Poisoning with cardiological drugs in patients hospitalized in the toxicological and cardiological department from 04/2013 to 12/2021
DOI:
https://doi.org/10.12775/JEHS.2023.14.01.010Keywords
cardiological drugs, poisoning, beta-blockers, intoxicationAbstract
Introduction and purpose: Cardiological drugs are widely used in the management of various cardiovascular diseases, such as hypertension, angina, heart failure, and arrhythmias. However, when these drugs are taken in excessive amounts or are not used as prescribed, they can become toxic and cause significant harm to the heart and other organs. Our study aims to illustrate the most frequent causes of poisoning with cardiological drugs in patients hospitalized in the toxicological and cardiological department from April 2013 to December 2021.
Brief description of the state of knowledge: Poisoning with cardiological drugs is a growing concern for healthcare professionals. In 2019, cardiovascular toxins were one of the top 10 categories of poisons evaluated by medical toxicologists. Data collected from the analyzed toxicology and cardiology department include a group of 387 hospitalized patients. The largest proportion were cases intoxicated by beta-adrenoreceptor antagonists. The second most common group was poisonings by angiotensin-converting-enzyme inhibitors. A slightly lower proportion implicated poisonings caused by other, unidentified substances affecting the cardiovascular system - calcium channel blockers and other antihypertensive drugs.
Conclusions: All of the data demonstrated in our study shows the importance of understanding the pharmacology, pathophysiology, and treatment strategies of poisonings caused by cardiological drugs which are one the most widely used medications worldwide.
References
https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
Correia MS, Whitehead E, Cantrell FL, Lasoff DR, Minns AB. A 10-year review of single medication double-dose ingestions in the nation's largest poison control system. Clin Toxicol (Phila). 2019;57(1):31-35. doi:10.1080/15563650.2018.1493205
Spyres MB, Farrugia LA, Kang AM, et al. The Toxicology Investigators Consortium
Case Registry-the 2019 Annual Report [published correction appears in J Med Toxicol. 2022 Jan;18(1):74]. J Med Toxicol. 2020;16(4):361-387. doi:10.1007/s13181-020-00810-7
A. Tykarski et al., “Polskie Towarzystwo Nadciśnienia Tętniczego Zasady postępowania w nadciśnieniu tętniczym-2019 rok Wytyczne Polskiego Towarzystwa Nadciśnienia Tętniczego,” Accessed: Mar. 21, 2023. [Online]. Available: www.ntwp.viamedica.pl.
V. Barrese and M. Taglialatela, “New advances in beta-blocker therapy in heart failure,” Front. Physiol., vol. 4, 2013, doi: 10.3389/FPHYS.2013.00323.
“Nadciśnienie tętnicze.” https://shiny.nfz.gov.pl/nadcisnienie_tetnicze/ (accessed Mar. 20, 2023).
“Niewydolność serca w Polsce Realia, koszty, sugestie poprawy sytuacji P O R O Z U M I E N I E O R G A N I Z A C J I K A R D I O L O G I C Z N Y C H,” Accessed: Mar. 20, 2023. [Online]. Available: https://marfan.org.pl/wp-content/uploads/2021/01/Niewydolność-RAPORT-A4-2021-NET.pdf.
M. Lauterbach, “Clinical toxicology of beta-blocker overdose in adults,” Basic Clin. Pharmacol. Toxicol., vol. 125, no. 2, pp. 178–186, Aug. 2019, doi: 10.1111/BCPT.13231.
A. Hassanein Omar, S. Fouad Abdel-aal, and H. El Sayed Salem, “A Triage for Disposition of Poisoned Patients with Cardiovascular Therapeutic Agents Presented to Poison Control Center of Ain Shams University Hospitals,” Ain Shams J. Forensic Med. Clin. Toxicol., vol. 38, no. 1, pp. 57–67, Jan. 2022, doi: 10.21608/AJFM.2022.212381.
M. Zeinvand, T. Hoseini, and A. Rahmani, “A Clinico-Epidemiological Study on Poisonings due to Cardiovascular Drugs in Ahvaz, Iran,” Asia Pacific J. Med. Toxicol., vol. 6, no. 1, pp. 25–28, Mar. 2017, doi: 10.22038/APJMT.2017.8473.
O. SAHİN, G. GÖKALP, N. HOCAOGLU, E. YILDIZTEPE, and Ş. KALKAN, “Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017,” J. Basic Clin. Heal. Sci., vol. 5, no. 2, pp. 156–161, May 2021, doi: 10.30621/JBACHS.855719.
R. Stoyanova and J. Radenkova-Saeva, “Acute poisoning with antihypertensive and antiarrhythmic medicines - Clinico-epidemiological study,” Med. News North Caucasus, vol. 12, no. 3, pp. 247–249, 2017, doi: 10.14300/MNNC.2017.12070.
N. Hetterich, E. Lauterbach, A. Stürer, L. S. Weilemann, and M. Lauterbach, “Toxicity of Antihypertensives in Unintentional Poisoning of Young Children,” J. Emerg. Med., vol. 47, no. 2, pp. 155–162, Aug. 2014, doi: 10.1016/J.JEMERMED.2014.02.006.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Marcin Wais, Krzysztof Antoniak, Dariusz Gruca, Marlena Zając, Michał Tchórz
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 228
Number of citations: 0