Influence of selected food in the profilactice and treatment of osteoporosis
DOI:
https://doi.org/10.12775/JEHS.2023.41.01.001Keywords
osteoporosis, diet, calcium, phosphorus, vitamin D, vitamin K, magnesium, isoflavonesAbstract
Introduction:
The proper diet plays an extremely important role in the development of the skeletal
system from an early age This is one of the few modifiable factors that we can influence by
choosing the right food. In the case of osteoporosis, nutrition is not only important during
the period of growth, but also for the rest of life, which allows to reduce pathological
changes in bones and counteract the effects of reduced bone mineral density such as
fractures or death.
Purpose of the work:
The aim of the study was to answer the question of which nutrients have a significant
impact on bone tissue metabolism and minimize the risk of osteoporosis and its
consequences, as well as what substances contained in food may be used in the future by
medicine for preventive purposes.
Summary:
Without a doubt, the provision of adequate recommended doses of nutrients with food is crucial for the prevention and treatment of osteoporosis and its consequences, but it should
be remembered that the recommended doses are averaged. As studies show, the absorption
of the described substances can vary depending on the food contained in the diet, as well as
the age of a person, so the recommended doses of patients should be obtained individually,
taking into account dietary preferences and laboratory results. In addition, compounds such as isoflavones, while promising in the prevention of this condition, should not be routinely used as a replacement for estrogen hormone therapy, due to the still small amount of research and their ambiguous results. It is worth remembering that often the diet turns out to be an insufficient preventive measure and should be combined with pharmacotherapy.
Materials and methods:
Literature review in the database PubMed, Google Scholar, Springer Link, MDPI,
using the keywords: Osteoporosis, diet, calcium, phosphorus, vitamin D, Vitamin K,
magnesium, isoflavone.
References
Słupski W, Jawień P, Nowak B. Botanicals in Postmenopausal Osteoporosis. Nutrients.
; 13(5):1609. https://doi.org/10.3390/nu13051609
Tella, S. H., & Gallagher, J. C. (2014). Prevention and treatment of postmenopausal
osteoporosis. The Journal of steroid biochemistry and molecular biology, 142, 155–170.
https://doi.org/10.1016/j.jsbmb.2013.09.008
Kanis, J. A., Norton, N., Harvey, N. C., Jacobson, T., Johansson, H., Lorentzon, M.,
McCloskey, E. V., Willers, C., & Borgström, F. (2021). SCOPE 2021: a new scorecard for osteoporosis in Europe. Archives of osteoporosis, 16(1), 82. https://doi.org/10.1007/s11657-020-00871-9
Shkembi, B., & Huppertz, T. (2021). Calcium Absorption from Food Products: Food
Matrix Effects. Nutrients, 14(1), 180. https://doi.org/10.3390/nu14010180
Vannucci, L., Fossi, C., Quattrini, S., Guasti, L., Pampaloni, B., Gronchi, G., Giusti, F.,
Romagnoli, C., Cianferotti, L., Marcucci, G., & Brandi, M. L. (2018). Calcium Intake in
Bone Health: A Focus on Calcium-Rich Mineral Waters. Nutrients, 10(12), 1930.
https://doi.org/10.3390/nu10121930
Szeleszczuk, Ł., & Kuras, M. (2014). Znaczenie wapnia w metabolizmie człowieka i
czynniki wpływające na jego biodostępność w diecie. Prospects in Pharmaceutical
Sciences, 12(3), 16-22.
Kumssa, D. B., Joy, E. J., Ander, E. L., Watts, M. J., Young, S. D., Walker, S., &
Broadley, M. R. (2015). Dietary calcium and zinc deficiency risks are decreasing but
remain prevalent. Scientific reports, 5, 10974. https://doi.org/10.1038/srep10974
Shkembi, B., & Huppertz, T. (2021). Calcium Absorption from Food Products: Food
Matrix Effects. Nutrients, 14(1), 180. https://doi.org/10.3390/nu1401018010
Dolińska, B., Mikulska, A., & Ryszka, F. (2009). Promotory wchłaniania wapnia.
In Annales Academiae Medicae Silesiensis (Vol. 63, No. 1, pp. 76-83). Śląski Uniwersytet
Medyczny w Katowicach.
