Gut microbiota disorders in obesity and colorectal cancer
DOI:
https://doi.org/10.12775/JEHS.2023.20.01.004Keywords
obesity, colorectal cancer, gut microbiome, short-chain fatty acids, Trimethylamine N-oxideAbstract
Obesity and related diseases such as colorectal cancer are an important clinical problem in highly developed countries. In this article, the relationship between the occurrence of these diseases and the gut microbiome is presented on the basis of scientific research. The gut microbiome increases the energy value of consumed meals by breaking down to simpler substances not digested by human enzymes, and is involved in the regulation of lipid and glucose metabolism in the body. A proper microbiota influences the formation of SCFAs, or short-chain fatty acids, which have a protective effect on intestinal cells. Intestinal dysbiosis affects endotoxaemia and inflammation, which accompanies cancer and obesity.
References
Peterson J, Garges S, Giovanni M i inni. The NIH Human Microbiome Project. 2009; 19: 2317- 23.
Vitetta L, Vitetta G, Hall S. Immunological Tolerance and Function: Associations Between Intestinal Bacteria, Probiotics, Prebiotics, and Phages. Front Immunol. 2018 Oct 9;9:2240. doi: 10.3389/fimmu.2018.02240. PMID: 30356736; PMCID: PMC6189397.
Halverson T, Alagiakrishnan K. Gut microbes in neurocognitive and mental health disorders. Ann Med. 2020 Dec;52(8):423-443. doi: 10.1080/07853890.2020.1808239. Epub 2020 Aug 31. PMID: 32772900; PMCID: PMC7877977.
Bunyavanich S, Berin MC. Food allergy and the microbiome: Current understandings and future directions. J Allergy Clin Immunol. 2019 Dec;144(6):1468-1477. doi: 10.1016/j.jaci.2019.10.019. PMID: 31812181; PMCID: PMC6905201
Ley R.E., Turnbaugh P.J., Klein S., Gordon J.I. Microbial ecology: human gut microbes associated with obesity. Nature 2006; 444: 1022–1023
O'Keefe SJ. Diet, microorganisms and their metabolites, and colon cancer. Nat Rev Gastroenterol Hepatol. 2016 Dec;13(12):691-706. doi: 10.1038/nrgastro.2016.165. Epub 2016 Nov 16. PMID: 27848961; PMCID: PMC6312102.
Odsetek osób w wieku powyżej 15 lat według indeksu masy ciała (BMI), 2019r Dane GUS https://stat.gov.pl/obszary-tematyczne/zdrowie/zdrowie/odsetek-osob-w-wieku-powyzej-15-lat-wedlug-indeksu-masy-ciala-bmi,23,1.html
Uranga RM, Keller JN. The Complex Interactions Between Obesity, Metabolism and the Brain. Front Neurosci. 2019 May 24;13:513. doi: 10.3389/fnins.2019.00513. PMID: 31178685; PMCID: PMC6542999.
https://www.who.int/health-topics/obesity
Peeters A, Barendregt JJ, Willekens F, Mackenbach JP, Al Mamun A, Bonneux L et al. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann Intern Med. 2003;138(1):24–32. doi: 10.7326/0003-4819-138-1-200301070-00008.
Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010 Mar;67(3):220-9. doi: 10.1001/archgenpsychiatry.2010.2. PMID: 20194822.
Lauby-Secretan, B., Scoccianti, C., Loomis, D., Grosse, Y., Bianchini, F., & Straif, K. (2016). Body Fatness and Cancer — Viewpoint of the IARC Working Group. New England Journal of Medicine, 375(8), 794–798. doi:10.1056/nejmsr1606602
Calle, E. E., & Kaaks, R. (2004). Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nature Reviews Cancer, 4(8), 579–591. doi:10.1038/nrc1408
Ma Y, Yang Y, Wang F, Zhang P, Shi C, Zou Y, Qin H. Obesity and risk of colorectal cancer: a systematic review of prospective studies. PLoS One. 2013;8(1):e53916. doi: 10.1371/journal.pone.0053916. Epub 2013 Jan 17. PMID: 23349764; PMCID: PMC3547959.
