Celiac disease in children - diagnosis in light of the current 2020 ESPGHAN guidelines
Keywordsceliac, Coeliac, ESPHGAN, coeliac disease
Celiac disease is a chronic immune disorder of the small intestine that is triggered by the consumption of gluten in genetically predisposed individuals. The disease is difficult to diagnose and treat, and its incidence is increasing. It can have different symptoms and clinical manifestations in individuals. Diagnosis is usually based on the presence of specific antibodies and histopathological examination of biopsy specimens from the small intestine. The only effective treatment is a gluten-free diet for life. Diagnosis of celiac disease in children is mainly based on the presence of specific an- tibodies in the blood, such as antibodies to tissue transglutaminase (tTG), antibodies to endomysium (EMA) or deamidated gliadin peptides (DGP). In addition, genetic testing is also used in diagnosis to detect the presence of HLA DQ2 or DQ8 genes, which are often present in people with celiac disease. The final diagnosis of celiac disease is based on a combination of the results of these tests and the presence of characteristic lesions in the small intestine, which are detected during endoscopy and small bowel biopsy.
Caio G, Volta U, Sapone A, Leffler DA, De Giorgio R, Catassi C, Fasano A. Celiac disease: a comprehensive current review. BMC Med. 2019 Jul 23;17(1):142.
Lebwohl B, Rubio-Tapia A. Epidemiology, Presentation, and Diagnosis of Celiac Disease. Gastroenterology. 2021 Jan;160(1):63-75.
Shan L, Molberg Ø, Parrot I, et al. Structural basis for gluten intolerance in celiac sprue. Science. 2002.
Bierla J. B., Trojanowska I, Konopka E, Czarnowska E, Sowinska A, Cukrowska B.. Diagnosis of celiac disease and screening in risk groups. Diagn Lab 2016; 52(3): 205-210.
Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C. The Oslo definitions for coeliac disease and related terms. Gut. 2013 Jan;62(1):43-52.
Jimenez J, Loveridge-Lenza B, Horvath K. Celiac Disease in Children. Pediatr Clin North Am. 2021 Dec;68(6):1205-1219.
Stazi, A.V.; Trecca, A.; Trinti, B. Osteoporosis in celiac disease and in endocrine and reproductive disorders. World J. Gastroenterol. 2008, 14, 498-505.
Ndez-Bañares, H.M.; Monzón, H.; Forné, M. A short review of malabsorption and anemia. World J. Gastroenterol. 2009, 15, 4644-4652.
Rondanelli, M.; Faliva, M.A.; Gasparri, C.; Peroni, G.; Naso, M.; Picciotto, G.; Riva, A.; Nichetti, M.; Infantino, V.; Alalwan, T.; et al. Micronutrient Dietary Supplementation Advices for Celiac Patients on Long-Term Gluten-Free Diet with Good Compliance: A Review. Medicina 2019, 55, 337.
Kreutz, J.M.; Adriaanse, M.P.M.; Van Der Ploeg, E.M.C.; Vreugdenhil, A.C.E. Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease. Nutrients 2020, 12, 500.
Green, P.H.; Fleischauer, A.T.; Bhagat, G.; Goyal, R.; Jabri, B.; Neugut, A.I. Risk of malignancy in patients with celiac disease. Am. J. Med. 2003, 115, 191-195.
Wahab, P.J.; Meijer, J.W.; Mulder, C.J. Histologic Follow-up of People With Celiac Disease on a Gluten-Free Diet. Am. J. Clin. Pathol. 2002, 118, 459-463.
Tursi, A.; Brandimarte, G.; Giorgetti, G.; Elisei, W.; Inchingolo, C.; Monardo, E.; Aiello, F. Endoscopic and histological findings in the duodenum of adults with celiac disease before and after changing to a gluten-free diet: A 2-year prospective study. Endoscopy 2006, 38, 702-707.
Soliman, A.T.; Laham, M.; Jour, C.; Shaat, M.; Souikey, F.; Itani, M.; Al-Safi, A.; Karmallah, A.; Qudaisat, A.; Alarabi, Z.; et al. Linear growth of children with celiac disease after the first two years on gluten- free diet: A controlled study. Acta Biomed 2019, 90, 20-27.
Kavak, U.S.; Yüce, A.; Koçak, N.; Demir, H.; Saltik, I.N.; Gürakan, F.; Özen, H. Bone Mineral Density in Children With Untreated and Treated Celiac Disease. J. Pediatr. Gastroenterol. Nutr. 2003, 37, 434-436.
Lerner, B.A.; Vo, L.T.P.; Yates, S.; Rundle, A.G.; Green, P.H.; Lebwohl, B. Detection of Gluten in Gluten-Free Labeled Restaurant Food: Analysis of Crowd-Sourced Data. Am. J. Gastroenterol. 2019, 114, 792-797.
Stevens, L.; Rashid, M. Gluten-Free and Regular Foods: A Cost Comparison. Can. J. Diet. Pr. Res. 2008, 69, 147-150.
Collin, P.; Thorell, L.; Kaukinen, K.; Mäki, M. The safe threshold for gluten contamination in gluten-free products. Can trace amounts be accepted in the treatment of coeliac disease? Aliment. Pharmacol. Ther. 2004, 19, 1277-1283.
Husby S., Koletzko S., Korponay-Szabo I. et al. European Society for Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for diagnosing coeliac disease 2020. Journal of Pediatric Gastroenterology and Nutrition, 2020; 70 (1): 141-156
Bierla JB, Konopka E, Trojanowska I et al. Prevalence of celiac disease in patients with type 1 diabetes mellitus - evaluation in a 3-year prospective study. IX National Congress of the Polish Society of Gastroenterology, Hepatology and Child Nutrition. Bydgoszcz 16-18.06.2016, P.34
Dubé C, Rostom A, Sy R, Cranney A, Saloojee N, Garritty C, Sampson M, Zhang L, Yazdi F, Mamaladze V, Pan I, Macneil J, Mack D, Patel D, Moher D. The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review. Gastroenterology. 2005 Apr;128(4 Suppl 1):S57-67.
. Szaflarska-Popławska A, Soroczyńska-Wrzyszcz A, Barg E, et al. Assessment of coeliac disease prevalence in patients with Down syndrome in Poland - a multi-center study. Przegl. Gastroenterol. 2016; 11: 41-46.
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