Tensioregulome as an accompaniment of quantitative-qualitative blood pressure clusters
DOI:
https://doi.org/10.12775/JEHS.2022.12.06.042Keywords
blood pressure, EEG, HRV, immunity, metabolome, pyelonephritisAbstract
Background. Earlier we studied the neural, endocrine, immune, microbiome and metabolome accompaniments of quantitative-qualitative blood pressure (BP) clusters of profile patients of Truskavets’ spa. The obtained results give us grounds to put forward the concept of tensioregulome by analogy with the metabolome and the microbiome. The purpose of this study is detailing this concept. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP. We determined parameters of EEG and HRV, plasma levels of adaptation hormones, electrolytes, lipids, and nitrogenous metabolites, components of humoral, cellular, and phagocytic links of immunity and markers of pyelonephritis. Results. The forward stepwise program identified 26 tensioregulome parameters as characteristic of quantitative-qualitative blood pressure clusters: 10 EEG, 6 metabolic, 6 immune, testosterone, cotrisol, sympathetic tone as well as sex. The accuracy of patient classification is 98,9%. Another 25 parameters were found to be characteristic, but were outside the discriminant model, including 11 EEG, 2 HRV, 5 metabolic, 4 immune, bacteriuria, body mass index, and age. Both linear and non-linear correlations between the BP and tensioregulome parameters were revealed. Conclusion. The quantitative-qualitative blood pressure clusters have a characteristic accompaniment named tensioregulome.
References
Acharya D, Li XRL, Heineman RE, Harrison RE. Complement Receptor-Mediated Phagocytosis Induces Proinflammatory Cytokine Production in Murine Macrophages. Front Immunol. 2020; 10: 3049.
Agita A, Alsagaff MT. Inflammation, Immunity, and Hypertension. Acta Med Indones. 2017; 49(2): 158-165.
Celis H, Den Hond E, Staessen JA. Self-measurement of blood pressure at home in the management of hypertension. Clin Med Res. 2005; 3(1): 19-26.
Chebanenko OI, Flyunt IS, Popovych IL, Balanovs’kyi VP, Lakhin PV. Water Naftussya and water-salt exchange [in Ukrainian]. Kyїv. Naukova dumka; 1997: 141.
Gozhenko АІ, Korda MM, Popadynets’ OO, Popovych IL. Entropy, Harmony, Synchronization and their Neuro-endocrine-immune Correlates. Odesa. Feniks; 2021: 232. [in Ukrainian].
Hirooka Y. Sympathetic Activation in Hypertension: Importance of the Central Nervous System. Am J Hypertens. 2020; 21; 33(10): 914-926.
Khaitov RM, Pinegin BV, Istamov KhI. Ecological Immunology [in Russian]. Мoskva. VNIRO; 1995: 219.
Klecka WR. Discriminant Analysis [trans. from English in Russian] (Seventh Printing, 1986). In: Factor, Discriminant and Cluster Analysis. Moskva. Finansy i Statistika; 1989: 78-138.
Kozyavkina NV, Popovych IL, Popovych DV, Zukow W, Bombushkar IS. Sexual dimorphism in some psycho-neuro-endocrine parameters at human. Journal of Education, Health and Sport. 2021; 11(5): 370-391.
Kozyavkina NV, Voronych-Semchenko NM, Vovchyna YV, Zukow W, Popovych IL. Quantitative and qualitative blood pressure clusters in patients of Truskavets’ spa and their hemodynamic accompaniment. Journal of Education, Health and Sport. 2020; 10(6): 445-454.
Kozyavkina NV, Voronych-Semchenko NM, Vovchyna YV, Zukow W, Popovych IL. Autonomic and endocrine accompaniments of quantitative-qualitative blood pressure clusters in patients of Truskavets’ spa. Journal of Education, Health and Sport. 2020; 10(7): 465-477.
Kozyavkina NV, Voronych-Semchenko NM, Vovchyna YV, Zukow W, Popovych IL. Electroencephalographic accompaniment of quantitative-qualitative blood pressure clusters in patients of Truskavets’ spa. Journal of Education, Health and Sport. 2021; 11(10): 435-444.
