Obsessive - compulsive disorder - course during pregnancy, exacerbation factors - literature review
DOI:
https://doi.org/10.12775/JEHS.2023.32.01.002Keywords
obsessive-compulsive disorder, pregnancy, OCD, puerperiumAbstract
Introduction and purpose of the work:
The period of pregnancy and puerperium is the time of increased vulnerability for mother’s mental deterioration. While disorders such as perinatal depression have been detailed, an impact of pregnancy on the course of other mental disorders such as OCD is less investigated. The purpose of this work was to draw attention to the factors that may influence exacerbation of obsessions and compulsions in pregnancy and during the postpartum period. The most common obsessions and compulsions of pregnant women and the influence of mother’s OCD on the newborn have also been described in this research.
State of knowledge:
Factors such as mother’s age, duration of pregnancy, method of delivery may be predictors of aggravation of obsessions and compulsions. Gestational diabetes, thyroid hormones levels, personality disorders of the mother, stress, cultural beliefs also have an impact on mother’s OCD. Infant being infected or hurt are the most common obsession subjects while cleaning and checking the baby happen to be the most frequent compulsions.
Summary:
It is important to disseminate knowledge about the course of OCD during pregnancy and postpartum period and pay attention to the inflammatory factors for earlier diagnosis and treatment. More research about factors worsening OCD through pregnancy are needed to be conducted.
References
Gałecki P.,Szulc A., Psychiatria, Edra Urban & Partner, Wrocław 2018, s.254-256.
McGuinness M, Blissett J, Jones C. OCD in the perinatal period: is postpartum OCD (ppOCD) a distinct subtype? A review of the literature. Behav Cogn Psychother. 2011 May;39(3):285-310. doi: 10.1017/S1352465810000718. Epub 2011 Jan 5. PMID: 21208486.
Holingue C, Samuels J, Guglielmi V, Ingram W, Nestadt G, Nestadt PS. Peripartum complications associated with obsessive compulsive disorder exacerbation during pregnancy. J Obsessive Compuls Relat Disord. 2021 Apr;29:100641. doi: 10.1016/j.jocrd.2021.100641. Epub 2021 Mar 22. PMID: 33968604; PMCID: PMC8104308.
Konstantakou P, Chalarakis N, Valsamakis G, Sakkas EG, Vousoura E, Gryparis A, Sakkas GE, Papadimitriou G, Zervas I, Mastorakos G. Associations of Thyroid Hormones Profile During Normal Pregnancy and Postpartum With Anxiety, Depression, and Obsessive/Compulsive Disorder Scores in Euthyroid Women. Front Neurosci. 2021 Aug 4;15:663348. doi: 10.3389/fnins.2021.663348. PMID: 34421508; PMCID: PMC8371251.
Fontenelle LF, Mendlowicz MV, Versiani M. The descriptive epidemiology of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2006 May;30(3):327-37. doi: 10.1016/j.pnpbp.2005.11.001. Epub 2006 Jan 18. PMID: 16412548.
Mahaffey BL, Levinson A, Preis H, Lobel M. Elevated risk for obsessive-compulsive symptoms in women pregnant during the COVID-19 pandemic. Arch Womens Ment Health. 2022 Apr;25(2):367-376. doi: 10.1007/s00737-021-01157-w. Epub 2021 Jul 16. Erratum in: Arch Womens Ment Health. 2021 Aug 18;: PMID: 34269873; PMCID: PMC8282770.
Viswasam K, Eslick GD, Starcevic V. Prevalence, onset and course of anxiety disorders during pregnancy: A systematic review and meta analysis. J Affect Disord. 2019 Aug 1;255:27-40. doi: 10.1016/j.jad.2019.05.016. Epub 2019 May 11. PMID: 31129461.
Russell, E. J., Fawcett, J. M., & Mazmanian, D. (2013). Risk of Obsessive-Compulsive Disorder in Pregnant and Postpartum Women. The Journal of Clinical Psychiatry, 74(04), 377–385. doi:10.4088/jcp.12r07917
Forray A, Focseneanu M, Pittman B, McDougle CJ, Epperson CN. Onset and exacerbation of obsessive-compulsive disorder in pregnancy and the postpartum period. J Clin Psychiatry. 2010 Aug;71(8):1061-8. doi: 10.4088/JCP.09m05381blu. Epub 2010 May 18. PMID: 20492843; PMCID: PMC4204467.
House SJ, Tripathi SP, Knight BT, Morris N, Newport DJ, Stowe ZN. Obsessive-compulsive disorder in pregnancy and the postpartum period: course of illness and obstetrical outcome. Arch Womens Ment Health. 2016 Feb;19(1):3-10. doi: 10.1007/s00737-015-0542-z. Epub 2015 Jul 16. PMID: 26173597; PMCID: PMC4715787.
