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Journal of Education, Health and Sport

Probiotics and gut-skin axis - new look on factors affecting skin condition
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Probiotics and gut-skin axis - new look on factors affecting skin condition

Authors

  • Aleksandra Małolepsza Bonifraterskie Centrum Medyczne sp. z o.o Oddział w Krakowie, ul. Trynitarska 11, 31-061 Kraków https://orcid.org/0000-0002-0645-7824
  • Tomasz Dembowski Bonifraterskie Centrum Medyczne sp. z o.o Oddział w Krakowie, ul. Trynitarska 11, 31-061 Kraków https://orcid.org/0000-0002-3323-4036

DOI:

https://doi.org/10.12775/JEHS.2023.31.01.005

Keywords

gut microbiota, probiotics, gut-skin axis, skin aging, dermatology

Abstract

Introduction and purpose 

The human gut microbiota consists of trillions of microscopic organisms, mostly bacterias. They play a significant role in nutrient metabolism, maintenance of structural integrity of the gut mucosal barrier, immunomodulation and protection against pathogens. Many factors can influence the composition of the intestinal microbiota, for example antibiotics, diet or stress. These factors may lead to dysbiosis which causes activation of neurotransmitters. It can results in the entry of metabolites to the blood stream, systemic immune dysregulation and alteration of skin microbiota. The aim of the study was to review the literature and determine the effects of intestinal microbiota and probiotics in selected skin diseases and what is new - skin aging process. 

State of knowledge 

We analyzed numerous studies which indicate that disturbed gut microbiota can be related to some chronic diseases, including skin disorders such as atopic dermatitis, acne vulgaris, psoriasis and rosacea. Additionally, it has been proven that bacterial dysbiosis can intensify the skin aging proces. In order to reproduce normal gut microbiota probiotics are used. Despite the fact that there are only a few studies showing the unequivocal effect of probiotics on skin diseases, their results seem to be encouraging. 

Conclusions 

Proper composition of the intestinal microbiome determines the homeostasis of the human body. Disturbance of the gut microbiome play a significant role not only in development and aggravation of many skin diseases, but also have an impact on the skin aging. Despite quite a lot number of studies assessing the impact of microbiota on certain skin disorders, there is still a need to evaluate impact of probiotics. Researches indicate that they can be used as a helpful therapeutic tool. Taking this into account, it is worth considering it in the treatment process. 

References

DAS B, Nair GB. Homeostasis and dysbiosis of the gut microbiome in health and disease. J Biosci. 2019 Oct;44(5):117. PMID: 31719226.

Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D. Role of the normal gut microbiota. World J Gastroenterol. 2015 Aug 7;21(29):8787-803. doi: 10.3748/wjg.v21.i29.8787. PMID: 26269668; PMCID: PMC4528021.

Vijay A, Valdes AM. Role of the gut microbiome in chronic diseases: a narrative review. Eur J Clin Nutr 76, 489–501 (2022). https://doi.org/10.1038/s41430-021-00991-6

De Pessemier B, Grine L, Debaere M, Maes A, Paetzold B, Callewaert C. Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions. Microorganisms. 2021 Feb 11;9(2):353. doi: 10.3390/microorganisms9020353. PMID: 33670115; PMCID: PMC7916842

Ratanapokasatit Y, Laisuan W, Rattananukrom T, Petchlorlian A, Thaipisuttikul I, Sompornrattanaphan M. How Microbiomes Affect Skin Aging: The Updated Evidence and Current Perspectives. Life (Basel). 2022 Jun 22;12(7):936. doi: 10.3390/life12070936. PMID: 35888025; PMCID: PMC9320090.

Amara AA, Shibl A. Role of Probiotics in health improvement, infection control and disease treatment and management. Saudi Pharm J. 2015 Apr;23(2):107-14. doi: 10.1016/j.jsps.2013.07.001. Epub 2013 Jul 18. PMID: 25972729; PMCID: PMC4421088.

Food and Agriculture Organization/World Health Organization (FAO/WHO), 2001. Health and nutritional properties of Probiotics in food including powder milk with live lactic acid bacteria, Report of a Joint FAO/WHO Expert Consultation on Evaluation of Health and Nutritional Properties of Probiotics in Food including Powder Milk with Live lactic acid bacteria, Córdoba, Argentina. Available at: http://www.who.int/foodsafety/publications/fs_management/en/probiotics.pdf.

Szántó M, Dózsa A, Antal D, Szabó K, Kemény L, Bai P. Targeting the gut-skin axis-Probiotics as new tools for skin disorder management? Exp Dermatol. 2019 Nov;28(11):1210-1218. doi: 10.1111/exd.14016. Epub 2019 Aug 28. PMID: 31386766.

Frazier W, Bhardwaj N. Atopic Dermatitis: Diagnosis and Treatment. Am Fam Physician. 2020 May 15;101(10):590-598. PMID: 32412211.