Steele CB, Thomas CC, Henley SJ, et al. Vital Signs: Trends in Incidence of Cancers Associated with Overweight and Obesity — United States, 2005–2014. MMWR Morb Mortal Wkly Rep 2017;66:1052–1058. DOI: http://dx.doi.org/10.15585/mmwr.mm6639e1
Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, Knight R. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11971-5. doi: 10.1073/pnas.1002601107. Epub 2010 Jun 21. PMID: 20566857; PMCID: PMC2900693.
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., … Ventura, M. (2017). The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota. Microbiology and Molecular Biology Reviews, 81(4). doi:10.1128/mmbr.00036-17
Arrieta MC, Stiemsma LT, Amenyogbe N, Brown EM, Finlay B. The intestinal microbiome in early life: health and disease. Front Immunol. 2014 Sep 5;5:427. doi: 10.3389/fimmu.2014.00427. PMID: 25250028; PMCID: PMC4155789.
Adlerberth, I., & Wold, A. (2009). Establishment of the gut microbiota in Western infants. Acta Paediatrica, 98(2), 229–238. doi:10.1111/j.1651-2227.2008.01060.x
Sanduzzi Zamparelli M, Compare D, Coccoli P, Rocco A, Nardone OM, Marrone G, Gasbarrini A, Grieco A, Nardone G, Miele L. The Metabolic Role of Gut Microbiota in the Development of Nonalcoholic Fatty Liver Disease and Cardiovascular Disease. Int J Mol Sci. 2016 Jul 29;17(8):1225. doi: 10.3390/ijms17081225. PMID: 27483246; PMCID: PMC5000623.
Hu J, Guo P, Mao R, Ren Z, Wen J, Yang Q, Yan T, Yu J, Zhang T, Liu Y. Gut Microbiota Signature of Obese Adults Across Different Classifications. Diabetes Metab Syndr Obes. 2022 Dec 29;15:3933-3947. doi: 10.2147/DMSO.S387523. PMID: 36601354; PMCID: PMC9807070.
Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11070-5. doi: 10.1073/pnas.0504978102. Epub 2005 Jul 20. PMID: 16033867; PMCID: PMC1176910.
Harris K, Kassis A, Major G, Chou CJ. Is the gut microbiota a new factor contributing to obesity and its metabolic disorders? J Obes. 2012;2012:879151. doi: 10.1155/2012/879151. Epub 2012 Jan 24. Erratum in: J Obes. 2012;2012:782920. PMID: 22315672; PMCID: PMC3270440.
De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, Collini S, Pieraccini G, Lionetti P. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14691-6. doi: 10.1073/pnas.1005963107. Epub 2010 Aug 2. PMID: 20679230; PMCID: PMC2930426.
Pinart M, Dötsch A, Schlicht K, Laudes M, Bouwman J, Forslund SK, Pischon T, Nimptsch K. Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis. Nutrients. 2021 Dec 21;14(1):12. doi: 10.3390/nu14010012. PMID: 35010887; PMCID: PMC8746372.
Duncan, S., Lobley, G., Holtrop, G. et al. Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes 32, 1720–1724 (2008). https://doi.org/10.1038/ijo.2008.155
Ley, Ruth E. Obesity and the human microbiome. Current Opinion in Gastroenterology 26(1):p 5-11, January 2010. | DOI: 10.1097/MOG.0b013e328333d751
Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23. doi: 10.1073/pnas.0407076101. Epub 2004 Oct 25. PMID: 15505215; PMCID: PMC524219
Grover M, Kashyap PC. Germ-free mice as a model to study effect of gut microbiota on host physiology. Neurogastroenterol Motil. 2014 Jun;26(6):745-8. doi: 10.1111/nmo.12366. PMID: 24860967; PMCID: PMC4083815.
