Diabetics suffer in silence – about sexual dysfunction and modern therapeutic possibilities in diabetes mellitus
DOI:
https://doi.org/10.12775/JEHS.2023.20.01.006Keywords
diabetes mellitus, sexual dysfunctions, erectile dysfunctions, premature ejaculation, treatment, risk factors, inhibitors PDE-5, sildenafil, voasoacvite substances, prostaglandines, alprostadil, diabetic neuropathy, diabetic vasculopathy, complications of diabetesAbstract
Introduction
Nowadays, the global incidence of diabetes is on the rise, indicating a growing medical concern due to the persistent increase in cases. This disease is insidious and silent. Despite its long-term asymptomatic course, it secretly damages many organs, leading to distant and often irreversible complications. Early diagnosis of asymptomatic patients with risk factors, the use of screening tests, as well as appropriate control of the disease can significantly delay the process of developing complications; ensuring a longer and better quality of life for patients. A seriously problematic, but rarely discussed, disorder, experienced by some within the male patient group, is erectile dysfunction. Understanding the pathophysiology and the mechanism responsible for this disorder enables early prevention and taking appropriate steps, implementing effective therapy; thus – enhancing and prolonging sexual function and enhancing quality of life of patients with diabetes.
Purpose of the work
This article reviews the state of knowledge based on available research on sexual dysfunction in men with diabetes. The purpose of this review is to present the general issues, pathophysiology, risk factors and contemporary therapeutic options for sexual dysfunction disorders in this group of patients.
Materials and methods
The authors based on databases such as PubMed, Scopus anf Google Scholar, created a work summarizing review of currently available publications on the issue of erectile dysfunction in patients with diabetes mellitus. The authors using the terms contained in the „keywords” column, searched for available information contained in other scientific works, on the basis of which they created the above review.
References
Maria G Tinajero Vasanti S Malik, An Update on the Epidemiology o f Type 2 Diabetes: A Global Perspective, Endocrinol Metab Clin North Am. 2021 Sep;50(3):337-355, DOI: 10.1016/j.ecl.2021.05.013
Anne M. Schmidt, Highlighting Diabetes Mellitus: The Epidemic Continues, Arterioscler Thromb Vasc Biol. 2018 Jan;38(1): e1-e8. DOI: 10.1161/ATVBAHA.117.310221
Dragan Lovic, Alexia Piperidou, Ioanna Zografou, Haralambos Grassos, Andreas Pittaras, Athanasios Manolis, The Growing Epidemic of Diabetes Mellitus, Curr Vasc Pharmacol. 2020;18(2):104-109, DOI: 10.2174/1570161117666190405165911
Lasantha S. Malavige and Jonathan C. Levy, Erectile Dysfunction in Diabetes Mellitus, J Sex Med. 2009 May;6(5):1232-47, DOI: 10.1111/j.1743-6109.2008.01168.x
Zhou B, Lu Y, Hajifathalian K, et al. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants. Lancet 2016; 387: 1513-30, DOI: 10.1016/S0140-6736(16)00618-8
S. C. Siu, S. K. Lo, K. W. Wong, K. M. Ip and Y. S. Wong, Prevalence of and risk factors for erectile dysfunction in Hong Kong diabetic patients, Diabet Med. 2001 Sep;18(9):732-8. DOI:10.1046/j.0742-3071.2001.00557.x
Gretchen M. Irwin, Erectile Dysfunction, MD, MBA, Prim Care. 2019 Jun;46(2):249-255, DOI:10.1016/j.pop.2019.02.006
Virendra N. Sehgal, Erectile Dysfunctions, Govind Srivastava, Skinmed. 2003 Nov-Dec;2(6):350-6 DOI:10.1111/j.1540-9740.2003.01950.x
Paola Caruso, Paolo Cirillo, Carla Carbone, Annalisa Sarnataro, Maria Ida Maiorino, Giuseppe Bellastella, Katherine Esposito, Sexual dysfunctions and short-term glucose variability in young men with type 1 diabetes, Hormones. 2021 Sep;20(3):475-482 DOI:0.1007/s42000-021-00295-1
Bobby B Najari, James A Kashanian, Erectile Dysfunction, JAMA. 2016 Nov 1;316(17):1838., DOI: 10.1001/jama.2016.12284
Adel Al-Hunayan, Manal Al-Mutar, Elijah O. Kehinde, Lukman Thalib and Mounir Al-Ghorory, The prevalence and predictors of erectile dysfunction in men with newly diagnosed with type 2 diabetes mellitus, BJU Int. 2007 Jan;99(1):130-4. DOI: 10.1111/j.1464-410X.2006.06550.x
HA Feldman, I Goldstein, D G Hatzichristou, R J Krane, J B McKinlay, Impotence and its medical and psychosocial correlates: results of the Massachusetts, J Urol. 1994, Jan;151(1):54-61, DOI: 10.1016/s0022-5347(17)34871-1
L.W. Yu, A.P.Kong, P.C.Tong, C. Tam, G. T. Ko, C-S Ho, W-Y So, R. C. Ma, C-C Chow, J C. Chan, Evaluation of erectile dysfunction and associated cardiovascular risk using structured questionnaires in Chinese type 2 diabetic men, Int J Androl. 2010 Dec;33(6):853-60, DOI: 10.1111/j.1365-2605.2009.01026.x