Watanabe S, Narisawa Y, Arase S, Okamatsu H, Ikenaga T, Tajiri Y, Kumemura M. Differences in fecal microflora between patients with atopic dermatitis and healthy control subjects. J Allergy Clin Immunol. 2003 Mar;111(3):587-91. doi: 10.1067/mai.2003.105. PMID: 12642841.

Zheng H, Liang H, Wang Y, Miao M, Shi T, Yang F, Liu E, Yuan W, Ji ZS, Li DK. Altered Gut Microbiota Composition Associated with Eczema in Infants. PLoS One. 2016 Nov 3;11(11):e0166026. doi: 10.1371/journal.pone.0166026. PMID: 27812181; PMCID: PMC5094743.

Li L, Han Z, Niu X et al. Probiotic Supplementation for Prevention of Atopic Dermatitis in Infants and Children: A Systematic Review and Meta-analysis. Am J Clin Dermatol 20, 367–377 (2019). https://doi.org/10.1007/s40257-018-0404-3

Umborowati MA, Damayanti D, Anggraeni S, Endaryanto A, Surono IS, Effendy I, Prakoeswa CRS. The role of probiotics in the treatment of adult atopic dermatitis: a meta-analysis of randomized controlled trials. J Health Popul Nutr. 2022 Aug 17;41(1):37. doi: 10.1186/s41043-022-00318-6. PMID: 35978397; PMCID: PMC9386980.

Rusu E, Enache G, Cursaru R, Alexescu A, Radu R, Onila O, Cavallioti T, Rusu F, Posea M, Jinga M, Radulian G. Prebiotics and probiotics in atopic dermatitis. Exp Ther Med. 2019 Aug;18(2):926-931. doi: 10.3892/etm.2019.7678. Epub 2019 Jun 14. PMID: 31384325; PMCID: PMC6639913.

Sánchez-Pellicer P, Navarro-Moratalla L, Núñez-Delegido E, Ruzafa-Costas B, Agüera-Santos J, Navarro-López V. Acne, Microbiome, and Probiotics: The Gut-Skin Axis. Microorganisms. 2022 Jun 27;10(7):1303. doi: 10.3390/microorganisms10071303. PMID: 35889022; PMCID: PMC9318165.

Buhaș MC, Gavrilaș LI, Candrea R, Cătinean A, Mocan A, Miere D, Tătaru A. Gut Microbiota in Psoriasis. Nutrients. 2022 Jul 20;14(14):2970. doi: 10.3390/nu14142970. PMID: 35889927; PMCID: PMC9321451.

Zhang, X., Shi, L., Sun, T. et al. Dysbiosis of gut microbiota and its correlation with dysregulation of cytokines in psoriasis patients. BMC Microbiol 21, 78 (2021). https://doi.org/10.1186/s12866-021-02125-1

Alesa DI, Alshamrani HM, Alzahrani YA, Alamssi DN, Alzahrani NS, Almohammadi ME. The role of gut microbiome in the pathogenesis of psoriasis and the therapeutic effects of probiotics. J Family Med Prim Care. 2019 Nov 15;8(11):3496-3503. doi: 10.4103/jfmpc.jfmpc_709_19. Retraction in: J Family Med Prim Care. 2021 Feb;10(2):1076. PMID: 31803643; PMCID: PMC6881942.

Metikurke Vijayashankar M, Raghunath N. Pustular psoriasis responding to probiotics – A new insight. Our Dermatol Online. 2012;3:326–8.

Weiss E, Katta R. Diet and rosacea: the role of dietary change in the management of rosacea. Dermatol Pract Concept. 2017 Oct 31;7(4):31-37. doi: 10.5826/dpc.0704a08. PMID: 29214107; PMCID: PMC5718124.

Daou H, Paradiso M, Hennessy K, Seminario-Vidal L. Rosacea and the Microbiome: A Systematic Review. Dermatol Ther (Heidelb). 2021 Feb;11(1):1-12. doi: 10.1007/s13555-020-00460-1. Epub 2020 Nov 10. PMID: 33170492; PMCID: PMC7859152.

Yang X. Relationship between Helicobacter pylori and Rosacea: review and discussion. BMC Infect Dis. 2018 Jul 11;18(1):318. doi: 10.1186/s12879-018-3232-4. PMID: 29996790; PMCID: PMC6042414.

Ali SM, Yosipovitch G. Skin pH: from basic science to basic skin care. Acta Derm Venereol. 2013 May;93(3):261-7. doi: 10.2340/00015555-1531. PMID: 23322028.

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Published

2023-05-17

How to Cite

1.
MAŁOLEPSZA, Aleksandra and DEMBOWSKI, Tomasz. Probiotics and gut-skin axis - new look on factors affecting skin condition. Journal of Education, Health and Sport. Online. 17 May 2023. Vol. 31, no. 1, pp. 55-60. [Accessed 17 May 2025]. DOI 10.12775/JEHS.2023.31.01.005.
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Vol. 31 No. 1 (2023)

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Review Articles

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Copyright (c) 2023 Aleksandra Małolepsza, Tomasz Dembowski

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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