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Journal of Education, Health and Sport

What do we know about the connection between gut microbiota and pain?
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What do we know about the connection between gut microbiota and pain?

Authors

  • Mateusz Lewandowski University Clinical Center Of Warsaw Medical University https://orcid.org/0000-0002-4968-1770
  • Nikola Siekierko Szpital Praski p.w. Przemienienia Pańskiego, Aleja Solidarności 67, 03-401 Warsaw https://orcid.org/0000-0002-1113-7112
  • Jakub Świętochowski Uniwersyteckie Centrum Kliniczne w Gdańsku, ul. Dębinki 7, 80-952 Gdansk https://orcid.org/0000-0003-3848-6520
  • Wiktoria Kotusiewicz Wojskowy Instytut Medyczny- Państwowy Instytut Badawczy, ul. Szaserów 128, 04-141 Warsaw https://orcid.org/0000-0003-4033-0648
  • Maja Żołnierek Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. św. Jana Pawła II https://orcid.org/0000-0001-9030-7505
  • Zuzanna Lubczyńska Szpital Grochowski im. dr med. Rafała Masztaka, ul. Grenadierów 51/59, 04-073 Warsaw https://orcid.org/0000-0002-4860-2508
  • Grzegorz Bienia Wojskowy Instytut Medyczny- Państwowy Instytut Badawczy, ul. Szaserów 128, 04-141 Warsaw https://orcid.org/0000-0001-9036-5510
  • Yevheniia Popravko Szpital Praski p.w. Przemienienia Pańskiego, Aleja Solidarności 67, 03-401 Warsaw https://orcid.org/0000-0002-1164-1802
  • Jakub Przeradzki Department of Pediatric Gastroenterology and Nutrition, Medical University of Warsaw https://orcid.org/0009-0001-2941-6670
  • Jakub Kucharski Department of Pediatric Gastroenterology and Nutrition, Medical University of Warsaw https://orcid.org/0009-0002-2517-7243

DOI:

https://doi.org/10.12775/JEHS.2023.20.01.007

Keywords

gut microbiome, pain, hypothalamic-pituitary-adrenal axis, probiotic supplementation, inflammation, fecal microbial transplantation

Abstract

Introduction and objective 

 

The relationship between gut microbiota and pain is crucial. Several studies demonstrate the evidence that gut microbiota play a key role in visceral, neuropathic and inflammatory pain. The proper profile of microbiota is also important in patients after surgeries and injuries who suffer from postoperative pain. In the present review study we assessed a comprehensive range of relevant literature to present the role of gut microbiota as the key factor in maintaining the structural integrity of the intestinal mucosal barrier, pain perception and modulation of the immune system. 

 

Review methods 

 

We conducted a literature review in February, 2023 searching for terms “Gut microbiome and pain", “Probiotic supplementation”, “Fecal microbial transplantation in patients with pain”. This publication includes the analysis of several case reports, which describe patients who were successfully treated with modification of gut microbiota composition. 

 

Brief description of the state of knowledge 

 

The gut microbiota is a diversity of many different microorganisms. They inhabit our gut and are the key to many aspects of human health. To understand how important the gut microbiome is we have to be aware of a bidirectional connection between the gut and the brain. The gut microbiota has an impact on the nervous system via the microbiome-gut-brain axis and the hypothalamic-pituitary-adrenal axis.

 

Summary

 

We propose novel therapeutic methods like probiotics or prebiotics or fecal microbiota transplantation as the new strategy for the management of pain. To reach this goal we need more clinical evidence to implement our theoretical knowledge to clinical practice. 



References

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Published

2023-04-13

How to Cite

1.
LEWANDOWSKI, Mateusz, SIEKIERKO, Nikola, ŚWIĘTOCHOWSKI, Jakub, KOTUSIEWICZ, Wiktoria, ŻOŁNIEREK, Maja, LUBCZYŃSKA, Zuzanna, BIENIA, Grzegorz, POPRAVKO, Yevheniia, PRZERADZKI, Jakub and KUCHARSKI, Jakub. What do we know about the connection between gut microbiota and pain? . Journal of Education, Health and Sport. Online. 13 April 2023. Vol. 20, no. 1, pp. 62-68. [Accessed 9 July 2025]. DOI 10.12775/JEHS.2023.20.01.007.
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Vol. 20 No. 1 (2023)

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Copyright (c) 2023 Mateusz Lewandowski, Nikola Siekierko, Jakub Świętochowski, Wiktoria Kotusiewicz, Maja Żołnierek, Zuzanna Lubczyńska, Grzegorz Bienia, Yevheniia Popravko, Jakub Przeradzki, Jakub Kucharski

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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