Trailokya, A., Srivastava, A., Bhole, M., & Zalte, N. (2017). Calcium and Calcium
Salts. The Journal of the Association of Physicians of India, 65(2), 100–103.
Kunachowicz, H., Iwanow, K., Ratkovska, B., Przygoda, B., & Nadolna, I. (2005).
Nowelizacja tabel składu i wartości odżywczej żywności. Zmiany w ciągu ostatnich
lat. Żywienie Człowieka i Metabolizm. Suplement, 32(1 cz. 1).
Bronner, F., & Pansu, D. (1999). Nutritional aspects of calcium absorption. The
Journal of nutrition, 129(1), 9–12. https://doi.org/10.1093/jn/129.1.9
Armas, L. A., Hollis, B. W., & Heaney, R. P. (2004). Vitamin D2 is much less effective than vitamin D3 in humans. The Journal of Clinical Endocrinology &
Metabolism, 89(11), 5387-5391.
Jarosz, M. (Ed.). (2008). Normy żywienia człowieka: podstawy prewencji otyłości i
chorób niezakaźnych. Wydawnictwo Lekarskie PZWL.
Zhang, R., & Naughton, D. P. (2010). Vitamin D in health and disease: current
perspectives. Nutrition journal, 9, 65. https://doi.org/10.1186/1475-2891-9-65
BOLANOWSKI, J., & BOLANOWSKI, M. (2005). Znaczenie wapnia i witaminy D w profilaktyce i leczeniu osteoporozy. Advances in Clinical and Experimental
Medicine, 14(5), 1057-1062.
Holick, M. F., Siris, E. S., Binkley, N., Beard, M. K., Khan, A., Katzer, J. T.,
Petruschke, R. A., Chen, E., & de Papp, A. E. (2005). Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. The Journal of clinical endocrinology and metabolism, 90(6), 3215–3224.
https://doi.org/10.1210/jc.2004-2364.
Lips, P., Duong, T., Oleksik, A., Black, D., Cummings, S., Cox, D., & Nickelsen, T.
(2001). A global study of vitamin D status and parathyroid function in postmenopausal
women with osteoporosis: baseline data from the multiple outcomes of raloxifene
evaluation clinical trial. The Journal of clinical endocrinology and metabolism, 86(3),
–1221. https://doi.org/10.1210/jcem.86.3.7327
Napiórkowska, L., Budlewski, T., Jakubas-Kwiatkowska, W., Hamzy, V., Gozdowski,
D., & Franek, E. (2009). Prevalence of low serum vitamin D concentration in an urban
population of elderly women in Poland. Pol Arch Med Wewn, 119(11), 699-703.
MacLaughlin, J., & Holick, M. F. (1985). Aging decreases the capacity of human skin to produce vitamin D3. The Journal of clinical investigation, 76(4), 1536-1538.
Bujko, J., & Bawa, S. (2006). Dietoterapia i dietoprofilaktyka osteoporozy. W: Bujko
J.(red.).: Podstawy dietetyki. Wydawnictwo SGGW, Warszawa.
Pastore, S. M., Gomes, P. C., Rostagno, H. S., Albino, L. F. T., Calderano, A. A.,
Vellasco, C. R., ... & Almeida, R. L. D. (2012). Calcium levels and calcium: available
phosphorus ratios in diets for white egg layers from 42 to 58 weeks of age. Revista
Brasileira de Zootecnia, 41, 2424-2432.
Brzozowska A.: Składniki mineralne. W: Gawęcki J., Hryniewiecki L. (red.). Żywienie
Człowieka. Podstawy nauki o żywieniu. Wydawnictwo Naukowe PWN, Warszawa 1998:
–240.
Swaminathan R. (2003). Magnesium metabolism and its disorders. The Clinical
biochemist. Reviews, 24(2), 47–66..
Herroeder, S., Schönherr, M. E., De Hert, S. G., & Hollmann, M. W. (2011).
