Comparative study of the effects of fresh and canned Naftussya bioactive water on neuro-endocrine-immune complex and metabolism in chronic pyelonephritis patients
DOI:
https://doi.org/10.12775/JEHS.2023.17.01.001Keywords
Naftussya bioactive water, Dovzhenko© conservation method, chronic pyelonephritis, urinary syndrome, microbiota, phagocytosis, diuresis, saluresis, HRV, adaptation hormonesAbstract
Background. There are several patented methods of preservation of medicinal waters of the Naftussya type. The authors of the patents as evidence of the correctness of the methods cite the facts of preservation of the ability of canned water to enhance motility rat’s v. portae in vitro and/or increase diuresis. However, such tests are not attributive. The most characteristic manifestation of the biological activity of Naftussya water is the stimulation of phagocytosis through the mediation of the nervous and endocrine systems. Another "Method of preservation of hydrogen sulfide mineral waters" was recently patented. The purpose of this study is to compare the impact of fresh and canned by this method Naftussya water on its targets in patients with chronic pyelonephritis. Materials and Methods. The object of clinical-physiological observation were residents of the city of Truskavets’ (21 men aged 24-67 years and 8 women 33-76 years) with chronic pyelonephritis in remission. The subject of the study were the phagocytic function of neutrophils, excretory function of kidneys, leukocyturia and bacteriuria levels, components of microbiota of feces as well as HRV and endocrine parameters. Results. Weekly use of fresh Naftussya water causes an increase in the reduced content of probiotics in the microbiota and a decrease in the increased content of conditionally pathogenic microflora, which is accompanied by an increase in reduced bactericidal capacity of neutrophils against both E. coli and Staph. aureus, normal diuresis, phosphaturia, magnesiumuria, ureauria while reduction of bacteriuria and leveling of leukocyturia as well as decrease in concentration of uric acid in urine and creatinine and cholesterol in plasma. Favorable changes in neuro-endocrine regulation were revealed. The beneficial effect on the listed parameters of canned Naftussya water is less pronounced, but the differences are statistically insignificant. Conclusion. The obtained results confirm the effectiveness of the Dovzhenko© method for Naftusya water conservation and provide grounds for continuing research into the effects of canned Naftusya water on the body of urological patients.
References
Androssova SO. Sanatorium treatment of persons with kidney diseases. In: Nephrology. A guide for doctors. Volume 2 (edited by IE Tareeva) [in Russian]. Moskva. Meditsina; 1995: 393-396.
Baevsky R.M., Berseneva A.P. Use Kardivar System for Determination of the Stress Level and Estimation of the Body Adaptability. Standards of measurements and physiological interpretation. Moscow – Prague. 2008: 41.
Bamigbade GB, Subhash AJ, Kamal-Eldin A, Nyström L, Ayyash M. An Updated Review on Prebiotics: Insights on Potentials of Food Seeds Waste as Source of Potential Prebiotics. Molecules. 2022; 27(18): 5947.
Dats’ko OR, Bubnyak AB, Ivassivka SV. The organic part in mineral water Naftussya. Development of knowledges about its composition and origination [in Ukrainian]. Medical Hydrology and Rehabilitation. 2008; 6(1): 168-174.
Goryachkovskiy АМ. Clinical Biochemistry [in Russian]. Odesa: Astroprint; 1998: 608.
Gozhenko AI, Kravchuk AV, Nykytenko OP, Moskalenko OM, Sirman VM. Functional Renal Reserve [in Ukrainian]. Odesa. Feniks; 2015: 182.
Gozhenko AI, Kushneruk AV, Zukow W, Popovych IL. Comparative study of electrolyte exchange in patients with varying severity of urinary syndrome of chronic pyelonephritis. Journal of Education, Health and Sport. 2015; 5(1): 305-310.
Gozhenko AI, Sydoruk NO, Babelyuk VYe, Dubkowa GI, Flyunt VR, Hubyts’kyi VYo, Zukow W, Barylyak LG, Popovych IL. Modulating effects of bioactive water Naftussya from layers Truskavets’ and Pomyarky on some metabolic and biophysic parameters at humans with dysfunction of neuro-endocrine-immune complex. Journal of Education, Health and Sport. 2016; 6(12): 826-842.
Hütt P, Shchepetova J, Lõivukene K, Kullisaar T, Mikelsaar M. Antagonistic activity of probiotic lactobacilli and bifidobacteria against entero- and uropathogens. J Appl Microbiol. 2006; 100(6): 1324-1332.
