Acne vulgaris and treatment with topical retinoids - adapalene and tretinoin
DOI:
https://doi.org/10.12775/JEHS.2023.23.01.011Keywords
acne, topical retinoid, skin, tretinoin, adapaleneAbstract
Introduction and purpose:
Acne vulgaris is a disease that mainly affects young people and is associated with overactive sebaceous glands. The disease mainly affects the face but can also occur on the back. Depending on the clinical picture, we can distinguish different types of acne and make our treatment dependent on it.
The aim of the study will be to compare the effects of topical retinoids on acne vulgaris.
State of knowledge:
Topical retinoids have a direct anti-inflammatory effect and prevent the formation of blackheads and microcomedones. Five retinoids are currently available for topical treatment of acne vulgaris. We distinguish three generations. The mechanism of action is not fully understood, but it is known that they react with the RAR and RXR receptors. In the review paper, we will compare the effects of adapalene with tretinoin.
Conclusion: According to the indicated study results, there is no significant difference in the effect of treatment with adapalene or tretinoin. Adapalene showed less irritation during treatment than tretinoin. The most important thing during acne treatment is choosing the right concentration and formulation by the dermatologist so that the patient does not stop treatment.
References
Zasada M, Budzisz E. Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments. Postepy Dermatol Alergol. 2019 Aug;36(4):392-397. doi: 10.5114/ada.2019.87443. Epub 2019 Aug 30. PMID: 31616211; PMCID: PMC6791161.
Jacek Szepietowski1, Monika Kapińska-Mrowiecka, Andrzej Kaszuba, Andrzej Langner, Waldemar Placek, Hanna Wolska, Łukasz Matusiak
Trądzik zwyczajny: patogeneza i leczenie. Konsensus Polskiego Towarzystwa Dermatologicznego
Pracownia Dermatologii, Ośrodek Alergii Zawodowej i Zdrowia Środowiskowego Instytutu Medycyny Pracy im. prof. J. Nofera w Łodzi, prof. dr hab. med. Marta Kieć-Świerczyńska, dr n. med. Beata Kręcisz, lek. Dorota Chomiczewska
Profilaktyka dermatoz zawodowych, red. Beata kręcisz
Leslie Baumann
Dermatologia Estetyczna, red. Kamila Padlewska
Vivat-Hannah V, Zusi FC. Retinoids as therapeutic agents: today and tomorrow. Mini Rev Med Chem. 2005 Aug;5(8):755-60. doi: 10.2174/1389557054553820. PMID: 16101411.
Varani J, Warner RL, Gharaee-Kermani M, Phan SH, Kang S, Chung JH, Wang ZQ, Datta SC, Fisher GJ, Voorhees JJ. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol. 2000 Mar;114(3):480-6. doi: 10.1046/j.1523-1747.2000.00902.x. PMID: 10692106.
Duester G. Retinoic acid synthesis and signaling during early organogenesis. Cell. 2008 Sep 19;134(6):921-31. doi: 10.1016/j.cell.2008.09.002. PMID: 18805086; PMCID: PMC2632951.
Zizola CF, Frey SK, Jitngarmkusol S, Kadereit B, Yan N, Vogel S. Cellular retinol-binding protein type I (CRBP-I) regulates adipogenesis. Mol Cell Biol. 2010 Jul;30(14):3412-20. doi: 10.1128/MCB.00014-10. Epub 2010 May 24. PMID: 20498279; PMCID: PMC2897568.
Shao Y, He T, Fisher GJ, Voorhees JJ, Quan T. Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo. Int J Cosmet Sci. 2017 Feb;39(1):56-65. doi: 10.1111/ics.12348. Epub 2016 Jul 4. PMID: 27261203; PMCID: PMC5136519.
Russell JJ. Topical therapy for acne. Am Fam Physician. 2000 Jan 15;61(2):357-66. PMID: 10670502.
Leyden J, Stein-Gold L, Weiss J. Why Topical Retinoids Are Mainstay of Therapy for Acne. Dermatol Ther (Heidelb). 2017 Sep;7(3):293-304. doi: 10.1007/s13555-017-0185-2. Epub 2017 Jun 5. PMID: 28585191; PMCID: PMC5574737.
Leyden JJ, Shalita A, Thiboutot D, Washenik K, Webster G. Topical retinoids in inflammatory acne: a retrospective, investigator-blinded, vehicle-controlled, photographic assessment. Clin Ther. 2005 Feb;27(2):216-24. doi: 10.1016/j.clinthera.2005.02.009. PMID: 15811485.
Akhavan, A., Bershad, S. Topical Acne Drugs. Am J Clin Dermatol 4, 473–492 (2003). https://doi.org/10.2165/00128071-200304070-00004
Wj Cunliffe, R Caputo, B Dreno, L Förström, M Heenen, Ce Orfanos, Y Privat, A Robledo Aguilar, M Poncet & M Verschoore (1997) Efficacy and safety comparison of adapalene (CD271) gel and tretinoin gel in the topical treatment of acne vulgaris. A European multicentre trial, Journal of Dermatological Treatment, 8:3, 173-178, DOI: 10.3109/09546639709160514
Tirado-Sánchez A, Espíndola YS, Ponce-Olivera RM, Bonifaz A. Efficacy and safety of adapalene gel 0.1% and 0.3% and tretinoin gel 0.05% for acne vulgaris: results of a single-center, randomized, double-blinded, placebo-controlled clinical trial on Mexican patients (skin type III-IV). J Cosmet Dermatol. 2013 Jun;12(2):103-7. doi: 10.1111/jocd.12031. PMID: 23725303.
Kolli SS, Pecone D, Pona A, Cline A, Feldman SR. Topical Retinoids in Acne Vulgaris: A Systematic Review. Am J Clin Dermatol. 2019 Jun;20(3):345-365. doi: 10.1007/s40257-019-00423-z. PMID: 30674002.
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Copyright (c) 2023 Maria Antos, Angelika Wawryszuk, Piotr Bator, Grzegorz Łyko, Krystian Rachwał, Adrian Bobrzyk, Weronika Makowska, Weronika Kamińska, Alicja Kosel, Maciej Rumian
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