Is breast cancer a civilization disease? Common components of type 2 diabetes and breast cancer
DOI:
https://doi.org/10.12775/JEHS.2023.24.01.008Keywords
Diabetes Mellitus, Hyperinsulinism, Breast CancerAbstract
Diabetes Mellitus is one of the most common civilization diseases.The incidence of this disease has been increasing over the last few decades. Research is still being conducted to show the relationship between diabetes and other diseases. Based on these studies, it can be concluded that it also plays a role in the development of cancer. In this review, we focus on analyzing studies on the relationship between type 2 diabetes and breast cancer. We show the influence of diabetes components on the pathomechanism of breast cancer development. We focus on hyperinsulinemia, inflammatory processes, oxidative stress, and obesity, which often accompany type 2 diabetes. Based on the analyzed studies, it can be concluded that type 2 diabetes is a significant factor contributing to cancerous processes associated with breast cancer. In this review, we used articles available in the PubMed database.
References
Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018 Feb;14(2):88-98. doi: 10.1038/nrendo.2017.151. Epub 2017 Dec 8. PMID: 29219149.
Caussy C, Aubin A, Loomba R. The Relationship Between Type 2 Diabetes, NAFLD, and Cardiovascular Risk. Curr Diab Rep. 2021 Mar 19;21(5):15. doi: 10.1007/s11892-021-01383-7. PMID: 33742318; PMCID: PMC8805985.
Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763. PMID: 36633525.
Min W, Wang B, Guo A, Mao G, Zhao Y, Zhang S, He R, Min Y, Huang Y. The Effect of Metformin on the Clinicopathological Features of Breast Cancer With Type 2 Diabetes. World J Oncol. 2020 Feb;11(1):23-32. doi: 10.14740/wjon1242. Epub 2020 Feb 2. PMID: 32095186; PMCID: PMC7011907.
Biello F, Platini F, D'Avanzo F, Cattrini C, Mennitto A, Genestroni S, Martini V, Marzullo P, Aimaretti G, Gennari A. Insulin/IGF Axis in Breast Cancer: Clinical Evidence and Translational Insights. Biomolecules. 2021 Jan 19;11(1):125. doi: 10.3390/biom11010125. PMID: 33477996; PMCID: PMC7835955.
Tokarz VL, MacDonald PE, Klip A. The cell biology of systemic insulin function. J Cell Biol. 2018 Jul 2;217(7):2273-2289. doi: 10.1083/jcb.201802095. Epub 2018 Apr 5. PMID: 29622564; PMCID: PMC6028526.
Samuel SM, Varghese E, Varghese S, Büsselberg D. Challenges and perspectives in the treatment of diabetes associated breast cancer. Cancer Treat Rev. 2018 Nov;70:98-111. doi: 10.1016/j.ctrv.2018.08.004. Epub 2018 Aug 10. PMID: 30130687.
Kang C, LeRoith D, Gallagher EJ. Diabetes, Obesity, and Breast Cancer. Endocrinology. 2018 Nov 1;159(11):3801-3812. doi: 10.1210/en.2018-00574. PMID: 30215698; PMCID: PMC6202853.
Ward CW, Lawrence MC. Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor. Bioessays. 2009 Apr;31(4):422-34. doi: 10.1002/bies.200800210. PMID: 19274663.
Eketunde AO. Diabetes as a Risk Factor for Breast Cancer. Cureus. 2020 May 7;12(5):e8010. doi: 10.7759/cureus.8010. PMID: 32528752; PMCID: PMC7279688.
Ianza A, Sirico M, Bernocchi O, Generali D. Role of the IGF-1 Axis in Overcoming Resistance in Breast Cancer. Front Cell Dev Biol. 2021 Mar 22;9:641449. doi: 10.3389/fcell.2021.641449. PMID: 33829018; PMCID: PMC8019779.
Werner H. BRCA1: An Endocrine and Metabolic Regulator. Front Endocrinol (Lausanne). 2022 Mar 31;13:844575. doi: 10.3389/fendo.2022.844575. PMID: 35432218; PMCID: PMC9009035.
Swerdloff RS, Ng JCM. Gynecomastia: Etiology, Diagnosis, and Treatment. 2023 Jan 6. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. PMID: 25905330.
Petrick HL, Foley KP, Zlitni S, Brunetta HS, Paglialunga S, Miotto PM, Politis-Barber V, O'Dwyer C, Philbrick DJ, Fullerton MD, Schertzer JD, Holloway GP. Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required. Function (Oxf). 2020 Aug 25;1(2):zqaa013. doi: 10.1093/function/zqaa013. PMID: 34278304; PMCID: PMC8276887.
