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Journal of Education, Health and Sport

Case report: Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 with severe myocardial dysfunction. Is there any hope in immunotherapy?
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  • Case report: Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 with severe myocardial dysfunction. Is there any hope in immunotherapy?
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  3. Vol. 26 No. 1 (2023) /
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Case report: Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 with severe myocardial dysfunction. Is there any hope in immunotherapy?

Authors

  • Julita Tokarek Medical University of Lodz https://orcid.org/0000-0003-4527-3355
  • Emilian Budny Medical University of Lodz https://orcid.org/0009-0006-7737-5689
  • Renata Szmigielska Medical University of Lodz https://orcid.org/0000-0002-3528-6139

DOI:

https://doi.org/10.12775/JEHS.2023.26.01.003

Keywords

COVID-19, PIMS-TS, anakinra, immunomodulatory therapy

Abstract

Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) develops in a small percentage of children after COVID-19, however, it might cause severe myocardial dysfunction. The pathogenesis of this disease includes systemic hyper-inflammation with cytokine storm. This case report concerns a 12-year-old boy with PIMS-TS who presented severe respiratory and circulatory failure with increased inflammatory markers and significant reduction of left ventricle ejaculatory fraction (LVEF) from 65% to 35%. The recommended therapy with the use of vasopressors, corticosteroids, intravenous immunoglobulins and mechanical ventilation was introduced and his condition gradually improved. However, after few days, aggravation of cardiac symptoms occurred again and among other treatment, the therapy with the use of anakinra - the human interleukin 1 receptor antagonist protein was introduced. This case highlights a satisfactory regression of cardiac disturbances and generally favorable outcome of the treatment in patients with PIMS-TS with the use of immunomodulatory therapy.

References

J. Klučka, M. Kratochvíl, P. Dominik, et al., ‘COVID-19 associated Paediatric Inflammatory Multisystem Syndrome (PIMS) in children’, Epidemiol Mikrobiol Imunol, vol. 70, no. 4, pp. 281–284, 2021.

J. S. Kim, J. Y. Lee, J. W. Yang, et al., ‘Immunopathogenesis and treatment of cytokine storm in COVID-19’, Theranostics, vol. 11, no. 1, pp. 316–329, 2021, doi: 10.7150/thno.49713.

E. Whittaker, A. Bamford, J. Kenny, et al., ‘Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2’, JAMA, vol. 324, no. 3, pp. 259–269, Jul. 2020, doi: 10.1001/jama.2020.10369.

S. Godfred-Cato, B. Bryant, J. Leung, et al., ‘COVID-19–Associated Multisystem Inflammatory Syndrome in Children — United States, March–July 2020’, MMWR Morb. Mortal. Wkly. Rep., vol. 69, no. 32, pp. 1074–1080, Aug. 2020, doi: 10.15585/mmwr.mm6932e2.

F. Sperotto, K. G. Friedman, M. B. F. Son, C. J. VanderPluym, J. W. Newburger, and A. Dionne, ‘Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach’, Eur J Pediatr, vol. 180, no. 2, pp. 307–322, Feb. 2021, doi: 10.1007/s00431-020-03766-6.

R. Szmigielska and B. Górczewska, ‘Post-COVID-19 syndrome in children – pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS)’, Klinika Pediatryczna, vol. 29, no. 2, pp. 1–5.

A. H. Rowley, ‘Understanding SARS-CoV-2-related multisystem inflammatory syndrome in children’, Nat Rev Immunol, vol. 20, no. 8, pp. 453–454, Aug. 2020, doi: 10.1038/s41577-020-0367-5.

R. Flisiak, A. Horban, J. Jaroszewicz, et al., ‘Management of SARS-CoV-2 infection: recommendations of the Polish Association of Epidemiologists and Infectiologists as of February 23, 2022’, Pol Arch Intern Med, vol. 132, no. 3, p. 16230, Mar. 2022, doi: 10.20452/pamw.16230.

J. M. Patel, ‘Multisystem Inflammatory Syndrome in Children (MIS-C)’, Curr Allergy Asthma Rep, Mar. 2022, doi: 10.1007/s11882-022-01031-4.

K. M. Farooqi, A. Chan, R. J. Weller, et al., ‘Longitudinal Outcomes for Multisystem Inflammatory Syndrome in Children’, Pediatrics, vol. 148, no. 2, p. e2021051155, Aug. 2021, doi: 10.1542/peds.2021-051155.

J. Fernández-Sarmiento, D. De Souza, R. Jabornisky, G. A. Gonzalez, M. del P. Arias López, and G. Palacio, ‘Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): a narrative review and the viewpoint of the Latin American Society of Pediatric Intensive Care (SLACIP) Sepsis Committee’, bmjpo, vol. 5, no. 1, p. e000894, Feb. 2021, doi: 10.1136/bmjpo-2020-000894.

M. V. Mastrolia, E. Marrani, G. B. Calabri, et al., ‘Fast recovery of cardiac function in PIMS-TS patients early using intravenous anti-IL-1 treatment’, Crit Care, vol. 25, no. 1, p. 131, Dec. 2021, doi: 10.1186/s13054-021-03548-y.

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Published

2023-05-04

How to Cite

1.
TOKAREK, Julita, BUDNY, Emilian and SZMIGIELSKA, Renata. Case report: Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 with severe myocardial dysfunction. Is there any hope in immunotherapy?. Journal of Education, Health and Sport. Online. 4 May 2023. Vol. 26, no. 1, pp. 27-30. [Accessed 14 June 2025]. DOI 10.12775/JEHS.2023.26.01.003.
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Issue

Vol. 26 No. 1 (2023)

Section

Case Reports

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Copyright (c) 2023 Julita Tokarek, Emilian Budny, Renata Szmigielska

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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