Magnesium--essentials for anesthesiologists. Anesthesiology, 114(4), 971–993.
https://doi.org/10.1097/ALN.0b013e318210483d
Rude, R. K., & Gruber, H. E. (2004). Magnesium deficiency and osteoporosis: animal and human observations. The Journal of nutritional biochemistry, 15(12), 710–716.
https://doi.org/10.1016/j.jnutbio.2004.08.001
Medalle, R., Waterhouse, C., & Hahn, T. J. (1976). Vitamin D resistance in magnesium deficiency. The American journal of clinical nutrition, 29(8), 854–858.
https://doi.org/10.1093/ajcn/29.8.854.
Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary
Reference Intakes. (1997). Dietary Reference Intakes for Calcium, Phosphorus,
Magnesium, Vitamin D, and Fluoride. National Academies Press (US).
Fusaro, M., Mereu, M. C., Aghi, A., Iervasi, G., & Gallieni, M. (2017). Vitamin K and bone. Clinical Cases in Mineral and Bone Metabolism, 14(2), 200.
Simes, D. C., Viegas, C. S. B., Araújo, N., & Marreiros, C. (2020). Vitamin K as a diet supplement with impact in human health: current evidence in age-related diseases.
Nutrients.
Hamidi, M. S., Gajic-Veljanoski, O., & Cheung, A. M. (2013). Vitamin K and bone
health. Journal of clinical densitometry : the official journal of the International Society
for Clinical Densitometry, 16(4), 409–413. https://doi.org/10.1016/j.jocd.2013.08.017
. Kovac̆ić, N., Lukic, I. K., Grcevic, D., Katavic, V., Croucher, P., & Marusic, A. (2007). The Fas/Fas ligand system inhibits differentiation of murine osteoblasts but has a limited role in osteoblast and osteoclast apoptosis. The Journal of Immunology, 178(6), 3379-
Nakamura, T., Imai, Y., Matsumoto, T., Sato, S., Takeuchi, K., Igarashi, K., ... & Kato, S. (2007). Estrogen prevents bone loss via estrogen receptor α and induction of Fas ligand in osteoclasts. Cell, 130(5), 811-823.
Burgess, T. L., Qian, Y. X., Kaufman, S., Ring, B. D., Van, G., Capparelli, C., ... &
Lacey, D. L. (1999). The ligand for osteoprotegerin (OPGL) directly activates mature
osteoclasts. The Journal of cell biology, 145(3), 527-538.
Candelaria, N. R., Liu, K., & Lin, C. Y. (2013). Estrogen receptor alpha: Molecular
mechanisms and emerging insights. Journal of Cellular Biochemistry, 114(10), 2203-2208.
Khalid, A. B., & Krum, S. A. (2016). Estrogen receptors alpha and beta in
bone. Bone, 87, 130-135.
Williams, C., Edvardsson, K., Lewandowski, S. A., Ström, A., & Gustafsson, J. Å.
(2008). A genome-wide study of the repressive effects of estrogen receptor beta on
estrogen receptor alpha signaling in breast cancer cells. Oncogene, 27(7), 1019-1032.
Nelson, A. W., Tilley, W. D., Neal, D. E., & Carroll, J. S. (2014). Estrogen receptor
beta in prostate cancer: friend or foe?. Endocrine-related cancer, 21(4), T219-T234.
Greenwood, S., Barnes, S., Clarkson, T. B., Eden, J., Helferich, W. G., Hughes, C., ...
& Setchell, K. D. R. (2000). The role of isoflavones in menopausal health: consensus
opinion of the North American Menopause Society. Menopause, 7(4), 215-229.
Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., ... &
Gustafsson, J. A. (2007). Estrogen receptors: how do they signal and what are their
targets. Physiological reviews, 87(3), 905-931.
Lambert, M. N. T., Hu, L. M., & Jeppesen, P. B. (2017). A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri-and postmenopausal women. The American journal of clinical nutrition, 106(3), 801-811.
Levis, S., Strickman-Stein, N., Ganjei-Azar, P., Xu, P., Doerge, D. R., & Krischer, J.
(2011). Soy isoflavones in the prevention of menopausal bone loss and menopausal
symptoms: a randomized, double-blind trial. Archives of internal medicine, 171(15), 1363-
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Rafał Gorzyński, Justyna Kurek, Anna Gadomska, Justyna Molczyk-Sieńczak, Michał Garstka, Hanna Dominik, Zuzanna Czudy, Wojciech Pawęska, Marika Polatowska, Jan Radwański
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 398
Number of citations: 0