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Journal of Education, Health and Sport

Some aspects of the toxic effects of cadmium on organism of experimental animals
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Some aspects of the toxic effects of cadmium on organism of experimental animals

Authors

  • N. S. Khopta Ivano-Frankivsk National Medical University
  • I. S. Bazalytska Ivano-Frankivsk National Medical University
  • A. M. Ersteniuk Ivano-Frankivsk National Medical University

Keywords

cadmium chloride, bone tissue, bone metabolism markers, osteotropic bioelements, bone tissue mineral density.

Abstract

The work investigates peculiarities of metabolic processes, bioelemental composition and structural changes in white rats’ bone tissue in the presence of cadmium ions (1/10 LD50 CdCl2) damage both singly and in combination. Administration of cadmium ions in male rats has been found to cause the development of dysmicroelementosis accompanied by the disturbance of metabolic processes in bone tissue. It has been observed the disturbance of phosphorous-calcium metabolism in terms of level of different forms of calcium, phosphates, acid and alkaline phosphatase in the dynamics of intoxication development. It has been investigated the content of osteotropic elements and bone tissue mineral density, collagen matrix damage degree by hydroxyproline level and histological examinations. Changes in parathormone and calcitonin levels have been detected. This comprehensive study showed that the most severe disturbances occur on the 14th day after ten-day period of animals’ intoxication with CdCl2. 

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Published

2017-03-29

How to Cite

1.
KHOPTA, N. S., BAZALYTSKA, I. S. & ERSTENIUK, A. M. Some aspects of the toxic effects of cadmium on organism of experimental animals. Journal of Education, Health and Sport [online]. 29 March 2017, T. 7, nr 3, s. 559–569. [accessed 22.3.2023].
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Issue

Vol. 7 No. 3 (2017)

Section

Research Articles

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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