Szponar, Czajkowska Short chain fatty acids (SCFA), the products of gut bacteria metabolism and their role in the host 2018, Postepy Hig Med Dosw 2018; 72 : 131-142, doi: 10.5604/01.3001.0011.6468, GICID: 01.3001.0011.6468
Kristina Harris, Amira Kassis, Geneviève Major, Chieh J. Chou, "Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders?", Journal of Obesity, vol. 2012, Article ID 879151, 14 pages, 2012. https://doi.org/10.1155/2012/879151
Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):979-84. doi: 10.1073/pnas.0605374104. Epub 2007 Jan 8. PMID: 17210919; PMCID: PMC1764762.
Lin SC, Hardie DG. AMPK: Sensing Glucose as well as Cellular Energy Status. Cell Metab. 2018 Feb 6;27(2):299-313. doi: 10.1016/j.cmet.2017.10.009. Epub 2017 Nov 16. PMID: 29153408.
Jeon SM. Regulation and function of AMPK in physiology and diseases. Exp Mol Med. 2016 Jul 15;48(7):e245. doi: 10.1038/emm.2016.81. PMID: 27416781; PMCID: PMC4973318.
Stappenbeck TS, Hooper LV, Gordon JI. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15451-5. doi: 10.1073/pnas.202604299. Epub 2002 Nov 13. PMID: 12432102; PMCID: PMC137737.
Bayer F, Ascher S, Pontarollo G, Reinhardt C. Antibiotic Treatment Protocols and Germ-Free Mouse Models in Vascular Research. Front Immunol. 2019 Sep 12;10:2174. doi: 10.3389/fimmu.2019.02174. PMID: 31572384; PMCID: PMC6751252.
Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults. JAMA. 1999 Dec 8;282(22):2131-5. doi: 10.1001/jama.282.22.2131. PMID: 10591334.
Kemalasari I, Fitri NA, Sinto R, Tahapary DL, Harbuwono DS. Effect of calorie restriction diet on levels of C reactive protein (CRP) in obesity: A systematic review and meta-analysis of randomized controlled trials. Diabetes Metab Syndr. 2022 Mar;16(3):102388. doi: 10.1016/j.dsx.2022.102388. Epub 2022 Jan 5. PMID: 35219261
Węgrzyn D, Adamek K, Łoniewska B. Structure of the intestinal barrier. Pomeranian J Life Sci. 2017; 63(3): 6–9.
Pendyala, S., J.M. Walker, and P.R. Holt, A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology, 2012. 142(5): p. 1100–1101.e2
Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007 Jul;56(7):1761-72. doi: 10.2337/db06-1491. Epub 2007 Apr 24. PMID: 17456850.
Martínez I, Wallace G, Zhang C, Legge R, Benson AK, Carr TP, Moriyama EN, Walter J. Diet-induced metabolic improvements in a hamster model of hypercholesterolemia are strongly linked to alterations of the gut microbiota. Appl Environ Microbiol. 2009 Jun;75(12):4175-84. doi: 10.1128/AEM.00380-09. Epub 2009 May 1. PMID: 19411417; PMCID: PMC2698331.
Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ. Mechanisms of NAFLD development and therapeutic strategies. Nat Med. 2018 Jul;24(7):908-922. doi: 10.1038/s41591-018-0104-9. Epub 2018 Jul 2. PMID: 29967350; PMCID: PMC6553468.
Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, Rothwell A, Fearnside J, Tatoud R, Blanc V, Lindon JC, Mitchell SC, Holmes E, McCarthy MI, Scott J, Gauguier D, Nicholson JK. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12511-6. doi: 10.1073/pnas.0601056103. Epub 2006 Aug 8. PMID: 16895997; PMCID: PMC1567909.
