Mathematical modeling of the dependence of the risk of vitamin D deficiency on anthropometric and laboratory parameters
DOI:
https://doi.org/10.12775/JEHS.2023.13.04.042Keywords
mathematical modeling, vitamin D, anthropometry, blood lipids, preventionAbstract
Recently, data on the use of mathematical models to determine the status of vitamin D in clinical practice in patients with various diseases appear in the literature, but there is no data on the creation of a mathematical model that allows screening in the general population. The creation of a mathematical model, with the help of which it is possible to identify groups at risk of vitamin D deficiency, will contribute to the reduction of laboratory research costs and allow screening of vitamin D status on a more massive and reasonable basis.
Goal. Study of the relationship between the risk of vitamin D deficiency and anthropometric and laboratory parameters using mathematical modeling methods.
Materials and methods. 928 residents of the southern region of Ukraine between the ages of 19 and 82 (average age - 47.2 years) were surveyed. Based on the correlation analysis of the studied data, the most influential data were selected as the following indicators: age, body mass index, atherogenicity coefficient, high-density lipoproteins, and the ratio of waist volume to hip volume.
Conclusions. The study emphasizes the importance of anthropometric and laboratory parameters in predicting the risk of vitamin D deficiency. The use of mathematical modeling methods makes it possible to identify the most important risk factors and quantify their contribution. The results of the study may have important implications for public health by helping to identify high-risk groups in a timely manner.
References
Abboud M, Liu X, Fayet-Moore F, et al. Effects of Vitamin D Status and Supplements on Anthropometric and Biochemical Indices in a Clinical Setting: A Retrospective Study. Nutrients. 2019;11(12):3032. Published 2019 Dec 12. doi: https://doi.org/10.3390/nu11123032
Bouillon R., Marcocci C., Carmeliet G., Bikle D., White J., Dawson-Hughes B., Lips P. Skeletal and extra-skeletal actions of vitamin D: Current evidence and outstanding questions. Endocr. Rev. 2019;40 doi: https://doi.org/10.1210/er.2018-00126
Shanyhin A.V. Znachennia ratsionu kharchuvannia ta rivnia insoliatsii v zabezpechenosti vitaminom D. Suchasni aspekty profilaktyky. Health of Society. 2022;11(1):16–22. https://doi.org/10.22141/2306-2436.11.1.2022.288 (in Ukrainian)
Prutiyan T.L., Dobrovolʹsʹka O.O. Otsinka yakosti zhyttya v zhinok u postmenopauzi z arterialʹnoyu hipertenziyeyu, ozhyrinnyam ta osteoporozom. Suchasni aspekty modernizatsiyi nauky: stan problemy, tendentsiyi rozvytku: Materialy XXIII Mizhnarodnoyi nauk.-prakt. konf.(m. Dikirkh (Lyuksemburh) 7 serp. 2022 r.). Dikirkh, 2022. S.105-110 https://repo.odmu.edu.ua:443/xmlui/handle/123456789/11608 (in Ukrainian)
Arredondo A., Azar A., Recamán A.L. Diabetes, a global public health challenge with a high epidemiological and economic burden on health systems in Latin America. Glob. Public Health. 2018;13:780–787. doi: https://doi.org/10.1080/17441692.2017.1316414
Panʹkiv V.I., Povoroznyuk V.V., Panʹkiv I.V., Boyko V.I., Hluhovsʹka S.V. Stan zabezpechennya vitaminom D naselennya Zakhidnoho rehionu Ukrayiny. International Journal of Endocrinology. 2019;15(3):268-271 doi: https://doi.org/10.22141/2224-0721.15.3.2019.172115 (in Ukrainian)
Cimmino G, Morello A, Conte S, et al. Vitamin D inhibits Tissue Factor and CAMs expression in oxidized low-density lipoproteins-treated human endothelial cells by modulating NF-κB pathway. Eur J Pharmacol. 2020;885:173422. doi: https://doi.org/10.1016/j.ejphar.2020.173422
Park C.Y., Han S.N. The Role of Vitamin D in Adipose Tissue Biology: Adipocyte Differentiation, Energy Metabolism, and Inflammation. J Lipid Atheroscler. 2021;10(2):130-144. doi: https://doi.org/10.12997/jla.2021.10.2.130
Setayesh L, Amini A, Bagheri R, Moradi N, Yarizadeh H, Asbaghi O, Casazza K, Yekaninejad MS, Wong A, Suzuki K, Mirzaei K. Elevated Plasma Concentrations of Vitamin D-Binding Protein Are Associated with Lower High-Density Lipoprotein and Higher Fat Mass Index in Overweight and Obese Women. Nutrients. 2021; 13(9):3223. doi: https://doi.org/10.3390/nu13093223
Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017;18(2):153-165 doi: https://doi.org/10.1007/s11154-017-9424-1
Sizar, O.; Khare, S.; Goyal, A.; Bansal, P.; Givler, A. Vitamin D Deficiency; Updated 21 July 2021; StatPearls Publishing: Treasure Island, FL, USA, 2021. Available online: https://www.ncbi.nlm.nih.gov/books/NBK532266/ (accessed on 19 February 2023).
Khmilʹ S.V., Franchuk U.YA., Malanchuk L.M., Franchuk M.V. Matematychna modelʹ prohnozuvannya vynyknennya preeklampsiyi serednʹoho stupenya u zhinok hrupy vysokoho ryzyku rozvytku piznʹoho hestozu na tli metabolichnoho syndromu. Zdobutky klinichnoyi i eksperymentalʹnoyi medytsyny. 2021;3:157-161 doi: https://doi.org/10.11603/1811-2471.2021.v.i3.12530 (in Ukrainian)
Holick, M.F., Binkley, N.C., Bischoff-Ferrari, H.A., Gordon, C.M., Hanley, D.A, Heaney, R.P., Murad, M.H., & Weaver, C.M. (2011). Evaluation, treatment, and prevention of vitamin D deficiency. An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab., 96 (7), 1911-1930.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Anton Shanyhin, Volodymyr Babienko, Yevhen Strakhov, Arina Korkhova
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 212
Number of citations: 0