Pedersen DJ, Guilherme A, Danai LV, Heyda L, Matevossian A, Cohen J, Nicoloro SM, Straubhaar J, Noh HL, Jung D, Kim JK, Czech MP. A major role of insulin in promoting obesity-associated adipose tissue inflammation. Mol Metab. 2015 May 1;4(7):507-18. doi: 10.1016/j.molmet.2015.04.003. PMID: 26137438; PMCID: PMC4481426.
Zhang AMY, Wellberg EA, Kopp JL, Johnson JD. Hyperinsulinemia in Obesity, Inflammation, and Cancer. Diabetes Metab J. 2021 May;45(3):285-311. doi: 10.4093/dmj.2020.0250. Epub 2021 Mar 29. Erratum in: Diabetes Metab J. 2021 Jul;45(4):622. PMID: 33775061; PMCID: PMC8164941.
Orliaguet L, Dalmas E, Drareni K, Venteclef N, Alzaid F. Mechanisms of Macrophage Polarization in Insulin Signaling and Sensitivity. Front Endocrinol (Lausanne). 2020 Feb 19;11:62. doi: 10.3389/fendo.2020.00062. PMID: 32140136; PMCID: PMC7042402.
Ley K. M1 Means Kill; M2 Means Heal. J Immunol. 2017 Oct 1;199(7):2191-2193. doi: 10.4049/jimmunol.1701135. PMID: 28923980.
Denroche HC, Nackiewicz D, Verchere CB. When beta cells talk back. Diabetologia. 2018 Jan;61(1):39-42. doi: 10.1007/s00125-017-4443-8. Epub 2017 Sep 20. PMID: 28932877.
Kazankov K, Jørgensen SMD, Thomsen KL, Møller HJ, Vilstrup H, George J, Schuppan D, Grønbæk H. The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Nat Rev Gastroenterol Hepatol. 2019 Mar;16(3):145-159. doi: 10.1038/s41575-018-0082-x. PMID: 30482910.
Ieronymaki E, Theodorakis EM, Lyroni K, Vergadi E, Lagoudaki E, Al-Qahtani A, Aznaourova M, Neofotistou-Themeli E, Eliopoulos AG, Vaporidi K, Tsatsanis C. Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype. J Immunol. 2019 Mar 15;202(6):1786-1797. doi: 10.4049/jimmunol.1800065. Epub 2019 Feb 4. PMID: 30718296.
Arranz A, Doxaki C, Vergadi E, Martinez de la Torre Y, Vaporidi K, Lagoudaki ED, Ieronymaki E, Androulidaki A, Venihaki M, Margioris AN, Stathopoulos EN, Tsichlis PN, Tsatsanis C. Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9517-22. doi: 10.1073/pnas.1119038109. Epub 2012 May 30. PMID: 22647600; PMCID: PMC3386059.
Singh A, Kukreti R, Saso L, Kukreti S. Oxidative Stress: A Key Modulator in Neurodegenerative Diseases. Molecules. 2019 Apr 22;24(8):1583. doi: 10.3390/molecules24081583. PMID: 31013638; PMCID: PMC6514564.
Singh A, Kukreti R, Saso L, Kukreti S. Mechanistic Insight into Oxidative Stress-Triggered Signaling Pathways and Type 2 Diabetes. Molecules. 2022 Jan 30;27(3):950. doi: 10.3390/molecules27030950. PMID: 35164215; PMCID: PMC8840622.
Campa CC, Ciraolo E, Ghigo A, Germena G, Hirsch E. Crossroads of PI3K and Rac pathways. Small GTPases. 2015;6(2):71-80. doi: 10.4161/21541248.2014.989789. Epub 2015 May 5. PMID: 25942647; PMCID: PMC4601376.
