Frontal cortex functional activity modulation impact on the stereotypic, emotional and postural behavior in rats during the interictal period of pilocarpine-induced chronic epileptogenesis
DOI:
https://doi.org/10.12775/JEHS.2023.13.03.051Keywords
pilocarpine, convulsive syndrome, chronic epileptogenesis, interictal period, non-convulsive forms of behavior, frontal cortex, pathogenetic mechanismsAbstract
The cholinergic mechanisms role determination in epileptogenesis attracts the attention of researchers. Pilocarpine administration in rats contributes to chronic form of epileptiform activity development characterized by the presence of a pronounced acute stage and an interictal period - free from behavioral convulsive reactions. We consider the most important feature of the pilocarpine-induced seizures interictal period might be the change of various forms of nonconvulsive behavior. Attempts to investigate the animals’ behavioral reactions details during the seizure-free interictal period, as well as to determine the mechanisms of similar types of behavior formation, are interesting. The purpose of the work is to investigate the motor, stereotypic and aggressive-defensive behavior of rats throughout the interictal period of pilocarpine-induced convulsive syndrome with a frontal cortex functional activity change. It was found that the severity of non-convulsive behavioral reactions in the interictal period during pilocarpine-induced chronic seizures is mostly determined by the frontal cortex functional state. At the same time, the frontal cortex hyperactivation is an important feature of pilocarpine-induced chronic epileptogenesis. The authors proved that when the frontal cortex is activated in rats, there is an increase in horizontal and vertical motor activity, as well as the expressiveness of emotional reactions in the “open field” test and the strengthening of the aggressive-defensive behavior. In conditions of this part of the cortex selective destruction the opposite behavioral effects are noted which confirms the important role of the frontal cortex in the interictal non-convulsive behavior formation. Observed behavioral effects during the frontal cortex functional activity modulation, according to the authors, indicate the reasonability of regulatory influences searching aiming forward this brain part to activate complex mechanisms aimed to pilocarpine-induced chronic epileptiform activity elimination.
References
Alexandrova Zh.G., Suvorov N.B., Shalin Yu.N., Tsygan V.N. Individual features of behavior, learning and adaptation of rats to extreme influences // Fiziol. J. 1984; 70(9): 1294-1300 [In Russian].
Vastyanov R.S. Study of the pathophysiological mechanisms of chronic epileptic activity as a possible way to develop a pathogenetically justified complex therapy of the convulsive syndrome. Bulletin of the Ukrainian Medical Stomatological Academy: Current problems of modern medicine. 2008; 8; 4(24): 191-197 [In Ukrainian].
Kashchenko O.A., Oliynyk A.A., Vastyanov R.S. Ictal and interictal behavioral disorders in rats under the conditions of the pilocarpine-induced model of epilepsy. Herald of emergency and rehabilitation medicine. 2002; 3(3): 432-435 [In Ukrainian].
Kashchenko O.A., Volokhova G.O., Talalaev K.O. Pilocarpine-induced changes in bioelectrogenesis in the cortex and subcortical structures of the brain. Current issues of transport medicine. 2022; 4(70): 118-130 [In Ukrainian].
Kashchenko O.A., Volokhova G.O., Stoyanov O.M., Dzygal O.F., Zayats L.M. The influence of modulation of the activity of neurotransmitter systems of the striatum on the severity of behavior during swimming in rats with pilocarpine-induced chronic convulsive activity. Current issues of transport medicine. 2023; 1-2(71-72): 281-231 [In Ukrainian].
Kryzhanovsky G.N., Shandra A.A., Godlevsky L.S., Mazarati A.M. Antiepileptic system. Successes of fiziol. nayk. 1992; 23(3): 53-77 [In Russian].
Shandra O.A., Godlevskyi L.S., Vastyanov R.S. The duality of the functional parcel of the antiepileptic system in the mechanisms of epileptization of the cerebral cortex. Integrative Anthropology. 2003; 1: 53-59 [In Ukrainian].
Ahmed Juvale I.I., Che Has A.T. The evolution of the pilocarpine animal model of status epilepticus. Heliyon. 2020; 6(7):e04557. doi: 10.1016/j.heliyon.2020.e04557.
Engel A.G., Ohno K., Sine S.M. Sleuthing molecular targets for neurological diseases at the neuromuscular junction. Nat Rev Neurosci. 2003; 4(5): 339-352.
Moroz V.M., Shandra O.A., Vastyanov R.S., Yoltukhivsky M.V., Omelchenko O.D. Physiology. Vinnytsia : Nova Knyha, 2016: 722.
Photographic Atlas of the Rat Brain the Cell and Fiber Architecture Illustrated in Three Planes With Stereotaxic Coordinates: A Photographic Guide to the Cell and Fiber Architecture of the Rat Brain Illustrated in Three Planes With Stereotaxic Coordinates. - / L. Kruger, S. Saporta, W. Larry (Eds.). Cambridge University Press, 1995: 299.
Post R.M., Squillace K.M., Pert A., Sass W. The effect of amygdala kindling on spontaneous and cocaine-induced motor activity and lidocaine seizures. Psychopharmacology (Berl). 1981; 72(2): 189-196.
Power A.E. Muscarinic cholinergic contribution to memory consolidation: with attention to involvement of the basolateral amygdala. Curr Med Chem. 2004; 11(8): 987-996.
Shandra A.A., Godlevsky L.S., Vastyanov R.S. Epileptic and antiepileptic systems interrelation as the systemic indicator of the complexity of epileptic activity manifestation. Pan-Brain Abnormal Neural Network in Epilepsy. Ed. by Feng Ru Tang. Singapore : Research Signpost, 2009. 99-120.
Shishmanova-Doseva M., Georgieva K., Uzunova Y., Ioanidu L., Atanasova M., Nenchovska Z., Tchekalarova J. Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences. Int J Mol Sci. 2022; 23(21): 13188. doi: 10.3390/ijms232113188.
Turski W.A., Czuczwar S.J., Kleinrok Z., Turski L. Cholinomimetics produce seizures and brain damage in rats. Experientia. 1983; 39(12): 1408-1411.
Turski W.A., Cavalheiro E.A., Bortolotto Z.A., Mello L.M., Schwarz M., Turski L. Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis. Brain Res. 1984; 321(2): 237-253.
Turski L., Cavalheiro E.A., Czuczwar S.J., Turski W.A., Kleinrok Z. The seizures induced by pilocarpine: behavioral, electroencephalographic and neuropathological studies in rodents. Pol J Pharmacol Pharm. 1987; 39(5): 545-555.
Turski W.A. Pilocarpine-induced seizures in rodents--17 years on. Pol J Pharmacol. 2000; 52(1): 63-65.
Vrijmoed-de Vries M.C., Cools A.R. Differential effects of striatal injections of dopaminergic, cholinergic and GABAergic drugs upon swimming behavior of rats. Brain Res. 1986; 364(1): 77-90.
Wasterlain C.G., Jonec V. Chemical kindling by muscarinic amygdaloid stimulation in the rat. Brain Res. 1983; 271(2): 311-323.
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