents.” Current diabetes reviews vol. 16,3 (2020): 220-229. doi:10.2174/1573399814666180608074510
Henderson, M et al. “Measuring insulin sensitivity in youth: How do the different indices compare with the gold-standard method?.” Diabetes & metabolism vol. 37,1 (2011): 72-8. doi:10.1016/j.diabet.2010.06.008
González-González, José G et al. “HOMA-IR as a predictor of Health Outcomes in Patients with Metabolic Risk Factors: A Systematic Review and Meta-analysis.” High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension vol. 29,6 (2022): 547-564. doi:10.1007/s40292-022-00542-5
Gün, Emrah et al. “Serum 25-hydroxyvitamin D is associated with insulin resistance independently of obesity in children ages 5-17.” Primary care diabetes vol. 14,6 (2020): 741-746. doi:10.1016/j.pcd.2020.06.006
Çığrı, Emrah, and Funda Çatan İnan. “The Relationship between Anthropometric Measurements and Vitamin D Levels and Insulin Resistance in Obese Children and Adolescents.” Children (Basel, Switzerland) vol. 9,12 1837. 27 Nov. 2022, doi:10.3390/children9121837
Cai, Bin et al. “Effect of vitamin D supplementation on markers of cardiometabolic risk in children and adolescents: A meta-analysis of randomized clinical trials.” Nutrition, metabolism, and cardiovascular diseases : NMCD vol. 31,10 (2021): 2800-2814. doi:10.1016/j.numecd.2021.06.013
Rajakumar, Kumaravel et al. “Effect of vitamin D3 supplementation on vascular and metabolic health of vitamin D-deficient overweight and obese children: a randomized clinical trial.” The American journal of clinical nutrition vol. 111,4 (2020): 757-768. doi:10.1093/ajcn/nqz340
Alvarez, Jessica A, and Ambika Ashraf. “Role of vitamin d in insulin secretion and insulin sensitivity for glucose homeostasis.” International journal of endocrinology vol. 2010 (2010): 351385. doi:10.1155/2010/351385
Sergeev, Igor N. “1,25-Dihydroxyvitamin D3 and type 2 diabetes: Ca2+-dependent molecular mechanisms and the role of vitamin D status.” Hormone molecular biology and clinical investigation vol. 26,1 (2016): 61-5. doi:10.1515/hmbci-2015-0069
Clemente-Postigo, Mercedes et al. “Serum 25-hydroxyvitamin D and adipose tissue vitamin D receptor gene expression: relationship with obesity and type 2 diabetes.” The Journal of clinical endocrinology and metabolism vol. 100,4 (2015): E591-5. doi:10.1210/jc.2014-3016
Szymczak-Pajor, Izabela, and Agnieszka Śliwińska. “Analysis of Association between Vitamin D Deficiency and Insulin Resistance.” Nutrients vol. 11,4 794. 6 Apr. 2019, doi:10.3390/nu11040794
Liu, Jiaye et al. “Estimating Global Prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease in Overweight or Obese Children and Adolescents: Systematic Review and Meta-Analysis.” International journal of public health vol. 66 1604371. 6 Oct. 2021, doi:10.3389/ijph.2021.1604371
Quek, Jingxuan et al. “Global prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in the overweight and obese population: a systematic review and meta-analysis.” The lancet. Gastroenterology & hepatology vol. 8,1 (2023): 20-30. doi:10.1016/S2468-1253(22)00317-X
Castera, Laurent et al. “Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease.” Gastroenterology vol. 156,5 (2019): 1264-1281.e4. doi:10.1053/j.gastro.2018.12.036
Black, Lucinda J et al. “Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity.” Journal of gastroenterology and hepatology vol. 29,6 (2014): 1215-22. doi:10.1111/jgh.12541
Zhu, Shanshan et al. “The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis.” BioMed research international vol. 2019 7643542. 14 Jul. 2019, doi:10.1155/2019/7643542
Eliades, Myrto, and Elias Spyrou. “Vitamin D: a new player in non-alcoholic fatty liver disease?.” World journal of gastroenterology vol. 21,6 (2015): 1718-27. doi:10.3748/wjg.v21.i6.1718
Sakpal, Mallikarjun et al. “Vitamin D supplementation in patients with nonalcoholic fatty liver disease: A randomized controlled trial.” JGH open : an open access journal of gastroenterology and hepatology vol. 1,2 62-67. 12 Oct. 2017, doi:10.1002/jgh3.12010
Franssen, Remco et al. “Obesity and dyslipidemia.” The Medical clinics of North America vol. 95,5 (2011): 893-902. doi:10.1016/j.mcna.2011.06.003
Riaz, Haris et al. “Association Between Obesity and Cardiovascular Outcomes: A Systematic Review and Meta-analysis of Mendelian Randomization Studies.” JAMA network open vol. 1,7 e183788. 2 Nov. 2018, doi:10.1001/jamanetworkopen.2018.3788
Brøndum-Jacobsen, Peter et al. “25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies.” Arteriosclerosis, thrombosis, and vascular biology vol. 32,11 (2012): 2794-802. doi:10.1161/ATVBAHA.112.248039
Parker, Johanna et al. “Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis.” Maturitas vol. 65,3 (2010): 225-36. doi:10.1016/j.maturitas.2009.12.013
Barbalho, Sandra Maria et al. “Association between vitamin D status and metabolic syndrome risk factors.” Diabetes & metabolic syndrome vol. 12,4 (2018): 501-507. doi:10.1016/j.dsx.2018.03.011
Vaidya, Anand, and John P Forman. “Vitamin D and vascular disease: the current and future status of vitamin D therapy in hypertension and kidney disease.” Current hypertension reports vol. 14,2 (2012): 111-9. doi:10.1007/s11906-012-0248-9
Szymczak-Pajor, Izabela et al. “The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders.” International journal of molecular sciences vol. 21,18 6644. 11 Sep. 2020, doi:10.3390/ijms21186644
Kassi, Eva et al. “Role of vitamin D in atherosclerosis.” Circulation vol. 128,23 (2013): 2517-31. doi:10.1161/CIRCULATIONAHA.113.002654
Surdu, Andrei Mihai et al. “Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis.” Biomedicines vol. 9,2 172. 9 Feb. 2021, doi:10.3390/biomedicines9020172
Gou, Hao et al. “Efficacy of vitamin D supplementation on child and adolescent overweight/obesity: a systematic review and meta-analysis of randomized controlled trials.” European journal of pediatrics vol. 182,1 (2023): 255-264. doi:10.1007/s00431-022-04673-8
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