Ivassivka SV, Bubnyak AB, Kovbasnyuk ММ, Popovych IL. Genesis and role of phenols in waters from Naftussya layer [in Ukrainian]. In: Problems of pathology in experiment and clinic. Scientific works of Drohobych Medical Institute. Vol XV. Drohobych. 1994: 6-11.
Ivassivka SV, Popovych IL, Aksentiychuk BI, Bilas VR. The Nature of Naftussya Water Balneofactors and the Essence of its Therapeutic and Preventive Action [in Ukrainian]. Truskavets’. Truskavets’kurort; 1999: 125.
Kaur AP, Bhardwaj S, Dhanjal DS, et al. Plant Prebiotics and Their Role in the Amelioration of Diseases. Biomolecules. 2021; 11(3): 440.
Kul’chyns’kyi AB, Gozhenko AI, Zukow W, Popovych IL. Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 3. Correlations between parameters EEG, HRV and Immunogram. Journal of Education, Health and Sport. 2017; 7(3): 53-71.
Kul’chyns’kyi AB, Kovbasnyuk MM, Korolyshyn TA, Kyjenko VM, Zukow W, Popovych IL. Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 2. Correlations between parameters EEG, HRV and Phagocytosis. Journal of Education, Health and Sport. 2016; 6(10): 377-401.
Moiseev AYu. Features of Chemical Conposition and Balneal Use of Mineral Waters [in Russian]. Kyїv. Publish Hous “KIM”; 2017: 464.
Patent UA 148377 U. The method of preservation of hydrogen sulfide mineral waters. Dovzhenko OM. Bull. N30. 28.07.2021.
Polovynko IS, Zajats LM, Zukow W, Yanchij RI, Popovych IL. Quantitative evaluation of integrated neuroendocrine and immune responses to chronic stress in rat male. Journal of Education, Health and Sport. 2016; 6(8): 154-166.
Popovych AI, Ruzhylo SV, Zakalyak NR, Popovych DV, Żukow X. Comparative study of the effects on the microbiota and leukocyturia of fresh and canned Naftussya water. Quality in Sport. 2022; 8(4): 67-72.
Popovych AI, Fil VM, Ruzhylo SV, Zakalyak NR, Żukow X, Popovych DV. Comparative study of the attributive effects of fresh and canned Naftussya water. Journal of Education, Health and Sport. 2023; 13(4): 142-149.
Popovych IL, Flyunt IS, Alyeksyeyev OI, Hrytsak LYa, Hrinchenko BV, Barylyak LG et al. Sanogenetic Bases of Rehabilitation on Spa Truskavets’ Urological Patients from Chornobylian Contingent [in Ukrainian]. Kyїv. Computerpress; 2003: 192.
Popovych IL, Kul’chyns’kyi AB, Gozhenko AI, Zukow W, Kovbasnyuk MM, Korolyshyn TA. Interrelations between changes in parameters of HRV, EEG and phagocytosis at patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2018; 8(2): 135-156.
Popovych IL, Gozhenko AI, Korda MM, Klishch IM, Popovych DV, Zukow W (editors). Mineral Waters, Metabolism, Neuro-Endocrine-Immune Complex. Odesa. Feniks; 2022: 252.
Serven AL. Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens. FEMS Microbiology Reviews. 2004; 28: 405-440.
Shestopalov VM, Moiseeva NP, Ishchenko AP, Kondratiuk YeI, Usov VYu, Moiseev AYu, et al. “Naftusia” Medicinal Waters of Ukrainian Carpathians and Podolia [in Russian]. Chernivtsi. Bukrek; 2013: 600.
Sydoruk NO, Chebanenko OI, Zukow VA, Popovych IL. A Comparative Study of the Physiological Activity of Naftusya Water of the Truskavetsian and Pomirets’ky deposits [in Ukrainian]. Kyїv. UNESCO-SOCIO; 2018: 176.
Truskavetsian mineral waters and methods of their internal use. Guidelines. Truskavets’; 1998: 39.
Yaremenko МS, Ivassivka SV, Popovych IL, Bilas VR, Yassevych HP, Zahorodnyuk VP et al. Physiological Bases of Curative Effect of Water Naftussya [in Russian]. Kyїv. Naukova dumka; 1989: 144.
Yessypenko BYe. Physiological Action of “Naftussya” Mineral Water [in Russian]. Kyїv. Naukova dumka; 1981: 216.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Andriy Popovych, Dariya Popovych, Sofiya Ruzhylo, Nataliya Zakalyak, Xawery Zukow, Yevstakhii Shypytiak, Vitalij Fil
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 308
Number of citations: 0