Vrieze A, Van Nood E, Holleman F, Salojärvi J, Kootte RS, Bartelsman JF, Dallinga-Thie GM, Ackermans MT, Serlie MJ, Oozeer R, Derrien M, Druesne A, Van Hylckama Vlieg JE, Bloks VW, Groen AK, Heilig HG, Zoetendal EG, Stroes ES, de Vos WM, Hoekstra JB, Nieuwdorp M. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012 Oct;143(4):913-6.e7. doi: 10.1053/j.gastro.2012.06.031. Epub 2012 Jun 20. Erratum in: Gastroenterology. 2013 Jan;144(1):250. PMID: 22728514.
Sowah SA, Milanese A, Schübel R, Wirbel J, Kartal E, Johnson TS, Hirche F, Grafetstätter M, Nonnenmacher T, Kirsten R, López-Nogueroles M, Lahoz A, Schwarz KV, Okun JG, Ulrich CM, Nattenmüller J, von Eckardstein A, Müller D, Stangl GI, Kaaks R, Kühn T, Zeller G. Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial. Genome Med. 2022 Mar 14;14(1):30. doi: 10.1186/s13073-022-01030-0. PMID: 35287713; PMCID: PMC8919571.
Leong KSW, Jayasinghe TN, Wilson BC, Derraik JGB, Albert BB, Chiavaroli V, Svirskis DM, Beck KL, Conlon CA, Jiang Y, Schierding W, Vatanen T, Holland DJ, O'Sullivan JM, Cutfield WS. Effects of Fecal Microbiome Transfer in Adolescents With Obesity: The Gut Bugs Randomized Controlled Trial. JAMA Netw Open. 2020 Dec 1;3(12):e2030415. doi: 10.1001/jamanetworkopen.2020.30415. PMID: 33346848; PMCID: PMC7753902.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12. Erratum in: CA Cancer J Clin. 2020 Jul;70(4):313. PMID: 30207593.
Giovannucci E. Modifiable risk factors for colon cancer. Gastroenterol Clin North Am. 2002 Dec;31(4):925-43. doi: 10.1016/s0889-8553(02)00057-2. PMID: 12489270
Tilg H, Adolph TE, Gerner RR, Moschen AR. The Intestinal Microbiota in Colorectal Cancer. Cancer Cell. 2018 Jun 11;33(6):954-964. doi: 10.1016/j.ccell.2018.03.004. Epub 2018 Apr 12. PMID: 29657127.
Tarallo S, Ferrero G, Gallo G, Francavilla A, Clerico G, Realis Luc A, Manghi P, Thomas AM, Vineis P, Segata N, Pardini B, Naccarati A, Cordero F. Altered Fecal Small RNA Profiles in Colorectal Cancer Reflect Gut Microbiome Composition in Stool Samples. mSystems. 2019 Sep 17;4(5):e00289-19. doi: 10.1128/mSystems.00289-19. Erratum in: mSystems. 2020 Feb 18;5(1): PMID: 31530647; PMCID: PMC6749105.
Dahm CC, Keogh RH, Spencer EA, Greenwood DC, Key TJ, Fentiman IS, Shipley MJ, Brunner EJ, Cade JE, Burley VJ, Mishra G, Stephen AM, Kuh D, White IR, Luben R, Lentjes MA, Khaw KT, Rodwell Bingham SA. Dietary fiber and colorectal cancer risk: a nested case-control study using food diaries. J Natl Cancer Inst. 2010 May 5;102(9):614-26. doi: 10.1093/jnci/djq092. Epub 2010 Apr 20. Erratum in: J Natl Cancer Inst. 2011 Oct 5;103(19):1484. PMID: 20407088.
Sánchez-Alcoholado L, Ordóñez R, Otero A, Plaza-Andrade I, Laborda-Illanes A, Medina JA, Ramos-Molina B, Gómez-Millán J, Queipo-Ortuño MI. Gut Microbiota-Mediated Inflammation and Gut Permeability in Patients with Obesity and Colorectal Cancer. Int J Mol Sci. 2020 Sep 16;21(18):6782. doi: 10.3390/ijms21186782. PMID: 32947866; PMCID: PMC7555154.