Uguz F, Akman C, Kaya N, Cilli AS. Postpartum-onset obsessive-compulsive disorder: incidence, clinical features, and related factors. J Clin Psychiatry. 2007 Jan;68(1):132-8. doi: 10.4088/jcp.v68n0118. PMID: 17284141.
Pittenger C, Adams TG Jr, Gallezot JD, Crowley MJ, Nabulsi N, James Ropchan, Gao H, Kichuk SA, Simpson R, Billingslea E, Hannestad J, Bloch M, Mayes L, Bhagwagar Z, Carson RE. OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding. J Affect Disord. 2016 May 15;196:87-96. doi: 10.1016/j.jad.2016.02.021. Epub 2016 Feb 9. PMID: 26919057; PMCID: PMC4808438.
Westwell-Roper C, Williams KA, Samuels J, Bienvenu OJ, Cullen B, Goes FS, Grados MA, Geller D, Greenberg BD, Knowles JA, Krasnow J, McLaughlin NC, Nestadt P, Shugart YY, Nestadt G, Stewart SE. Immune-Related Comorbidities in Childhood-Onset Obsessive Compulsive Disorder: Lifetime Prevalence in the Obsessive Compulsive Disorder Collaborative Genetics Association Study. J Child Adolesc Psychopharmacol. 2019 Oct;29(8):615-624. doi: 10.1089/cap.2018.0140. Epub 2019 Jun 6. PMID: 31170001; PMCID: PMC6786333.
Gerentes M, Pelissolo A, Rajagopal K, Tamouza R, Hamdani N. Obsessive-Compulsive Disorder: Autoimmunity and Neuroinflammation. Curr Psychiatry Rep. 2019 Aug 1;21(8):78. doi: 10.1007/s11920-019-1062-8. PMID: 31367805.
Abba-Aji A, Li D, Hrabok M, Shalaby R, Gusnowski A, Vuong W, Surood S, Nkire N, Li X-M, Greenshaw AJ. COVID-19 Pandemic and mental health: prevalence and correlates of new-onset obsessive-compulsive symptoms in a Canadian province. Int J Environ Res Public Health. 2020;17(19):6986. doi: 10.3390/ijerph17196986
Benatti B, Albert U, Maina G, Fiorillo A, Celebre L, Girone N, Fineberg N, Bramante S, Rigardetto S, Dell’Osso B. What happened to patients with Obsessive Compulsive Disorder during the COVID-19 pandemic? A multicentre report from tertiary clinics in northern italy. Front Psych. 2020;11:720. doi: 10.3389/fpsyt.2020.00720.
Buchholz, Jennifer L., Samantha N. Hellberg, and Jonathan S. Abramowitz. "Phenomenology of perinatal obsessive–compulsive disorder." Biomarkers of postpartum psychiatric disorders. Academic Press, 2020. 79-93.
de Pender AM, Lambregtse-van den Berg MP, Raats ME. Obsessieve-compulsieve stoornis tijdens de zwangerschap en post-partumperiode [Obsessive compulsive disorder during pregnancy and the postpartum period]. Tijdschr Psychiatr. 2012;54(6):549-53. Dutch. PMID: 22753187.
Abramowitz JS, Schwartz SA, Moore KM, Luenzmann KR. Obsessive-compulsive symptoms in pregnancy and the puerperium: a review of the literature. J Anxiety Disord. 2003;17(4):461-78. doi: 10.1016/s0887-6185(02)00206-2. PMID: 12826092.
Abramowitz, J. S., McKay, D. and Taylor, S.(2005). Special series: subtypes of obsessive compulsivedisorder. Introduction.Behaviour Therapy, 36, 367–369
Uguz, Faruk, et al. "Birth weight and gestational age in newborns exposed to maternal obsessive-compulsive disorder." Psychiatry research 226.1 (2015): 396-398.
Miller ML, O'Hara MW. Obsessive-compulsive symptoms, intrusive thoughts and depressive symptoms: a longitudinal study examining relation to maternal responsiveness. J Reprod Infant Psychol. 2020 Jul;38(3):226-242. doi: 10.1080/02646838.2019.1652255. Epub 2019 Aug 20. PMID: 31431052; PMCID: PMC7031018.
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Copyright (c) 2023 Julia Czarnota, Katarzyna Cichoń, Małgorzata Chyćko, Agata Kromer, Magdalena Alicja Zapała, Agnieszka Gawryś, Agnieszka Środoń, Monika Łapaj, Joanna Wilk, Małgorzata Maria Cholewa

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