Kozyavkina NV, Voronych-Semchenko NM, Vovchyna YV, Zukow W, Popovych IL. Metabolic accompaniment of quantitative-qualitative blood pressure clusters in patients of Truskavets’ spa. Journal of Education, Health and Sport. 2022; 12(2): 377-386.
Kozyavkina NV, Vovchyna YV, Voronych-Semchenko NM, Zukow W, Popovych DV, Popovych IL. Immune accompaniment of quantitative-qualitative blood pressure clusters in patients of Truskavets’ spa. Journal of Education, Health and Sport. 2022; 12(3): 320-329.
Kul’chyns’kyi AB, Gozhenko AI, Zukow W, Popovych IL. Neuro-immune relationships at patients with chronic pyelonephritis and cholecystitis. Communication 3. Correlations between parameters EEG, HRV and Immunogram. Journal of Education, Health and Sport. 2017; 7(3): 53-71.
Kul’chyns’kyi AB, Kovbasnyuk MM, Korolyshyn TA, Kyjenko VM, Zukow W, Popovych IL. Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 2. Correlations between parameters EEG, HRV and Phagocytosis. Journal of Education, Health and Sport. 2016; 6(10): 377-401.
Lapovets’ LY, Lutsyk BD. Handbook of Laboratory Immunology [in Ukrainian]. Lviv; 2002: 173.
Lin HJ, Wang TD, Yu-Chih Chen M, et al. 2020 Consensus Statement of the Taiwan Hypertension Society and the Taiwan Society of Cardiology on Home Blood Pressure Monitoring for the Management of Arterial Hypertension. Acta Cardiol Sin. 2020; 36(6): 537-561.
McMaster WG, Kirabo A, Madhur MS, Harrison DG. Inflammation, immunity, and hypertensive end-organ damage. Circ Res. 2015; 116(6): 1022-1033.
Mikolajczyk TP, Guzik TJ. Adaptive Immunity in Hypertension. Curr Hypertens Rep. 2019; 21(9): 68.
Parati G, Stergiou GS, Asmar R, Bilo G, de Leeuw P, Imai Y; Kario K. et al on behalf of the ESH Working Group on Blood Pressure Monitoring. European Society of Hypertension guidelines for blood pressure monitoring at home: a summary report of the Second International Consensus Conference on Home Blood Pressure Monitoring. J Hypertension. 2008; 26(8): 1505-1526.
Popovych IL, Gozhenko AI, Korda MM, Klishch IM, Popovych DV, Zukow W (editors). Mineral Waters, Metabolism, Neuro-Endocrine-Immune Complex. Odesa. Feniks; 2022: 252.
Popovych IL, Kul’chyns’kyi AB, Gozhenko AI, Zukow W, Kovbasnyuk MM, Korolyshyn TA. Interrelations between changes in parameters of HRV, EEG and phagocytosis at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2018; 8(2): 135-156.
Rai A, Narisawa M, Li P, Piao L, Li Y, Yang G, Cheng XW. Adaptive immune disorders in hypertension and heart failure: focusing on T-cell subset activation and clinical implications. J Hypertension. 2020; 38(10): 1878-1889.
Rodriguez-Iturbe B, Pons H, Johnson RJ. Role of the Immune System in Hypertension. Physiol Rev. 2017; 97(3): 1127-1164.
Stolk RF, van der Poll T, Angus DC, van der Hoeven JG, Pickkers P, Kox M. Potentially inadvertent immunomodulation: norepinephrine use in sepsis. Am J Respir Crit Care Med. 2016; 194: 550–558.
Zhang RM, McNerney KP, Riek AE, Bernal-Mizrachi C. Immunity and Hypertension. Acta Physiol (Oxf). 2021; 231(1): e13487.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Igor Popovych, Nataliya Kozyavkina, Yuliya Vovchyna, Nataliya Voronych-Semchenko; Walery Zukow; Dariya Popovych
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 191
Number of citations: 0