Velázquez OC, Lederer HM, Rombeau JL. Butyrate and the colonocyte. Implications for neoplasia. Dig Dis Sci. 1996 Apr;41(4):727-39. doi: 10.1007/BF02213129. PMID: 8674394.
Hague A, Manning AM, Hanlon KA, Huschtscha LI, Hart D, Paraskeva C. Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. Int J Cancer. 1993 Sep 30;55(3):498-505. doi: 10.1002/ijc.2910550329. PMID: 8397167.
Boursi B, Werner TJ, Gholami S, Houshmand S, Mamtani R, Lewis JD, Wu GD, Alavi A, Yang YX. Functional imaging of the interaction between gut microbiota and the human host: A proof-of-concept clinical study evaluating novel use for 18F-FDG PET-CT. PLoS One. 2018 Feb 15;13(2):e0192747. doi: 10.1371/journal.pone.0192747. PMID: 29447210; PMCID: PMC5813966.
Hong J, Guo F, Lu SY, Shen C, Ma D, Zhang X, Xie Y, Yan T, Yu T, Sun T, Qian Y, Zhong M, Chen J, Peng Y, Wang C, Zhou X, Liu J, Liu Q, Ma X, Chen YX, Chen H, Fang JY. F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer. Gut. 2021 Nov;70(11):2123-2137. doi: 10.1136/gutjnl-2020-322780. Epub 2020 Dec 14. PMID: 33318144.
Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, Lee JR, Offermanns S, Ganapathy V. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9. PMID: 24412617; PMCID: PMC4305274.
Vinolo MA, Rodrigues HG, Hatanaka E, Sato FT, Sampaio SC, Curi R. Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils. J Nutr Biochem. 2011 Sep;22(9):849-55. doi: 10.1016/j.jnutbio.2010.07.009. Epub 2010 Dec 16. PMID: 21167700.
Bae S, Ulrich CM, Neuhouser ML, Malysheva O, Bailey LB, Xiao L, Brown EC, Cushing-Haugen KL, Zheng Y, Cheng TY, Miller JW, Green R, Lane DS, Beresford SA, Caudill MA. Plasma choline metabolites and colorectal cancer risk in the Women's Health Initiative Observational Study. Cancer Res. 2014 Dec 15;74(24):7442-52. doi: 10.1158/0008-5472.CAN-14-1835. Epub 2014 Oct 21. PMID: 25336191; PMCID: PMC4268282.
Li D, Lu Y, Yuan S, Cai X, He Y, Chen J, Wu Q, He D, Fang A, Bo Y, Song P, Bogaert D, Tsilidis K, Larsson SC, Yu H, Zhu H, Theodoratou E, Zhu Y, Li X. Gut microbiota-derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis. Am J Clin Nutr. 2022 Jul 6;116(1):230-243. doi: 10.1093/ajcn/nqac074. PMID: 35348578; PMCID: PMC9257469.
Yang S, Dai H, Lu Y, Li R, Gao C, Pan S. Trimethylamine N-Oxide Promotes Cell Proliferation and Angiogenesis in Colorectal Cancer. J Immunol Res. 2022 Jul 4;2022:7043856. doi: 10.1155/2022/7043856. PMID: 35832644; PMCID: PMC9273394.
van Vliet MJ, Harmsen HJ, de Bont ES, Tissing WJ. The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis. PLoS Pathog. 2010 May 27;6(5):e1000879. doi: 10.1371/journal.ppat.1000879. PMID: 20523891; PMCID: PMC2877735.
Li W, Deng Y, Chu Q, Zhang P. Gut microbiome and cancer immunotherapy. Cancer Lett. 2019 Apr 10;447:41-47. doi: 10.1016/j.canlet.2019.01.015. Epub 2019 Jan 23. PMID: 30684593.
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