Anders A. F. Sima, Pathological Definition and Evaluation of Diabetic Neuropathy and Clinical Correlations, DOI: 10.1017/s0317167100040695
A. A. Sima, S. A. Lattimer, S. Yagihashi, D. A. Greene, Axo-glial dysjunction. A novel structural lesion that accounts for poorly reversible slowing of nerve conduction in the spontaneously diabetic bio-breeding rat, DOI: 10.1172/JCI112326
Soroku Yagihashi, Shin-Ichiro Yamagishi, Ryuichi Wada, Pathology and pathogenetic mechanisms of diabetic neuropathy: correlation with clinical signs and symptoms, Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S184-9, DOI: 10.1016/j.diabres.2007.01.054
Saikat Dewanjeea, Sonjit Dasa, Anup Kumar Dasb, Niloy Bhattacharjeea, Anjum Dihingiac, Tarun K. Duaa, Jatin Kalitac, Prasenjit Manna, Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets, Eur J Pharmacol. 2018 Aug 15;833:472-523, DOI: 10.1016/j.ejphar.2018.06.034
Aaron I. Vinik, Marie-Laure Nevoret, Carolina Casellini, Henri Parson, Diabetic Neuropathy, Endocrinol Metab Clin North Am. 2013 Dec;42(4):747-87, DOI: 10.1016/j.ecl.2013.06.001
Michael Halim, Alice Halim, The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes), Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1165-1172, DOI: 10.1016/j.dsx.2019.01.040
Lawrence S. Hakim, and Irwin Goldstein, Diabetic sexual dysfunction, Endocrinol Metab Clin North Am. 1996 Jun;25(2):379-400, DOI:10.1016/s0889-8529(05)70329-7
Ansu Basu and Robert E.J. Ryde, New Treatment Options for Erectile Dysfunction in Patients with Diabetes Mellitus, Drugs; 64(23):2667-88, DOI: 10.2165/00003495-200464230-00004
A. J. Boulton, J. L. Selam, M. Sweeney, D. Ziegler, Sildenafil citrate for the treatment of erectile dysfunction in men with Type II diabetes mellitus, Diabetologia. 200 Oct; 44(10):1296-301, DOI: 10.1007/s001250100656
Sivaprakasam Sivalingam, Hashim Hashim and Hartwig Schwaibold , An Overview of the Diagnosis and Treatment of Erectile Dysfunction, Drugs. 2006;66(18):2339-55, DOI: 10.2165/00003495-200666180-00006
Konstantinos Hatzimouratidis & Dimitrios Hatzichristou, How to treat erectile dysfunction in men with diabetes: from pathophysiology to treatment, Curr Diab Rep. 2014;14(11):545, DOI: 10.1007/s11892-014-0545-6
A. Schafer, D. Fraccarollo, S. Pfortsch, U. Flierl, C.Vogt, J. Pfrang, A. Kobsar, T.Renne, M.Eigenthaler, G.Ertl and J.Bauersachs, Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitus, Br J Pharmacol. 2008 Mar;153(5):886-93, DOI: 10.1038/sj.bjp.0707459
Utku Kirilmaz Ozer Guzel, Yilmaz Aslan, Melih Balci, Altug Tuncel, Ali Atan, The effect of lifestyle modification and glycemic control on the efficiency of sildenafil citrate in patients with erectile dysfunction due to type-2 diabetes mellitus, Aging Male. 2015;18(4):244-8, DOI: 10.3109/13685538.2015.1072154
Antonio Aversa, Roberto Bruzziches, Cristiana Vitale, Giuseppe Marazzi, Davide Francomano, Giuseppe Barbaro, Giovanni Spera & Giuseppe MC Rosano, Chronic sildenafil in men with diabetes and erectile dysfunction, Expert Opin Drug Metab Toxicol. 2007 Jun;3(3):451-64, DOI: 10.1517/17425255.3.3.451
Yoram Vardi, Boaz Appel, Yaron Ofer, Ilan Greunwald, Lior Dayan, Giris Jacob, Effect of Chronic Sildenafil Treatment on Penile Endothelial Function: A Randomized, Double-Blind,Placebo Controlled Study, J Urol. 2009 Dec;182(6):2850-5 DOI: 10.1016/j.juro.2009.08.025
Fatih Can Karaca, Tuncay Taş, Early Effect of Metabolic Surgery on Erectile Function and Ejaculation: a Pilot Study of Obese Men with Type 2 Diabetes Mellitus, Obes Surg. 2020 Dec;30(12):4768-4773, DOI: 10.1007/s11695-020-04879-5
Abul Kalam Azad, Sumudu Setunge, Shahjada Selim, Shahabul Huda Chowdhury, Mohammad Ferdousur Rahaman, Md Abdul Jalil Chowdhury, Barbora de Courten, Dragan Ilic, Md Nazmul Karim, Dyslipidaemia as a risk factor for erectile dysfunction in type 2 diabetes mellitus patients, Diabetes Metab Syndr. 2019 Jan-Feb;13(1):748-75, DOI: 10.1016/j.dsx.2018.11.052
Giuseppe Defeudis, Alfonso Maria Di Tommaso, Claudia Di Rosa, Danilo Cimadomo, Yeganeh Manon Khazrai, Antongiulio Faggiano, Raffaele Ivan Cincione, Nicola Napoli, and Rossella Mazzilli, The Role of Antihyperglycemic Drugs and Diet on Erectile Function: Results from a Perspective Study on a Population with Prediabetes and Diabetes, J Clin Med. 2022 Jun 13;11(12):338, DOI: 10.3390/jcm11123382
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Karolina Madej, Paulina Krawiec, Izabela Wolanin, Bartłomiej Zielonka, Ilona Kowalczyk, Bartłomiej Stachyra, Marta Wolanin, Cezary Stawikowski, Barbara Dengler, Aleksandra Osińska
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 539
Number of citations: 0