GBD 2015 Obesity Collaborators; Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, Marczak L, Mokdad AH, Moradi-Lakeh M, Naghavi M, Salama JS, Vos T, Abate KH, Abbafati C, Ahmed MB, Al-Aly Z, Alkerwi A, Al-Raddadi R, Amare AT, Amberbir A, Amegah AK, Amini E, Amrock SM, Anjana RM, Ärnlöv J, Asayesh H, Banerjee A, Barac A, Baye E, Bennett DA, Beyene AS, Biadgilign S, Biryukov S, Bjertness E, Boneya DJ, Campos-Nonato I, Carrero JJ, Cecilio P, Cercy K, Ciobanu LG, Cornaby L, Damtew SA, Dandona L, Dandona R, Dharmaratne SD, Duncan BB, Eshrati B, Esteghamati A, Feigin VL, Fernandes JC, Fürst T, Gebrehiwot TT, Gold A, Gona PN, Goto A, Habtewold TD, Hadush KT, Hafezi-Nejad N, Hay SI, Horino M, Islami F, Kamal R, Kasaeian A, Katikireddi SV, Kengne AP, Kesavachandran CN, Khader YS, Khang YH, Khubchandani J, Kim D, Kim YJ, Kinfu Y, Kosen S, Ku T, Defo BK, Kumar GA, Larson HJ, Leinsalu M, Liang X, Lim SS, Liu P, Lopez AD, Lozano R, Majeed A, Malekzadeh R, Malta DC, Mazidi M, McAlinden C, McGarvey ST, Mengistu DT, Mensah GA, Mensink GBM, Mezgebe HB, Mirrakhimov EM, Mueller UO, Noubiap JJ, Obermeyer CM, Ogbo FA, Owolabi MO, Patton GC, Pourmalek F, Qorbani M, Rafay A, Rai RK, Ranabhat CL, Reinig N, Safiri S, Salomon JA, Sanabria JR, Santos IS, Sartorius B, Sawhney M, Schmidhuber J, Schutte AE, Schmidt MI, Sepanlou SG, Shamsizadeh M, Sheikhbahaei S, Shin MJ, Shiri R, Shiue I, Roba HS, Silva DAS, Silverberg JI, Singh JA, Stranges S, Swaminathan S, Tabarés-Seisdedos R, Tadese F, Tedla BA, Tegegne BS, Terkawi AS, Thakur JS, Tonelli M, Topor-Madry R, Tyrovolas S, Ukwaja KN, Uthman OA, Vaezghasemi M, Vasankari T, Vlassov VV, Vollset SE, Weiderpass E, Werdecker A, Wesana J, Westerman R, Yano Y, Yonemoto N, Yonga G, Zaidi Z, Zenebe ZM, Zipkin B, Murray CJL. Health Effects of Overweight and Obesity in 195 Countries over 25 Years. N Engl J Med. 2017 Jul 6;377(1):13-27. doi: 10.1056/NEJMoa1614362. Epub 2017 Jun 12. PMID: 28604169; PMCID: PMC5477817.
Goodwin PJ, Stambolic V. Impact of the obesity epidemic on cancer. Annu Rev Med. 2015;66:281-96. doi: 10.1146/annurev-med-051613-012328. Epub 2014 Nov 12. PMID: 25423596.
Lee YC, Chen YJ, Wu CC, Lo S, Hou MF, Yuan SS. Resistin expression in breast cancer tissue as a marker of prognosis and hormone therapy stratification. Gynecol Oncol. 2012 Jun;125(3):742-50. doi: 10.1016/j.ygyno.2012.02.032. Epub 2012 Feb 24. PMID: 22370603.
Wang CH, Wang PJ, Hsieh YC, Lo S, Lee YC, Chen YC, Tsai CH, Chiu WC, Chu-Sung Hu S, Lu CW, Yang YF, Chiu CC, Ou-Yang F, Wang YM, Hou MF, Yuan SS. Resistin facilitates breast cancer progression via TLR4-mediated induction of mesenchymal phenotypes and stemness properties. Oncogene. 2018 Feb 1;37(5):589-600. doi: 10.1038/onc.2017.357. Epub 2017 Oct 9. PMID: 28991224.
Surmacz E. Leptin and adiponectin: emerging therapeutic targets in breast cancer. J Mammary Gland Biol Neoplasia. 2013 Dec;18(3-4):321-32. doi: 10.1007/s10911-013-9302-8. Epub 2013 Oct 18. PMID: 24136336.
Dustin D, Gu G, Fuqua SAW. ESR1 mutations in breast cancer. Cancer. 2019 Nov 1;125(21):3714-3728. doi: 10.1002/cncr.32345. Epub 2019 Jul 18. PMID: 31318440; PMCID: PMC6788940.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Karolina Wijas, Karolina Szala-Czerwonka, Adrian Rejmer, Natalia Woś, Katarzyna Rojek, Lucjan Bednarz, Kinga Bialic, Rafał Bakalarczyk, Artur Bialic, Paweł Majewski
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 102
Number of citations: 0
